RolandBWalterMDPhD MS

Hematology • Seattle, WA

Hematologic Oncology

Professor, Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center

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Office
1100 Fairview Ave N, D1-100
Seattle, WA 98109
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Education & Training

University of WashingtonFellowship, Hematology and Medical Oncology, 2005 - 2007
University of Zurich Faculty of MedicineClass of 1996

Certifications & Licensure

WA State Medical License 2006 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Clinical Trials

Vorinostat and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Start of enrollment: 2008 Mar 01
Terminated
Phase 2
Early Discharge and Outpatient Care After Chemotherapy in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Start of enrollment: 2008 Dec 01
Completed
Not Applicable
Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML Start of enrollment: 2009 May 01
Completed
Phase 1, Phase 2
Biomarker Study in Tissue Samples From Patients With Acute Myeloid Leukemia Start of enrollment: 2010 Oct 01
Completed
Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy Start of enrollment: 2010 Dec 01
Completed
Phase 2
Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Start of enrollment: 2011 Apr 01
Terminated
Phase 1, Phase 2
A Study of CSL362 in Patients With CD123+ Acute Myeloid Leukemia Currently in Remission Start of enrollment: 2012 Jul 01
Completed
Phase 1
Decitabine Followed by Mitoxantrone Hydrochloride, Etoposide, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Start of enrollment: 2012 Dec 20
Completed
Phase 1, Phase 2
Liposomal Cytarabine-Daunorubicin CPX-351 in Treating Patients With Untreated Myelodysplastic Syndrome or Acute Myeloid Leukemia Start of enrollment: 2013 May 07
Completed
Not Applicable
A Safety Study of SGN-CD33A in AML Patients Start of enrollment: 2013 Jul 01
Completed
Phase 1
Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Acute Myeloid Leukemia Start of enrollment: 2013 Oct 01
Terminated
Phase 2
Filgrastim, Cladribine, Cytarabine, and Mitoxantrone Hydrochloride in Treating Patients With Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Start of enrollment: 2014 Jan 23
Completed
Phase 1, Phase 2
Telemonitoring Device in Managing Outpatient Care of Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia After Intensive Chemotherapy Start of enrollment: 2015 Jan 09
Terminated
Not Applicable
Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm Start of enrollment: 2016 Dec 30
Completed
Phase 2
Gemtuzumab Ozogamicin With G-CSF, Cladribine, Cytarabine & Mitoxantrone for Untreated AML & High-Grade Myeloid Neoplasm Start of enrollment: 2018 Sep 14
Completed
Phase 1, Phase 2
CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients Start of enrollment: 2020 Mar 11
Recruiting
Phase 2
Allogeneic Engineered Hematopoietic Stem Cell Transplant (HCT) Lacking the CD33 Protein, and Post-HCT Treatment With Mylotarg, for Patients With CD33+ AML or MDS Start of enrollment: 2021 Dec 16
Recruiting
Phase 1, Phase 2
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Publications & Presentations

