SafiShahdaMD

PubMed

• 26 citations
  Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
  Xiaoling Zhong, Ashok Narasimhan, Libbie M Silverman, Andrew R Young, Safi Shahda, Sheng Liu, Jun Wan, Yunlong Liu, Leonidas G Koniaris, Teresa A Zimmers> ;Journal of Cachexia, Sarcopenia and Muscle. 2022 Aug 1
• 13 citations
  A multi-center, single-arm, phase Ib study of pembrolizumab (MK-3475) in combination with chemotherapy for patients with advanced colorectal cancer: HCRN GI14-186
  Cameron Herting, Matthew R. Farren, Yan Tong, Ziyue Liu, Bert H. O'Neil, Tanios Bekaii-Saab, Anne M. Noonan, Christopher McQuinn, Thomas A. Mace, Walid L. Shaib, Chris...> ;Cancer Immunology, Immunotherapy. 2021 Jun 23
• 9 citations
  Profiling of Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways.
  Ashok Narasimhan, Xiaoling Zhong, Ernie P. Au, Eugene P. Ceppa, Atilla Nakeeb, Michael G. House, Nicholas J. Zyromski, C. Max Schmidt, Katheryn N. H. Schloss, Daniel E...> ;Cancers. 2021 Apr 20
• 22 citations
  Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform
  Ashok Narasimhan, Safi Shahda, Joshua K. Kays, Susan M. Perkins, Lijun Cheng, Katheryn N. H. Schloss, Daniel E. I. Schloss, Leonidas G. Koniaris, Teresa A. Zimmers> ;Cancers. 2020 Dec 15
• 31 citations
  Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer
  Efrat Dotan, Dana Backlund Cardin, Heinz-Josef Lenz, Wells A. Messersmith, Bert H. O'Neil, Steven J. Cohen, Crystal S. Denlinger, Safi Shahda, Igor Astsaturov, Ann M. ...> ;Clinical Cancer Research. 2020 Jul 21
• 60 citations
  A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastat...
  S. Lindsey Davis, Dana Backlund Cardin, Safi Shahda, Heinz-Josef Lenz, Efrat Dotan, Bert H. O'Neil, Ann M. Kapoun, Jordan Berlin, Wells A. Messersmith, Steven J. Cohen> ;Investigational New Drugs. 2020 Jun 1
• 4 citations
  Phase I, Pharmacogenomic, Drug Interaction Study of Sorafenib and Bevacizumab in Combination with Paclitaxel in Patients with Advanced Refractory Solid Tumors.
  E. Gabriela Chiorean, Susan M. Perkins, R. Matthew Strother, Anne Younger, Jennifer M. Funke, Safi Shahda, Noah M. Hahn, Kumar Sandrasegaran, David R. Jones, Todd C. S...> ;Molecular Cancer Therapeutics. 2020 Aug 26
• 41 citations
  The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.
  Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E. Sandusky, Safi Shahda, Attila Nakeeb, C. Max Schmidt, Michael G. House, Eugene ...> ;Journal of Cachexia, Sarcopenia and Muscle. 2019 Jul 8
• 11 citations
  Social correlates of mental health in gastrointestinal cancer patients and their family caregivers: Exploring the role of loneliness
  Ekin Secinti, Kevin L. Rand, Shelley A. Johns, Bert H. O'Neil, Paul R. Helft, Safi Shahda, Shadia I. Jalal, Catherine E. Mosher> ;Supportive Care in Cancer. 2019 Jun 1
• 25 citations
  Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study
  Olumide B. Gbolahan, Yan Tong, Amikar Sehdev, Bert H. O'Neil, Safi Shahda> ;BMC Cancer. 2019 May 17
• 32 citations
  A Phase Ib/II Study of the JAK1 Inhibitor, Itacitinib, plus nab‐Paclitaxel and Gemcitabine in Advanced Solid Tumors
  Gregory L. Beatty, Safi Shahda, Thaddeus Beck, Nikhil Uppal, Steven J. Cohen, Ross C. Donehower, Afshin Eli Gabayan, Albert Assad, Julie Switzky, Hui-Ling Zhen, Daniel...> ;The Oncologist. 2019 Jan 1
• 53 citations
  Germline and somatic DNA damage repair gene mutations and overall survival in metastatic pancreatic adenocarcinoma patients treated with FOLFIRINOX
  Amikar Sehdev, Olumide B. Gbolahan, Bradley A. Hancock, Melissa Stanley, Safi Shahda, Jun Wan, Howard H. Wu, Milan Radovich, Bert H. O'Neil> ;Clinical Cancer Research. 2018 Dec 15
• 12 citations
  Simultaneous inhibition of MEK and Hh signaling reduces pancreatic cancer metastasis
  Dongsheng Gu, Hai Lin, Xiaoli Zhang, Qipeng Fan, Shaoxiong Chen, Safi Shahda, Yunlong Liu, Jie Sun, Jingwu Xie> ;Cancers. 2018 Oct 26
• 51 citations
  Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer.
