Samuel A McLean MD FACEP

Jeffrey Houpt Distinguished Investigator and Professor of Emergency Medicine, Psychiatry, and Anesthesiology, University of North Carolina at Chapel Hill School of Medicine

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101 Manning DrChapel Hill, NC 27514
Phone+1 919-966-4131

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Education & Training

Boston University Medical CenterResidency, Emergency Medicine, 1998 - 2001
Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1995 - 1998
University of Michigan Medical SchoolClass of 1995

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Certifications & Licensure

NC State Medical License 2007 - 2027
MI State Medical License 2001 - 2008
MA State Medical License 1997 - 2002
American Board of Emergency Medicine Emergency Medicine

Awards, Honors, & Recognition

Fellow (FACEP) American College of Emergency Physicians

Clinical Trials

Burn Healing and Analgesia With Propranolol
COMPLETED
PHASE2
TRAUMA HELP: Healing and Analgesia With Propranolol
WITHDRAWN
PHASE2
Healing With Venlafaxine After Injury (HELP)
COMPLETED
PHASE2

Publications & Presentations

PubMed

Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.
E Kate Webb, Anthony S Zannas, Sarah D Linnstaedt, Stacey L House, Francesca L Beaudoin
Journal of Psychiatric Research. 2026-08-01
The role of posttraumatic stress disorder symptoms in pain severity, interference, and variability after sexual assault: An ecological momentary assessment study.
Nicole A Short, Mattea Pezza, Lauren D Reyes, Jenny Black, Karen Serrano
Journal of Psychopathology and Clinical Science. 2026-08-01
Prior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma.
Emily J Mellen, Tate Poplin, Tanja Jovanovic, Grace E Rowland, Stacey L House
JAMA Psychiatry. 2026-07-29

Journal Articles

Nausea in the Peri-Traumatic Period Is Associated with Prospective Risk for PTSD Symptom Development
Elizabeth I Roger, Samuel A McLean, Ian M Kronish, Kerry J Ressler, Barbara O Rothbaum, Lauren Hudak, Charles F Gillespie, Jennifer A Sumner, Nature
Archival Report Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms over Early Posttrauma Periods
Samuel A McLean, Israel Liberzon, Kristopher R Brickman, Marijo B Tamburrino, ScienceDirect
A Functional riboSNitch in the 3′UTR of FKBP5 Alters microRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Posttraumatic Pain
Phyllis L Hendry, Robert Domeier, Samuel A McLean, Michael C Kurz, Christopher Lewandowski, The Journal of Neuroscience

Press Mentions

Health News | Feeling of Detachment After Trauma Has Worse Impact on Mental Health, Reveals StudyJune 22nd, 2022
App Measures Mental Wellness of Front Line Workers, RespondersJuly 24th, 2020
UNC Helps Launch COVID-19 Mental Health App for Health WorkersJuly 22nd, 2020

Grant Support

FKBP51 antagonism to prevent chronic pain: optimizing efficacy & evaluating safety and mechanismsUNIV OF NORTH CAROLINA CHAPEL HILL2020–2025
Applying Biopsychosocial Model To Post-Mvc Pain Development In African AmericansNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
Genetic Predictors Of Acute And Chronic Musculoskeletal Pain After Minor MVCNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008–2011
Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2007–2008
Development Of Chronic Pain After Motor Vehicle TraumaNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2006–2007