SaraChaffeeMD

Pediatric Hematology & Oncology • Lebanon, NH

Associate Professor, Pediatrics, Geisel School of Medicine

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Office
1 Medical Center Dr
Dhmc - Department Of Pediatrics
Lebanon, NH 03756
Phone+1 603-650-5541

Fax+1 606-650-0591
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Education & Training

Duke University HospitalFellowship, Pediatric Hematology/Oncology, 1983 - 1987
Duke University HospitalResidency, Pediatrics, 1980 - 1983
Geisel School of Medicine at DartmouthClass of 1980

Certifications & Licensure

NH State Medical License 1993 - 2021
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011
Fellow (FAAP) American Academy of Pediatrics

Clinical Trials

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment Start of enrollment: 2014 Mar 05
Recruiting
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Start of enrollment: 2014 Oct 04
Active, not recruiting
Phase 3
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Start of enrollment: 2014 Jul 11
Active, not recruiting
Phase 2, Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
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Publications & Presentations

PubMed

32 citations
Pulmonary arteriovenous malformations: an uncharacterised phenotype of dyskeratosis congenita and related telomere biology disorders
Payal P. Khincha, Alison A. Bertuch, Suneet Agarwal, Danielle M. Townsley, Neal S. Young, Sioban Keel, Akiko Shimamura, Farid Boulad, Tregony Simoneau, Henri Justino, ...> ;The European Respiratory Journal. 2017 Jan 25
5 citations
Pediatric palliative care.
Sara Chaffee> ;Primary Care. 2001 Jun 1
8 citations
Toxicity, pharmacology and feasibility of administration of PEG-L-asparaginase as consolidation therapy in patients undergoing bone marrow transplantation for acute ly...
Michael L. Graham, Barbara L. Asselin, James E. Herndon, J. R. Casey, Sara Chaffee, G. Ciocci, Charles Daeschner, A. R. Davis, Stuart H. Gold, Edward C. Halperin, Mary...> ;Bone Marrow Transplantation. 1998 May 1
131 citations
High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors.
Michael L. Graham, James E. Herndon, J. R. Casey, Sara Chaffee, G. Ciocci, Jeffrey P. Krischer, Joanne Kurtzberg, Mary J. Laughlin, Darryl C. Longee, Janice F. Olson, ...> ;Journal of Clinical Oncology. 1997 May 1
18 citations
Health insurance access to young adult survivors of childhood cancer in North Carolina.
Julie C. Jacobson Vann, Andrea K. Biddle, Charles Daeschner, Sara Chaffee, Stuart H. Gold> ;Medical and Pediatric Oncology. 1995 Nov 1
15 citations
Pneumonia Due to Fonsecaea pedrosoi and Cerebral Abscesses Due to Emericella nidulans in a Bone Marrow Transplant Recipient
Arthur J. Morris, Wiley A. Schell, Deirdre McDonagh, Sara Chaffee, John R. Perfect> ;Clinical Infectious Diseases. 1995 Nov 1
9 citations
epsilon-Aminocaproic acid-associated myopathy in a child.
Stuart S. Winter, Sara Chaffee, Stephen G. Kahler, Michael L. Graham> ;Journal of Pediatric Hematology/oncology. 1995 Feb 1
12 citations
Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia m...
L C Gravatt, Sara Chaffee, Mary E. Hebert, Edward C. Halperin, Henry S. Friedman, Joanne Kurtzberg> ;Leukemia. 1993 Aug 1
17 citations
Suppression of an antibody to adenosine-deaminase (ADA) in an ADA-deficient patient receiving polyethylene glycol modified adenosine deaminase.
J D Chun, N Lee, R H Kobayashi, Sara Chaffee, Michael S. Hershfield, E R Stiehm> ;Annals of Allergy. 1993 Jun 1
60 citations
Enzyme replacement therapy with polyethylene glycol-adenosine deaminase in adenosine deaminase deficiency: overview and case reports of three patients, including two n...
Michael S. Hershfield, Sara Chaffee, Ricardo U. Sorensen> ;Pediatric Research. 1993 Jan 1
76 citations
IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency.
Sara Chaffee, Ann Mary, E R Stiehm, D Girault, Alain Fischer, Michael S. Hershfield> ;The Journal of Clinical Investigation. 1992 May 1
