SandraZinkelMDPhD

Hematology • Nashville, TN

Associate Professor, Medicine, Vanderbilt University School of Medicine

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Office
3601 Tvc
Nashville, TN 37232
Phone+1 615-322-3000
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Education & Training

Washington University/B-JH/SLCH ConsortiumFellowship, Hematology and Medical Oncology, 1997 - 1998
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1995 - 1997
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1995

Certifications & Licensure

TN State Medical License 2005 - 2025
MA State Medical License 1999 - 2006
American Board of Internal Medicine Hematology

Publications & Presentations

PubMed

2 citations
Programmed necroptosis is upregulated in low-grade myelodysplastic syndromes and may play a role in the pathogenesis
Jing Zou, Qiong Shi, Heidi Chen, Ridas Juskevicius, Sandra S. Zinkel> ;Experimental Hematology. 2021 Sep 23
2 citations
Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation.
Haley E. Ramsey, Kristy R. Stengel, James C. Pino, Gretchen Johnston, Merrida A Childress, Agnieszka E. Gorska, Pia Arrate, Londa Fuller, Matthew T. Villaume, Melissa ...> ;Targeted Oncology. 2021 Jul 29
22 citations
Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice
Patrice N. Wagner, Qiong Shi, Christi T Salisbury-Ruf, Jing Zou, Michael R. Savona, Yuri Fedoriw, Sandra S. Zinkel> ;Blood. 2019 Jan 10
17 citations
Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
Christi T Salisbury-Ruf, Clinton C. Bertram, Aurelia Vergeade, Daniel S. Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W. Gray Jerome, Quinn S....> ;Elife. 2018 Oct 3
23 citations
Cardiolipin Fatty Acid Remodeling Regulates Mitochondrial Function by Modifying the Electron Entry Point in the Respiratory Chain
Aurelia Vergeade, Clinton C. Bertram, Alfiya Bikineyeva, William E. Zackert, Sandra S. Zinkel, James M. May, Sergey Dikalov, L. Jackson Roberts, Olivier Boutaud> ;Mitochondrion. 2016 May 1
39 citations
Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research
Ting Zhou, Marsha C. Kinney, Linda M. Scott, Sandra S. Zinkel, Vivienne I. Rebel> ;Blood. 2015 Aug 27
15 citations
In aged mice, low surrogate light chain promotes pro‐B‐cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylc...
Michelle Ratliff, Sarah Alter, Kelly McAvoy, Daniela Frasca, Jacqueline A. Wright, Sandra S. Zinkel, Wasif N. Khan, Bonnie B. Blomberg, Richard L. Riley> ;Aging Cell. 2015 Jun 1
11 citations
Rejuvenating Bi(d)ology.
Sandra S. Zinkel, Xiao Ming Yin, Atan Gross> ;Oncogene. 2013 Jul 4
14 citations
The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice
S Biswas, Qiong Shi, A Wernick, A Aiello, Sandra S. Zinkel> ;Cell Death and Differentiation. 2013 Mar 8
6 citations
Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress
Y Liu, A Aiello, Sandra S. Zinkel> ;Cell Death and Differentiation. 2012 Oct 1
19 citations
MTG16 contributes to colonic epithelial integrity in experimental colitis
Christopher S. Williams, Amber Bradley, Rupesh Chaturvedi, Kshipra Singh, Maria Blanca Piazuelo, Xi Chen, Elizabeth M. McDonough, David A. Schwartz, Caroline T. Brown,...> ;Gut. 2013 Oct 1
14 citations
Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation.
Huiyong Yin, Aurelia Vergeade, Qiong Shi, William E. Zackert, Katherine Gruenberg, Magdalena Bokiej, Taneem Amin, Weizhen Ying, Tina S. Masterson, Sandra S. Zinkel, Jo...> ;Biochemical and Biophysical Research Communications. 2012 Jun 29
