SeanKhozinMDMPH

PubMed

• 1 citations
  Real-world evidence for regulatory decision-making: updated guidance from around the world.
  Leah Burns, Nadege Le Roux, Robert Kalesnik-Orszulak, Jennifer Christian, Jennifer Dudinak, Frank Rockhold, John O'Donnell, Sean Khozin> ;Frontiers in Medicine. 2023 Jan 1
• A novel approach to reducing disparities in health outcomes by enhancing interpretation of cancer clinical trials for underrepresented patient groups.
  Sean Khozin, Roger M Stein> ;Biochimica Et Biophysica Acta. Reviews on Cancer. 2022 Nov 1
• 4 citations
  The design and evaluation of hybrid controlled trials that leverage external data and randomization.
  Steffen Ventz, Sean Khozin, Bill Louv, Jacob Sands, Patrick Y Wen, Rifaquat Rahman, Leah Comment, Brian M Alexander, Lorenzo Trippa> ;Nature Communications. 2022 Oct 2
• 18 citations
  Immune-related adverse events associated with immune checkpoint inhibitors: a call to action for collecting and sharing clinical trial and real-world data.
  Kerry L. Reynolds, Shaily Arora, Ravikumar Komandur Elayavilli, William C Louv, Teilo H Schaller, Aakanksha Khandelwal, Mace L. Rothenberg, Sean Khozin, Amanda C. Guid...> ;Journal for Immunotherapy of Cancer. 2021 Jul 1
• 4 citations
  A digital highway for data fluidity and data equity in precision medicine.
  Lynda Chin, Sean Khozin> ;Biochimica Et Biophysica Acta. Reviews on Cancer. 2021 May 29
• 19 citations
  Impact of Broadening Trial Eligibility Criteria for Patients with Advanced Non-Small Cell Lung Cancer: Real-World Analysis of Select ASCO-Friends Recommendations.
  R. Donald Harvey, Suanna S. Bruinooge, Li Chen, Elizabeth Garrett-Mayer, Whitney Rhodes, Edward J. Stepanski, Thomas S. Uldrick, Gwynn Ison, Sean Khozin, Wendy S. Rubi...> ;Clinical Cancer Research. 2021 Feb 9
• 26 citations
  Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials.
  Johnique T. Atkins, Goldy C. George, Kenneth R. Hess, Kathrina L. Marcelo-Lewis, Ying Yuan, Gautam Borthakur, Sean Khozin, Patricia LoRusso, David S. Hong> ;British Journal of Cancer. 2020 Sep 1
• 1 citations
  Patient-Centered Approach to Benefit-Risk Characterization Using Number Needed to Benefit and Number Needed to Harm: Advanced Non-Small-Cell Lung Cancer.
  G. K. Raju, Sean Khozin, Karthik Gurumurthi, Reuben Domike, Janet Woodcock> ;JCO Clinical Cancer Informatics. 2020 Aug 27
• 14 citations
  Status Update on Data Required to Build a Learning Health System.
  Monica M. Bertagnolli, Brian Anderson, Kelly J. Norsworthy, Steven Piantadosi, Andre Quina, Richard L. Schilsky, Robert S. Miller, Sean Khozin> ;Journal of Clinical Oncology. 2020 Mar 25
• Author's Response to "A Letter in Support of Real-World RECIST".
  Sandra D. Griffith, Melisa Tucker, Bryan Bowser, Geoffrey Calkins, Che-Hsu Joe Chang, Ellie Guardino, Sean Khozin, Josh Kraut, Paul You, Deborah Schrag, Rebecca A. Miksad> ;Advances in Therapy. 2020 Feb 13
• 90 citations
  Real‐world progression, treatment, and survival outcomes during rapid adoption of immunotherapy for advanced non–small cell lung cancer
  Sean Khozin, Rebecca A. Miksad, Johan Adami, Mariel Elena Boyd, Nicholas R Brown, Anala Gossai, Irene Kaganman, Deborah Kuk, Jillian Motyl Rockland, Richard Pazdur, Ar...> ;Cancer. 2019 Nov 15
• 18 citations
  Association Between FDA Label Restriction and Immunotherapy and Chemotherapy Use in Bladder Cancer
  Ravi B. Parikh, Blythe J.S. Adamson, Sean Khozin, Matthew D. Galsky, Shrujal S. Baxi, Aaron Cohen, Ronac Mamtani> ;JAMA. 2019 Sep 24
• 14 citations
  Machine-Learning and Stochastic Tumor Growth Models for Predicting Outcomes in Patients With Advanced Non-Small-Cell Lung Cancer.
  Kien Wei Siah, Sean Khozin, Chi Heem Wong, Andrew W. Lo> ;JCO Clinical Cancer Informatics. 2019 Sep 20
• 58 citations
  Characterizing the Feasibility and Performance of Real-World Tumor Progression End Points and Their Association With Overall Survival in a Large Advanced Non-Small-Cel...
