RussellMSmithMD

PubMed

• 1 citations
  Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping
  Anne Van Vlaslaer, Russell J. Mortishire-Smith, Claire Mackie, Xavier Langlois, Mark E. Schmidt> ;EJNMMI Research. 2013 Feb 14
• 14 citations
  Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background.
  Filip Cuyckens, Lieve Dillen, W. Cools, Marc Bockx, Liesbeth Vereyken, Ronald de Vries, Russell J. Mortishire-Smith> ;Bioanalysis. 2012 Mar 12
• 10 citations
  A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses
  Reza M. Salek, Michael R. Pears, Jonathan D. Cooper, Hannah M. Mitchison, David A. Pearce, Russell J. Mortishire-Smith, Julian L. Griffin> ;Journal of Biomolecular NMR. 2011 Apr 3
• 40 citations
  Development and Validation of a Higher-Throughput Equilibrium Dialysis Assay for Plasma Protein Binding
  Sebastiaan van Liempd, Denise Morrison, Leen Sysmans, Paul Nelis, Russell J. Mortishire-Smith> ;Journal of Laboratory Automation. 2011 Feb 1
• 14 citations
  Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.
  Michael R. Pears, Sandra Codlin, Rebecca L. Haines, Ian J. White, Russell J. Mortishire-Smith, Sara E. Mole, Julian L. Griffin> ;Molecular Biosystems. 2010 May 18
• 46 citations
  Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters.
  Russell J. Mortishire-Smith, Jose Castro-Perez, Kate Yu, John P. Shockcor, Jeff Goshawk, Mike J. Hartshorn, Alastair Hill> ;Rapid Communications in Mass Spectrometry. 2009 Apr 15
• 37 citations
  Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration.
  Filip Cuyckens, Rob Hurkmans, Jose Castro-Perez, Laurent Leclercq, Russell J. Mortishire-Smith> ;Rapid Communications in Mass Spectrometry. 2009 Jan 30
• 17 citations
  IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.
  Laurent Leclercq, Russell J. Mortishire-Smith, Maarten T. Huisman, Filip Cuyckens, Michael J. Hartshorn, Alastair Hill> ;Rapid Communications in Mass Spectrometry. 2009 Jan 1
• 17 citations
  Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep.
  Michael R. Pears, Reza M. Salek, David Palmer, Graham W. Kay, Russell J. Mortishire-Smith, Julian L. Griffin> ;Journal of Neuroscience Research. 2007 Nov 15
• 27 citations
  High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra performance liquid chromatography coupled with time-of-flight mass spectr...
  Desmond O'Connor, Russell J. Mortishire-Smith> ;Analytical and Bioanalytical Chemistry. 2006 Apr 8
• 42 citations
  Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stabili...
  Desmond O'Connor, Russell J. Mortishire-Smith, Denise Morrison, Amy Davies, María Domínguez> ;Rapid Communications in Mass Spectrometry. 2006 Mar 15
• 45 citations
  4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
  Ian Churcher, Dirk Beher, Jonathan D. Best, José L. Castro, Earl E. Clarke, Amy Gentry, Timothy Harrison, Laure Hitzel, Euan R. Kay, Sonia Kerrad, Huw D. Lewis, Pablo ...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Jan 15
• 109 citations
  High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
  Michael R. Pears, Jonathan D. Cooper, Hannah M. Mitchison, Russell J. Mortishire-Smith, David A. Pearce, Julian L. Griffin> ;The Journal of Biological Chemistry. 2005 Dec 30
• 91 citations
  Accelerated throughput metabolic route screening in early drug discovery using high‐resolution liquid chromatography/quadrupole time‐of‐flight mass spectrometry and au...
  Russell J. Mortishire-Smith, Desmond O'Connor, Jose Castro-Perez, Jane Kirby> ;Rapid Communications in Mass Spectrometry. 2005 Sep 30
• 133 citations
  `All-in-One' analysis for metabolite identification using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry with collision energy switching
  Mark Wrona, Timo Mauriala, Kevin P. Bateman, Russell J. Mortishire-Smith, Desmond O'Connor> ;Rapid Communications in Mass Spectrometry. 2005 Sep 30
• 2 citations
  1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.
  Richard H. Herbert, Ute Gerhard, Russell J. Mortishire-Smith, Steven R. Thomas, Gregory John Hollingworth> ;Magnetic Resonance in Chemistry. 2005 Aug 1
• 46 citations
  A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling
  Gareth Jones, E Sang, C. A. Goddard, Russell J. Mortishire-Smith, Brian C. Sweatman, John N. Haselden, Kay E. Davies, Andrew A. Grace, Kieran Clarke, Julian L. Griffin> ;The Journal of Biological Chemistry. 2005 Mar 4
• 36 citations
  A proteomic investigation of drug-induced steatosis in rat liver.
  Georgina Meneses-Lorente, Paul C. Guest, Jeffrey W. Lawrence, Nagaraja Muniappa, Michael R. Knowles, Heather A. Skynner, Kamran Salim, Ileana M. Cristea, Russell J. Mo...> ;Chemical Research in Toxicology. 2004 May 1
• 93 citations
  Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.
  Russell J. Mortishire-Smith, Gary L. Skiles, Jeffrey W. Lawrence, Stan Spence, Andrew W. Nicholls, Bruce A. Johnson, Jeremy K. Nicholson> ;Chemical Research in Toxicology. 2004 Jan 24
• 21 citations
  Length preferences and periodicity in beta-strands. Antiparallel edge beta-sheets are more likely to finish in non-hydrogen bonded rings.
  Simon Penel, R. Gwilym Morrison, Paul D. Dobson, Russell J. Mortishire-Smith, Andrew J. Doig> ;Protein Engineering. 2003 Dec 1
• 170 citations
  NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.
  Andrew W. Nicholls, Russell J. Mortishire-Smith, Jeremy K. Nicholson> ;Chemical Research in Toxicology. 2003 Oct 25
• 10 citations
  Accelerated metabolite identification by "extraction-NMR".
  Ute Gerhard, Steven R. Thomas, Russell J. Mortishire-Smith> ;Journal of Pharmaceutical and Biomedical Analysis. 2003 Jul 14
• 37 citations
  Metabolite identification in drug discovery.
  Alan P. Watt, Russell J. Mortishire-Smith, Ute Gerhard, Steven R. Thomas> ;Current Opinion in Drug Discovery & Development. 2003 Jan 1
• 1 citations
  Enantiomeric separation of substituted 2-arylindoles on derivatised polysaccharide chiral stationary phases
  Alan P. Watt, Laure Hitzel, Russell J. Mortishire-Smith> ;Journal of Biochemical and Biophysical Methods. 2002 Dec 31
• 13 citations
  Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring.
  Karl Richard Gibson, Laure Hitzel, Russell J. Mortishire-Smith, Ute Gerhard, Richard Alexander Jelley, Austin John Reeve, Michael Rowley, and Alan Nadin, Andrew Pate O...> ;The Journal of Organic Chemistry. 2002 Nov 20
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