SanjeetSinghDadwalMDFACP

Transplant/Immunocompromised States

Chief, Division of Infectious Disease Clinical Professor Director, Antimicrobial Stewardship Infectious Disease Lead, Transplant Disease Team

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Office
Division of Infectious Diseases
1500 East Duarte Road
Duarte, CA 91010
Phone+1 626-256-4673

Fax+1 626-301-8954
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Summary

I am a board certified infectious disease physician with expertise in the management of opportunistic infections, especially in patients with hematologic malignancies, recipients of hematopoietic stem cell transplant and CAR-T cell recipients. My research interests span epidemiology of infectious complications (fungal, viral and bacterial) in immunocompromised host, infection control and antimicrobial stewardship in cancer patients.

Education & Training

SUNY Health Science Center at BrooklynResidency, Internal Medicine, 1997 - 2000
All India Institute of Medical SciencesClass of 1997

Certifications & Licensure

CA State Medical License 2000 - 2025
UT State Medical License 2002 - 2006
CT State Medical License 1999 - 2002

Clinical Trials

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Examine the Effects of DAS181 in Immunocompromised Subjects With Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxygen Start of enrollment: 2014 Mar 01
Completed
Phase 2
Letermovir (MK-8228) Versus Placebo in the Prevention of Clinically-Significant Cytomegalovirus (CMV) Infection in Adult, CMV-Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients (MK-8228-001) Start of enrollment: 2014 Jun 06
Completed
Phase 3
Presatovir in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus Infection of the Upper Respiratory Tract Start of enrollment: 2015 Jan 23
Completed
Phase 2
Presatovir in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract Start of enrollment: 2015 Jan 31
Completed
Phase 2
Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir Start of enrollment: 2016 Dec 22
Completed
Phase 3
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study Start of enrollment: 2019 May 23
Recruiting
Phase 3
Extension of Letermovir (LET) From Day 100 to Day 200 Post-transplant for the Prevention of Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant (HSCT) Participants (MK-8228-040) Start of enrollment: 2019 Jun 21
Completed
Phase 3
Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy Start of enrollment: 2021 Jan 07
Active, not recruiting
Phase 1, Phase 2
SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer Start of enrollment: 2021 Sep 27
Recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Final Outcomes from a Phase 2 Trial of Posoleucel in Allogeneic Hematopoietic Cell Transplant Recipients.
Michael Schuster, Gary Douglas Myers, Michelle Elizabeth Matzko, Sama Adnan, David McNeel, Julie Ma, Sarah A Gilmore, Spyridoula Vasileiou, Ann M Leen, Joshua A Hill, ...> ;Blood Advances. 2024 Apr 9
2 citations
Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients With Pneumonia: A Prospective Observational Study.
Stephen P Bergin, Roy F Chemaly, Sanjeet S Dadwal, Joshua A Hill, Yeon Joo Lee, Ghady Haidar, Alfred Luk, Alexander Drelick, Peter V Chin-Hong, Esther Benamu, Fareed K...> ;Clinical Infectious Diseases. 2024 Mar 20
1 citations
HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation.
Al Malki, M. M., Jana K Dickter, Ahmed Aribi, Angelo A Cardoso, Sara Gianella, Ketevan Gendzekhadze, Shirley Li, Ye Feng, Antoine Chaillon, Gregory M Laird, Diana L Br...> ;The New England Journal of Medicine. 2024 Feb 15
HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant.
Joshua A Hill, Yeon Joo Lee, Lisa K Vande Vusse, Hu Xie, E Lisa Chung, Alpana Waghmare, Guang-Shing Cheng, Haiying Zhu, Meei-Li Huang, Geoffrey R Hill, Keith R Jerome,...> ;Nature Communications. 2024 Jan 16
3 citations
Efficacy and safety of extended duration letermovir prophylaxis in recipients of haematopoietic stem-cell transplantation at risk of cytomegalovirus infection: a multi...
Russo, D., Schmitt, M., Pilorge, S., Stelljes, M., Kawakita, T., Teal, V., Haber, B., Bopp, C., Badshah, C., Dadwal, S.> ;The Lancet. Haematology. 2024 Feb 1
Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplant...
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, J...> ;Vaccines. 2023 Sep 15
1 citations
Impact of Baseline and Week 2 and Week 4 Posttransplant CMV Cell-Mediated Immunity on Risk of CMV Infections and Mortality in Recipients of Allogeneic Hematopoietic Ce...
Ella J Ariza-Heredia, Drew J Winston, Scott D Rowley, Kathleen Mullane, Pranatharthi Chandrasekar, Parameswaran Hari, Robin K Avery, Karl S Peggs, Deepali Kumar, Rajne...> ;Open Forum Infectious Diseases. 2023 Aug 1
Use of monoclonal antibody therapy in hematologic patients with mild-to-moderate COVID-19: A retrospective single-center experience.
Al Malki, M. M., Idoroenyi Amanam, Janny Yao, Alfredo Puing, Ni-Chun Tsai, Diana Samuels, Dat Ngo, Stephanie Ho, Haris Ali, Ahmed Aribi, Shukaib Arslan, Andrew Artz, M...> ;Cancer Medicine. 2023 May 1
2 citations
The impact of SARS-CoV2 vaccines on the incidence of graft versus host disease in allogeneic hematopoietic stem cell transplant recipients: a single-center retrospecti...
Dat Ngo, Jason Chen, Jose Tinajero, Ahmed Aribi, Shukaib Arslan, Guido Marcucci, Ryotaro Nakamura, Monzr M Al Malki, Stephen J Forman, Sanjeet Dadwal, Haris Ali> ;Stem Cell Research & Therapy. 2023 Apr 18
1 citations
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection.
Wenjuan Dong, Jing Wang, Lei Tian, Jianying Zhang, Erik W Settles, Chao Qin, Daniel R Steinken-Kollath, Ashley N Itogawa, Kimberly R Celona, Jinhee Yi, Mitchell Bryant...> ;Nature Communications. 2023 Apr 6
1 citations
Frequently Asked Questions about Mpox (Formerly Monkeypox Disease) for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Recipients from the Amer...
Emily S Ford, Genovefa A Papanicolaou, Sanjeet S Dadwal, Steve Pergam, Amy Spallone> ;Transplantation and Cellular Therapy. 2023 May 1
Our Third Hand: Stethoscope Hygiene in the Era of Alcohol-Resistant Organisms.
W Frank Peacock, Francesca J Torriani, Zainab Shahid, Abhay Dhand, Alfred Luk, Sanjeet Dadwal> ;The American Journal of Medicine. 2023 Jun 1
Leflunomide Confers Rapid Recovery from COVID-19 and is Coupled with Temporal Immunologic Changes.
Ada Alice Dona, James F Sanchez, Joycelynne M Palmer, Timothy W Synold, Flavia Chiuppesi, Sandra Thomas, Enrico Caserta, Mahmoud Singer, Theophilus Tandoh, Arnab Chowd...> ;Journal of Immunological Sciences. 2023 Jan 1
6 citations
Frequently Asked Questions on Coronavirus Disease 2019 Vaccination for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Recipients From the Amer...
Fareed Khawaja, Genovefa Papanicolaou, Sanjeet Dadwal, Steven A Pergam, John R Wingard, Zeinab El Boghdadly, Maheen Z Abidi, Alpana Waghmare, Zainab Shahid, Laura Mich...> ;Transplantation and Cellular Therapy. 2023 Jan 1
2 citations
Functional SARS-CoV-2-specific T cells of donor origin in allogeneic stem cell transplant recipients of a T-cell-replete infusion: A prospective observational study.
