SamirEzzeldahWittaMD

PubMed

• 8 citations
  Histone deacetylase inhibitors in non-small-cell lung cancer.
  Samir E. Witta> ;Journal of Thoracic Oncology. 2012 Dec 1
• 139 citations
  Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy
  Samir E. Witta, Robert M. Jotte, Katrik Konduri, Marcus A. Neubauer, Alexander I. Spira, Robert L. Ruxer, Marileila Varella-Garcia, Paul A. Bunn, Fred R. Hirsch> ;Journal of Clinical Oncology. 2012 Apr 16
• Santa Monica SupplementSupportive Care
  Samir E. Witta> ;Journal of Thoracic Oncology. 2010 Dec 1
• 103 citations
  Insulin-like Growth Factor Receptor 1 (IGF1R) Gene Copy Number Is Associated With Survival in Operable Non–Small-Cell Lung Cancer: A Comparison Between IGF1R Fluoresce...
  Rafal Dziadziuszko, Daniel T. Merrick, Samir E. Witta, Adelita D. Mendoza, Barbara Szostakiewicz, Amelia Szymanowska, Witold Rzyman, Katarzyna Dziadziuszko, Jacek Jass...> ;Journal of Clinical Oncology. 2010 May 1
• Synergistic effect of SNDX-275 with lapatinib or erlotinib in breast, lung, or head and neck cancer cell lines expressing HER- 2.
  Witta SE, Franekova V, Yoshida K, Igolnikov I, Frederick B, Varella-Garcia M, Bunn PA, Hirsch FR> ;J. Clin. Oncol.. 2009-05-20
• Results from a phase I safety lead-in study investigating the combination of erlotinib and the histone deacetylase inhibitor entinostat in patients with advanced NSCLC.
  Konduri K, Spira AI, Jotte RM, Boyd T, Boyd T, Gaffar YA, Reynolds C, Witta SE> ;J. Clin. Oncol.. 2009-05-20
• Insulin-like growth factor receptor 1 (IGF1R) protein expression, mRNA expression and gene copy number in operable non-small cell lung cancer (NSCLC).
  Dziadziuszko R, Merrick DT, Witta SE, Mendoza AD, Szostakiewicz B, Rzyman W, Jassem J, Bunn PA, Varella-Garcia M, Hirsch FR> ;J. Clin. Oncol.. 2009-05-20
• 34 citations
  ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC)
  Samir E. Witta, Rafal Dziadziuszko, K. Yoshida, K. Hedman, M. Varella-Garcia, P. A. Bunn, Fred R. Hirsch> ;Annals of Oncology. 2009 Apr 1
• 74 citations
  A Phase I Biological and Pharmacologic Study of the Heparanase Inhibitor PI-88 in Patients with Advanced Solid Tumors
  Michele Basche, Daniel L. Gustafson, Scott N. Holden, Cindy L. O'Bryant, Lia Gore, Samir E. Witta, Mary Kay Schultz, Mark Morrow, Adrah Levin, Brian R. Creese, Michael...> ;Clinical Cancer Research. 2006 Sep 15
• 106 citations
  Baseline Gene Expression Predicts Sensitivity to Gefitinib in Non–Small Cell Lung Cancer Cell Lines
  Christopher D. Coldren, Barbara Helfrich, Samir E. Witta, Michio Sugita, Razvan Lapadat, Chan Zeng, Anna E. Barón, Wilbur A. Franklin, Fred R. Hirsch, Mark W. Geraci, ...> ;Molecular Cancer Research. 2006 Aug 1
• Predicting clinical benefit from EGFR TKIs: Not all EGFR mutations are equal.
  Hirsch FR, Franklin WA, McCoy J, Cappuzzo F, Varella-Garcia M, Witta SE, Gumerlock P, West H, Gandara DR, Bunn PA> ;J. Clin. Oncol.. 2006-06-20
• 52 citations
  Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy.
