SamuelKleinMD

PubMed

• Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity.
  Max C Petersen, Gordon I Smith, Hector H Palacios, Sarah S Farabi, Mihoko Yoshino, Jun Yoshino, Kevin Cho, Victor G Davila-Roman, Mahalakshmi Shankaran, Ruteja A Barve...> ;Cell Metabolism. 2024 Apr 2
• Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight/obesity.
  Chondronikola, M., Yoshino, J., Giardina, J., Laforest, R., Wahl, R., Patterson, B., Mittendorfer, B., Ramaswamy, R., Klein, S.> ;Cell Reports. Medicine. 2024 Jan 16
• 5 citations
  Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes.
  Joseph W Beals, Brandon D Kayser, Gordon I Smith, George G Schweitzer, Kyleigh Kirbach, Monica L Kearney, Jun Yoshino, Gibraan Rahman, Rob Knight, Bruce W Patterson, S...> ;Nature Metabolism. 2023 Jul 1
• 6 citations
  Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases.
  Yehuda Handelsman, Javed Butler, George L Bakris, Ralph A DeFronzo, Gregg C Fonarow, Jennifer B Green, George Grunberger, James L Januzzi Jr, Samuel Klein, Pamela R Ku...> ;Journal of Diabetes and Its Complications. 2023 Feb 1
• 8 citations
  The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.
  Cox, A., Masschelin, P., Saha, P., Felix, J., Sharp, R., Lian, Z., Xia, Y., Chernis, N., Bader, D., Kim, K., Li, X., Yoshino, J., Li, X., Li, G., Sun, Z., Wu, H., Coar...> ;Cell Metabolism. 2022 Dec 6
• 10 citations
  Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
  Haopeng Xiao, Luiz H M Bozi, Yizhi Sun, Christopher L Riley, Vivek M Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L Mills, Margo P Emont, Wenfei Sun, Anita Reddy...> ;Cell. 2022 Nov 23
• 11 citations
  ADRA1A-Gαsignalling potentiates adipocyte thermogenesis through CKB and TNAP.
  Janane F Rahbani, Charlotte Scholtes, Damien M Lagarde, Mohammed F Hussain, Anna Roesler, Christien B Dykstra, Jakub Bunk, Bozena Samborska, Shannon L O'Brien, Emma Tr...> ;Nature Metabolism. 2022 Nov 1
• 6 citations
  Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes.
  Mihoko Yoshino, Jun Yoshino, Gordon I Smith, Richard I Stein, Adam J Bittel, Daniel C Bittel, Dominic N Reeds, David R Sinacore, W Todd Cade, Bruce W Patterson, Kevin ...> ;Cell Metabolism. 2022 Oct 4
• 2 citations
  Do lifestyle factors and quality of life differ in people with metabolically healthy and unhealthy obesity?
  Sarah S Farabi, Gordon I Smith, George G Schweitzer, Richard I Stein, Samuel Klein> ;International Journal of Obesity. 2022 Oct 1
• 15 citations
  Complex physiology and clinical implications of time-restricted eating.
  Max C Petersen, Molly R Gallop, Stephany Flores Ramos, Amir Zarrinpar, Josiane L Broussard, Maria Chondronikola, Amandine Chaix, Samuel Klein> ;Physiological Reviews. 2022 Oct 1
• 23 citations
  Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles.
  Ibon Martínez-Arranz, Chiara Bruzzone, Mazen Noureddin, Ruben Gil-Redondo, Itziar Mincholé, Maider Bizkarguenaga, Enara Arretxe, Marta Iruarrizaga-Lejarreta, David Fer...> ;Hepatology. 2022 Oct 1
• 17 citations
  Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial.
  Jeremy Pettus, Schafer C Boeder, Mark P Christiansen, Douglas S Denham, Timothy S Bailey, Halis K Akturk, Leslie J Klaff, Julio Rosenstock, Mickie H M Cheng, Bruce W B...> ;Nature Medicine. 2022 Oct 1
• 5 citations
  Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity.
  William Todd Cade, Bettina Mittendorfer, Bruce W Patterson, Debra Haire-Joshu, Alison G Cahill, Richard I Stein, Kenneth B Schechtman, Rachel A Tinius, Katherine Brown...> ;Obesity. 2022 Oct 1
