SatheeshChonatMD

Pediatric Hematology & Oncology • Atlanta, GA

Associate Professor, Department of Pediatrics, Emory University and Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta

Join to view full profile

Dr. Chonat is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Chonat's full profile

Already have an account?

Office
1405 Clifton Rd NE
Atlanta, GA 30322
Phone+1 404-785-5252

Fax+1 404-785-2034
Is this information wrong?

Education & Training

Cincinnati Children's Hospital Medical CenterFellowship, Pediatric Hematology/Oncology, 2012 - 2015
Sparrow HospitalResidency, Pediatrics, 2009 - 2012
Cambridge University Hospitals and London School of PaediatricsSpeciality Training Registrar, General Pediatrics, Neonatology and Hematology/Oncology, 2003 - 2009
M.S. Ramaiah Medical CollegeClass of 2003

Certifications & Licensure

GA State Medical License 2015 - 2025
OH State Medical License 2012 - 2017
MI State Medical License 2009 - 2012
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Pyruvate Kinase Deficiency Natural History Study Start of enrollment: 2013 Dec 01
Completed
A Study of Ravulizumab (ALXN1210) in Children and Adolescents With Paroxysmal Nocturnal Hemoglobinuria Start of enrollment: 2018 Feb 22
Completed
Phase 3
Pyruvate Kinase Deficiency Global Longitudinal Registry Start of enrollment: 2018 Apr 23
Recruiting
A Study to Evaluate Efficacy and Safety of AG-348 in Not Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD) Start of enrollment: 2018 Aug 09
Completed
Phase 3
A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD) Start of enrollment: 2018 Jun 26
Completed
Phase 3
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period Start of enrollment: 2022 Jun 08
Active, not recruiting
Phase 3
A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period Start of enrollment: 2022 Jun 06
Recruiting
Phase 3
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). Start of enrollment: 2022 Mar 26
Recruiting
Phase 1
Join now to see all

