RyotaroNakamuraMD

Hematology • Duarte, CA

Hematologic Oncology

Associate Professor

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Office
Division of Leukemia
1500 East Duarte Road
Duarte, CA 91010
Phone+1 626-256-4673

Fax+1 626-389-3059
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Education & Training

National Institutes of Health Clinical CenterFellowship, Hematology and Medical Oncology, 1998 - 2001
OtherClass of 1991

Certifications & Licensure

CA State Medical License 2002 - 2025
MD State Medical License 1998 - 2025

Clinical Trials

Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402) Start of enrollment: 2006 Nov 01
Completed
Phase 3
Fusion Protein Cytokine Therapy After Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma Start of enrollment: 2008 Jan 01
Completed
Phase 1
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant Start of enrollment: 2010 Dec 01
Completed
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant Start of enrollment: 2012 Oct 29
Completed
Phase 1
A Study of De-immunized DI-Leu16-IL2 Administered Subcutaneously in Participants With B-cell NHL Start of enrollment: 2013 Nov 25
Terminated
Phase 1, Phase 2
Allo vs Hypomethylating/Best Supportive Care in MDS (BMTCTN1102) Start of enrollment: 2013 Dec 16
Completed
Phase 2
Open-Label Extension Study of De-immunized DI-Leu16-IL2 Immunocytokine Administered in Participants With B-cell NHL Start of enrollment: 2014 Nov 04
Terminated
Phase 1, Phase 2
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant Start of enrollment: 2018 Dec 01
Withdrawn
Phase 2
CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant Start of enrollment: 2018 Aug 20
Active, not recruiting
Phase 1
CBM588 in Improving Clinical Outcomes in Patients Who Have Undergone Donor Hematopoietic Stem Cell Transplant Start of enrollment: 2019 Apr 18
Active, not recruiting
Phase 1
Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation Start of enrollment: 2019 Nov 27
Active, not recruiting
Phase 2
MM CAR-T to Upgrade Response BMTCTN1902 Start of enrollment: 2022 Jan 05
Active, not recruiting
Phase 2
Roles: Contact
A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia Start of enrollment: 2024 Aug 01
Recruiting
Phase 1
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Yttrium-90 Anti-CD25-BEAM-Conditioning for Autologous Hematopoietic Cell Transplantation in Peripheral T Cell Lymphoma.
Jasmine Zain, Ni-Chun Tsai, Joycelynne M Palmer, Jennifer R Simpson, Vikram Adhikarla, James Bading, Paul Yazaki, Eileen Patricia Smith, Savita Dandapani, Joo Y Song, ...> ;Blood Advances. 2024 Jun 5
A Validated Risk Stratification That Incorporates MAGIC Biomarkers Predicts Long-Term Outcomes in Pediatric Patients with Acute GVHD.
Kapoor, U., Muna Qayed, Urvi Kapoor, Scott Gillespie, Adrianna Westbrook, Paibel Aguayo-Hiraldo, Francis A Ayuk, Mina Aziz, Janna Baez, Hannah Choe, Zachariah DeFilipp...> ;Transplantation and Cellular Therapy. 2024 Jun 1
Toxicities associated with tyrosine kinase inhibitor maintenance following allogeneic hematopoietic cell transplantation in Philadelphia chromosome-positive acute lymp...
Al Malki, M. M., Mansour, J., Tamer Othman, Paul Koller, Ni-Chun Tsai, Dongyun Yang, Hoda Pourhassan, Vaibhav Agrawal, Dat Ngo, Jason Chen, Leonardo Farol, Ricardo Spi...> ;American Journal of Hematology. 2024 May 28
SARS-CoV-2 vaccination in the first year after hematopoietic cell transplant or chimeric antigen receptor T cell therapy: A prospective, multicenter, observational study.
Joshua A Hill, Michael J Martens, Jo-Anne H Young, Kavita Bhavsar, Jianqun Kou, Min Chen, Lik Wee Lee, Aliyah Baluch, Madhav V Dhodapkar, Ryotaro Nakamura, Kristin Pey...> ;Clinical Infectious Diseases. 2024 May 27
Outcomes following allogeneic hematopoietic cell transplantation relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Tamer Othman, Shanpeng Li, Jianying Zhang, Hoda Pourhassan, Vaibhav Agrawal, Dat Ngo, Jason Chen, Leonardo Farol, Firoozeh Sahebi, Karamjeet Sandhu, Ricardo Spielberge...> ;American Journal of Hematology. 2024 May 27
Simultaneous targeting of B-cell malignancies and human immunodeficiency virus with bispecific chimeric antigen receptor T cells.
Ryan Urak, Saghar Pahlavanneshan, Brenna Gittins, John A Zaia, Mary C Clark, Xiuli Wang, Ryotaro Nakamura, John H Baird, Stephen J Forman> ;Haematologica. 2024 May 23
The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD.
Zachariah DeFilipp, Haesook T Kim, Nikolaos Spyrou, Nikolaos Katsivelos, Steven Kowalyk, Gilbert W Eng, Stelios Kasikis, Rahnuma Beheshti, Janna Baez, Yu Akahoshi, Fra...> ;Blood Advances. 2024 Apr 19
High remission rates and transition to allogeneic transplant in older patients with newly diagnosed FLT-3 mutated acute myelogenous leukemia with midostaurin plus inte...
Jose Tinajero, Dat Ngo, Jianying Zhang, Ni-Chun Tsai, Ahmed Aribi, Ibrahim Aldoss, Vaibhav Agrawal, Shukaib Arslan, Idoroenyi Amanam, Hoda Pourhassan, Karamjeet Sandhu...> ;Leukemia & Lymphoma. 2024 Apr 18
1 citations
A Day 14 Endpoint for Acute GVHD Clinical Trials.
