SamirSofticMD

PubMed

• De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics.
  Martin Varea Romo, Kishor Acharya, Nathan R Shelman, Phillip Minar, Lee A Denson, Samir Softic> ;Journal of Pediatrics, Perinatology and Child Health. 2024 Jan 1
• 6 citations
  The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease.
  Keisuke Sawada, Hak Chung, Samir Softic, Maria E Moreno-Fernandez, Senad Divanovic> ;Cell Metabolism. 2023 Nov 7
• Direct cost variance analysis of peroral endoscopic myotomyheller myotomy for management of achalasia: A tertiary referral center experience.
  Syedreza Ali Haider, Gregory S Bills, C Prakash Gyawali, Passisd Laoveeravat, Jordan Miller, Samir Softic, Mihir S Wagh, Moamen Gabr> ;World Journal of Gastrointestinal Endoscopy. 2023 Oct 16
• 1 citations
  Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice.
  Mikala M Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E Mead, Zachary A Kipp, Evelyn A Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan ...> ;Molecular Metabolism. 2023 Dec 1
• 2 citations
  Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice.
  Yoshiyuki Watanabe, Shiho Fujisaka, Yoshitomo Morinaga, Shiro Watanabe, Allah Nawaz, Hideki Hatta, Tomonobu Kado, Ayumi Nishimura, Muhammad Bilal, Muhammad Rahil Aslam...> ;Molecular Metabolism. 2023 Nov 1
• 1 citations
  Fructose Metabolism and Metabolic Dysfunction in Adolescents and Young Adults.
  Samir Softic, Miguel A Lanaspa, Brian DeBosch> ;Nutrients. 2023 Jul 16
• 7 citations
  Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
  Se-Hyung Park, Robert N Helsley, Taghreed Fadhul, Jennifer L S Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H Solheim, Shiho Fujisaka, Hui Pan, Jonathan M Dreyfuss, Jo...> ;Metabolism. 2023 Aug 1
• 8 citations
  Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation.
  Robert N Helsley, Se-Hyung Park, Hemendra J Vekaria, Patrick G Sullivan, Lindsey R Conroy, Ramon C Sun, María Del Mar Romero, Laura Herrero, Joanna Bons, Christina D K...> ;Journal of Hepatology. 2023 Jul 1
• Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
  Se-Hyung Park, Robert N Helsley, Taghreed Fadhul, Jennifer L S Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H Solheim, Shiho Fujisaka, Hui Pan, Jonathan M Dreyfuss, Jo...> ;Biorxiv. 2023 Jan 27
• 3 citations
  Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.
  Francois Moreau, Bruna Brasil Brunao, Xiang-Yu Liu, Frederic Tremblay, Kevin Fitzgerald, Julian Avila-Pacheco, Clary Clish, Ronald C Kahn, Samir Softic> ;Journal of Lipid Research. 2023 Feb 1
• 12 citations
  Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD.
  Mustafa Kutlu Inci, Se-Hyung Park, Robert N Helsley, Suzanna L Attia, Samir Softic> ;The Journal of Nutritional Biochemistry. 2023 Apr 1
• 2 citations
  Pediatric NASH therapies: A speedbump on the road to success.
  Samir Softic, Rohit Kohli> ;Hepatology. 2022 Aug 1
• 3 citations
  Dietary Counseling Aimed at Reducing Sugar Intake Yields the Greatest Improvement in Management of Weight and Metabolic Dysfunction in Children with Obesity.
  Aurelia Radulescu, Mary Killian, Qiwen Kang, Qingcong Yuan, Samir Softic> ;Nutrients. 2022 Apr 3
• 18 citations
  Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents.
  Justin F Creeden, Zachary A Kipp, Mei Xu, Robert M Flight, Hunter N B Moseley, Genesee J Martinez, Wang-Hsin Lee, Khaled Alganem, Ali S Imami, Megan R McMullen, Sanjoy...> ;Hepatology. 2022 Nov 1
• 6 citations
  Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non-alcoholic fatty liver disease and metabolic dysfunction
  Aurelia Radulescu, Adam Dugan, Mary Killian, Suzanna L Attia, Marialena Mouzaki, George J. Fuchs, Rohit Kohli, Henrietta S. Bada, Philip A. Kern, Samir Softic> ;Pediatric Obesity. 2021 Oct 18
• 10 citations
  Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue.
  Erica P. Homan, Bruna B. Brandão, Samir Softic, Abdelfattah El Ouaamari, Brian T. O’Neill, Rohit N. Kulkarni, Jason K. Kim, C. Ronald Kahn> ;The Journal of Clinical Investigation. 2021 Oct 1
• 5 citations
  A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes.
  Se-Hyung Park, Robert N. Helsley, Leila Noetzli, Ho-Chou Tu, Kristina Wallenius, Gavin O'Mahony, Jeremie Boucher, Jianming Liu, Samir Softic> ;STAR Protocols. 2021 Aug 9
• 4 citations
  Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
  Michelle S M A Damen, Traci E. Stankiewicz, Se-Hyung Park, Robert N. Helsley, Calvin C. Chan, Maria E. Moreno-Fernandez, Jessica R Doll, Sara Szabo, De’Broski R. Herbe...> ;International Journal of Obesity. 2021 Jul 23
• 17 citations
  Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens.
  Weikang Cai, Xuemei Zhang, Thiago M. Batista, Ruben Garcia-Martin, Samir Softic, Guoxiao Wang, Alfred K. Ramirez, Masahiro Konishi, Brian T. O’Neill, Jong Hun Kim, Jas...> ;Diabetes. 2021 May 24
• 72 citations
  Evolving Role for Pharmacotherapy in NAFLD/NASH.
  Suzanna L Attia, Samir Softic, Marialena Mouzaki> ;Clinical and Translational Science. 2021 Jan 1
• 1 citations
  Author Correction: Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin
  Mari Saif, Wilhelmus J. Kwanten, Jessica A. Carr, Ivy X. Chen, Jessica M. Posada, Amitabh Srivastava, Juanye Zhang, Yi Zheng, Matthias Pinter, Sampurna Chatterjee, Sam...> ;Nature Biomedical Engineering. 2020 Nov 24
• 3 citations
  Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells
  Manoj K. Gupta, Heidrun Vethe, Samir Softic, Tata Nageswara Rao, Vilas Wagh, Jun Shirakawa, Harald Barsnes, Marc Vaudel, Tomozumi Takatani, Sevim Kahraman, Masaji Saka...> ;Stem Cell Reports. 2020 Nov 10
• 32 citations
  Tissue-Specific Fructose Metabolism in Obesity and Diabetes.
  Robert N. Helsley, Francois Moreau, Manoj K. Gupta, Aurelia Radulescu, Brian J. DeBosch, Samir Softic> ;Current Diabetes Reports. 2020 Oct 15
• 8 citations
  Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.
  Guoxiao Wang, Yingying Yu, Weikang Cai, Thiago M. Batista, Sujin Suk, Hye Lim Noh, Michael F. Hirshman, Pasquale Nigro, Mengyao Ella Li, Samir Softic, Laurie J. Goodye...> ;Diabetes. 2020 Aug 31
• 19 citations
  Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
  Mari Saif, Wilhelmus J. Kwanten, Jessica A. Carr, Ivy X. Chen, Jessica M. Posada, Amitabh Srivastava, Juanye Zhang, Yi Zheng, Matthias Pinter, Sampurna Chatterjee, Sam...> ;Nature Biomedical Engineering. 2020 Jun 22
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