  John M. DeWitt, Kumar Sandrasegaran, Bert H. O'Neil, Michael G. House, Nicholas J. Zyromski, Amikar Sehdev, Susan M. Perkins, Janet Flynn, Lynne McCranor, Safi Shahda> ;Gastrointestinal Endoscopy. 2018 Jun 1
• 84 citations
  Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer.
  Joshua K. Kays, Safi Shahda, Melissa Stanley, Teresa M. Bell, Bert H. O'Neill, Marc D. Kohli, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers> ;Journal of Cachexia, Sarcopenia and Muscle. 2018 Jul 5
• 3 citations
  Metachronous gastric metastasis from lung primary, with synchronous pancreatic neuroendocrine carcinoma.
  Ihab I. El Hajj, Karen A. Lawrence, Temel Tirkes, Safi Shahda, Stuart Sherman> ;Clinical Case Reports. 2018 May 8
• 30 citations
  Examining the effect of peer helping in a coping skills intervention: a randomized controlled trial for advanced gastrointestinal cancer patients and their family care...
  Catherine E. Mosher, Ekin Secinti, Shelley A. Johns, Bert H. O'Neil, Paul R. Helft, Safi Shahda, Shadia I. Jalal, Victoria L. Champion> ;Quality of Life Research. 2018 Feb 1
• 14 citations
  Homologous Recombination Deficiency in Patients With Pancreatic Ductal Adenocarcinoma and Response to Chemotherapy
  Safi Shahda, Kirsten Timms, Ashley A. Ibrahim, Julia Reid, Harvey M. Cramer, Milan Radovich, Sulfikar Ibrahim, Brian Allen, Bert H. O'Neil> ;JCO Precision Oncology. 2018 Jan 19
• 2 citations
  Two Months of Therapy: A Case of Pathologic Complete Response to Chemoimmunotherapy in a Patient With Metastatic Colorectal Cancer.
  Samantha Armstrong, Hayma Al-Ghawi, Paul R. Helft, Michael G. House, Aaron John Spittler, Howard H. Wu, Safi Shahda> ;Clinical Colorectal Cancer. 2017 Dec 13
• 12 citations
  Impact of Nab-Paclitaxel-based Second-line Chemotherapy in Metastatic Pancreatic Cancer.
  Neelakanta Dadi, Melissa Stanley, Safi Shahda, Bert H. O'Neil, Amikar Sehdev> ;Anticancer Research. 2017 Oct 1
• 12 citations
  Clinical Characteristics of Patients Experiencing Pathologic Complete Response Following Neoadjuvant Therapy for Borderline Resectable/Locally Advanced Pancreatic Aden...
  Neda Hashemi-Sadraei, Olumide B. Gbolahan, Hai Salfity, Bert H. O'Neil, Michael G. House, Safi Shahda> ;American Journal of Clinical Oncology. 2017 Sep 1
• LBA-002A phase 1b/II study of cancer stemness inhibitor napabucasin in combination with gemcitabine (gem) & nab-paclitaxel (nabptx) in metastatic pancreatic adenocarci...
  Bekaii-Saab, T.,Starodub, A.,El-Rayes, B.,O'Neil, B.,Shahda, S.,Ciombor, K.,Noonan, A.,Hanna, W.,Sehdev, A.,Shaib, W.,Mikhail, S.,Neki, A.,Oh, C.,Li, Y. Z.,Li, W.,Boro...> ;Ann. Oncol.. 2018 Jul 28
• 5 citations
  Myeloid sarcoma of the sigmoid colon: An unusual presentation of a rare condition.
  Ihab I. El Hajj, Jeffrey J. Easler, Eugene P. Ceppa, Safi Shahda> ;Digestive and Liver Disease. 2017 May 24
• 31 citations
  A systematic review of psychosocial interventions for colorectal cancer patients.
  Catherine E. Mosher, Joseph G. Winger, Barbara A. Given, Safi Shahda, Paul R. Helft> ;Supportive Care in Cancer. 2017 Apr 22
• 87 citations
  A Multidisciplinary Approach to Pancreas Cancer in 2016: A Review.
  Evan L. Fogel, Safi Shahda, Kumar Sandrasegaran, John M. DeWitt, Jeffrey J. Easler, David M. Agarwal, Mackenzie A. Eagleson, Nicholas J. Zyromski, Michael G. House, Su...> ;The American Journal of Gastroenterology. 2017 Jan 31
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Journal Articles

• Phase I Study of EUS-Guided Photodynamic Therapy for Locally Advanced Pancreatic Cancer  
  John M Dewitt, Bert O'Neil, Amikar Sehdev, Safi Shahda, Gastrointestinal Endoscopy
• Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX  
  Olumide Gbolahan, Amikar Sehdev, Howard H Wu, Safi Shahda, Clinical Cancer Research

Lectures

• A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors. 
  2019 ASCO Annual Meeting - 6/1/2019
• Prospective trial of preoperative FOLFIRINOX in patients with resectable pancreatic ductal adenocarcinoma (PDAC): Report of early endpoints. 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018