• 3 citations
  Physiological interindividual variability in endogenous estradiol concentration does not influence adipose tissue and hepatic lipid kinetics in women.
  Faidon Magkos, Elisa Fabbrini, Bruce W Patterson, Bettina Mittendorfer, Samuel Klein> ;European Journal of Endocrinology. 2022 Sep 1
• 4 citations
  Glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, and glucagon receptor poly-agonists: a new era in obesity pharmacotherapy.
  Is-Haq O Malik, Max C Petersen, Samuel Klein> ;Obesity. 2022 Sep 1
• 18 citations
  Licogliflozin for nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a study.
  Stephen A Harrison, Federico Perez Manghi, William B Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Cha...> ;Nature Medicine. 2022 Jul 1
• 16 citations
  Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids.
  Michael R Martino, Manuel Gutiérrez-Aguilar, Nicole K H Yiew, Andrew J Lutkewitte, Jason M Singer, Kyle S McCommis, Daniel Ferguson, Kim H H Liss, Jun Yoshino, M Katie...> ;Cell Reports. 2022 Apr 26
• 139 citations
  Why does obesity cause diabetes?
  Samuel Klein, Amalia Gastaldelli, Hannele Yki-Järvinen, Philipp E Scherer> ;Cell Metabolism. 2022 Jan 4
• 138 citations
  Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes.
  Clair Crewe, Jan-Bernd Funcke, Shujuan Li, Nolwenn Joffin, Christy M. Gliniak, Alexandra L. Ghaben, Yu An, Hesham A. Sadek, Ruth Gordillo, Yucel Akgul, Shiuhwei Chen, ...> ;Cell Metabolism. 2021 Sep 7
• 71 citations
  Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease.
  Anja Fuchs, Dmitri Samovski, Gordon I. Smith, Vincenza Cifarelli, Sarah S. Farabi, Jun Yoshino, Terri A. Pietka, Shin-Wen Chang, Sarbani Ghosh, Terence M. Myckatyn, Sa...> ;Gastroenterology. 2021 Sep 1
• 14 citations
  Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis.
  Yi Zhu, Na Li, Mingyang Huang, Mason Bartels, Sophie Dogné, Shangang Zhao, Xi Chen, Clair Crewe, Leon G. Straub, Lavanya Vishvanath, Zhuzhen Zhang, Mengle Shao, Yongji...> ;Nature Communications. 2021 Aug 10
• Response to Comment on “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”
  Samuel Klein, Mihoko Yoshino> ;Science. 2021 Jul 30
• 44 citations
  Preparing for the NASH Epidemic: A Call to Action.
  Fasiha Kanwal, Zobair M. Younossi, Yamini Natarajan, Elisabetta Bugianesi, Mary E. Rinella, Stephen A. Harrison, Christos S. Mantzoros, Kim Pfotenhauer, Samuel Klein, ...> ;Diabetes Care. 2021 Jul 26
• 5 citations
  Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release
  Caroline E. Geisler, Susma Ghimire, Chelsea Hepler, Kendra E. Miller, Stephanie M. Bruggink, Kyle P. Kentch, Mark R. Higgins, Christopher T. Banek, Jun Yoshino, Samuel...> ;Cell Reports. 2021 Jun 29
• 19 citations
  A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity
  Caroline E. Geisler, Susma Ghimire, Stephanie M. Bruggink, Kendra E. Miller, Savanna N. Weninger, Jason M. Kronenfeld, Jun Yoshino, Samuel Klein, Frank A. Duca, Benjam...> ;Cell Reports. 2021 Jun 29
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Journal Articles

• Effects of Sleeve Gastrectomy vs. Roux-en-Y Gastric Bypass on Eating Behavior and Sweet Taste Perception in Subjects with Obesity  
  Samuel Klein, J Christopher Eagon, MDPI

Lectures

• Advances and Controversies in Clinical Nutrition 2012 
  American Society for Nutrition, Chicago, Illinois - 6/22/2012