Al Malki, M. M., Nikolaos Spyrou, Yu Akahoshi, Steven Kowalyk, George Morales, Rahnuma Beheshti, Paibel Aguayo-Hiraldo, Monzr M Al Malki, Francis Ayuk, Peter Bader, Ja...> ;Transplantation and Cellular Therapy. 2024 Apr 1
Coronary artery calcium and cardiovascular outcomes in patients with lymphoma undergoing autologous hematopoietic cell transplantation.
Stephanie Wu, June-Wha Rhee, Aleksi Iukuridze, Alysia Bosworth, Sitong Chen, Liezl Atencio, Venkat Manubolu, Rusha Bhandari, Faizi Jamal, Matthew Mei, Alex Herrera, Fa...> ;Cancer. 2024 Jun 15
SARS-CoV-2 vaccination in the first year after hematopoietic cell transplant or chimeric antigen receptor T cell therapy: A prospective, multicenter, observational stu...
Hill, J., Martens, M., Young, J., Bhavsar, K., Kou, J., Chen, M., Lee, L., Baluch, A., Dhodapkar, M., Nakamura, R., Peyton, K., Howard, D., Ibrahim, U., Shahid, Z., Ar...> ;Medrxiv. 2024 Jan 25
Cost-Effectiveness of Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Older Patients With High-Risk Myelodysplastic Syndrome: Analysis of BMT CTN 1...
Wael Saber, Aasthaa Bansal, Lily Li, Bart L Scott, Lindsey R Sangaralingham, Viengneesee Thao, Joshua A Roth, Winona Wright, Lotte M G Steuten, Joseph A Pidala, Asmita...> ;JCO Oncology Practice. 2024 Apr 1
Lack of RBC transfusion independence by Day 30 following allogeneic hematopoietic stem cell transplant strongly predicts inferior survival and high non-relapse mortali...
Al Malki, M. M., Al Malki, M. M., Al Malki, M. M., Al Malki, M. M., Al Malki, M. M., Shan Yuan, Dongyun Yang, Ryotaro Nakamura, Monzr M Al Malki, Amandeep Salhotra, Mi...> ;Transfusion. 2024 Feb 1
2 citations
Treatment of relapsed or refractory FLT-3 acute myelogenous leukemia with a triplet regimen of hypomethylating agent, venetoclax, and gilteritinib.
Ngo, D., Tinajero, J., Li, S., Palmer, J., Pourhassan, H., Aribi, A., Nakamura, R., Stein, A., Marcucci, G., Salhotra, A., Sandhu, K., Pullarkat, V., Ball, B., Koller, P.> ;Leukemia & Lymphoma. 2024 Mar 1
1 citations
Thrombotic Microangiopathy After Hematopoietic Stem Cell and Solid Organ Transplantation: A Review for Intensive Care Physicians.
Sanober Nusrat, Hugh Davis, Kira MacDougall, James N George, Ryotaro Nakamura, Azra Borogovac> ;Journal of Intensive Care Medicine. 2024 May 1
2 citations
Sirolimus Is an Acceptable Alternative to Tacrolimus for Graft-versus-Host Disease Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation with Pos...
Al Malki, M. M., Hany Elmariah, Salman Otoukesh, Ambuj Kumar, Haris Ali, Shukaib Arslan, Geoffrey Shouse, Hoda Pourhassan, Taiga Nishihori, Rawan Faramand, Asmita Mish...> ;Transplantation and Cellular Therapy. 2024 Feb 1
A review of low dose interleukin-2 therapy in management of chronic graft-versus-host-disease.
Amandeep Salhotra, Leah Falk, Gabriel Park, Karamjeet Sandhu, Haris Ali, Badri Modi, Susanta Hui, Ryotaro Nakamura> ;Expert Review of Clinical Immunology. 2024 Feb 1
1 citations
Oral Chronic Graft-versus-Host Disease in Post-Hematopoietic Stem Cell Transplant Patients Following SARS-CoV-2 Vaccination: Case Reports.
Joel B Epstein, Raymond S Hernandez, Ryotaro Nakamura, Susan E Yost, Haris Ali> ;Case Reports in Oncology. 2023 Nov 3
Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplant...
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, J...> ;Vaccines. 2023 Sep 15
3 citations
The utility of biomarkers in acute GVHD prognostication.
Nikolaos Spyrou, Yu Akahoshi, Francis Ayuk, Ernst Holler, Hannah Choe, Aaron Etra, William J Hogan, Wolf Rösler, Elizabeth Hexner, Zachariah DeFilipp, Ran Reshef, Chan...> ;Blood Advances. 2023 Sep 12
Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow...
Jurjen Versluis, Wael Saber, Harrison K Tsai, Christopher J Gibson, Laura W Dillon, Asmita Mishra, Joseph McGuirk, Richard T Maziarz, Peter Westervelt, Pranay Hegde, D...> ;Journal of Clinical Oncology. 2023 Oct 1
2 citations
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD.
Yu Akahoshi, Nikolaos Spyrou, William J Hogan, Francis Ayuk, Zachariah DeFilipp, Daniela Weber, Hannah K Choe, Elizabeth O Hexner, Wolf Rösler, Aaron M Etra, Karamjeet...> ;Blood Advances. 2023 Aug 22
-mutated acute myeloid leukemia is sensitive to fludarabine-based chemotherapy and conditioning regimens.
Ahmed Aribi, Amandeep Salhotra, Michelle Afkhami, Anamaria Munteanu, Haris Ali, Ibrahim Aldoss, Salman Otoukesh, Monzr M Al Malki, Karamjeet S Sandhu, Paul Koller, Shu...> ;Leukemia & Lymphoma. 2023 Aug 3
3 citations
Effective treatment with the selective cytokine inhibitor BNZ-1 reveals the cytokine dependency of T-LGL leukemia.
Jonathan E Brammer, Karen Ballen, Lubomir Sokol, Christiane Querfeld, Ryotaro Nakamura, Anjali Mishra, Eric M McLaughlin, David Feith, Nazli Azimi, Thomas A Waldmann, ...> ;Blood. 2023 Oct 12
2 citations
Conditional survival and standardized mortality ratios of patients with severe aplastic anemia surviving at least one year after hematopoietic cell transplantation or ...
Ryotaro Nakamura, Bhavisha A Patel, Soyoung Kim, F Lennie Wong, Saro H Armenian, Emma M Groarke, Kyle M Hebert, Michael Heim, Mary Eapen, Neal S Young, Keesler, D.> ;Haematologica. 2023 Dec 1
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Abstracts/Posters

