SaulMGenuthMD

Endocrinology • Cleveland, OH

Diabetes, Lipid Metabolism

Professor, Medicine, Case Western Reserve University School of Medicine

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Office
11100 Euclid Ave
Cleveland, OH 44106
Phone+1 216-844-8500
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Education & Training

Duke University HospitalResidency, Internal Medicine, 1961 - 1964
The MetroHealth System/Case Western Reserve UniversityResidency, Internal Medicine, 1958 - 1959
Mount Sinai Medical Center of ClevelandInternship, Transitional Year, 1957 - 1958
Case Western Reserve University School of MedicineClass of 1957

Certifications & Licensure

OH State Medical License 1957 - 2019

Clinical Trials

Epidemiology of Diabetes Interventions and Complications (EDIC) Start of enrollment: 1994 Apr 01
Active, not recruiting

Publications & Presentations

PubMed

12 citations
Plasma advanced glycation end products and the subsequent risk of microvascular complications in type 1 diabetes in the DCCT/EDIC.
Vincent M Monnier, David R Sell, Xiaoyu Gao, Saul M Genuth, John M Lachin, Ionut Bebu> ;BMJ Open Diabetes Research & Care. 2022 Jan 1
1 citations
BARI 2D: A Reanalysis Focusing on Cardiovascular Events
Saul Genuth, Helen Vlachos, Maria M. Brooks, John P. Bantle, Bernard R. Chaitman, Jennifer B. Green, Sheryl F. Kelsey, Spencer B. King, Robert D. McBane, Edward Y. Sak...> ;Mayo Clinic Proceedings. 2019 Nov 1
28 citations
Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.
Lee M. Jampol, Adam R. Glassman, Danni Liu, Lloyd Paul Aiello, Neil M. Bressler, Elia J. Duh, Susan E. Quaggin, John A. Wells, Charles C. Wykoff, David J. Browning, An...> ;Ophthalmology. 2018 Mar 7
The Role of Diabetes Care and Its Contributions to the Field of Diabetes: A Profile in Progress.
Lyn Reynolds, Saul Genuth> ;Diabetes Care. 2018 Feb 1
46 citations
SYNTAX Score and Long-Term Outcomes: The BARI-2D Trial
Fumiaki Ikeno, Maria M. Brooks, Kaori Nakagawa, Min Kyu Kim, Hideaki Kaneda, Yoshiaki Mitsutake, Helen Vlachos, Leonard Schwartz, Robert L. Frye, Sheryl F. Kelsey, Kat...> ;Journal of the American College of Cardiology. 2017 Jan 31
60 citations
Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complication...
Rodica Pop-Busui, Barbara H. Braffett, B. Zinman, Catherine L. Martin, Neil H. White, William H. Herman, Saul Genuth, Rose Gubitosi-Klug> ;Diabetes Care. 2017 Jan 1
39 citations
Coprogression of cardiovascular risk factors in type 1 diabetes during 30 years of follow-up in the DCCT/EDIC study
Barbara H. Braffett, Ionut Bebu, John M. Lachin, Samuel Dagogo-Jack, Mary E. Larkin, William I. Sivitz, Orville G. Kolterman, Saul Genuth> ;Diabetes Care. 2016 Sep 1
88 citations
Persistent effects of intensive glycemic control on retinopathy in type 2 diabetes in the action to control cardiovascular risk in diabetes (ACCORD) follow-on study
Emily Y. Chew, James Lovato, Matthew D. Davis, Hertzel C. Gerstein, Ronald P. Danis, Faramarz Ismail-Beigi, Saul Genuth, Craig M. Greven, Letitia H Perdue, William C. ...> ;Diabetes Care. 2016 Jul 1
23 citations
The pecking order of skin Advanced Glycation Endproducts (AGEs) as long-term markers of glycemic damage and risk factors for micro- and subclinical macrovascular disea...
Vincent M. Monnier, Saul Genuth, David R. Sell> ;Glycoconjugate Journal. 2016 Jun 25
157 citations
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Zhuo Chen, Feng Miao, Andrew D. Paterson, John M. Lachin, Lingxiao Zhang, Dustin E. Schones, Xiwei Wu, Jinhui Wang, Joshua D. Tompkins, Saul Genuth, Barbara H. Braffet...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 May 24
123 citations
Nine-year effects of 3.7 years of intensive glycemic control on cardiovascular outcomes
Hertzel C. Gerstein, Daniel P. Beavers, Alain G. Bertoni, J. Thomas Bigger, John B. Buse, Timothy E. Craven, William C. Cushman, Vivian Fonseca, Nancy L. Geller, Steph...> ;Diabetes Care. 2016 May 1
21 citations
Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes
David R. Sell, Wanjie Sun, Xiaoyu Gao, Christopher Strauch, John M. Lachin, Patricia A. Cleary, Saul Genuth, Vincent M. Monnier> ;Cardiovascular Diabetology. 2016 Feb 11
7 citations
