Sarah A. Holstein MD PhD, FACP

Hematologic Oncology

Professor

986840 Nebraska Medical CtrOmaha, NE 68198
Phone+1 402-559-8500
Fax+1 402-559-6520

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Education & Training

University of Iowa Health Care Medical CenterFellowship, Hematology and Medical Oncology, 2006 - 2010
University of Iowa Health Care Medical CenterResidency, Internal Medicine, 2004 - 2006
University of Iowa Roy J. and Lucille A. Carver College of MedicineClass of 2004

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Certifications & Licensure

IA State Medical License 2021 - 2027
NE State Medical License 2016 - 2026
NY State Medical License 2013 - 2017
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology
National Board of Physicians and Surgeons Hematology
National Board of Physicians and Surgeons Internal Medicine
National Board of Physicians and Surgeons Medical Oncology

Awards, Honors, & Recognition

Fellowship American College of Physicians, 2018
CMS Meaningful Use Stage 2 Certification Beacon Oncology 2014 Certified Module, Epic Systems Corporation, 2012-2014, 2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2012-2014, 2017

Clinical Trials

QUILT-3.005: A Study of N-803 in Patients With Relapsed or Refractory Multiple Myeloma Start of enrollment: 2014 Oct 06
TERMINATED
PHASE1
Continued, Long-Term Follow-Up and Lenalidomide Maintenance Therapy for Patients on BMT CTN 0702 Protocol (BMT CTN 07LT)
COMPLETED
PHASE3
Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone Start of enrollment: 2016 Nov 29
TERMINATED
PHASE3

Publications & Presentations

PubMed

Incorporation of an alpha-hydroxy substituent modulates activity of triazole bisphosphonate-based geranylgeranyl diphosphate synthase inhibitors.
Md Ayub Ali, Dan Feng, Staci L Haney, David F Wiemer, Sarah A Holstein
Bioorganic & Medicinal Chemistry. 2026-06-01
2 citations
A phase 2 randomized study of modakafusp alfa as a single agent for patients with relapsed/refractory multiple myeloma.
Sarah A Holstein, Shebli Atrash, Hira Mian, Meletios A Dimopoulos, Fredrik Schjesvold
Blood. 2025-08-28
3 citations
The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease.
Molly E Muehlebach, Sarah A Holstein
Bone Research. 2025-08-28

Abstracts/Posters

Geranylgeranyl Diphosphate Synthase Inhibitor and Proteasome Inhibitor Combination Therapy in Multiple Myeloma
Sarah A. Holstein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
In Vitro and in Vivo Activity of Melflufen in Amyloidosis
Sarah A. Holstein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
The Effect of Age and CD34+ Stem Cell Dose on Autologous Hematopoietic Stem Cell Transplantation Outcomes in Multiple Myeloma _ Single Institution Experience
Sarah A. Holstein, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

Results of a Phase I Study of Pnk-007, Allogeneic, Off the Shelf NK Cell, Post Autologous Transplant in Multiple Myeloma (NCT02955550)
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
Friday Scientific Workshop on Immune Profiling and Minimal Residual Disease Testing in Multiple Myeloma
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase InhibitorsClinically Relevant Abstract
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Pulled Myeloma Drug Improves Survival in TrialDecember 12th, 2024
Distinguished Scientist: Sarah Holstein, MD, PhDFebruary 11th, 2021
Finding a Needle in a Haystack of Mutations: Using Whole Genome Sequencing to Identify Patients with Low-Risk MyelomaJuly 20th, 2020