  Sandra D. Griffith, Rebecca A. Miksad, Geoff Calkins, Paul You, Nicole G. Lipitz, Ariel B. Bourla, Erin Williams, Daniel J. George, Deborah Schrag, Sean Khozin, Willia...> ;JCO Clinical Cancer Informatics. 2019 Aug 12
• 160 citations
  Artificial intelligence and machine learning in clinical development: a translational perspective
  Pratik Shah, Francis Kendall, Sean Khozin, Ryan Goosen, Jianying Hu, Jason M. Laramie, Michael Ringel, Nicholas J. Schork> ;NPJ Digital Medicine. 2019 Jul 26
• 69 citations
  An Exploratory Analysis of Real-World End Points for Assessing Outcomes Among Immunotherapy-Treated Patients With Advanced Non-Small-Cell Lung Cancer.
  Mark Stewart, Andrew D. Norden, Nancy A Dreyer, Henry J. Henk, Amy P. Abernethy, Elizabeth A. Chrischilles, Lawrence H. Kushi, Aaron S. Mansfield, Sean Khozin, Elad Sh...> ;JCO Clinical Cancer Informatics. 2019 Jul 23
• 53 citations
  Decentralized Trials in the Age of Real-World Evidence and Inclusivity in Clinical Investigations
  Sean Khozin, Andrea Coravos> ;Clinical Pharmacology and Therapeutics. 2019 Jul 1
• 6 citations
  Assessing function of electronic health records for real-world data generation
  Daphne Guinn, Erin E Wilhelm, Grazyna Lieberman, Sean Khozin> ;BMJ Evidence-Based Medicine. 2019 Jun 1
• 99 citations
  Generating Real-World Tumor Burden Endpoints from Electronic Health Record Data: Comparison of RECIST, Radiology-Anchored, and Clinician-Anchored Approaches for Abstra...
  Sandra D. Griffith, Melisa Tucker, Bryan Bowser, Geoffrey Calkins, Che-Hsu Joe Chang, Ellie Guardino, Sean Khozin, Josh Kraut, Paul You, Deborah Schrag, Rebecca A. Miksad> ;Advances in Therapy. 2019 May 28
• 17 citations
  Erratum: Author Correction: Developing and adopting safe and effective digital biomarkers to improve patient outcomes.
  Andrea Coravos, Sean Khozin, Kenneth D. Mandl> ;NPJ Digital Medicine. 2019 May 10
• 57 citations
  Real-World Outcomes of Patients with Metastatic Non-Small Cell Lung Cancer Treated with Programmed Cell Death Protein 1 Inhibitors in the Year Following U.S. Regulator...
  Sean Khozin, Kenneth R. Carson, Jizu Zhi, Melisa Tucker, Shannon E. Lee, David E. Light, Melissa D. Curtis, Marta Bralic, Irene Kaganman, Anala Gossai, Philip P. Hofme...> ;The Oncologist. 2019 May 1
• 38 citations
  Analysis of time-to-treatment discontinuation of targeted therapy, immunotherapy, and chemotherapy in clinical trials of patients with non-small-cell lung cancer.
  G M Blumenthal, Y Gong, K Kehl, P Mishra-Kalyani, K B Goldberg, S Khozin, P G Kluetz, G R Oxnard, R Pazdur> ;Annals of Oncology. 2019 May 1
• 134 citations
  Developing and adopting safe and effective digital biomarkers to improve patient outcomes
  Andrea Coravos, Sean Khozin, Kenneth D. Mandl> ;NPJ Digital Medicine. 2019 Mar 11
• 66 citations
  Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study.
  Vineeta Agarwala, Sean Khozin, Gaurav Singal, Claire O'Connell, Deborah Kuk, Gerald Li, Anala Gossai, Vincent A. Miller, Amy P. Abernethy> ;Health Affairs. 2018 May 7
• 10 citations
  INFORMED: an incubator at the US FDA for driving innovations in data science and agile technology
  Sean Khozin, Richard Pazdur, Anand Shah> ;Nature Reviews. Drug Discovery. 2018 Apr 6
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Lectures

• Real-world outcomes of patients with advanced non-small cell lung cancer (aNSCLC) and autoimmune disease (AD) receiving immune checkpoint inhibitors (ICIs). 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/3/2019
• Real-world characteristics and outcomes of patients with advanced non-small cell lung cancer (aNSCLC) receiving immune checkpoint inhibitor. 
  ASCO Annual Meeting 2019 - Chicago, IL - 6/2/2019
• FDA's Informed: Real-World Evidence Comes of Age 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018