SangeetaRIyerMD(She/Her)

PubMed

• 41 citations
  Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG.
  Sangeetha Iyer, Feba S. Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica P. Lao, Eva Morava, Ethan O. Perlstein> ;Disease Models & Mechanisms. 2019 Nov 1
• 13 citations
  Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
  Sangeetha Iyer, Joshua D. Mast, Hillary Tsang, Tamy Portillo Rodriguez, Nina DiPrimio, Madeleine Prangley, Feba S. Sam, Zachary Parton, Ethan O. Perlstein> ;Disease Models & Mechanisms. 2019 Nov 1
• 3 citations
  A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo
  Luisa L. Scott, Sangeetha Iyer, Ashley E. Philpo, Melva Avalos, Natalie S. Wu, Ted Shi, Brooke A. Prakash, Thanh-Tu Nguyen, S. John Mihic, Richard W. Aldrich, Jonathan...> ;The Journal of Pharmacology and Experimental Therapeutics. 2018 Nov 1
• 20 citations
  High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model
  Sudip Mondal, Evan Hegarty, James J. Sahn, Luisa L. Scott, Sertan Kutal Gokce, Chris Martin, Navid Ghorashian, Praveen Satarasinghe, Sangeetha Iyer, Wisath Sae-Lee, Ti...> ;ACS Chemical Neuroscience. 2018 Feb 9
• 10 citations
  A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus.
  Luisa L. Scott, Elliott J. Brecht, Ashley E. Philpo, Sangeetha Iyer, N. S. Wu, S. J. Mihic, Richard W. Aldrich, Jonathan T. Pierce, Joseph P. Walton> ;Scientific Reports. 2017 Feb 14
• 80 citations
  Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease
  Bitna Yi, James J. Sahn, Pooneh Memar Ardestani, Andrew K. Evans, Luisa L. Scott, Jessica Z. Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan T. Pierce, ...> ;Journal of Neurochemistry. 2017 Feb 1
• 6 citations
  E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding
  Jason H. Rogers, Kristin S. Owens, Jeffrey L. Kurkewich, Nathan Klopfenstein, Sangeeta R. Iyer, M. Celeste Simon, Richard Dahl> ;Biomed Research International. 2016 Jan 28
• 7 citations
  GABAA-R α4 Subunits are Required for the Low Dose Locomotor Stimulatory Effect of Alphaxalone, But Not for Several Other Behavioral Responses to Alphaxalone, Etomidate...
  Sangeetha Iyer, Dave Chandra, Gregg E. Homanics> ;Neurochemical Research. 2014 Jun 1
• 2 citations
  Worming our way to Alzheimer's disease drug discovery.
  Sangeetha Iyer, Jonathan T. Pierce-Shimomura> ;Biological Psychiatry. 2013 Mar 1
• 9 citations
  Trifluoroacetate is an allosteric modulator with selective actions at the glycine receptor.
  Megan E. Tipps, Sangeetha Iyer, S. John Mihic> ;Neuropharmacology. 2012 Sep 1
• 24 citations
  Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols
  Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris> ;The Journal of Pharmacology and Experimental Therapeutics. 2012 Feb 1
• 7 citations
  α4-Containing GABAA Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513
  Sangeetha Iyer, Rodrigo A. Benavides, Dev Chandra, James M. Cook, Sundari Rallapalli, Harry L. June, Gregg E. Homanics> ;Frontiers in Pharmacology. 2011 Apr 4
• 32 citations
  Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABAA receptor subunits that are resistant to isoflurane
  David F. Werner, A. Swihart, Vinuta Rau, F. Jia, Cecilia M. Borghese, Mandy L. McCracken, Sangeetha Iyer, M. S. Fanselow, Irene Oh, J. M. Sonner, Edmond I. Eger, Neil ...> ;The Journal of Pharmacology and Experimental Therapeutics. 2011 Jan 1
• 47 citations
  Loss of Ethanol Conditioned Taste Aversion and Motor Stimulation in Knockin Mice with Ethanol-Insensitive α2-Containing GABAA Receptors
  Yuri A. Blednov, Cecilia M. Borghese, Mandy L. McCracken, Jillian M. Benavidez, C. R. Geil, Elizabeth A. Osterndorff-Kahanek, David F. Werner, Sangeetha Iyer, A. Swiha...> ;The Journal of Pharmacology and Experimental Therapeutics. 2011 Jan 1
• 19 citations
  Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.
  Yuri A. Blednov, D. Walker, Sangeetha Iyer, Gregg E. Homanics, Adron R. Harris> ;Addiction Biology. 2010 Jan 1
• 31 citations
  Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
  Vinuta Rau, Sangeetha Iyer, Irene Oh, Dev Chandra, Neil L. Harrison, Edmond I. Eger, Michael S. Fanselow, Gregg E. Homanics, James M. Sonner> ;Anesthesia and Analgesia. 2009 Dec 1
• 63 citations
  The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.
  Richard Dahl, Sangeeta R. Iyer, Kristin S. Owens, Dorothy D. Cuylear, M. Celeste Simon> ;The Journal of Biological Chemistry. 2007 Mar 2
• The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
  Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M, Tucci M, Persico MG, Acharya KR> ;J. Biol. Chem.. 2001-04-13
• Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide.
  Iyer S, Kontoyiannis D, Chevrier D, Woo J, Mori N, Cornejo M, Kollias G, Buelow R> ;J. Biol. Chem.. 2000-06-02
• Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells.
  Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S, Smulson M> ;J. Biol. Chem.. 1999-08-13
• Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis.
  Simbulan-Rosenthal CM, Rosenthal DS, Iyer S, Boulares AH, Smulson ME> ;J. Biol. Chem.. 1998-05-29
• Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.
  Iyer S, Woo J, Cornejo MC, Gao L, McCoubrey W, Maines M, Buelow R> ;J. Biol. Chem.. 1998-01-30
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