SandraHaefnerBignerMD

Pathology • Burlington, NC

Cytopathology, Neuropathology, Anatomic Pathology, Clinical Pathology

Physician

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Office
2039 Willow Springs Lane
Burlington, NC 27215
Phone+1 336-436-6122

Fax+1 336-436-6125
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Summary

Dr. Sandra Bigner, MD is a board certified pathologist in Burlington, North Carolina. She is currently licensed to practice medicine in North Carolina, Maryland, and Virginia.

Education & Training

Duke University HospitalResidency, Pathology-Anatomic and Clinical, 1975 - 1975
Duke University HospitalResidency, Pathology-Anatomic and Clinical, 1973 - 1974
Duke University HospitalResidency, Pathology-Anatomic and Clinical, 1972 - 1972
University of Tennessee Health Science Center College of MedicineClass of 1971

Certifications & Licensure

VA State Medical License 2006 - 2024
TN State Medical License 2006 - 2023
GA State Medical License 2006 - 2023
SC State Medical License 1998 - 2023
NC State Medical License 1975 - 2023
MD State Medical License 2009 - 2022
American Board of Pathology Anatomic Pathology
American Board of Pathology Cytopathology
American Board of Pathology Neuropathology

Publications & Presentations

PubMed

26 citations
Molecular cytogenetics of brain tumors.
Sandra H. Bigner, Evelin Schröck> ;Journal of Neuropathology and Experimental Neurology. 1997 Nov 1
103 citations
Patterns of the early, gross chromosomal changes in malignant human gliomas
Sandra H. Bigner, Joachim Mark, M. Stephen Mahaley, Darell D. Bigner> ;Hereditas. 2008 Feb 14
34 citations
Comparative Genomic Hybridization Analysis of Astrocytomas: Prognostic and Diagnostic Implications
Rodney N. Wiltshire, James E. Herndon, Annie Lloyd, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner, Roger E. McLendon> ;The Journal of Molecular Diagnostics. 2004 Aug 1
48 citations
Molecular markers of prognosis in astrocytic tumors
Ahmed Rasheed, James E. Herndon, Timothy T. Stenzel, Jacqueline G. M. Raetz, Jason Kendelhardt, Henry S. Friedman, Allan H. Friedman, Darell D. Bigner, Sandra H. Bigne...> ;Cancer. 2002 May 15
129 citations
MYCC and MYCN Oncogene Amplification in Medulloblastoma
Naji Aldosari, Sandra H. Bigner, Peter C. Burger, Laurence E. Becker, James L. Kepner, Henry S. Friedman, Roger E. McLendon> ;Archives of Pathology & Laboratory Medicine. 2002 May 1
32 citations
Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft.
Naji Aldosari, Rodney N. Wiltshire, Amalia Dutra, Evelin Schröck, Roger E. McLendon, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner> ;Neuro-Oncology. 2002 Apr 1
27 citations
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
Sihong Chen, Sandra H. Bigner, Paul Modrich> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov 20
18 citations
HAM56-Immunoreactive Macrophages in Untreated Infiltrating Gliomas
Thomas J. Cummings, Christine M. Hulette, Sandra H. Bigner, Gregory J. Riggins, Roger E. McLendon> ;Archives of Pathology & Laboratory Medicine. 2001 May 1
94 citations
Phase I Trial Results of Iodine-131–Labeled Antitenascin Monoclonal Antibody 81C6 Treatment of Patients With Newly Diagnosed Malignant Gliomas
Ilkcan Cokgor, Gamal Akabani, Chien-Tsun Kuan, Henry S. Friedman, Allan H. Friedman, R. Edward Coleman, Roger E. McLendon, Sandra H. Bigner, Xiao-Guang Zhao, Ana M. Ga...> ;Journal of Clinical Oncology. 2000 Nov 15
52 citations
Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor.
Roger E. McLendon, Carol J. Wikstrand, Mark R. Matthews, Raid Al-Baradei, Sandra H. Bigner, Darell D. Bigner> ;The Journal of Histochemistry and Cytochemistry. 2000 Aug 1
43 citations
Comparative genetic patterns of glioblastoma multiforme: potential diagnostic tool for tumor classification.
Rodney N. Wiltshire, B.K. Ahmed Rasheed, Henry S. Friedman, Allan H. Friedman, Sandra H. Bigner> ;Neuro-Oncology. 2000 Jul 1
1 citations