17 citations
Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine.
Mary E. Hebert, Michael L. Greenberg, Sara Chaffee, Lee Gravatt, Michael S. Hershfield, Gertrude B. Elion, Joanne Kurtzberg> ;Transplantation. 1991 Oct 1
70 citations
Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol.
Michael S. Hershfield, Sara Chaffee, Lillian Koro-Johnson, Ann Mary, Albert A. Smith, Steven A. Short> ;Proceedings of the National Academy of Sciences of the United States of America. 1991 Aug 15
23 citations
Reversible focal neurologic deficits in severe iron deficiency anemia
Carol S. Bruggers, Russell E. Ware, Adam J. Altman, Malcolm Henderson Rourk, V. Vedanarayanan, Sara Chaffee> ;The Journal of Pediatrics. 1990 Sep 1
28 citations
Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency.
Francisco X. Arredondo-Vega, Joanne Kurtzberg, Sara Chaffee, Ines Santisteban, Emily G. Reisner, M. S. Povey, Michael S. Hershfield> ;The Journal of Clinical Investigation. 1990 Aug 1
8 citations
Familial erythrophagocytic lymphohistiocytosis: late relapse despite continuous high-dose VP-16 chemotherapy.
Russell E. Ware, Henry S. Friedman, Thomas R. Kinney, Joanne Kurtzberg, Sara Chaffee, John M. Falletta> ;Medical and Pediatric Oncology. 1990 Jan 1
Re: "A phase I trial with chlorambucil administered in short pulses in patients with advanced malignancies".
Mark D. Moncino, Sara Chaffee> ;Cancer Investigation. 1990 Jan 1
18 citations
Basis for resistance to 3-deazaaristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase, in human B-lymphoblasts.
Michael L. Greenberg, Sara Chaffee, Michael S. Hershfield> ;The Journal of Biological Chemistry. 1989 Jan 15
48 citations
Phenotypic variation in the response to the human immunodeficiency virus among derivatives of the CEM T and WIL-2 B cell lines.
Sara Chaffee, J M Leeds, T J Matthews, Kent J. Weinhold, Michael A. Skinner, Dani P. Bolognesi, Michael S. Hershfield> ;The Journal of Experimental Medicine. 1988 Aug 1
25 citations
Childhood hepatic mesenchymoma: Successful treatment with surgery and multiple‐agent chemotherapy
Russell E. Ware, Henry S. Friedman, Howard C. Filston, Sara Chaffee, Joanne Kurtzberg, Thomas R. Kinney, John M. Falletta> ;Medical and Pediatric Oncology. 1988 Jan 1
24 citations
Efficacy of intravenous gamma globulin in autoimmune-mediated pediatric blood dyscrasias
Joanne Kurtzberg, Henry S. Friedman, Sara Chaffee, John M. Falletta, Thomas R. Kinney, Roger Kurlander, Thomas J. Matthews, Richard S. Schwartz> ;The American Journal of Medicine. 1987 Oct 23
15 citations
Treatment of platelet alloimmunization with intravenous immunoglobulin. Two case reports and review of the literature.
Joanne Kurtzber, Henry S. Friedman, Thomas R. Kinney, Sara Chaffee, John M. Falletta> ;The American Journal of Medicine. 1987 Oct 23
9 citations
Treatment of lymphohistiocytic erythrophagocytosis with VP-16 and aziridinylbenzoquinone.
David L. Becton, Joanne Kurtzberg, Thomas R. Kinney, Henry S. Friedman, Sara Chaffee, John M. Falletta> ;Medical and Pediatric Oncology. 1987 Jan 1
1 citations
Bacterial endocarditis in a child with a Broviac catheter.
David L. Becton, Henry S. Friedman, Brenda E. Armstrong, Joanne Kurtzburg, Sara Chaffee, John M. Falletta, Thomas R. Kinney> ;Pediatric Hematology and Oncology. 1987 Jan 1
9 citations
Management of human immunodeficiency virus-associated thrombocytopenia with intravenous gamma globulin.
Joanne Kurtzberg, Henry S. Friedman, Thomas R. Kinney, Sara Chaffee, Kimo C. Stine, John M. Falletta, Kent J. Weinhold> ;The American Journal of Pediatric Hematology/oncology. 1987 Jan 1
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Professional Memberships

American Academy of Pediatrics - AAP
Fellow

Hospital Affiliations

Dartmouth-Hitchcock Medical CenterLebanon, New Hampshire

SaraChaffeeMD

Dr. Chaffee is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Professional Memberships

Hospital Affiliations

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