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Roy Perlis, MD, Psychiatry, Boston, MA

Roy Howard Perlis MD

Psychiatry•Boston, MA

Director of the Center for Experimental Drugs and Diagnostics (CEDD) and Associate Director of the Psychiatric Genetics Program in Mood and Anxiety Disorders in the MGH Psychiatry Department Associate Professor of Psychiatry at Harvard Medical School and serves as a consultant to the American Psychiatric Association's bipolar treatment guidelines workshop

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  • 15 Parkman Street Wac 812Psychiatry Outpatient DepartmentBoston, MA 02114

  • Phone+1 617-724-5600

  • Fax+1 617-724-3028

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Education & Training

  • Mass General Brigham/Massachusetts General Hospital/McLean Hospital
    Mass General Brigham/Massachusetts General Hospital/McLean HospitalResidency, Psychiatry, 1997 - 2001
  • Mass General Brigham/Massachusetts General Hospital
    Mass General Brigham/Massachusetts General HospitalInternship, Internal Medicine, 1997 - 1998
  • Harvard Medical School
    Harvard Medical SchoolClass of 1997

Certifications & Licensure

  • AR State Medical License
    AR State Medical License 2025 - 2028
  • WA State Medical License
    WA State Medical License 2025 - 2028
  • FL State Medical License
    FL State Medical License 2025 - 2028
  • MI State Medical License
    MI State Medical License 2025 - 2028
  • MA State Medical License
    MA State Medical License 1998 - 2028
  • SC State Medical License
    SC State Medical License 2025 - 2027
  • ND State Medical License
    ND State Medical License 2025 - 2027
  • Psychiatry
    American Board of Psychiatry and Neurology Psychiatry
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Psychiatry and COVID-19  
    Roy Perlis, Donald Goff, JAMA
  • Can Electronic Health Records Revive Central Nervous System Clinical Trials?  
    Maurizio Fava, Roy H Perlis, Nature
  • Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017  
    Roy Perlis, MD, JAMA

Lectures

  • Effect of Cytochrome CYP2C19 Metabolizing Activity on Antidepressant Response and Side Effects: Meta-Analysis of Data from Genome-Wide Association Studies 
    162nd Annual Meeting, San Francisco, California, USA
  • Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging 
    American Psychiatric Association, 162nd Annual Meeting, San Francisco, California, USA

Authored Content

  • The Time Has Come for Over-the-Counter AntidepressantsApril 2024
  • Genome-Wide Association Study of Dimensional Psychopathology Using Electronic Health RecordsFebruary 2018
  • High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health RecordsFebruary 2018

Press Mentions

  • JAMA at Kidney Week, JAMA Summit Report on Firearm Violence Reduction, AI for Drug Discovery, and More
    JAMA at Kidney Week, JAMA Summit Report on Firearm Violence Reduction, AI for Drug Discovery, and MoreNovember 7th, 2025
  • Is COVID-19 During Pregnancy Linked to Autism? What a New Study Shows, and What It Doesn't
    Is COVID-19 During Pregnancy Linked to Autism? What a New Study Shows, and What It Doesn'tNovember 3rd, 2025
  • Researchers Say Covid Infection During Pregnancy Is Tied to Autism — but They Aren’t yet Sure Why
    Researchers Say Covid Infection During Pregnancy Is Tied to Autism — but They Aren’t yet Sure WhyOctober 31st, 2025

Grant Support

  • Scalable Phenotyping to Assay Risk in Childhood after eXposures in Pregnancy: SPARC-XPMASSACHUSETTS GENERAL HOSPITAL2025–2029
  • JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental HealthMASSACHUSETTS GENERAL HOSPITAL2024–2029
  • JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental HealthMASSACHUSETTS GENERAL HOSPITAL2024–2029
  • Characterization of schizophrenia liability genes in models of human microglial synaptic pruningMASSACHUSETTS GENERAL HOSPITAL2023–2028
  • Depression, Isolation, and Social Connectivity Online (DISCO)MASSACHUSETTS GENERAL HOSPITAL2022–2025

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Dr. Roy Perlis, Dr. Roy Perlis, MD, Dr. R Perlis, Dr. Roy Howard Perlis