Sara Isabel Pai MD PhD
Head & Neck Oncologic Surgery
Massachusetts General Hospital, Harvard Medical School/ Director, Translational Head and Neck Cancer Research
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35 Park StSmilow Cancer Hospital at Yale New HavenNew Haven, CT 06510
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Education & Training
Johns Hopkins UniversityResidency, Otolaryngology - Head and Neck Surgery, 2003 - 2007- Johns Hopkins UniversityInternship, Surgery, 2002 - 2003
- Johns Hopkins UniversityInternship, Otolaryngology - Head and Neck Surgery, 2002 - 2003
- Johns Hopkins University School of MedicineClass of 2002
Certifications & Licensure
MD State Medical License 2007 - 2027
CT State Medical License 2023 - 2026
MA State Medical License 2014 - 2026
ME State Medical License 2020 - 2021
American Board of Otolaryngology - Head and Neck Surgery Otolaryngology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
- Fellow (FACS) American College of Surgeons
- Fellow (FAAO-HNS) American Academy of Otolaryngology - Head and Neck Surgery
Clinical Trials
Publications & Presentations
PubMed
- A Clinical Consensus Statement on Pulmonary Recurrent Respiratory Papillomatosis.Nikita Kohli, Sara I Pai, Julia Buckingham, Yvonne M Carter, Nabil F Saba
The Laryngoscope. 2025-08-01 - Can the co-localization of CD8+, PD-1, PD-L1 AND PD-L2 patterns provide guidance in clinical outcomes of patients with head and neck cutaneous squamous cell carcinoma?Gustavo Nunes Bento, Andre Bandiera de Oliveira Santos, Leandro Luongo Matos, William C Faquin, Sara I Pai
Brazilian Journal of Otorhinolaryngology. 2025-05-24 - Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer.Juhyun Oh, Jan Hoelzl, Jonathan C T Carlson, Ruben Bill, Hannah M Peterson
Cell Reports. Medicine. 2025-05-20
Lectures
- A phase II study of pembrolizumab for HPV-associated papilloma patients with laryngeal, tracheal, and/or pulmonary involvement.2019 ASCO Annual Meeting - 6/1/2019
- ICR gene signature to identify differential immune landscapes in anatomic subsites of head and neck squamous cell carcinomas and implications in personalized medicine.2018 ASCO Annual Meeting - Chicago, Illinois - 06/2/2018
Press Mentions
Yale Surgeon-Scientist Secures FDA Orphan Drug Designation for Pembrolizumab in Rare Respiratory DiseaseJanuary 7th, 2025- Research Spotlight: The Effects of Periodontitis on Cancer Outcomes in the Era of ImmunotherapyJune 29th, 2023
Grant Support
- Cue-101 and TCR-T cell Combinatorial Strategy for HPV+ Head and Neck CancersYALE UNIVERSITY2024–2029
- Early detection and risk of head and neck cancer through immune based spatial omicsYALE UNIVERSITY2024–2028
- FAST-FNA immune cell profiling in HNSCCMASSACHUSETTS GENERAL HOSPITAL2021–2025
- Strategies to Overcome Immune Resistance in Head and Neck CancersYALE UNIVERSITY2019–2025
- HPV Vaccine Therapy And Correlates Of Response In Head And Neck Squamous CellNational Institute Of Dental &Craniofacial Research2007–2011
Professional Memberships
- Fellow
- Member
- Member
- Member
Other Languages
- Spanish, Korean
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