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Sarah Sartain, MD, Pediatric Hematology & Oncology, Houston, TX, Texas Children's Hospital

SarahESartainMD

Pediatric Hematology & Oncology • Houston, TX

Pediatric Coagulation Disorder Hematology

Associate Professor of Pediatrics, Texas Children's Hospital, Baylor College of Medicine Director, Hemostasis and Thrombosis Program

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Summary

  • I am a physician-scientist with a growing knowledge base in endothelial dysfunction and a particular interest in microvascular thrombosis. As an Assistant Professor at Baylor College of Medicine (BCM), I am dedicated to delineating disease mechanisms and discovering new treatments for thrombotic microangiopathy and other thromboinflammatory disorders in a basic science laboratory. As a pediatric hematologist at Texas Children’s Hospital, I treat patients with bleeding and clotting disorders and focus on those involving catastrophic microvascular thrombosis caused by inflammation and alternative complement pathway overactivation. The alternative complement pathway is one of three pathways within the innate immune system responsible for ridding the body of unwanted or foreign invaders, but overactivation may lead to human disease. My patients’ experiences have inspired my specific laboratory investigations, and because I know firsthand how breakthroughs in this area would improve patient morbidity and mortality, I want to pinpoint mechanisms of alternative complement pathway activation, endothelial injury, and microvascular thrombosis in thromboinflammation. I have gained technical fluency in endothelial cell functional studies in the laboratory, and with these competencies, I have elucidated mechanisms for cytokine-mediated alternative complement pathway activation by endothelial cells, detected differences in complement regulation amongst varying types of microvascular endothelial cells, discovered that patients with transplantation-associated thrombotic microangiopathy have elevated plasma levels of the alternative complement pathway activation product Ba, and linked von Willebrand factor (VWF) to the activation of the alternative complement pathway in thromboinflammation in vivo.

Education & Training

  • Baylor College of Medicine
    Baylor College of MedicineFellowship, Pediatric Hematology/Oncology, 2012 - 2015
  • Children's Hospital/Boston Medical Center
    Children's Hospital/Boston Medical CenterResidency, Pediatrics, 2009 - 2012
  • Tulane University School of Medicine
    Tulane University School of MedicineClass of 2009

Certifications & Licensure

  • TX State Medical License
    TX State Medical License 2012 - 2024
  • MA State Medical License
    MA State Medical License 2009 - 2012
  • American Board of Pediatrics Pediatrics
  • American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

  • Power of Professionalism (POP) Award Baylor College of Medicine, 2021
  • Norton Rose Fulbright Faculty Excellence Award in Teaching and Evaluation Baylor College of Medicine, 2021
  • Best Poster Presentation, “Von Willebrand Factor Activates the Alternative Complement Pathway in vivo in Murine Thromboinflammation.” Texas Children’s Cancer and Hematology Centers 17th Annual Research Symposium, 2021
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Publications & Presentations

PubMed

Journal Articles

  • Downregulation of thrombomodulin-thrombin-activated protein C pathway as a mechanism for SARS-CoV-2 induced endotheliopathy and microvascular thrombosis.  
    Agarwal S, Cohen CT, Zobeck M, Jacobi PM, Sartain SE., Thrombosis Update, 8/8/2022

Books/Book Chapters

  • Management of Bleeding Patients 
    Chapter: Bleeding Associated with Thrombocytopenia 
    Sartain S, Despotovic JSpringer International PublishingEdition 2,2021
  • Hematology in the Adolescent Female 
    Chapter: Thrombotic Microangiopathy 
    Cohen C, Singleton T, Sartain SEditors: Srivaths, L.Springer NatureEdition 1,2020
  • Handbook of Benign Hematology 
    Chapter: Platelet Disorders 
    Han H, Sartain S.Demos Medical, An Imprint of Springer PublishingEdition 1,2020
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Abstracts/Posters

  • PLASMIC-KID score for pediatric thrombotic thrombocytopenic purpura (TTP)
    Rairikar M, Sartain SE, Solomon C, Hui SK, Srivaths P, Hemostasis and Thrombosis Research Society Scientific Symposium, Orlando, FL, 3/12/2023
  • Complement Activation Is Associated with Endothelial Damage in Hematopoietic Stem Cell Transplant Associated-Thrombotic Microangiopathy
    Jacobi P, Coffiel R, Chang C, Kim S, Sartain SE, American Society of Hematology Annual Meeting, New Orleans, LA, 12/11/2022
  • Exploring the risk factors for venous thromboembolism in children with sickle cell disease
    Agarwal S, Foster K, Johnson S, Shapiro M, Han HJ, Scherer ME, Airewele G, Sartain SE, Thrombosis and Hemostasis Summit of North America, Chicago, IL, 8/17/2022
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Grant Support

  • ASH Scholar AwardAmerican Society of Hematology2019–2021
  • Pediatric Pilot AwardBaylor College of Medicine2016–2017
  • Mentored Research AwardHemostasis and Thrombosis Research Society2014–2016

Professional Memberships

Hospital Affiliations

Industry Relationships

  • Advisory Board Member and Research Collaborator, Alexion Pharmaceuticals2020 - Present

Dr. Sarah Sartain, Dr. Sarah Sartain, MD, Dr. S Sartain, Dr. Sarah E Sartain