PubMed

CPX-351 Pharmacokinetics and Safety in Adults with Hematologic Malignancies and Renal Function Impairment: Phase 1 Trial.
Scott R Solomon, Bayard L Powell, Jamie Koprivnikar, Catherine Lai, Heather Male, Laura C Michaelis, Laura F Newell, David Sanford, Jack Jenkins, Amy Zelaya, Sheryl Co...> ;Cancers. 2024 Feb 24
Impact of socioeconomic disparities on outcomes in adults undergoing allogeneic hematopoietic cell transplantation for acute myeloid leukemia.
Daniel J Olivieri, Megan Othus, Corentin Orvain, Eduardo Rodríguez-Arbolí, Filippo Milano, Brenda M Sandmaier, Irum Khan, Chris Davis, Ryan S Basom, Frederick R Appelb...> ;Leukemia. 2024 Apr 1
Preclinical Characterization of the Anti-Leukemia Activity of the CD33/CD16a/NKG2D Immune-Modulating TriNKETCC-96191.
Margaret C Lunn-Halbert, George S Laszlo, Sarah Erraiss, Mark T Orr, Heidi K Jessup, Heather J Thomas, Henry Chan, Mahan A Jahromi, Jonathan Lloyd, Ann F Cheung, Grego...> ;Cancers. 2024 Feb 22
Relative prognostic value of flow cytometric measurable residual disease before allogeneic hematopoietic cell transplantation for adults with MDS/AML or AML.
Corentin Orvain, Naveed Ali, Megan Othus, Eduardo Rodríguez-Arbolí, Filippo Milano, Calvin M Le, Brenda M Sandmaier, Bart L Scott, Frederick R Appelbaum, Roland B Walter> ;American Journal of Hematology. 2024 May 1
Crenolanib and Intensive Chemotherapy in Adults With Newly Diagnosed FLT3-Mutated AML.
Vigil, C., Collins, R., Jain, V., Wang, E., Goldberg, A., Tallman, M., Walter, R., Karanes, C., Sandhu, K., Stone, R.> ;Journal of Clinical Oncology. 2024 Feb 7
Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts.
Jacob S Appelbaum, Andrew H Wei, Sumithra J Mandrekar, Ing S Tiong, Chong Chyn Chua, Tse-Chieh Teh, Chun Yew Fong, Stephen B Ting, Daniela Weber, Axel Benner, Hannah H...> ;Leukemia. 2024 Feb 1
Time independent factors that predict relapse in adults with acute myeloid leukemia.
Lim, J., Othus, M., Shaw, C., Russell, K., Estey, E., Halpern, A., Appelbaum, J., Hendrie, P., Walter, R., Percival, M.> ;Blood Cancer Journal. 2024 Jan 15
Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates.
Nicholas E Petty, Stefan Radtke, Emily Fields, Olivier Humbert, Mallory J Llewellyn, George S Laszlo, Haiying Zhu, Keith R Jerome, Roland B Walter, Hans-Peter Kiem> ;Molecular Therapy. Methods & Clinical Development. 2023 Dec 14
1 citations
Perspective on measurable residual disease testing in acute myeloid leukemia.
Roland B Walter> ;Leukemia. 2024 Jan 1
Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML.
Anna B Halpern, Eduardo Rodríguez-Arbolí, Megan Othus, Kelsey-Leigh A Garcia, Mary-Elizabeth M Percival, Ryan D Cassaday, Vivian G Oehler, Pamela S Becker, Jacob S App...> ;Blood Advances. 2023 Sep 12
3 citations
Measurable residual disease monitoring in patients with acute myeloid leukemia treated with lower-intensity therapy: Roadmap from an ELN-DAVID expert panel.
Farhad Ravandi, Jacqueline Cloos, Francesco Buccisano, Richard Dillon, Konstanze Döhner, Sylvie D Freeman, Christopher S Hourigan, Gerrit J Ossenkoppele, Gail J Roboz,...> ;American Journal of Hematology. 2023 Dec 1
3 citations
Standardising acute myeloid leukaemia classification systems: a perspective from a panel of international experts.
Shallis, R., Daver, N., Altman, J., Komrokji, R., Pollyea, D., Badar, T., Bewersdorf, J., Bhatt, V., de Botton, S., de la Fuente Burguera, A., Carraway, H., Desai, P.,...> ;The Lancet. Haematology. 2023 Sep 1
2 citations
Invasive fungal infections after CLAG-M/CLAG chemotherapy for acute myeloid leukemia and high-grade myeloid neoplasms.
Julian Lindsay, Carla S Walti, Anna B Halpern, Hu Xie, E Lisa Chung, Kelda G Schonhoff, Emily M Huebner, Guang-Shing Cheng, Louise E Kimball, Wendy M Leisenring, Matth...> ;Blood Advances. 2023 Jul 11
[At]astatine-based anti-CD22 radioimmunotherapy for B-cell malignancies.
George S Laszlo, Brenda M Sandmaier, Allie R Kehret, Johnnie J Orozco, Donald K Hamlin, Shannon L Dexter, Sheryl Y T Lim, Frances M Cole, Jenny Huo, D Scott Wilbur, Ro...> ;Leukemia & Lymphoma. 2023 May 11
2 citations
Association between Prior Cytotoxic Therapy, Antecedent Hematologic Disorder, and Outcome after Allogeneic Hematopoietic Cell Transplantation in Adult Acute Myeloid Le...
Corentin Orvain, Eduardo Rodríguez-Arbolí, Megan Othus, Brenda M Sandmaier, H Joachim Deeg, Frederick R Appelbaum, Roland B Walter> ;Cancers. 2023 Jan 5
2 citations
Comparison of reduced intensity and nonmyeloablative conditioning for adults with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation in fi...
Roland B Walter, Brenda M Sandmaier, Megan Othus, Corentin Orvain, Eduardo Rodríguez-Arbolí, Masumi U Oshima, Gary Schoch, Chris Davis, H Joachim Deeg, Rainer Storb> ;Bone Marrow Transplantation. 2023 Apr 1
1 citations
Time for Dynamic Assessment of Fitness in Acute Myeloid Leukemia.
Raffaele Palmieri, Luca Maurillo, Maria Ilaria Del Principe, Giovangiacinto Paterno, Roland Bruno Walter, Adriano Venditti, Francesco Buccisano> ;Cancers. 2022 Dec 26
A randomized phase II/III study of 'novel therapeutics' versus azacitidine in newly diagnosed patients with acute myeloid leukemia (AML), high-risk myelodysplastic syn...
Sarit Assouline, Laura C Michaelis, Megan Othus, Annette E Hay, Roland B Walter, Meagan A Jacoby, Mark A Schroeder, Geoffrey L Uy, Lisa Y Law, Faisal Cheema, Kendra L ...> ;Leukemia & Lymphoma. 2023 Feb 1
3 citations
Infectious complications after intensive chemotherapy with CLAG-M versus 7+3 for AML and other high-grade myeloid neoplasms.
Carla S Walti, Anna B Halpern, Hu Xie, Erika S Kiem, E Lisa Chung, Kelda G Schonhoff, Emily M Huebner, Colleen Delaney, Catherine Liu, Steven A Pergam, Guang-Shing Che...> ;Leukemia. 2023 Feb 1
18 citations
The present and future of measurable residual disease testing in acute myeloid leukemia.
James S Blachly, Roland B Walter, Christopher S Hourigan> ;Haematologica. 2022 Dec 1
3 citations
Effect of ECOG performance status on outcomes in patients with acute myeloid leukemia and other high-grade myeloid neoplasms.
Gabrielle Paras, Megan Othus, Kelda Schonhoff, Carole Shaw, Mohamed Sorror, Anna B Halpern, Jacob Appelbaum, Paul Hendrie, Roland B Walter, Elihu H Estey, Mary-Elizabe...> ;Leukemia. 2023 Jan 1
12 citations
North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need.
Naveen Pemmaraju, Hagop Kantarjian, Kendra Sweet, Eunice Wang, Jayastu Senapati, Nathaniel R Wilson, Marina Konopleva, Arthur E Frankel, Vikas Gupta, Ruben Mesa, Matth...> ;Blood. 2023 Feb 9
14 citations
Association of hematologic response and assay sensitivity on the prognostic impact of measurable residual disease in acute myeloid leukemia: a systematic review and me...
Nicholas J Short, Chenqi Fu, Donald A Berry, Roland B Walter, Sylvie D Freeman, Christopher S Hourigan, Xuelin Huang, Graciela Nogueras Gonzalez, Hyunsoo Hwang, Xinyue...> ;Leukemia. 2022 Dec 1
Early mortality risk with non-intensive acute myeloid leukemia (AML) therapies: analysis of 1336 patients from MRC/NCRI and SWOG.
Megan Othus, Ian Thomas, Xu Wang, Cono Ariti, Priyanka Mehta, Mia Sydenham, Robert K Hills, Alan K Burnett, Sucha Nand, Sarit Assouline, Laura C Michaelis, Harry P Erb...> ;Leukemia & Lymphoma. 2023 Jan 1
7 citations
Relationship Between Pretransplantation Nutritional Status and Outcome in Adults with Acute Myelogenous Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation.
Corentin Orvain, Mariia Byelykh, Megan Othus, Brenda M Sandmaier, Gary Schoch, Chris Davis, Frederick R Appelbaum, Roland B Walter> ;Transplantation and Cellular Therapy. 2022 Dec 1
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Journal Articles

