SabinaSignorettiMD

PubMed

• Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes.
  Renée Maria Saliby, Chris Labaki, Tejas R Jammihal, Wanling Xie, Maxine Sun, Valisha Shah, Eddy Saad, M Harry Kane, Soki Kashima, Katherine Sadak, Talal El Zarif, Deep...> ;Cancer Cell. 2024 Apr 4
• Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects.
  Yufei Wang, Alicia Buck, Brandon Piel, Luann Zerefa, Nithyassree Murugan, Christian D Coherd, Andras G Miklosi, Haraman Johal, Ricardo Nunes Bastos, Kun Huang, Miriam ...> ;Molecular Cancer. 2024 Mar 16
• 1 citations
  PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients.
  Denize, T., Jegede, O., Matar, S., El Ahmar, N., West, D., Walton, E., Bagheri, A., Savla, V., Nabil Laimon, Y., Gupta, S., Vemula, S., Braun, D., Burke, K., Catalano,...> ;Clinical Cancer Research. 2024 Feb 16
• 1 citations
  Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model.
  Wang, Y., Cho, J., Kastrunes, G., Buck, A., Razimbaud, C., Culhane, A., Sun, J., Braun, D., Choueiri, T., Wu, C., Jones, K., Nguyen, Q., Zhu, Z., Wei, K., Zhu, Q., Sig...> ;Iscience. 2024 Feb 16
• 1 citations
  Regulation of HHLA2 expression in kidney cancer and myeloid cells.
  Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F McDermott, Gordon J...> ;BMC Cancer. 2023 Oct 27
• 2 citations
  Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states.
  Jackson Nyman, Thomas Denize, Ziad Bakouny, Chris Labaki, Breanna M Titchen, Kevin Bi, Surya Narayanan Hari, Jacob Rosenthal, Nicita Mehta, Bowen Jiang, Bijaya Sharma,...> ;Cell Reports. Medicine. 2023 Sep 19
• 7 citations
  KDM6A epigenetically regulates subtype plasticity in small cell lung cancer.
  Leslie Duplaquet, Yixiang Li, Matthew A Booker, Yingtian Xie, Sarah Naomi Olsen, Radhika A Patel, Deli Hong, Charlie Hatton, Thomas Denize, Emily Walton, Yasmin N Laim...> ;Nature Cell Biology. 2023 Sep 1
• 2 citations
  Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases.
  David A Schoenfeld, Myrto Moutafi, Sandra Martinez, Dijana Djureinovic, Ross D Merkin, Adebowale Adeniran, David A Braun, Sabina Signoretti, Toni K Choueiri, Fabio Par...> ;Journal for Immunotherapy of Cancer. 2023 Aug 1
• 5 citations
  Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer.
  Luigi Perelli, Federica Carbone, Li Zhang, Justin K Huang, Courtney Le, Hania Khan, Francesca Citron, Edoardo Del Poggetto, Tony Gutschner, Hideo Tomihara, Melinda Soe...> ;Nature Cancer. 2023 Jul 1
• 2 citations
  Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma.
  Renee Maria Saliby, Talal El Zarif, Ziad Bakouny, Valisha Shah, Wanling Xie, Ronan Flippot, Thomas Denize, M Harry Kane, Katrine N Madsen, Miriam Ficial, Laure Hirsch,...> ;Cancer Immunology Research. 2023 Aug 3
• The Role of the Pathologist in Renal Cell Carcinoma Management.
  Sayed Matar, Nourhan El Ahmar, Yasmin Nabil Laimon, Fatme Ghandour, Sabina Signoretti> ;Hematology/oncology Clinics of North America. 2023 Oct 1
• 2 citations
  Phase II study of nivolumab and salvage nivolumab/ipilimumab in treatment-naïve patients with advanced non-clear cell renal cell carcinoma (HCRN GU16-260-Cohort B).
  Michael B Atkins, Opeyemi A Jegede, Naomi B Haas, David F McDermott, Mehmet A Bilen, Mark Stein, Jeffrey A Sosman, Robert Alter, Elizabeth R Plimack, Moshe C Ornstein,...> ;Journal for Immunotherapy of Cancer. 2023 Mar 1
• 9 citations
  Combinatorial biomarker for predicting outcomes to anti-PD-1 therapy in patients with metastatic clear cell renal cell carcinoma.
  Julie Stein Deutsch, Evan J Lipson, Ludmila Danilova, Suzanne L Topalian, Jaroslaw Jedrych, Ezra Baraban, Yasser Ged, Nirmish Singla, Toni K Choueiri, Saurabh Gupta, R...> ;Cell Reports. Medicine. 2023 Feb 21
• Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states.
