ScottWCannaMD

PubMed

• SPAK inhibitor ZT-1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia.
  Mohammad Iqbal H Bhuiyan, Khadija Habib, Md Tipu Sultan, Fenghua Chen, Israt Jahan, Zhongfang Weng, Md Shamim Rahman, Rabia Islam, Lesley M Foley, T Kevin Hitchens, Xi...> ;CNS Neuroscience & Therapeutics. 2024 Mar 1
• Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne.
  Lee, W., Stone, D., Hoffmann, P., Rosenzweig, S., Tsai, W., Gadina, M., Romeo, T., Lee, C., Randazzo, D., Pimpale Chavan, P., Manthiram, K., Canna, S., Park, Y., Ombre...> ;Annals of the Rheumatic Diseases. 2024 Feb 26
• Part 5: Allogeneic HSCT in refractory SJIA with lung disease; recent cases from centers in North America & Europe.
  Grom, A., Canna, S., Abu-Arja, R., Sinha, R., Peixoto, L., Cannizzaro, E., Chandrakasan, S., Driest, K., Marsh, R., Neven, B., Onel, K., Prahalad, S., Prockop, S., Qua...> ;Pediatric Rheumatology Online Journal. 2024 Jan 5
• The 4NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?
  De Benedetti, F., Canna, S.> ;Pediatric Rheumatology Online Journal. 2024 Jan 5
• 1 citations
  Biological and clinical roles of IL-18 in inflammatory diseases.
  Landy, E., Ring, A., Carol, H., Canna, S.> ;Nature Reviews. Rheumatology. 2024 Jan 1
• 1 citations
  Complementary HLH susceptibility factors converge on CD8 T-cell hyperactivation.
  Emily Landy, Jemy Varghese, Vinh Dang, Andrea Szymczak-Workman, Lawrence P Kane, Scott W Canna> ;Blood Advances. 2023 Nov 28
• 1 citations
  Type I interferon signature and cycling lymphocytes in macrophage activation syndrome.
  Zhengping Huang, Kailey E Brodeur, Liang Chen, Yan Du, Holly Wobma, Evan E Hsu, Meng Liu, Joyce C Chang, Margaret H Chang, Janet Chou, Megan Day-Lewis, Fatma Dedeoglu,...> ;The Journal of Clinical Investigation. 2023 Nov 15
• 1 citations
  Emapalumab for the treatment of refractory cytokine release syndrome in pediatric patients.
  Matthew R Schuelke, Hamid Bassiri, Edward M Behrens, Scott Canna, Colleen Croy, Amanda DiNofia, Kandace Gollomp, Stephan Grupp, Michele Lambert, Arathi Lambrix, Shanno...> ;Blood Advances. 2023 Sep 26
• Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis.
  Emely L Verweyen, Kairavee Thakkar, Sanjeev Dhakal, Elizabeth Baker, Kashish Chetal, Daniel Schnell, Scott Canna, Alexei A Grom, Nathan Salomonis, Grant S Schulert> ;The Journal of Clinical Investigation. 2023 Nov 15
• 3 citations
  The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (...
  Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid...> ;Arthritis & Rheumatology. 2023 Oct 1
• 9 citations
  The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (...
  Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid...> ;Annals of the Rheumatic Diseases. 2023 Oct 1
• TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.
  James P Grayczyk, Marisa S Egan, Luying Liu, Emily Aunins, Meghan A Wynosky-Dolfi, Scott Canna, Andy J Minn, Sunny Shin, Igor E Brodsky> ;Biorxiv. 2023 May 4
• 1 citations
  Cytokine Storm Syndromes in Pediatric Patients.
  Caroline Diorio, David T Teachey, Scott W Canna> ;The Journal of Allergy and Clinical Immunology. in Practice. 2023 Jun 1
• 1 citations
  Deep neural networks with knockoff features identify nonlinear causal relations and estimate effect sizes in complex biological systems.
  Zhenjiang Fan, Kate F Kernan, Aditya Sriram, Panayiotis V Benos, Scott W Canna, Joseph A Carcillo, Soyeon Kim, Hyun Jung Park> ;Gigascience. 2022 Dec 28
• 11 citations
  mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.
  Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H Chang, Alexandra Wac...> ;Nature Communications. 2022 Nov 28
• 14 citations
  Improvement of Refractory Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease with Single-Agent Blockade of IL-1β and IL-18.
  Julia E Rood, Ayman Rezk, Jennifer Pogoriler, Laura S Finn, Jon M Burnham, Maureen B Josephson, Amit Bar-Or, Edward M Behrens, Scott W Canna> ;Journal of Clinical Immunology. 2023 Jan 1
• 3 citations
  NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise.
  Shaymaa Hegazy, Mariana C Marques, Scott W Canna, Raphaela Goldbach-Mansky, Adriana A de Jesus, Miguel Reyes-Múgica, Claudia M Salgado> ;The American Journal of Dermatopathology. 2022 Jun 1
• 1 citations
  IL-1 receptor antagonist, MIS-C, and the peculiar autoimmunity of SARS-CoV-2.
  Hamid Bassiri, Scott W Canna> ;The Lancet. Rheumatology. 2022 May 1
• 117 citations
  American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVI...
  Lauren A Henderson, Scott W Canna, Kevin G Friedman, Mark Gorelik, Sivia K Lapidus, Hamid Bassiri, Edward M Behrens, Kate F Kernan, Grant S Schulert, Philip Seo, Mary ...> ;Arthritis & Rheumatology. 2022 Apr 1
• 7 citations
  Sepsis with liver dysfunction and coagulopathy predicts an inflammatory pattern of macrophage activation.
  Renee R Anderko, Hernando Gómez, Scott W Canna, Bita Shakoory, Derek C Angus, Donald M Yealy, David T Huang, John A Kellum, Joseph A Carcillo> ;Intensive Care Medicine Experimental. 2022 Feb 21
• 20 citations
  Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis.
  Guangbo Chen, Gail H Deutsch, Grant S Schulert, Hong Zheng, SoRi Jang, Bruce Trapnell, Pui Y Lee, Claudia Macaubas, Katherine Ho, Corinne Schneider, Vivian E Saper, Ad...> ;Arthritis & Rheumatology. 2022 Jul 1
• 30 citations
  Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction.
  Caroline Diorio, Rawan Shraim, Laura A Vella, Josephine R Giles, Amy E Baxter, Derek A Oldridge, Scott W Canna, Sarah E Henrickson, Kevin O McNerney, Frances Balamuth,...> ;Nature Communications. 2021 Dec 10
• 19 citations
  DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
  Shaobin Wang, Siddharth Narendran, Shuichiro Hirahara, Akhil Varshney, Felipe Pereira, Ivana Apicella, Meenakshi Ambati, Vidya L. Ambati, Praveen Yerramothu, Kameshwar...> ;Science Immunology. 2021 Dec 3
• 42 citations
  Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.
  Vivian E. Saper, Michael J. Ombrello, Adriana H. Tremoulet, Gonzalo Montero-Martín, Sampath Prahalad, Scott W. Canna, Chisato Shimizu, Gail H. Deutsch, Serena Y Tan, E...> ;Annals of the Rheumatic Diseases. 2021 Nov 17
• 18 citations
  Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in PSTPIP1
  Deborah L. Stone, Amanda K. Ombrello, Juan I. Aróstegui, Corinne Schneider, Vinh Dang, Adriana de Jesus, Charlotte Girard-Guyonvarc'h, Cem Gabay, Jae Jin Chae, Ivona A...> ;Arthritis & Rheumatology. 2021 Sep 7
• Join now to see all