  Paul A. Bunn, Rafal Dziadziuszko, Marileila Varella-Garcia, Wilbur A. Franklin, Samir E. Witta, Karen Kelly, Fred R. Hirsch> ;Clinical Cancer Research. 2006 Jun 15
• 80 citations
  Epidermal Growth Factor Receptor Messenger RNA Expression, Gene Dosage, and Gefitinib Sensitivity in Non ^Small Cell Lung Cancer
  Rafal Dziadziuszko, Samir E. Witta, Federico Cappuzzo, Seongjin Park, Koji Tanaka, Peter V. Danenberg, Anna E. Barón, Lucio Crinò, Wilbur A. Franklin, Paul A. Bunn, Ma...> ;Clinical Cancer Research. 2006 May 15
• 410 citations
  Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.
  Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla J. Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio...> ;Cancer Research. 2006 Jan 15
• 62 citations
  Characterization of the Bex gene family in humans, mice, and rats.
  Enrique Alvarez, Wenbo Zhou, Samir E. Witta, Curt R. Freed> ;Gene. 2005 Aug 29
• Overcoming resistance to EGFR inhibitors in NSCLC cell lines by sequential treatment with histone deacetylase inhibitors.
  Witta SE, Helfrich B, Chan D, Hirsch F, Franklin W, Drabkin HA, Gemmill RM, Bunn PA> ;J. Clin. Oncol.. 2005-06-01
• 1307 citations
  Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer
  Federico Cappuzzo, Fred R. Hirsch, Elisa Rossi, Stefania Bartolini, Giovanni Luca Ceresoli, Lynne T. Bemis, Jerry Haney, Samir E. Witta, Kathleen D. Danenberg, I. Dome...> ;Journal of the National Cancer Institute. 2005 May 4
• 52 citations
  Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer
  Fred R. Hirsch, Samir E. Witta> ;Current Opinion in Oncology. 2005 Mar 1
• 20 citations
  A phase I and pharmacokinetic study of exisulind and docetaxel in patients with advanced solid tumors.
  Samir E. Witta, Daniel L. Gustafson, A. Scott Pierson, Alexander Menter, Scott N. Holden, Michele Basche, Martha Persky, Cindy L. O'Bryant, Chan Zeng, Anna E. Barón, M...> ;Clinical Cancer Research. 2004 Nov 1
• Defining gefitinib sensitivity/resistance in non-small cell lung cancer (NSCLC) cell lines by affymetrix gene arrays.
  Hirsch FR, Franklin WA, Witta SE, Helfrich B, Lapadat R, Coldren CD, Sugita M, Bunn PA> ;J. Clin. Oncol.. 2004-07-15
• Updated results from a phase I trial of the histone deacetylase (HDAC) inhibitor MS-275 in patients with refractory solid tumors.
  Gore L, Holden SN, Basche M, Raj SKS, Arnold I, O'Bryant C, Witta S, Rohde B, McCoy C, Eckhardt SG> ;J. Clin. Oncol.. 2004-07-15
• 53 citations
  Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortal...
  Edward D. Clarkson, Francisco G. La Rosa, Judith Edwards-Prasad, David A. Weiland, Samir E. Witta, Curt R. Freed, Kedar N. Prasad> ;Proceedings of the National Academy of Sciences of the United States of America. 1998 Feb 3
• 46 citations
  Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats
  W. Michael Zawada, Jose B. Cibelli, Paul K. Choi, Edward D. Clarkson, P. Golueke, Samir E. Witta, K.Pat Bell, J.J. Kane, F. Abel Ponce de Leon, D. Joseph Jerry, James ...> ;Nature Medicine. 1998 Jan 1
• 18 citations
  XIPOU 2 is a potential regulator of Spemann's Organizer.
  Samir E. Witta, Sheryl M. Sato> ;Development. 1997 Mar 15
• XIPOU 2, a noggin-inducible gene, has direct neuralizing activity.
  Witta, S. E., Agarwal, V. R., Sato, S. M.> ;Development. 1995 Mar
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