SamuelChasSilversteinMD

Allergy & Immunology • New York, NY

Professor, Physiology & Cellular Biophysics, Columbia University College of Phys & Surg

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Office
630 W 168th St
New York, NY 10032
Phone+1 212-305-3546
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Education & Training

Albert Einstein College of MedicineClass of 1963

Certifications & Licensure

NY State Medical License 1964 - 2019

Awards, Honors, & Recognition

Elected Member Institute of Medicine, 1996
Elected Member The American Society for Clinical Investigation, 1973

Publications & Presentations

PubMed

214 citations
A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease
Mercy PrabhuDas, Cynthia L. Baldwin, Paul L. Bollyky, Dawn M. E. Bowdish, Kurt Drickamer, Maria Febbraio, Joachim Herz, Lester Kobzik, Monty Krieger, John D. Loike, Be...> ;Journal of Immunology. 2017 May 15
134 citations
Standardizing scavenger receptor nomenclature
Mercy PrabhuDas, Dawn M. E. Bowdish, Kurt Drickamer, Maria Febbraio, Joachim Herz, Lester Kobzik, Monty Krieger, John D. Loike, Terry K. Means, Søren K. Moestrup, Stev...> ;Journal of Immunology. 2014 Mar 1
4 citations
How many neutrophils are enough (redux, redux)?
Samuel C. Silverstein, Raul Rabadan> ;The Journal of Clinical Investigation. 2012 Aug 1
38 citations
Toward integrative cancer immunotherapy: targeting the tumor microenvironment
Leisha A. Emens, Samuel C. Silverstein, Samir N. Khleif, Francesco M. Marincola, Jérôme Galon> ;Journal of Translational Medicine. 2012 Apr 10
76 citations
Complement Component C1q Mediates Mitochondria-Driven Oxidative Stress in Neonatal Hypoxic–Ischemic Brain Injury
Vadim S. Ten, Jun Yao, Veniamin Ratner, Sergey A. Sosunov, Deborah A. Fraser, Marina Botto, Baalasubramanian Sivasankar, B. Paul Morgan, Samuel C. Silverstein, Raymond...> ;The Journal of Neuroscience. 2010 Feb 10
97 citations
CD8+ T cell concentration determines their efficiency in killing cognate antigen–expressing syngeneic mammalian cells in vitro and in mouse tissues
Sadna Budhu, John D. Loike, Ashley Pandolfi, Soo Han, Geoffrey Catalano, Andrei Constantinescu, Raphael Clynes, Samuel C. Silverstein> ;The Journal of Experimental Medicine. 2010 Jan 18
16 citations
Teachers’ Participation in Research Programs Improves Their Students’ Achievement in Science
Samuel C. Silverstein, Jay Dubner, Jon K. Miller, Sherry Glied, John D. Loike> ;Science. 2009 Oct 16
18 citations
Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages
Ronit Reich-Slotky, Christina A. Kabbash, Phyllis Della-Latta, John S. Blanchard, Steven J. Feinmark, Sherry Freeman, Gilla Kaplan, Howard A. Shuman, Samuel C. Silvers...> ;Journal of Bacteriology. 2009 Aug 15
1 citations
How teaching matters.
Samuel C. Silverstein> ;CBE Life Sciences Education. 2006 Dec 21
7 citations
PAF-receptor antagonists, lovastatin, and the PTK inhibitor genistein inhibit H2O2 secretion by macrophages cultured on oxidized-LDL matrices.
Indra Sethy-Coraci, Lara W. Crock, Samuel C. Silverstein> ;Journal of Leukocyte Biology. 2005 Nov 1
57 citations
Statin Inhibition of Fc Receptor–Mediated Phagocytosis by Macrophages Is Modulated by Cell Activation and Cholesterol
John D. Loike, D. Y. Shabtai, R. Neuhut, S. Malitzky, Emily Lu, Jens Husemann, Ira J. Goldberg, Samuel C. Silverstein> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 Nov 1
54 citations
Determination of the Critical Concentration of Neutrophils Required to Block Bacterial Growth in Tissues
