ScottParleyBrownMD

PubMed

• A unified, probabilistic framework for structure- and ligand-based virtual screening.
  Swann, S.L., Brown, S.P., Muchmore, S.W., Patel, H., Merta, P., Locklear, J., Hajduk, P.J.> ;J Med Chem. 2011 Mar 10
• Molecular shape and medicinal chemistry: a perspective.
  Nicholls, A., McGaughey, G.B., Sheridan, R.P., Good, A.C., Warren, G., Mathieu, M., Muchmore, S.W., Brown, S.P., Grant, J.A., Haigh, J.A., Nevins, N., Jain, A.N., Kell...> ;J Med Chem. 2010 May 27
• Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes.
  Brown, S.P., Muchmore, S.W.> ;J Med Chem. 2009-05-28
• Healthy skepticism: assessing realistic model performance.
  Brown, S. P.,Muchmore, S. W.,Hajduk, P. J.> ;Drug Discov. Today. 2009 Apr 03
• Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
  Wang, X., Sarris, K., Kage, K., Zhang, D., Brown, S.P., Kolasa, T., Surowy, C., El Kouhen, O.F., Muchmore, S.W., Brioni, J.D., Stewart, A.O.> ;J Med Chem. 2009-01-08
• Contrasting disease and nondisease protein aggregation by molecular simulation.
  Fawzi, N.L., Yap, E., Okabe, Y., Kohlstedt, K.L., Brown, S.P., Head-Gordon, T.> ;Acc Chem Res. 2008 Aug
• Application of belief theory to similarity data fusion for use in analog searching and lead hopping.
  Muchmore, S.W., Debe, D.A., Metz, J.T., Brown, S.P., Martin, Y.C., Hajduk, P.J.> ;J Chem Inf Model. 2008 May
• Rapid estimation of relative protein-ligand binding affinities using a high-throughput version of MM-PBSA.
  Brown, S.P., Muchmore, S.W.> ;J Chem Inf Model. 2007-07-01
• High-throughput calculation of protein-ligand binding affinities: modification and adaptation of the MM-PBSA protocol to enterprise grid computing.
  Brown, S.P., Muchmore, S.W.> ;J Chem Inf Model. 2006-05-01
• Join now to see all