SamuelZacharyGoldhaberMD

Preventive Cardiology, Vascular Medicine

Professor of Medicine, Harvard Medical School; Associate Chief and Clinical Director, Division of Cardiovascular Medicine, BWH; Director, Thrombosis Research Group, BWH

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Office
75 Francis St
Boston, MA 02115
Phone+1 857-307-1932
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Education & Training

Brigham and Women's HospitalFellowship, Cardiovascular Disease, 1979 - 1982
Brigham and Women's HospitalResidency, Internal Medicine, 1976 - 1979
Harvard Medical SchoolClass of 1976

Certifications & Licensure

MA State Medical License 1979 - 2025
ME State Medical License 2021 - 2024
NH State Medical License 2022 - 2024
RI State Medical License 2022 - 2024
FL State Medical License 2022 - 2024
CT State Medical License 2021 - 2023
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Fellow (FAHA) American Heart Association
Fellow (FESC) European Society of Vascular Medicine)
Fellow (FACC) American College of Cardiology
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Super Doctor SuperDoctors.com
Whos Who in Medicine and Healthcare Marquis Whos Who
Top MD Consumers Checkbook
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Clinical Trials

Multi-Center Human Alert Trial to Prevent DVT and PE Start of enrollment: 2006 Mar 01
Completed
Gastrointestinal Ulceration in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Once Daily Enoxaparin for Outpatient Treatment of Acute DVT and/or Pulmonary Embolism Start of enrollment: 2006 May 01
Completed
Not Applicable
Fondaparinux as Monotherapy for DVT and/or Pulmonary Embolism Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Heparin Induced Thrombocytopenia: Pharmacoeconomics Start of enrollment: 2006 Jul 01
Completed
Epidemiology of Venous Thromboembolism Start of enrollment: 2006 Apr 01
Completed
Heparin-Induced Thrombocytopenia Registry Start of enrollment: 2005 Oct 01
Completed
Registry of Hospitalized Patients Treated With Fondaparinux Start of enrollment: 2007 Jul 01
Completed
3 Screen Electronic Alert Start of enrollment: 2007 Jul 01
Completed
Retrospective Study to Review Patients at Risk for VTE at Hospital Discharge Start of enrollment: 2008 Feb 01
Completed
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Start of enrollment: 2009 Nov 01
Completed
Phase 3
Discharge ALERT: Quality Improvement Initiative Start of enrollment: 2009 Apr 01
Completed
Not Applicable
Submassive and Massive Pulmonary Embolism Treatment With Ultrasound Accelerated Thrombolysis Therapy Start of enrollment: 2012 Jun 07
Completed
Phase 3
A Randomized, Open-Label, Parallel-Group, Multi-Center Study for the Evaluation of Efficacy and Safety of Edoxaban Monotherapy Versus Low Molecular Weight (LMW) Heparin/Warfarin in Subjects With Symptomatic Deep-Vein Thrombosis Start of enrollment: 2012 Aug 01
Completed
Phase 2
Randomized Controlled Trial of Alert-Based Computerized Decision Support for Optimizing Low-Density Lipoprotein Management Start of enrollment: 2021 Oct 08
Active, not recruiting
Not Applicable
Roles: Sub-Investigator
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Publications & Presentations