Quality Control Measures over 30 Years in a Multicenter Clinical Study: Results from the Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventi...
Gayle M. Lorenzi, Barbara H. Braffett, Valerie L. Arends, Ronald P. Danis, Lisa Diminick, Kandace A. Klumpp, Anthony D. Morrison, Elsayed Z. Soliman, Michael W. Steffe...> ;Plos One. 2015 Nov 3
Data sharing is desirable, but benefits should not be exaggerated.
David M. Nathan, Saul Genuth, Bernard Zinman, John M. Lachin> ;BMJ. 2015 Oct 21
32 citations
Insulin Dose and Cardiovascular Mortality in the ACCORD Trial
Elias S. Siraj, Daniel J. Rubin, Matthew C. Riddle, Michael E. Miller, Fang-Chi Hsu, Faramarz Ismail-Beigi, Shyh-Huei Chen, Walter T. Ambrosius, Abraham Thomas, Willia...> ;Diabetes Care. 2015 Oct 12
Erratum to: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
Vincent M Monnier, Wanjie Sun, Xiaoyu Gao, David R Sell, Patricia A Cleary, John M Lachin, Saul Genuth> ;Cardiovascular Diabetology. 2015 Oct 9
10 citations
Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes.
Vincent M Monnier, Wanjie Sun, Xiaoyu Gao, David R Sell, Patricia A Cleary, John M Lachin, Saul Genuth> ;Cardiovascular Diabetology. 2015 Sep 5
1 citations
Response to Comment on Genuth. Should Sulfonylureas Remain an Acceptable First-Line Add-on to Metformin Therapy in Patients With Type 2 Diabetes? No, It’s Time to Move...
Saul Genuth> ;Diabetes Care. 2015 Jun 1
10 citations
Triglyceride High-Density Lipoprotein Ratios Predict Glycemia-Lowering in Response to Insulin Sensitizing Drugs in Type 2 Diabetes: A Post Hoc Analysis of the BARI 2D.
Joel Zonszein, Manuel Lombardero, Faramarz Ismail-Beigi, Pasquale Palumbo, Suzy Foucher, Yolanda Groenewoud, Gary W. Cushing, Bernardo Léo Wajchenberg, Saul Genuth> ;Journal of Diabetes Research. 2015 May 27
8 citations
Sex, Prescribing Practices and Guideline Recommended, Blood Pressure, and LDL Cholesterol Targets at Baseline in the BARI 2D Trial
Michelle F. Magee, Jacqueline E. Tamis-Holland, Jiang Lu, Vera Bittner, Maria M. Brooks, Neuza Lopes, Alice K. Jacobs, Katherine M. Detre, Sheryl F. Kelsey, Trevor J. ...> ;International Journal of Endocrinology. 2015 Mar 19
33 citations
Should sulfonylureas remain an acceptable first-line add-on to metformin therapy in patients with type 2 diabetes? No, it's time to move on!
Saul Genuth> ;Diabetes Care. 2015 Jan 1
98 citations
Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression ...
Saul Genuth, Wanjie Sun, Patricia A. Cleary, Xiaoyu Gao, David R. Sell, John M. Lachin, Vincent M. Monnier> ;Diabetes. 2015 Jan 1
25 citations
Self-Reported Prevalence of Diabetes Screening in the U.S., 2005–2010
Sarah Stark Casagrande, Catherine C. Cowie, Saul Genuth> ;American Journal of Preventive Medicine. 2014 Dec 1
40 citations
Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci
Claire L. Simpson, Robert Wojciechowski, Konrad Oexle, Federico Murgia, Laura Portas, Xiaohui Li, J. M.Verhoeven Virginie, Veronique Vitart, Maria Schache, S. Mohsen H...> ;Plos One. 2014 Sep 18
199 citations
The effects of medical management on the progression of diabetic retinopathy in persons with type 2 diabetes: the Action to Control Cardiovascular Risk in Diabetes (AC...
Emily Y. Chew, Matthew D. Davis, Ronald P. Danis, James Lovato, Letitia H Perdue, Craig M. Greven, Saul Genuth, David C. Goff, Lawrence A. Leiter, Faramarz Ismail-Beig...> ;Ophthalmology. 2014 Dec 1
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Press Mentions

Future Directions for Landmark Diabetes Study in Journal Diabetes CareJanuary 28th, 2014

Grant Support

AccordDivision Of Epidemiology And Clinical Applications2009
Prevention Of Cardiovascular Disease In Diabetes MellituNational Heart, Lung, And Blood Institute2007
Diabetes Control And Complications TrialNational Institute Of Diabetes And Digestive And Kidney Diseases1988–1993
Diabetes Control And Complications Trial (DCCT)National Institute Of Diabetes And Digestive And Kidney Diseases1986–1987
Diabetes Control &Complications Trial (DCCT)National Institute Of Diabetes And Digestive And Kidney Diseases1986
Diabetes Control And Complications Trial (DCCT)Nat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985