SamiNMalekMD

Oncology • Ann Arbor, MI

Hematologic Oncology

Physician

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Office
1500 East Medical Center Dr
B1 Floor Cancer Ctr Recp B
Ann Arbor, MI 48109
Phone+1 734-936-6000
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 2001 - 2004
Baylor College of MedicineResidency, Internal Medicine, 1997 - 2001
University Hamburg, Krankenhaus Eppendorf, Fak MedClass of 1993

Certifications & Licensure

MI State Medical License 2004 - 2026
MD State Medical License 2001 - 2005
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL Start of enrollment: 2012 Nov 01
Active, not recruiting
Phase 2

Publications & Presentations

PubMed

8 citations
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency.
Fangyang Wang, Ying Yang, Gabriel Boudagh, Eeva-Liisa Eskelinen, Daniel J Klionsky, Sami N Malek> ;Autophagy. 2022 Aug 1
Mutations in V-ATPase in follicular lymphoma activate autophagic flux creating a targetable dependency.
Fangyang Wang, Ying Yang, Daniel J Klionsky, Sami N Malek> ;Autophagy. 2023 Feb 1
1 citations
Targeted Therapies for Follicular Lymphoma
Jennifer Girard, Yasmin Karimi, Shannon A. Carty, Ryan A. Wilcox, Mark S. Kaminiski, Sami N. Malek, Tycel Phillips> ;Current Hematologic Malignancy Reports. 2021 Feb 1
14 citations
Follicular Lymphoma-associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
Nan Hu, Fangyang Wang, Tianyu Sun, Zhengfan Xu, Jing Zhang, Denzil Bernard, Shilin Xu, Shaomeng Wang, Mark S. Kaminski, Sumana Devata, Tycel Phillips, Sami N. Malek> ;Clinical Cancer Research. 2021 Apr 15
19 citations
Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin.
Yin Wang, Yan Liu, Christopher Bailey, Huixia Zhang, Miao He, Duxin Sun, Peng Zhang, Brian Parkin, Maria R. Baer, Pan Zheng, Sami N. Malek, Yang Liu> ;Oncogene. 2020 Feb 15
91 citations
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology
William G. Wierda, John C. Byrd, Jeremy S. Abramson, Syed Bilgrami, Greg Bociek, Danielle M. Brander, Jennifer R. Brown, Asher Chanan-Khan, Julio C. Chavez, S. E. Cout...> ;Journal of the National Comprehensive Cancer Network. 2020 Feb 1
17 citations
The Genomic Landscape of Centromeres in Cancers.
Anjan K. Saha, Mohamad Mourad, Mark H. Kaplan, Ilana Chefetz, Sami N. Malek, Ronald J. Buckanovich, David M. Markovitz, Rafael Contreras-Galindo> ;Scientific Reports. 2019 Aug 2
19 citations
Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and MTOR
Fangyang Wang, Damián Gatica, Zhang Xiao Ying, Luke F. Peterson, Peter K. Kim, Denzil Bernard, Kamlai Saiya-Cork, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Tyc...> ;The Journal of Clinical Investigation. 2019 Apr 1
18 citations
NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019.
William G Wierda, John C Byrd, Jeremy S Abramson, Syed F Bilgrami, Greg Bociek, Danielle Brander, Jennifer Brown, Asher A Chanan-Khan, Julio C Chavez, Steve E Coutre, ...> ;Journal of the National Comprehensive Cancer Network. 2019 Jan 1
1 citations
Gene Disruption Using CRISPR-Cas9 Technology
Nan Hu, Sami N. Malek> ;Methods in Molecular Biology. 2019 Jan 1
1 citations
CRISPR/Cas9-Based Gene Dropout Screens.
Kai Wu, Sami N. Malek> ;Methods in Molecular Biology. 2019 Jan 1
33 citations
Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia.
Nisar A. Amin, Sriram Balasubramanian, Kamlai Saiya-Cork, Kerby Shedden, Nan Hu, Sami N. Malek> ;Clinical Cancer Research. 2017 Feb 15
27 citations
Hairy cell Leukemia, Version 2.2018: Clinical practice guidelines in oncology
William G. Wierda, John C. Byrd, Jeremy S. Abramson, Seema A. Bhat, Greg Bociek, Danielle M. Brander, Jennifer R. Brown, Asher Chanan-Khan, S. E. Coutre, Randall S. Da...> ;Journal of the National Comprehensive Cancer Network. 2017 Nov 1