PubMed

Community Socioeconomic Status, Acute Cardiovascular Hospitalizations, and Mortality in Medicare, 2003 to 2019.
Jiaman Xu, Yang Song, Rishi K Wadhera, Eric A Secemsky, Robert W Yeh, Samuel Z Goldhaber> ;Circulation. Cardiovascular Quality and Outcomes. 2024 Apr 10
Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease.
Azita H Talasaz, Parham Sadeghipour, Luis Ortega-Paz, Hessam Kakavand, Maryam Aghakouchakzadeh, Craig Beavers, John Fanikos, John W Eikelboom, Deborah M Siegal, Manuel...> ;Nature Reviews. Cardiology. 2024 Mar 20
Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT ...
Keith M Sterling, Samuel Z Goldhaber, Andrew S P Sharp, Nils Kucher, Noah Jones, Robert Maholic, Nicolas Meneveau, David Zlotnick, Sameh Sayfo, Stavros V Konstantinide...> ;Circulation. Cardiovascular Interventions. 2024 Mar 1
1 citations
When Direct Oral Anticoagulants Should Not Be Standard Treatment: JACC State-of-the-Art Review.
Antoine Bejjani, Candrika D Khairani, Ali Assi, Gregory Piazza, Parham Sadeghipour, Azita H Talasaz, John Fanikos, Jean M Connors, Deborah M Siegal, Geoffrey D Barnes,...> ;Journal of the American College of Cardiology. 2024 Jan 23
2 citations
Developmental or Procedural Vena Cava Interruption and Venous Thromboembolism: A Review.
Bikdeli, B., Sadeghipour, P., Lou, J., Bejjani, A., Khairani, C., Rashedi, S., Lookstein, R., Lansky, A., Vedantham, S., Sobieszczyk, P., Mena-Hurtado, C., Aghayev, A....> ;Seminars in Thrombosis and Hemostasis. 2024 Jan 4
Obesity and Pulmonary Embolism: Can We Dismantle the "Obesity Paradox".
Samuel Z Goldhaber> ;Thrombosis and Haemostasis. 2024 Jan 1
Comparing U.S. and Canadian treatment patterns on venous thromboembolism outcomes in the GARFIELD-VTE registry.
Adrian C Chen, Amit S Rao, Alisha Oropallo, Samuel Z Goldhaber, Meg E Fluharty, Uma Maheshwari, Marc Carrier, Alexander G G Turpie, Karen Pieper, Gloria Kayani, Ajay K...> ;Thrombosis Research. 2023 Dec 1
Clinical Outcomes in Older Patients with Atrial Fibrillation: Insights from the GARFIELD-AF Registry.
Samuel Z Goldhaber, Jean-Pierre Bassand, A John Camm, Saverio Virdone, Karen Pieper, Frank Cools, Ramon Corbalan, Bernard J Gersh, Shinya Goto, Sylvia Haas, Frank Miss...> ;The American Journal of Medicine. 2024 Feb 1
Antiplatelet Therapy in Patients With Abdominal Aortic Aneurysm Without Symptomatic Atherosclerotic Disease.
Chalotte W Nicolajsen, Mette Søgaard, Martin Jensen, Nikolaj Eldrup, Torben B Larsen, Samuel Z Goldhaber, Christian-Alexander Behrendt, Peter B Nielsen> ;JAMA Network Open. 2023 Oct 2
4 citations
Major cardiovascular events after COVID-19, event rates post-vaccination, antiviral or anti-inflammatory therapy, and temporal trends: Rationale and methodology of the...
Behnood Bikdeli, Candrika D Khairani, Darsiya Krishnathasan, Antoine Bejjani, Andre Armero, Anthony Tristani, Julia Davies, Nicole Porio, Ali A Assi, Victor Nauffal, U...> ;Thrombosis Research. 2023 Aug 1
1 citations
Atorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial.
Azita H Talasaz, Parham Sadeghipour, Hooman Bakhshandeh, Babak Sharif-Kashani, Farid Rashidi, Mohammad Taghi Beigmohammadi, Keivan Gohari Moghadam, Somaye Rezaian, Ali...> ;Thrombosis and Haemostasis. 2023 Jul 1
Electronic alerts for ambulatory patients with atrial fibrillation not prescribed anticoagulation: A randomized, controlled trial (AF-ALERT2).
Gregory Piazza, Shelley Hurwitz, Umberto Campia, Behnood Bikdeli, Junyang Lou, Candrika D Khairani, Antoine Bejjani, Julia E Snyder, Mariana Pfeferman, Briana Barns, S...> ;Thrombosis Research. 2023 Jul 1
Guideline-directed medical therapies for comorbidities among patients with atrial fibrillation: results from GARFIELD-AF.
Alan John Camm, Jan Steffel, Saverio Virdone, Jean-Pierre Bassand, Keith A A Fox, Samuel Z Goldhaber, Shinya Goto, Sylvia Haas, Alexander G G Turpie, Freek W A Verheug...> ;European Heart Journal Open. 2023 May 1
2 citations
Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study.
Behnood Bikdeli, Alfonso Muriel, Yun Wang, Gregory Piazza, Candrika D Khairani, Rachel P Rosovsky, Ghazaleh Mehdipoor, Michelle L O'Donoghue, Olga Madridano, Juan Bosc...> ;Seminars in Thrombosis and Hemostasis. 2023 Oct 1
Healthcare Resource Utilization in Patients with Newly Diagnosed Atrial Fibrillation: A Global Analysis from the GARFIELD-AF Registry.
Lorenzo G Mantovani, Paolo Cozzolino, Pietro Ferrara, Saverio Virdone, A John Camm, Freek W A Verheugt, Jean-Pierre Bassand, Alexander G G Turpie, Werner Hacke, Gloria...> ;Healthcare. 2023 Feb 21
2 citations
Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial.
Viviany R Taqueti, Amil M Shah, Brendan M Everett, Aruna D Pradhan, Gregory Piazza, Courtney Bibbo, Jon Hainer, Victoria Morgan, Ana Carolina do A H de Souza, Hicham S...> ;JACC. Basic to Translational Science. 2023 Feb 1
Meningioma resection and venous thromboembolism incidence, management, and outcomes.
Samantha M Rizzo, Sherwin Tavakol, Wenya Linda Bi, Siling Li, Eric A Secemsky, Umberto Campia, Gregory Piazza, Samuel Z Goldhaber, Alec A Schmaier> ;Research and Practice in Thrombosis and Haemostasis. 2023 Feb 1
1 citations
Stroke and Myocardial Infarction in Patients with Abdominal Aortic Aneurysm and New-Onset Atrial Fibrillation.
Chalotte W Nicolajsen, Peter B Nielsen, Martin Jensen, Nikolaj Eldrup, Torben B Larsen, Gregory Y H Lip, Samuel Z Goldhaber, Mette Søgaard> ;Thrombosis and Haemostasis. 2023 May 1
Guideline adherence and clinical outcomes of patients with acute pulmonary embolism evaluated by a multidisciplinary response team at a quaternary care center.
Romain Chopard, Umberto Campia, Karola S Jering, Zaid I Almarzooq, Julia Elizabeth Snyder, Samantha Rizzo, Aaron B Waxman, Samuel Z Goldhaber, Gregory Piazza> ;Thrombosis Research. 2023 Feb 1
3 citations
External validation of the ADA score for predicting thrombosis among acutely ill hospitalized medical patients from the APEX Trial.
Gerald Chi, Francesco Violi, Pasquale Pignatelli, Annarita Vestri, Alessandra Spagnoli, Lorenzo Loffredo, Adrian F Hernandez, Russell D Hull, Alexander T Cohen, Robert...> ;Journal of Thrombosis and Thrombolysis. 2023 Feb 1
18 citations
Catheter-Directed Thrombolysis vs Anticoagulation in Patients With Acute Intermediate-High-risk Pulmonary Embolism: The CANARY Randomized Clinical Trial.
Parham Sadeghipour, Yaser Jenab, Jamal Moosavi, Kaveh Hosseini, Bahram Mohebbi, Ali Hosseinsabet, Saurav Chatterjee, Hamidreza Pouraliakbar, Shapour Shirani, Mehdi H S...> ;JAMA Cardiology. 2022 Dec 1
24 citations
Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients With Antiphospholipid Syndromes: Meta-Analysis of Randomized Trials.
Candrika D Khairani, Antoine Bejjani, Gregory Piazza, David Jimenez, Manuel Monreal, Saurav Chatterjee, Vittorio Pengo, Scott C Woller, Josefina Cortes-Hernandez, Jean...> ;Journal of the American College of Cardiology. 2023 Jan 3
2 citations
Risk of Recurrent Venous Thromboembolism in Selected Subgroups of Men: A Danish Nationwide Cohort Study.
Ida Ehlers Albertsen, Stavros V Konstantinides, Gregory Piazza, Samuel Z Goldhaber, Torben Bjerregaard Larsen, Mette Søgaard, Peter Brønnum Nielsen> ;TH Open. 2022 Oct 1
2 citations
On-treatment Comparative Effectiveness of Vitamin K Antagonists and Direct Oral Anticoagulants in GARFIELD-VTE, and Focus on Cancer and Renal Disease.
Sylvia Haas, Alfredo E Farjat, Karen Pieper, Walter Ageno, Pantep Angchaisuksiri, Henri Bounameaux, Samuel Z Goldhaber, Shinya Goto, Lorenzo Mantovani, Paolo Prandoni,...> ;TH Open. 2022 Oct 1
5 citations
Trends in management and outcomes of pulmonary embolism with a multidisciplinary response team.
Romain Chopard, Umberto Campia, Lucas Morin, Karola S Jering, Zaid I Almarzooq, Julia Elizabeth Snyder, Samantha Rizzo, Aaron B Waxman, Samuel Z Goldhaber, Gregory Piazza> ;Journal of Thrombosis and Thrombolysis. 2022 Oct 1
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Journal Articles