Publications & Presentations

PubMed

Pharmacokinetics, pharmacodynamics, efficacy, and safety of ravulizumab in pediatric paroxysmal nocturnal hemoglobinuria.
Alexander Kulagin, Alexey Maschan, Marije Bartels, Jochen Buechner, Michael Richards, Masayo Ogawa, Eden Hicks, Ji Yu, André Baruchel, Austin G Kulasekararaj, Satheesh...> ;Blood Advances. 2024 Mar 29
Compassionate Use Narsoplimab for Severe Refractory Transplantation-Associated Thrombotic Microangiopathy in Children.
Michelle L Schoettler, Seema Patel, Elyse Bryson, Laura Deeb, Benjamin Watkins, Muna Qayed, Shanmuganathan Chandrakasan, Taylor Fitch, Katherine Silvis, Jayre Jones, S...> ;Transplantation and Cellular Therapy. 2024 Mar 1
Diagnosis and management of pyruvate kinase deficiency: international expert guidelines.
Al-Samkari, H., Shehata, N., Lang-Robertson, K., Bianchi, P., Glenthøj, A., Sheth, S., Neufeld, E., Rees, D., Chonat, S., Kuo, K., Rothman, J., Barcellini, W., van Bee...> ;The Lancet. Haematology. 2024 Mar 1
Voxelotor improves red blood cell functionality in children with sickle cell anaemia: An ancillary study of the HOPE-KIDS 1 trial.
Fields, E., Baratz, H., Watt, A., Pochron, M., Dixon, S., Tonda, M., Brown, C., Archer, D., Chonat, S.> ;Ejhaem. 2024 Feb 1
D-dimer and sinusoidal obstructive syndrome-novel poor prognostic features of thrombotic microangiopathy in children after hematopoietic cellular therapy in a single i...
French, K., Harris, A., Bryson, E., Deeb, L., Hudson, Z., Obordo, J., Westbrook, A., Switchenko, J., Schoettler, M., Chandrakasan, S., Parikh, S., Watkins, B., Stenger...> ;American Journal of Hematology. 2024 Mar 1
Pediatric transplant-associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy.
Michelle L Schoettler, Leslie Lehmann, Pei-Chi Kao, Nan Chen, Sonata Jodele, Satheesh Chonat, Kirsten M Williams, Wendy B London, Christine Duncan, Christopher Dandoy> ;Blood Advances. 2024 Mar 12
1 citations
Frequency of HLA-DRCD38T cells identifies and quantifies T-cell activation in hemophagocytic lymphohistiocytosis, hyperinflammation, and immune regulatory disorders.
Thinh H Nguyen, Deepak Kumar, Chengyu Prince, Dylan Martini, Jocelyn R Grunwell, Taylor Lawrence, Trenton Whitely, Karin Chappelle, Satheesh Chonat, Sampath Prahalad, ...> ;The Journal of Allergy and Clinical Immunology. 2024 Jan 1
8 citations
Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression.
Ryan P Jajosky, Kashyap R Patel, Jerry William L Allen, Patricia E Zerra, Satheesh Chonat, Diyoly Ayona, Cheryl L Maier, Dominique Morais, Shang-Chuen Wu, C John Lucke...> ;Blood. 2023 Sep 21
Factor H autoantibodies contribute to complement dysregulation in multisystem inflammatory syndrome in children (MIS-C).
Patricia E Zerra, Jennifer Stowell, Hans Verkerke, James McCoy, Jayre Jones, Sara Graciaa, Austin Lu, Laila Hussaini, Evan J Anderson, Christina A Rostad, Sean R Stowe...> ;American Journal of Hematology. 2023 May 1
4 citations
Storage differentially impacts alloimmunization to distinct red cell antigens following transfusion in mice.
Cheryl L Maier, Ryan P Jajosky, Seema R Patel, Hans P Verkerke, Megan D Fuller, Jerry William Allen, Patricia E Zerra, Ross M Fasano, Satheesh Chonat, Cassandra D Jose...> ;Transfusion. 2023 Mar 1
2 citations
Pulmonary Manifestations and Vascular Changes in Pediatric Transplantation-Associated Thrombotic Microangiopathy.
Michelle L Schoettler, Blachy D Saldana, Lisa Berkenkamp, Satheesh Chonat, Benjamin Watkins, Seth J Rotz, Dawn Simons, Emily Graf, Christopher Rossi, Jinjun Cheng, Yuk...> ;Transplantation and Cellular Therapy. 2023 Jan 1
2 citations
Clinical features and neurological outcomes in pediatric immune-mediated thrombotic thrombocytopenic purpura: A report from a large pediatric hematology center.
Sara Graciaa, Segun Adeagbo, Grace Fong, Margo Rollins, Patricia McElfresh, Patricia E Zerra, Carolyn Bennett, Cassandra D Josephson, Michael Briones, Ross M Fasano, S...> ;Pediatric Blood & Cancer. 2022 Dec 1
1 citations
A virtuosic CADENZA played by sutimlimab.
Satheesh Chonat, Sean R Stowell> ;Blood. 2022 Sep 1
6 citations
Sickle cell disease is a risk factor for transplant-associated thrombotic microangiopathy in children.
Michelle Schoettler, Elizabeth Stenger, Kathleen Spencer, Deborah Lutterman, Savanah Rumbika, Jayre Jones, Ann Haight, Suhag Parikh, Muna Qayed, Benjamin Watkins, Laks...> ;Blood Advances. 2023 May 9
13 citations
