ScottAOakesMD

Pathology • San Francisco, CA

Anatomic Pathology, Clinical Pathology

Assistant Professor, Pathology, UCSF School of Medicine

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Office
505 Parnassus Ave
San Francisco, CA 94143
Phone+1 415-514-3424

Fax+1 415-514-3165
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Education & Training

Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1998 - 2000
Uconn School Of MedicineClass of 1998

Certifications & Licensure

IL State Medical License 2020 - 2026
CA State Medical License 2005 - 2021
MA State Medical License 2002 - 2005
American Board of Pathology Anatomic Pathology

Publications & Presentations

PubMed

8 citations
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity.
Adrienne E D Stormo, Farbod Shavarebi, Molly FitzGibbon, Elizabeth M Earley, Hannah Ahrendt, Lotus S Lum, Erik Verschueren, Danielle L Swaney, Gaia Skibinski, Abinaya ...> ;The Journal of Cell Biology. 2022 Apr 4
35 citations
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Dongbo Yang, Long Chi Nguyen, Vlad Nicolaescu, Thomas J. Best, Shao-Nong Chen, J. Brent Friesen, Nir Drayman, Adil Mohamed, Christopher Dann, Diane Silva, Haley Gula, ...> ;Biorxiv. 2021 Mar 10
165 citations
Endoplasmic Reticulum Stress Signaling in Cancer Cells.
Scott A. Oakes> ;The American Journal of Pathology. 2020 Feb 27
21 citations
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
Paul Moore, Jenny Y. Qi, Maike Thamsen, Rajarshi Ghosh, Justin Peng, Micah J. Gliedt, Rosa Meza-Acevedo, Rachel E. Warren, Annie Hiniker, Grace E. Kim, Dustin J. Maly,...> ;Cancer Research. 2019 Dec 15
14 citations
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
Paul Moore, Jessica T. Cortez, Chester E. Chamberlain, Diana L. Alba, Amy C. Berger, Zoe Quandt, Alice Y. Chan, Mickie H. Cheng, Jhoanne L. Bautista, Justin Peng, Mich...> ;The Journal of Clinical Investigation. 2019 Nov 1
2 citations
A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence.
Sam Brondfield, Christy Boscardin, Gordon J Strewler, Katherine Hyland, Scott A. Oakes, Holly Nishimura, Jenny Crawford, Karen E. Hauer> ;Academic Medicine. 2019 Apr 1
1 citations
Bilateral Choroidal Metastases from Pancreatic Adenocarcinoma
Annie Hiniker, Scott A. Oakes, Rajesh C. Rao> ;Ophthalmology. 2017 Dec 1
5 citations
CPEB4 links the clock and the UPR to protect the liver.
Paul Moore, Scott A. Oakes> ;Nature Cell Biology. 2017 Jan 31
70 citations
Endoplasmic reticulum proteostasis: a key checkpoint in cancer.
Scott A. Oakes> ;American Journal of Physiology. Cell Physiology. 2017 Feb 1
12 citations
Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Eric S. Wang, Nichole A. Reyes, Collin Melton, Noelle E. Huskey, Olga Momcilovic, Andrei Goga, Robert Blelloch, Scott A. Oakes> ;Current Biology. 2015 Dec 7
10 citations
Erratum: Proteostasis control by the unfolded protein response.
Claudio Hetz, Eric Chevet, Scott A. Oakes> ;Nature Cell Biology. 2015 Aug 1
31 citations
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryon...
Wei Guo, Wang Xw, Yan Yl, Ya-Pu Li, Yin X, Zhang Q, Collin Melton, Archana Shenoy, Nichole A. Reyes, Scott A. Oakes, Robert Blelloch, Yangming Wang> ;Cell Death and Differentiation. 2015 Jul 1
514 citations
Proteostasis control by the unfolded protein response.
Claudio Hetz, Eric Chevet, Scott A. Oakes> ;Nature Cell Biology. 2015 Jul 1
55 citations
CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma Formation