Phase 1/2 Trial of Cladribine, High-Dose Cytarabine, Mitoxantrone, and G-CSF with Dose-Escalated Mitoxantrone for relapsed/refractory Acute Myeloid Leukemia or Other H...
Kelda M Gardner, Vivian G Oehler, Heather A Smith, Anna B Halpern, Paul C Hendrie, Sarah A Buckley, Roland B Walter, Pamela S Becker, Ryan D Cassaday, Asma Anwar, Bart..., Haematologica
Second Cycle Remission Achievement with 7+3 and Survival in Adults with Newly Diagnosed Acute Myeloid Leukemia: Analysis of Recent SWOG Trials
Brent L Wood, Roland B Walter, John E Godwin, James K Weick, Elihu H Estey, Derek L Stirewalt, Frederick R Appelbaum, Nature
Relationship Between CD33 Expression, Splicing Polymorphism, and in Vitro Cytotoxicity of Gemtuzumab Ozogamicin and the CD33/CD3 BiTErAMG 330
Colin D Godwin, Roland B Walter, Haematologica
A Phase 1 Trial of Vadastuximab Talirine Combined with Hypomethylating Agents in Patients with CD33 Positive AML
Eytan M Stein, Anand Jillella, Anthony S Stein, Amir T Fathi, Roland B Walter, Jeffrey E Lancet, Tibor J Kovacsovics, Anjali S Advani, Phoenix A Ho, Dale Bixby, Blood
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Abstracts/Posters

