RonFiresteinMD

PubMed

• ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.
  Evangeline R Jackson, Ryan J Duchatel, Dilana E Staudt, Mika L Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, W Samantha Nilanth...> ;Cancer Research. 2023 May 5
• 5 citations
  Development of T-cell engagers selective for cells co-expressing two antigens.
  Danielle M Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R Leong, Genee Lee, Shang-Fan Yu, Andrew G Polson, Nicholas J Agard> ;Mabs. 2022 Oct 7
• 3 citations
  Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.
  Wai Chin Chong, W. Samantha N. Jayasekara, Vijesh Vaghjiani, Sarah Parackal, Claire Sun, Dean Popovski, Elizabeth M. Algar, Ron Firestein, Paul Wood, Sara Khan, Annie ...> ;Cancers. 2021 Oct 14
• Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids
  Ron Firestein, Cezary Marcinkiewicz, Linyan Nie, Hui Kheng Chua, Ines Velazquez Quesada, Marco D. Torelli, Mark Sternberg, Bojana Gligorijevic, Olga Shenderova, Romana...> ;Nanotechnology, Science and Applications. 2021 Sep 7
• 22 citations
  Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer.
  Chunhua Wan, Sylvia Mahara, Claire Sun, Anh Doan, Hui Kheng Chua, Dakang Xu, Jia Bian, Yue Li, Danxi Zhu, Dhanya Sooraj, Tomasz Cierpicki, Jolanta Grembecka, Ron Fires...> ;Science Advances. 2021 May 1
• 137 citations
  Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
  Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu, Jiayi Ji, Anna Calinawan, Jeff...> ;Cell. 2020 Dec 23
• 114 citations
  Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer.
  Jia Bian, Marius Volker Dannappel, Chunhua Wan, Ron Firestein> ;Cells. 2020 Sep 19
• Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
  Sunil Bhakta, Lisa M Crocker, Yvonne Chen, Meredith Hazen, Melissa M Schutten, Dongwei Li, Coenraad Kuijl, Rachana Ohri, Fiona Zhong, Kirsten A Poon, Mary Ann T Go, Er...> ;Molecular Cancer Therapeutics. 2019 Nov 1
• 38 citations
  Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules.
  Marius Volker Dannappel, Dhanya Sooraj, Jia Jian Loh, Ron Firestein> ;Frontiers in Cell and Developmental Biology. 2019 Jan 14
• 52 citations
  Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
  Anneleen Daemen, Bonnie Liu, Kyung Song, Mandy Kwong, Min Gao, Rebecca Hong, Michelle Nannini, David A. Peterson, Bianca M. Liederer, Cecile de la Cruz, Dewakar Sangar...> ;Cell Metabolism. 2018 Sep 4
• 42 citations
  PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells
  Monika Raab, Mourad Sanhaji, Yves Matthess, Albrecht Hörlin, Ioana Lorenz, Christina Dötsch, Nils Habbe, Oliver Waidmann, Elisabeth Kurunci-Csacsko, Ron Firestein, Sve...> ;Nature Communications. 2018 Mar 16
• 4 citations
  An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
  Sunil Bhakta, Lisa M Crocker, Yvonne Chen, Meredith Hazen, Melissa M Schutten, Dongwei Li, Coenraad Kuijl, Rachana Ohri, Fiona Zhong, Kirsten A Poon, Mary Ann T Go, Er...> ;Molecular Cancer Therapeutics. 2018 Mar 1
• Targeting the seeds of small cell lung cancer
  Sylvia Mahara, Ron Firestein> ;Annals of Translational Medicine. 2017 Mar 1
• 28 citations
  Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET.
  Anton G.T. Terwisscha van Scheltinga, Annie Ogasawara, Glenn Pacheco, Alexander N. Vanderbilt, Jeff N. Tinianow, Nidhi Gupta, Dongwei Li, Ron Firestein, Jan Marik, Suz...> ;Molecular Cancer Therapeutics. 2017 Jan 1
• 63 citations
  Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pan...