Asymptomatic Deep Vein Thrombosis Is Associated with an Increased Risk of Death: Insights from the APEX Trial
Iqra Qamar, Gerald Chi, Adrian F Hernandez, C Michael Gibson, Serge Korjian, Samuel Z Goldhaber, Thrombosis and Haemostasis

Lectures

ECMO and Surgical Embolectomy
Harvard Medical School, Boston, Massachusetts - 10/18/2012
Thromboembolism Prophylaxis for Patients Discharged from the Hospital Easier Said Than Done
Harvard Medical School ,Department Of Continuing Education, Boston, Massachusetts - 3/4/2013
Panelist: Case 1
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Prospective Study of Apixaban for Primary Prevention of Venous Thromboembolism in Patients with Multiple Myeloma Receiving Immunomodulatory Therapy
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Protecting Our Vulnerable, Medically Ill Patients From Venous Thromboembolism
60th American Society of Hematology Annual Meeting - 11/30/2018
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Authored Content

ECMO and Surgical EmbolectomyAugust 2020
Thromboembolism Prophylaxis for Patients Discharged from the Hospital Easier Said Than DoneJune 2020

Press Mentions

Blood Clot Prevention: Three Stretches That Could Help You Prevent the Deadly ConditionApril 7th, 2021
Covid Vaccine Side Effects: Thrombosis Reported in Patients - What Is It?March 12th, 2021
Surgical Management of Acute PE Provides Good OutcomesAugust 20th, 2020
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