Large-Scale Manufacturing of CMV-CD19CAR T Cells and Characterization of Their Biologic and Immunologic Properties
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Optimization of Tacrolimus Serum Levels When Combined with Post-Transplant Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis after Hematopoietic Cell Transplan...
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizu...
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Allogeneic Transplantation for Myelodysplastic Syndrome in Adults over 50 Years Old Using Reduced Intensity/Non-Myeloablative Conditioning: Haploidentical Relative Ver...
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Incidence and Risk Factors of De Novo Skin Cancer in a Contemporary Cohort of Hematopoietic Cell Transplantation Survivors
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Updated Analysis: Novel Machine-Learning-Based Sepsis Prediction Model for Patients Undergoing Hematopoietic Stem Cell Transplantation (Early Sepsis Prediction/Identif...
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Flurabine Improves Transplant Outcomes in Older MDS Patients
Ryotaro Nakamura, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Cytokine Gene Polymorphisms Are Associated with Disease Response to Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Clinical Outcomes of MDS Patients Who Were Allogeneic Hematopoietic Stem Cell Transplant Candidates but Did Not Proceed with Transplantation
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
MIPSS70+ V2.0 and Revised Cytogenetics Changes Predict Outcomes of Allogeneic Transplantation with Fludarabine and Melphalan Conditioning in Patients with Myelofibrosis
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

CD8 T Cells May Fight COVID-19 Infection in Hematological Cancer When B Cells, Antibodies WaneJune 11th, 2021
City of Hope Now Enrolling Patients for Phase 1 Type 1 Diabetes Investigational Vaccine TrialDecember 10th, 2020
City of Hope Doctors Present Innovative Therapies to Better Treat Blood Cancers at American Society of Hematology Virtual ConferenceDecember 8th, 2020
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