  Joyce F. Liu, Kathleen N. Moore, Michael J. Birrer, Suzanne Berlin, Ursula A. Matulonis, J. R. Infante, Brian M. Wolpin, Kirsten Achilles Poon, Ron Firestein, J. Xu, R...> ;Annals of Oncology. 2016 Nov 1
• 157 citations
  Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
  Aaron Boudreau, Hans E. Purkey, Anna Hitz, Kirk Robarge, David Peterson, Sharada Labadie, Mandy Kwong, Rebecca Hong, Min Gao, Christopher Del Nagro, Raju V. Pusapati, ...> ;Nature Chemical Biology. 2016 Oct 1
• 22 citations
  ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1
  Simon-Peter Williams, Annie Ogasawara, Jeff N. Tinianow, Judith E. Flores, David Kan, Jeffrey Lau, Mary Ann Go, Alexander N. Vanderbilt, Herman Gill, Li Miao, Joshua G...> ;Oncotarget. 2016 May 3
• 39 citations
  Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8
  Philippe Bergeron, Michael F. T. Koehler, Elizabeth Blackwood, Krista K. Bowman, Kevin R Clark, Ron Firestein, James R. Kiefer, Klaus Maskos, Mark McCleland, Linda Orr...> ;ACS Medicinal Chemistry Letters. 2016 Apr 6
• 167 citations
  CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer
  Mark McCleland, Kathryn Mesh, Edward Lorenzana, Vivek S. Chopra, Ehud Segal, Colin K. Watanabe, Benjamin Haley, Oleg Mayba, Murat Yaylaoglu, Florian Gnad, Ron Firestein> ;The Journal of Clinical Investigation. 2016 Feb 1
• 64 citations
  Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.
  Michael F. T. Koehler, Philippe Bergeron, Elizabeth Blackwood, Krista K. Bowman, Kevin R Clark, Ron Firestein, James R. Kiefer, Klaus Maskos, Mark McCleland, Linda Orr...> ;ACS Medicinal Chemistry Letters. 2016 Jan 20
• 174 citations
  Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
  Elaine E. Storm, Steffen Durinck, Felipe De Sousa E Melo, Jarrod Tremayne, Noelyn M. Kljavin, Christine Tan, Xiaofen Ye, Cecilia Chiu, Thinh S Pham, Jo Anne Hongo, Tra...> ;Nature. 2016 Jan 7
• 50 citations
  Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.
  Mark McCleland, Tim M. Soukup, Scot D. Liu, Jonathan H. Esensten, Felipe De Sousa E Melo, Murat Yaylaoglu, Søren Warming, Merone Roose-Girma, Ron Firestein> ;The Journal of Pathology. 2015 Dec 1
• 111 citations
  Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer
  Melissa R. Junttila, Weiguang Mao, Xi Wang, Bu Er Wang, Thinh S Pham, John A. Flygare, Shang Fan Yu, Sharon Yee, David M. Goldenberg, Carter Fields, Jeffrey Eastham-An...> ;Science Translational Medicine. 2015 Nov 18
• 24 citations
  An Antibody–Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies
  Jyoti Asundi, Lisa Crocker, Jarrod Tremayne, Peter Chang, Chie Sakanaka, Josh Tanguay, Susan D. Spencer, Sreedevi Chalasani, Elizabeth Luis, Karen E. Gascoigne, Rupal ...> ;Clinical Cancer Research. 2015 Jul 15
• 51 citations
  Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody–Drug Conjugate as a Therapeutic for Non–Small Cell Lung and Ovarian Cancers
  Kedan Lin, Bonnee Rubinfeld, Crystal Zhang, Ron Firestein, Eric Harstad, Leslie Roth, Siao Ping Tsai, Melissa Schutten, Keyang Xu, Maria Hristopoulos, Paul Polakis> ;Clinical Cancer Research. 2015 Jul 8
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