SethMRubinMD

Obstetrics & Gynecology • Flemington, NJ

Physician

Join to view full profile

Dr. Rubin is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Rubin's full profile

Already have an account?

Office
4 Walter E Foran Blvd
Ste 302
Flemington, NJ 08822
Phone+1 908-806-0080

Fax+1 908-806-3478
Is this information wrong?

Education & Training

University of Pennsylvania Health SystemResidency, Obstetrics and Gynecology, 1989 - 1993
Albert Einstein College of MedicineClass of 1989

Certifications & Licensure

NJ State Medical License 1993 - 2025
PA State Medical License 1991 - 1993
American Board of Obstetrics and Gynecology Obstetrics & Gynecology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2011-2012
Fellow (FACOG) American Congress of Obstetricians and Gynecologists

Publications & Presentations

PubMed

Molecular mimicry: HUWE1 binds an atypical site in MIZ1 by adopting a typical BTB fold
Anushweta Asthana, Seth M. Rubin> ;Structure. 2021 Nov 4
3 citations
E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6.
Renin Hazan, Munemasa Mori, Paul S. Danielian, Vincent J Guen, Seth M. Rubin, Wellington V. Cardoso, Jacqueline A. Lees> ;Molecular Biology of the Cell. 2021 Jul 14
110 citations
Integrating Old and New Paradigms of G1/S Control.
Seth M. Rubin, Julien Sage, Jan M. Skotheim> ;Molecular Cell. 2020 Oct 15
8 citations
A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Carmen Schwechheimer, Kassidy Hebert, Sarvind Tripathi, Praveen K. Singh, Kyle A. Floyd, Elise R. Brown, Monique E. Porcella, Jacqueline Osorio, Joseph T. M. Kiblen, F...> ;Plos Pathogens. 2020 Aug 25
4 citations
A long lost key opens an ancient lock:Myb causes a synthetic multivulval phenotype in nematodes.
Paul J Vorster, Paul Goetsch, Tilini U Wijeratne, Keelan Z Guiley, Laura Andrejka, Sarvind Tripathi, Braden J Larson, Seth M Rubin, Susan Strome, Joseph S Lipsick> ;Biology Open. 2020 May 7
111 citations
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Keelan Z. Guiley, Jack W. Stevenson, Kevin Lou, Krister J. Barkovich, Vishnu Kumarasamy, Tilini U. Wijeratne, Katharine L. Bunch, Sarvind Tripathi, Erik S. Knudsen, Ag...> ;Science. 2019 Dec 13
40 citations
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Julius Rabl, Richard D. Bunker, Andreas D. Schenk, Simone Cavadini, M.E. Gill, W. Abdulrahman, A. Andres-Pons, Luijsterburg, Adel F. M. Ibrahim, Emma Branigan, Jacob D...> ;Molecular Cell. 2019 Aug 8
42 citations
E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family
Jenny Hsu, Julia Arand, Andrea C. Chaikovsky, Nancie Mooney, Janos Demeter, Caileen M Brison, Romane Oliverio, Hannes Vogel, Seth M. Rubin, Peter K. Jackson, Julien Sage> ;Nature Communications. 2019 Jul 3
23 citations
An order-to-disorder structural switch activates the FoxM1 transcription factor.
Aimee H. Marceau, Caileen M Brison, Santrupti Nerli, Heather E. Arsenault, Andrew C. McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A. Benanti, Nikolaos G. Sgourakis, Set...> ;Elife. 2019 May 28
142 citations
Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.
Benjamin R. Topacio, Evgeny Zatulovskiy, Sandra Cristea, Shicong Xie, Carrie S. Tambo, Seth M. Rubin, Julien Sage, