SanjayKNigamMD

PubMed

• 26 citations
  The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology
  Sanjay K. Nigam, Kevin T. Bush, Vibha Bhatnagar, Samuel M. Poloyac, Jeremiah D. Momper> ;Clinical Pharmacology and Therapeutics. 2020 Jul 1
• 40 citations
  Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease
  Kevin T. Bush, Prabhleen Singh, Sanjay K. Nigam> ;JCI Insight. 2020 Apr 9
• 19 citations
  Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress.
  Darcy C. Engelhart, Priti Azad, Suwayda Ali, Jeffry C. Granados, Gabriel G. Haddad, Sanjay K. Nigam> ;International Journal of Molecular Sciences. 2020 Mar 15
• 37 citations
  Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs
  Darcy C. Engelhart, Jeffry C. Granados, Da Shi, Milton H. Saier, Michael E. Baker, Ruben Abagyan, Sanjay K. Nigam> ;International Journal of Molecular Sciences. 2020 Mar 5
• 29 citations
  Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
  Anisha K. Nigam, Julia G. Li, Kaustubh Lall, Da Shi, Kevin T. Bush, Vibha Bhatnagar, Ruben Abagyan, Sanjay K. Nigam> ;The Journal of Biological Chemistry. 2020 Feb 14
• 42 citations
  A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.
  Sara Brin Rosenthal, Kevin T. Bush, Sanjay K. Nigam> ;Scientific Reports. 2019 Aug 15
• 11 citations
  Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation
  Jeremiah D. Momper, Jin Yang, Mary Gockenbach, Florin Vaida, Sanjay K. Nigam> ;Clinical Journal of the American Society of Nephrology. 2019 Apr 5
• 78 citations
  Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.
  Sanjay K. Nigam, Kevin T. Bush> ;Nature Reviews. Nephrology. 2019 May 1
• 2 citations
  Gene-targeted deletion in mice of the Ets-1 transcription factor, a candidate gene in the Jacobsen syndrome kidney "critical region," causes abnormal kidney development.
  Maoqing Ye, Lian Xu, Mengxia Fu, Dong-Rui Chen, Teresa Mattina, Orsetta Zufardi, Elena Rossi, Kevin T. Bush, Sanjay K. Nigam, Paul Grossfeld> ;American Journal of Medical Genetics. Part A. 2019 Jan 1
• 6 citations
  Temporal transcriptomic analysis of metabolic genes in maternal organs and placenta during murine pregnancy.
  Alison G. Paquette, Priyanka Baloni, Sanjay K. Nigam, Theo K. Bammler, Qingcheng Mao, Nathan D. Price, Anisa B Holloman> ;Biology of Reproduction. 2018 Dec 1
• 54 citations
  The systems biology of uric acid transporters: the role of remote sensing and signaling.
  Sanjay K. Nigam, Vibha Bhatnagar> ;Current Opinion in Nephrology and Hypertension. 2018 Jul 1
• 17 citations
  Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communic...
  Jeremiah D. Momper, Sanjay K. Nigam> ;Expert Opinion on Drug Metabolism & Toxicology. 2018 Jun 4
• 22 citations
  Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.
  Yiling Fu, Davorka Breljak, Akira Onishi, Falk Batz, Rohit Patel, Winnie Huang, Panai Song, Brent Freeman, Eric Mayoux, Hermann Koepsell, Naohiko Anzai, Sanjay K. Niga...> ;American Journal of Physiology. Renal Physiology. 2018 Aug 1
• 140 citations
  The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease
  Sanjay K. Nigam> ;Annual Review of Pharmacology and Toxicology. 2018 Jan 8
• 68 citations
  The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut–liver–kidney axis
  Kevin T. Bush, Wei Wu, Christina Lun, Sanjay K. Nigam> ;The Journal of Biological Chemistry. 2017 Sep 22
• 145 citations
  Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
  Wei Wu, Kevin T. Bush, Sanjay K. Nigam> ;Scientific Reports. 2017 Jul 10
• 53 citations
  Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach
  Henry C. Liu, Anne Goldenberg, Yu-Chen Chen, Christina Lun, Wei Wu, Kevin T. Bush, Natasha Balac, Paul Rodriguez, Ruben Abagyan, Sanjay K. Nigam> ;The Journal of Pharmacology and Experimental Therapeutics. 2016 Oct 1
• 36 citations
  An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
  Henry C. Liu, Neema Jamshidi, Yu-Chen Chen, Satish A. Eraly, Sai Yee Cho, Vibha Bhatnagar, Wei Wu, Kevin T. Bush, Ruben Abagyan, Bernhard O. Palsson, Sanjay K. Nigam> ;The Journal of Biological Chemistry. 2016 Sep 9
• 19 citations
  Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.
  Gleb Martovetsky, Kevin T. Bush, Sanjay K. Nigam> ;Drug Metabolism and Disposition. 2016 Jul 1
• 74 citations
  Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling
  Vibha Bhatnagar, Erin Richard, Wei Wu, Caroline M. Nievergelt, Michael S. Lipkowitz, Janina M. Jeff, Adam X. Maihofer, Sanjay K. Nigam> ;Clinical Kidney Journal. 2016 Jun 1
• 3 citations
  Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2
  Xiao He, Denisse Garza, Sanjay K. Nigam, Geoffrey Chang> ;Plos One. 2016 Apr 5
• 16 citations
  Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors
  Wei Wu, Kevin T. Bush, Henry C. Liu, Christopher Zhu, Ruben Abagyan, Sanjay K. Nigam> ;Drug Metabolism and Disposition. 2015 Dec 1
• 21 citations
  Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
  Nathan Kumar, Jenna Richter, Josh Cutts, Kevin T. Bush, Cleber A. Trujillo, Sanjay K. Nigam, Terry Gaasterland, David A. Brafman, Karl Willert> ;Elife. 2015 Nov 10
• 166 citations
  Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters
  Sanjay K. Nigam, Wei Wu, Kevin T. Bush, Melanie P. Hoenig, Roland C. Blantz, Vibha Bhatnagar> ;Clinical Journal of the American Society of Nephrology. 2015 Nov 6
• 54 citations
  Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.
  Christopher Zhu, Kabir B. Nigam, Rishabh C. Date, Kevin T. Bush, Stevan A. Springer, Milton H. Saier, Wei Wu, Sanjay K. Nigam> ;Plos One. 2015 Nov 4
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Journal Articles

• Gene‐Targeted Deletion in Mice of the Ets−1 Transcription Factor, a Candidate Gene in the Jacobsen Syndrome Kidney “Critical Region,” Causes Abnormal Kidney Development  
  Paul Grossfeld, Sanjay K Nigam, American Journal of Medical Genetics Part A