Noelle E. Huskey, Tingxia Guo, Kimberley J. Evason, Olga Momcilovic, David M. Pardo, Katelyn J. Creasman, Robert L. Judson, Robert Blelloch, Scott A. Oakes, Matthias H...> ;Stem Cell Reports. 2015 Mar 10
847 citations
The Role of Endoplasmic Reticulum Stress in Human Pathology
Scott A. Oakes, Feroz R. Papa> ;Annual Review of Pathology. 2015 Jan 26
130 citations
Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients
Courtney A. Crane, Kathryn Austgen, Kristen Haberthur, Carly Hofmann, Kara White Moyes, Lia Avanesyan, Lawrence Fong, Michael J. Campbell, Stewart Cooper, Scott A. Oak...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Sep 2
324 citations
Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
Rajarshi Ghosh, Likun Wang, Eric S. Wang, B. Gayani K. Perera, Aeid Igbaria, Shuhei Morita, Kris Prado, Maike Thamsen, Deborah Caswell, Hector Macias, Kurt F. Weiberth...> ;Cell. 2014 Jul 31
41 citations
Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
Vera van Dis, Marijn Kuijpers, Elize D. Haasdijk, Eva Teuling, Scott A. Oakes, Casper C. Hoogenraad, Dick Jaarsma> ;Acta Neuropathologica Communications. 2014 Apr 7
146 citations
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
Likun Wang, B. Gayani K. Perera, Sanjay B. Hari, Barun Bhhatarai, Bradley J. Backes, Markus A. Seeliger, Stephan C. Schürer, Scott A. Oakes, Feroz R. Papa, Dustin J. Maly> ;Nature Chemical Biology. 2012 Dec 1
490 citations
IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
John-Paul Upton, Likun Wang, Dan Han, Eric S. Wang, Noelle E. Huskey, Lionel Lim, Morgan L. Truitt, Michael T. McManus, Davide Ruggero, Andrei Goga, Feroz R. Papa, Sco...> ;Science. 2012 Nov 9
627 citations
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner, John-Paul Upton, P. V.K. Praveen, Rajarshi Ghosh, Yoshimi Nakagawa, Aeid Igbaria, Sarah Shen, Vinh Son Nguyen, Bradley J. Backes, Myriam Heiman, Natha...> ;Cell Metabolism. 2012 Aug 8
30 citations
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma
Christine K. Cheng, W. Clay Gustafson, Elizabeth Charron, Benjamin T. Houseman, Eli R. Zunder, Andrei Goga, Nathanael S. Gray, Brian A. Pollok, Scott A. Oakes, C. Davi...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Jul 31
19 citations
Multiple Defects, Including Premature Apoptosis, Prevent Kaposi's Sarcoma-Associated Herpesvirus Replication in Murine Cells
Kathryn Austgen, Scott A. Oakes, Don Ganem> ;Journal of Virology. 2012 Feb 1
28 citations
The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress
Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom Curran, Scott A. Oakes> ;Nature Cell Biology. 2012 Jan 1
295 citations
Signaling cell death from the endoplasmic reticulum stress response.
Gordon C. Shore, Feroz R. Papa, Scott A. Oakes> ;Current Opinion in Cell Biology. 2011 Apr 1
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Press Mentions

A Revealing FlawFebruary 12th, 2021
Gene Discovery Solves 51-Year-Old Mystery Cause of Inherited PancreatitisOctober 29th, 2019
Artificial Intelligence Melanoma Detector Wins Cancer Center Impact GrantJune 19th, 2017

Grant Support

Signaling Cell Death From The Endoplasmic ReticulumNational Cancer Institute2009–2012
BAX/BAK Control Er-Mitochondria Apoptotic CrosstalkNational Institute Of Allergy And Infectious Diseases2005–2007
BAX/BAK Control Er-Mitochondria Apoptotic CrosstalkNational Institute Of Allergy And Infectious Diseases2003–2005

Hospital Affiliations

Zuckerberg San Francisco General Hospital and Trauma CenterSan Francisco, California