Yongmei Li, Arthur Karlin, John D. Loike, Samuel C. Silverstein> ;The Journal of Experimental Medicine. 2004 Sep 6
651 citations
Adult mouse astrocytes degrade amyloid-beta in vitro and in situ.
Tony Wyss-Coray, John D. Loike, Thomas C. Brionne, Emily Lu, Roman Anankov, Fengrong Yan, Samuel C. Silverstein, Jens Husemann> ;Nature Medicine. 2003 Mar 3
270 citations
Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system.
Jens Husemann, John D. Loike, Roman Anankov, Maria Febbraio, Samuel C. Silverstein> ;Glia. 2002 Nov 1
92 citations
A critical concentration of neutrophils is required for effective bacterial killing in suspension.
Yongmei Li, Arthur Karlin, John D. Loike, Samuel C. Silverstein> ;Proceedings of the National Academy of Sciences of the United States of America. 2002 Jun 11
29 citations
Different Gi-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils
Miles Berger, Sadna Budhu, Emily Lu, Yongmei Li, Devora Loike, Samuel C. Silverstein, John D. Loike> ;Journal of Leukocyte Biology. 2002 May 1
13 citations
The bacterial peptide N-formyl-Met-Leu-Phe inhibits killing of Staphylococcus epidermidis by human neutrophils in fibrin gels.
Yongmei Li, John D. Loike, Julia A. Ember, P. Patrick Cleary, Emily Lu, Sadna Budhu, Long Cao, Samuel C. Silverstein> ;Journal of Immunology. 2002 Jan 15
305 citations
CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyl...
Indra Sethy Coraci, Jens Husemann, Joan W. Berman, Christine M. Hulette, Jennifer H. Dufour, Gabriele K. Campanella, Andrew D. Luster, Samuel C. Silverstein, Joseph El...> ;The American Journal of Pathology. 2002 Jan 1
27 citations
CD11b/CD18 Mediates Production of Reactive Oxygen Species by Mouse and Human Macrophages Adherent to Matrixes Containing Oxidized LDL
Jens Husemann, Amrom E. Obstfeld, Maria Febbraio, Tatsuhiko Kodama, Samuel C. Silverstein> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2001 Aug 1
37 citations
Blockade of alpha 5 beta 1 integrins reverses the inhibitory effect of tenascin on chemotaxis of human monocytes and polymorphonuclear leukocytes through three-dimensi...
John D. Loike, Long Cao, Sadna Budhu, Stanley Hoffman, Samuel C. Silverstein> ;Journal of Immunology. 2001 Jun 15
14 citations
Leprosy research in the post-genome era.
Roy Curtiss, Sally Blower, Kevin Cooper, David W. Russell, Samuel C. Silverstein, Lowell Young> ;Leprosy Review. 2001 Mar 1
93 citations
Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid
Jens Husemann, John D. Loike, Tatsuhiko Kodama, Samuel C. Silverstein> ;Journal of Neuroimmunology. 2001 Mar 1
87 citations
Expression of Scavenger Receptor Class B, Type I, by Astrocytes and Vascular Smooth Muscle Cells in Normal Adult Mouse and Human Brain and in Alzheimer’s Disease Brain
Jens Husemann, Samuel C. Silverstein> ;The American Journal of Pathology. 2001 Mar 1
214 citations
Protection from Lethal Gram-Positive Infection by Macrophage Scavenger Receptor–Dependent Phagocytosis
Christian A. Thomas, Yongmei Li, Tatsuhiko Kodama, Hiroshi Suzuki, Samuel C. Silverstein, Joseph El Khoury> ;The Journal of Experimental Medicine. 2000 Jan 3
52 citations
Differential Regulation of β1 Integrins by Chemoattractants Regulates Neutrophil Migration through Fibrin
John D. Loike, Long Cao, Sadna Budhu, Eugene E. Marcantonio, Joseph El Khoury, Stanley Hoffman, Ted Yednock, Samuel C. Silverstein> ;The Journal of Cell Biology. 1999 Mar 8
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