Detection of Trisomy 12 by Fluorescence in Situ Hybridization on Archival Cytopathologic Material in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Katharine Liu, Leslie G. Dodd, Jennifer A. Powers, Sandra H. Bigner> ;Acta Cytologica. 2000 May 1
59 citations
Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis.
Thomas J. Cummings, James M. Provenzale, S. B. Hunter, Allan H. Friedman, Gordon K. Klintworth, Sandra H. Bigner, Roger E. McLendon> ;Acta Neuropathologica. 2000 May 1
18 citations
Characterization of chromosome 17 abnormalities in medulloblastomas.
Naji Aldosari, B.K.A. Rasheed, Roger E. McLendon, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner> ;Acta Neuropathologica. 2000 Apr 1
30 citations
Evaluation of an Automated Technique for Assessment of Marrow Engraftment After Allogeneic Bone Marrow Transplantation Using a Commercially Available Kit
J. Dean Nuckols, B.K.A. Rasheed, Ronald C. McGlennen, Sandra H. Bigner, Timothy T. Stenzel> ;American Journal of Clinical Pathology. 2000 Jan 1
216 citations
Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization
Sandra H. Bigner, Mark R. Matthews, B.K.A. Rasheed, Rodney N. Wiltshire, Henry S. Friedman, Allan H. Friedman, Timothy T. Stenzel, Donald M. Dawes, Roger E. McLendon, ...> ;The American Journal of Pathology. 1999 Aug 1
170 citations
Molecular pathogenesis of malignant gliomas.
B.K. Ahmed Rasheed, Rodney N. Wiltshire, Sandra H. Bigner, Darell D. Bigner> ;Current Opinion in Oncology. 1999 May 1
21 citations
Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study.
Roger E. McLendon, Henry S. Friedman, Herbert E. Fuchs, Kun Le, Sandra H. Bigner> ;Histopathology. 1999 Feb 1
49 citations
Morphologic and molecular genetic aspects of oligodendroglial neoplasms
Sandra H. Bigner, B.K. Ahmed Rasheed, Rodney N. Wiltshire, Roger E. McLendon> ;Neuro-Oncology. 1999 Jan 1
319 citations
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.
Henry S. Friedman, Roger E. McLendon, Tracy Kerby, M Dugan, Sandra H. Bigner, AJ Henry, David M. Ashley, J Krischer, Shelley Lovell, Karima Rasheed, F Marchev, AJ Sema...> ;Journal of Clinical Oncology. 1998 Dec 1
143 citations
Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.
Darell D. Bigner, M T Brown, Allan H. Friedman, R.E. Coleman, Gamal Akabani, Henry S. Friedman, W L Thorstad, Roger E. McLendon, Sandra H. Bigner, Xiao Guang Zhao, Cha...> ;Journal of Clinical Oncology. 1998 Jun 1
30 citations
Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.
Roger E. McLendon, Cleveland L, Charles N. Pegram, Sandra H. Bigner, Darell D. Bigner, Henry S. Friedman> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 1998 May 1
93 citations
Multicenter masked evaluation of AutoCyte PREP thin layers with matched conventional smears. Including initial biopsy results.
John W. Bishop, Sandra H. Bigner, Terry J. Colgan, Mujtaba Husain, Lydia P. Howell, Karen M. McIntosh, Dugald A. Taylor, Masood Sadeghi> ;Acta Cytologica. 1998 Jan 1
315 citations
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
B.K. Ahmed Rasheed, Timothy T. Stenzel, Roger E. McLendon, Ramon Parsons, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, Sandra H. Bigner> ;Cancer Research. 1997 Oct 1
93 citations
Chromosomal characteristics of childhood brain tumors.
Sandra H. Bigner, Roger E. McLendon, McLbert Fuchs, Paul E. McKeever, Henry S. Friedman> ;Cancer Genetics and Cytogenetics. 1997 Sep 1
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Grant Support

Growth Control And Cytogenetics Of Malignant GliomasNational Cancer Institute1987–2003
Core--Tissue Procurement And CytogeneticsNational Cancer Institute1999–2002
Molecular Markers Of Prognosis In MedulloblastomaNational Cancer Institute1996–2000
Core--Human Tissue Bank And CytogeneticsNational Cancer Institute1996–1999
Tumor Suppressor Genes In Human MedulloblastomaNational Institute Of Neurological Disorders And Stroke1996–1998
Growth Control And Cytogenetics Of Malignant GliomasNational Cancer Institute1991–1998