39 citations
Ultrasensitive mutation detection identifies rare residual cells causing acute myelogenous leukemia relapse
Brian Parkin, Angelina I. Londoño-Joshi, Qing Kang, Muneesh Tewari, Andrew D. Rhim, Sami N. Malek> ;The Journal of Clinical Investigation. 2017 Aug 21
40 citations
NCCN guidelines® insights chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia, Version 1.2017: Featured updates to the NCCN guidelines
William G. Wierda, Andrew D. Zelenetz, Leo I. Gordon, Jeremy S. Abramson, Ranjana H. Advani, C. Babis Andreadis, Nancy L. Bartlett, John C. Byrd, Paolo Caimi, Luis Fay...> ;Journal of the National Comprehensive Cancer Network. 2017 Mar 1
34 citations
Colony-stimulating Factor-1 Receptor is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia
Avery Polk, Ye Lu, Tianjiao Wang, Erlene K. Seymour, Nathanael G. Bailey, Jack W. Singer, Philip S. Boonstra, Megan S. Lim, Sami N. Malek, Ryan A. Wilcox> ;Clinical Cancer Research. 2016 Dec 15
26 citations
Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.
Zhang Xiao Ying, Meiyan Jin, Luke F. Peterson, Denzil Bernard, Kamlai Saiya-Cork, Mehmet Yildiz, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Daniel J. Klionsky, ...> ;Clinical Cancer Research. 2016 Nov 1
22 citations
Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model
Haiyan Qin, Sami N. Malek, John K. Cowell, Mingqiang Ren> ;Oncogene. 2016 Oct 27
170 citations
Loss of the HVEM tumor suppressor in lymphoma and restoration by modified CAR-T cells
Michael Boice, Darin Salloum, Frédéric Mourcin, Viraj Sanghvi, Rada Amin, Elisa Oricchio, Man Jiang, Anja Mottok, Nicolas Denis-Lagache, Giovanni Ciriello, Wayne Tam, ...> ;Cell. 2016 Oct 6
53 citations
A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia
Nisar A. Amin, Erlene K. Seymour, Kamlai Saiya-Cork, Brian Parkin, Kerby Shedden, Sami N. Malek> ;Clinical Cancer Research. 2016 Sep 1
17 citations
Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models
Qing Wu, Aaron Bhole, Haiyan Qin, Judith E. Karp, Sami N. Malek, John K. Cowell, Mingqiang Ren> ;Oncotarget. 2016 Jul 6
10 citations
Gene mutations in chronic lymphocytic leukemia.
Nisar A. Amin, Sami N. Malek> ;Seminars in Oncology. 2016 Apr 1
38 citations
Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner
Shihan He, Bhavna Malik, Dmitry Borkin, Hongzhi Miao, Shirish Shukla, Katarzyna Kempińska, Trupta Purohit, Jingya Wang, Lili Chen, Brian Parkin, Sami N. Malek, Gwenn D...> ;Leukemia. 2016 Feb 1
18 citations
Integrated Genomic Profiling, Therapy Response, and Survival in Adult Acute Myelogenous Leukemia
Brian Parkin, Peter Ouillette, Mehmet Yildiz, Kamlai Saiya-Cork, Kerby Shedden, Sami N. Malek> ;Clinical Cancer Research. 2015 May 1
48 citations
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells
Morgan Jones, Jennifer Chase, Michelle L. Brinkmeier, Jing Xu, Daniel N. Weinberg, Julien Schira, Ann Friedman, Sami N. Malek, Jolanta Grembecka, Tomasz Cierpicki, Yal...> ;The Journal of Clinical Investigation. 2015 May 1
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Abstracts/Posters

Paired Analyses of AML at Diagnosis and Relapse By Single-Cell RNA Sequencing Identifies Two Distinct Relapse Patterns
Sami Malek, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

Impact of Disease Burden in Acute Myeloid Leukemia
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018

Grant Support

Genomic Complexity And Clinical Outcome In Chronic Lymphocytic LeukemiaNational Cancer Institute2009–2012
Genomic Profiling And Clinical Outcome In Chronic Lymphocytic LeukemiaNational Cancer Institute2007–2008