Corinna La Rosa, Flavia Chiuppesi, Yoonsuh Park, Qiao Zhou, Dongyun Yang, Ketevan Gendzekhadze, Minh Ly, Jing Li, Teodora Kaltcheva, Sandra Ortega Francisco, Miguel-An...> ;Frontiers in Immunology. 2023 Jan 1
12 citations
Osteoarticular Mycoses.
Maria N Gamaletsou, Blandine Rammaert, Barry Brause, Marimelle A Bueno, Sanjeet S Dadwal, Michael W Henry, Aspasia Katragkou, Dimitrios P Kontoyiannis, Matthew W McCar...> ;Clinical Microbiology Reviews. 2022 Dec 21
Association of pre-transplant vancomycin resistant enterococcus colonization status on long-term outcomes of allogeneic-hematopoietic cell transplantation.
Amandeep Salhotra, Karamjeet S Sandhu, Dongyun Yang, Sally Mokhtari, James O'Hearn, Bernard Tegtmeier, Monzr M Al Malki, Justine Abella, Akemi Meguro, Jana Dickter, Sw...> ;Bone Marrow Transplantation. 2023 Mar 1
9 citations
How I prevent viral reactivation in high-risk patients.
Sanjeet S Dadwal, Genovefa A Papanicolaou, Michael Boeckh> ;Blood. 2023 Apr 27
8 citations
Revised Guidelines for Coronavirus Disease 19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients (August 2022).
Veronica Dioverti, Zeinab El Boghdadly, Zainab Shahid, Alpana Waghmare, Maheen Z Abidi, Steven Pergam, Michael Boeckh, Sanjeet Dadwal, Mini Kamboj, Susan Seo, Roy F Ch...> ;Transplantation and Cellular Therapy. 2022 Dec 1
9 citations
Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants.
Flavia Chiuppesi, John A Zaia, Katelyn Faircloth, Daisy Johnson, Minh Ly, Veronica Karpinski, Corinna La Rosa, Jennifer Drake, Joan Marcia, Ann Marie Acosta, Shannon D...> ;Iscience. 2022 Aug 19
The COVID-19 infection control response at a large stand-alone comprehensive cancer center in Los Angeles County.
Hannah Battey, Brenna Doran, Annemarie Flood, Juliet Nussbaum, Tyler Seto, Suwannee Srisatidnarakul, Bernard Tegtmeier, Sanjeet Dadwal> ;Cancer Reports. 2023 Jan 1
3 citations
Letermovir and maribavir for pan-resistant cytomegalovirus infection in a patient with haematologic malignancy: Consideration for combination therapy.
Jana K Dickter, Justine A Ross, Jasmine M Zain, Bernard R Tegtmeier, Brian V Lee, Sanjeet S Dadwal> ;Journal of Clinical Pharmacy and Therapeutics. 2022 May 1
16 citations
Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial.
Flavia Chiuppesi, John A Zaia, Paul H Frankel, Rodica Stan, Jennifer Drake, Brenda Williams, Anne Marie Acosta, Karyn Francis, Randy A Taplitz, Janet K Dickter, Sanjee...> ;The Lancet. Microbe. 2022 Apr 1
4 citations
Successful outcome of pre-engraftment COVID-19 in an HCT patient: impact of targeted therapies and cellular immunity.
Hoda Pourhassan, Corinna La Rosa, Flavia Chiuppesi, Alfredo Puing, Ibrahim Aldoss, Yoonsuh Park, Qiao Zhou, Veronica Karpinski, Katelyn Faircloth, Teodora Kaltcheva, D...> ;Blood Advances. 2022 Mar 22
11 citations
Variation in Clinical Practice and Attitudes on Antibacterial Management of Fever and Neutropenia in Patients With Hematologic Malignancy: A Survey of Cancer Centers A...
Jason N Barreto, Samuel L Aitken, Elizabeth M Krantz, Jerod L Nagel, Sanjeet S Dadwal, Susan K Seo, Catherine Liu> ;Open Forum Infectious Diseases. 2022 Mar 1
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Abstracts/Posters

Draft Genome Sequence of a Clinical Isolate of Fusarium Fujikuroi Isolated from a Male Patient with Acute Myeloid Leukemia
Sanjeet Dadwal, MD, mBio, Orlando, FL, 12/9/2019

Press Mentions

AlloVir Announces Positive Final Results in Phase 2 Posoleucel Multi-Virus Prevention Study in Oral Presentation at the 64th ASH Annual Meeting and ExpositionDecember 10th, 2022
Testing COVID-19 Treatments for Patients with Cancer: An Ongoing NeedFebruary 20th, 2021