Comparison of Acute Myeloid Leukemia Measurable Residual Disease Detection By Flow Cytometry in Peripheral Blood and Bone Marrow
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Younger Patients with Newly Diagnosed FLT3-Mutant AML Treated with Crenolanib Plus Chemotherapy Achieve Adequate Free Crenolanib Levels and Durable Remissions
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Frequency, and Effect on Survival, of Ineligibility for Clinical Trials in Newly Diagnosed Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Flotetuzumab, an Investigational CD123 x CD3 Bispecific Dart¬ Protein, in Salvage Therapy for Primary Refractory and Early Relapsed Acute Myeloid Leukemia (AML) Patients
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Comparison of Outcomes after Early Hospital Discharge (EHD) Following Intensive Induction Vs. Post-Remission Chemotherapy for Adults with Acute Myeloid Leukemia (AML) ...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Preliminary Results from a Phase 1 First-in-Human Study of AMG 673, a Novel Half-Life Extended (HLE) Anti-CD33/CD3 BiTE¬ (Bispecific T-Cell Engager) in Patients with R...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Accrual Barriers and Detection of Early Toxicity Signal in Older Less-Fit Patients Treated with Azacitidine and Nivolumab for Newly Diagnosed Acute Myeloid Leukemia (A...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
First in Human Study of SEL24/MEN1703, First in Class, Orally Available Dual PIM/FLT3 Kinase Inhibitor, in Patients with Acute Myeloid Leukemia
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Tolerability and Efficacy of Crenolanib and Cytarabine/Anthracycline Chemotherapy in Older Patients (Aged 61 to 75) with Newly Diagnosed FLT3-Mutated Acute Myeloid Leu...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Myelodysplastic Syndrome with Excess Blasts and Secondary Acute Myeloid Leukemia: Same Disease with Different Blast Count
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Treatment of Refractory Acute Myeloid Leukemia and High-Grade Myelodysplastic Syndrome: Implications of Further Care at an Academic Center Versus Community Setting
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Treatment Decision Making in AML: Factors of Importance to Clinicians, AML Patients and Their Family
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
A Multi-Omic Precision Medicine Clinical Trial in Acute Leukemia
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Anti-Apoptotic BCL-2 Family Members Confer Resistance to Calicheamicin-Based Antibody-Drug Conjugate Therapy of Acute Leukemia
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Phase 1 Trial of Cladribine, High-Dose Cytarabine, G-CSF, and Dose-Escalated Mitoxantrone (CLAG-M) Plus Gemtuzumab Ozogamicin in Adults with Newly-Diagnosed Acute Myel...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Mini- Vs. Regular-Dose CLAG-M (Cladribine, Cytarabine, G-CSF, and Mitoxantrone) in Medically Less Fit Adults with Newly-Diagnosed Acute Myeloid Leukemia (AML) and Othe...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Additional Cytotoxic Chemotherapy Is Unlikely to Eliminate Measurable Residual Acute Myeloid Leukemia (AML)
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
CRISPR/Cas9-Mediated Protection of Normal Hematopoiesis Combined with the CD33/CD3 Bispecific T-Cell Engager (BiTE) Antibody AMG330 for Improved AML Therapy
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Comparison of Outcomes after Early Hospital Discharge (EHD) Following Intensive Induction Vs. Post-Remission Chemotherapy for Adults with Acute Myeloid Leukemia (AML) ...
Roland B. Walter, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
COVA4231, a Potent CD3/CD33 Bispecific FynomAb with IgG-like Pharmacokinetics for the Treatment of Acute Myeloid Leukemia
Roland Walter, MD, Nature, Orlando, FL, 12/7/2019
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Lectures

Treating Acute Myeloid Leukemia: Case Challenges and Emerging Therapies
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
A Phase 1 First-in-Human Study of AMG 330, an Anti-CD33 Bispecific T-Cell Engager (BiTE®) Antibody Construct, in Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Addition of Crenolanib to Induction Chemotherapy Overcomes the Poor Prognostic Impact of Co- Occurring Driver Mutations in Patients with Newly Diagnosed FLT3-Mutated AML
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Predicting Induction Toxicity with 7+3: Analysis of SWOG Trial S1203
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Engineering Resistance to CD33-Targeted Immunotherapy in Normal Hematopoiesis By CRISPR/Cas9-Deletion of CD33 Exon 2
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Novel Therapies for AML: Expanding Future Options
60th American Society of Hematology Annual Meeting - 11/30/2018
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Press Mentions

MRD and Relapse in Patients with AMLAugust 17th, 2022
NCI Partners with Cancer Research UK, JADPRO Appoints Beth Faiman as Editor-in-Chief, and MoreOctober 1st, 2020
Shop TalkSeptember 5th, 2020
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Grant Support

Prognostic And Functional Significance Of Adhesion Molecules In Pediatric AMLNational Cancer Institute2012
Impact Of Genetic Variation On Response To GO Therapy In Cog-Aml Clinical TrialsNational Cancer Institute2012
AML Stem Cell Heterogeneity: Implications For Gemtuzumab Ozogomicin-Based TherapyNational Cancer Institute2009

Hospital Affiliations

UW Medicine/University of Washington Medical CenterSeattle, Washington
Fred Hutchinson Cancer CenterSeattle, Washington