22 citations
BID binds to replication protein A and stimulates ATR function following replicative stress.
Yang Liu, Sivaraja Vaithiyalingam, Qiong Shi, Walter J. Chazin, Sandra S. Zinkel> ;Molecular and Cellular Biology. 2011 Nov 1
23 citations
Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Y Liu, Clinton C. Bertram, Qiong Shi, Sandra S. Zinkel> ;Cell Death and Differentiation. 2011 May 1
13 citations
A role for proapoptotic Bax and Bak in T-cell differentiation and transformation.
Subhrajit Biswas, Qiong Shi, Lauren A. Matise, Susan M. Cleveland, Utpal P. Davé, Sandra S. Zinkel> ;Blood. 2010 Dec 9
33 citations
Bid regulates the pathogenesis of neurotropic reovirus.
Pranav Danthi, Andrea J. Pruijssers, Angela K. Berger, Geoffrey H. Holm, Sandra S. Zinkel, Terence S. Dermody> ;Plos Pathogens. 2010 Jul 1
8 citations
Investigation of the proapoptotic BCL-2 family member bid on the crossroad of the DNA damage response and apoptosis.
Sandra S. Zinkel> ;Methods in Enzymology. 2008 Jan 1
20 citations
Bid Plays a Role in the DNA Damage Response
Sandra S. Zinkel, Kristen E. Hurov, Atan Gross> ;Cell. 2007 Jul 13
369 citations
BCL2 family in DNA damage and cell cycle control
Sandra S. Zinkel, Atan Gross, E Yang> ;Cell Death and Differentiation. 2006 Aug 1
183 citations
A role for proapoptotic BID in the DNA-damage response.
Sandra S. Zinkel, Kristen E. Hurov, Christy C. Ong, Atan Gross, Stanley J. Korsmeyer> ;Cell. 2005 Aug 26
87 citations
Conditional MLL‐CBP targets GMP and models therapy‐related myeloproliferative disease
Jing Wang, Hiromi Iwasaki, Andrei V. Krivtsov, Phillip G. Febbo, Aaron R. Thorner, Patricia Ernst, Erna Anastasiadou, Jeffery L. Kutok, Scott C. Kogan, Sandra S. Zinke...> ;The EMBO Journal. 2005 Jan 26
132 citations
Proapoptotic BID is required for myeloid homeostasis and tumor suppression
Sandra S. Zinkel, Christy C. Ong, David O. Ferguson, Hiromi Iwasaki, Koichi Akashi, Roderick T. Bronson, Jeffery L. Kutok, Frederick W. Alt, Stanley J. Korsmeyer> ;Genes & Development. 2003 Jan 15
26 citations
Function of BID -- a molecule of the bcl-2 family -- in ischemic cell death in the brain.
Nikolaus Plesnila, Sandra S. Zinkel, Sepideh Amin-Hanjani, Jianhua Qiu, Stanley J. Korsmeyer, Michael A. Moskowitz> ;European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes. 2002 Jan 1
197 citations
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
Nikolaus Plesnila, Sandra S. Zinkel, Dean A. Le, Sepideh Amin-Hanjani, Yonqin Wu, Jianhua Qiu, Alberto Chiarugi, Sunu S. Thomas, Daniel S. Kohane, Stanley J. Korsmeyer...> ;Proceedings of the National Academy of Sciences of the United States of America. 2001 Dec 18
810 citations
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
Xiao Ming Yin, Kun Wang, Atan Gross, Yongge Zhao, Sandra S. Zinkel, Barbara J. Klocke, Kevin A. Roth, Stanley J. Korsmeyer> ;Nature. 1999 Aug 26
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Journal Articles

Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study
Salisury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Well QS, Fessel J, Moslehi J, Chen H, Roberts LJ 2nd, Boutaud O..., Elife, 10/3/2018
Increased Ripk1-Mediated Bone Marrow Necroptosis Leads to Myelodysplasia and Bone Marrow Failure in Mice
Yuri Fedoriw, Sandra S Zinkel, Blood