  Jackson Nyman, Thomas Denize, Ziad Bakouny, Chris Labaki, Breanna M Titchen, Kevin Bi, Surya Narayanan Hari, Jacob Rosenthal, Nicita Mehta, Bowen Jiang, Bijaya Sharma,...> ;Biorxiv. 2023 Feb 20
• 7 citations
  Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.
  Amin H Nassar, Sarah Abou Alaiwi, Sylvan C Baca, Elio Adib, Rosario I Corona, Ji-Heui Seo, Marcos A S Fonseca, Sandor Spisak, Talal El Zarif, Viktoria Tisza, David A B...> ;Nature Communications. 2023 Jan 21
• 19 citations
  Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma.
  Brian I Rini, Sabina Signoretti, Toni K Choueiri, David F McDermott, Robert J Motzer, Saby George, Thomas Powles, Frede Donskov, Scott S Tykodi, Sumanta K Pal, Saurabh...> ;Journal for Immunotherapy of Cancer. 2022 Dec 1
• 1 citations
  Mitochondrial transporter expression patterns distinguish tumor from normal tissue and identify cancer subtypes with different survival and metabolism.
  Hartmut Wohlrab, Sabina Signoretti, Lucia E Rameh, Derrick K DeConti, Steen H Hansen> ;Scientific Reports. 2022 Oct 11
• 8 citations
  Obesity in Relation to Renal Cell Carcinoma Incidence and Survival in Three Prospective Studies.
  Rebecca E Graff, Kathryn M Wilson, Alejandro Sanchez, Steven L Chang, David F McDermott, Toni K Choueiri, Eunyoung Cho, Sabina Signoretti, Edward L Giovannucci, Mark A...> ;European Urology. 2022 Sep 1
• 8 citations
  Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
  Hsiao-Yun Chen, Yavuz T Durmaz, Yixiang Li, Amin H Sabet, Amir Vajdi, Thomas Denize, Emily Walton, Yasmin Nabil Laimon, John G Doench, Navin R Mahadevan, Julie-Aurore ...> ;Nature Communications. 2022 Aug 25
• 13 citations
  Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.
  Thomas Denize, Yue Hou, Jean-Christophe Pignon, Emily Walton, Destiny J West, Gordon J Freeman, David A Braun, Catherine J Wu, Saurabh Gupta, Robert J Motzer, Michael ...> ;Clinical Cancer Research. 2022 Sep 15
• 1 citations
  Impact of MET status on treatment outcomes in papillary renal cell carcinoma: A pooled analysis of historical data.
  Laurence Albiges, Daniel Y C Heng, Jae Lyun Lee, Stephen Walker, Anders Mellemgaard, Lone Ottesen, Melanie M Frigault, Anne L'Hernault, Jonathan Wessen, Toni Choueiri,...> ;European Journal of Cancer. 2022 Jul 1
• 8 citations
  Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma.
  Matthew Bootsma, Rana R McKay, Hamid Emamekhoo, Rory M Bade, Jennifer L Schehr, Matthew C Mannino, Anupama Singh, Serena K Wolfe, Zachery D Schultz, Jamie Sperger, Wan...> ;Journal of Clinical Oncology. 2022 Nov 1
• 3 citations
  Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer.
  Xueliang Gao, Yubao Wang, Caroline F Ribeiro, Cherubin Manokaran, Hyeyoun Chang, Thanh Von, Silvia Rodrigues, Onur Cizmecioglu, Shidong Jia, Manav Korpal, Joshua M Kor...> ;Molecular Cancer Research. 2022 May 4
• 28 citations
  Phase II Study of Nivolumab and Salvage Nivolumab/Ipilimumab in Treatment-Naive Patients With Advanced Clear Cell Renal Cell Carcinoma (HCRN GU16-260-Cohort A).
  Michael B Atkins, Opeyemi A Jegede, Naomi B Haas, David F McDermott, Mehmet A Bilen, Mark Stein, Jeffrey A Sosman, Robert Alter, Elizabeth R Plimack, Moshe Ornstein, M...> ;Journal of Clinical Oncology. 2022 Sep 1
• 10 citations
  Sensitivity ofmutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
  Laura A Stransky, Sean M Vigeant, Bofu Huang, Destiny West, Thomas Denize, Emily Walton, Sabina Signoretti, William G Kaelin Jr> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr 5
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Journal Articles

• Genomic Correlates of Response to Immune Checkpoint Blockade in Microsatellite-Stable Solid Tumors  
  Jeffrey A Engelman, David A Barbie, Nicole G Chau, Glenn J Hanna, Natalie I Vokes, Sabina Signoretti, Pasi A Janne, Robert I Haddad, Lynette M Sholl, Rizwan Haq, Peter..., Nature