Mitapivat in adult patients with pyruvate kinase deficiency receiving regular transfusions (ACTIVATE-T): a multicentre, open-label, single-arm, phase 3 trial.
Andreas Glenthøj, Eduard J van Beers, Hanny Al-Samkari, Vip Viprakasit, Kevin H M Kuo, Frédéric Galactéros, Satheesh Chonat, John Porter, Erin Zagadailov, Rengyi Xu, A...> ;The Lancet. Haematology. 2022 Oct 1
Characteristics and outcomes of pediatric oncology patients at risk for guardians declining transfusion of blood components.
Jason Stevenson, Nicholas P DeGroote, Frank Keller, Katharine E Brock, D John Bergsagel, Tamara P Miller, Patricia Cornwell, Ross Fasano, Satheesh Chonat, Sharon M Cas...> ;Cancer Reports. 2023 Jan 1
2 citations
Evaluating ravulizumab for the treatment of children and adolescents with paroxysmal nocturnal hemoglobinuria.
Justin J Yoo, Satheesh Chonat> ;Expert Review of Hematology. 2022 May 1
9 citations
Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice.
Connie M Arthur, Seema R Patel, Asish Sharma, Patricia E Zerra, Satheesh Chonat, Ryan P Jajosky, Ross M Fasano, Ravi Patel, Ashley Bennett, Xiaoxi Zhou, C John Luckey,...> ;Transfusion. 2022 May 1
31 citations
Mitapivat versus Placebo for Pyruvate Kinase Deficiency.
Rothman, J., Rothman, J., Hanny Al-Samkari, Frédéric Galactéros, Andreas Glenthøj, Jennifer A Rothman, Oliver Andres, Rachael F Grace, Marta Morado-Arias, D Mark Layto...> ;The New England Journal of Medicine. 2022 Apr 14
11 citations
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation.
Alexandra Gerogianni, Jordan D Dimitrov, Alessandra Zarantonello, Victoria Poillerat, Satheesh Chonat, Kerstin Sandholm, Karin E McAdam, Kristina N Ekdahl, Tom E Molln...> ;Frontiers in Immunology. 2022 Jan 1
6 citations
Emerging therapeutic and preventive approaches to transplant-associated thrombotic microangiopathy
Michelle Long Schoettler, Satheesh Chonat, Kirsten M. Williams, Leslie Lehmann> ;Current Opinion in Hematology. 2021 Nov 1
10 citations
Health-Related Quality of Life and Fatigue in Children and Adults with Pyruvate Kinase Deficiency.
Hanny Al-Samkari, Eduard J. van Beers, D. Holmes Morton, Stefan W. Eber, Satheesh Chonat, Kevin H.M. Kuo, Nina Kollmar, Heng Wang, Vicky R. Breakey, Sujit Sheth, Mukta...> ;Blood Advances. 2021 Sep 1
10 citations
T follicular helper cell expansion and chronic T cell activation are characteristic immune anomalies in Evans syndrome.
Deepak Kumar, Chengyu Prince, Carolyn M. Bennett, Michael Briones, Laura Lucas, Athena Liza Russell, Kiran Patel, Satheesh Chonat, Sara H Graciaa, Holly Edington, Mich...> ;Blood. 2021 Aug 23
Correction to: T Cell‑Epstein‑Barr Virus-Associated Hemophagocytic Lymphohistiocytosis (HLH) Occurs in Non‑Asians and Is Associated with a T Cell Activation State that...
Oded Shamriz, Deepak Kumar, Jenny Shim, Michael Briones, Maa-Ohui Quarmyne, Satheesh Chonat, Laura Lucas, Holly Edington, Michael H White, Advay Mahajan, Sunita Park, ...> ;Journal of Clinical Immunology. 2021 Nov 1
9 citations
T Cell-Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis (HLH) Occurs in Non-Asians and Is Associated with a T Cell Activation State that Is Comparable ...
Oded Shamriz, Deepak Kumar, Jenny Shim, Michael Briones, Maa-Ohui Quarmyne, Satheesh Chonat, Laura Lucas, Holly Edington, Michael H White, Advay Mahajan, Sunita Park, ...> ;Journal of Clinical Immunology. 2021 Oct 1
Join now to see all

Abstracts/Posters

Characterization of the Severe Phenotype of Pyruvate Kinase Deficiency
Satheesh Chonat, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Pyruvate Kinase (PK) Protein and Enzyme Levels in the Diagnosis and Clinical Phenotype of PK Deficiency
Satheesh Chonat, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Congenital Dyserythropoietic Anemia Type I Due to Biallelic CDAN1 mutations: Report from the Congenital Dyserythropoietic Anemia Registry (CDAR)
Satheesh Chonat, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Comorbidities and Complications in Adults with Pyruvate Kinase Deficiency
Satheesh Chonat, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
Join now to see all

Press Mentions

Rezurock Approved for Chronic Graft-vs-Host DiseaseAugust 4th, 2021
Ultomiris Approved for Pediatric Patients with Paroxysmal Nocturnal HemoglobinuriaJune 8th, 2021
Alexion Announces FDA Approval of ULTOMIRIS® (Ravulizumab-Cwvz) for Children and Adolescents with Paroxysmal Nocturnal Hemoglobinuria (PNH)June 7th, 2021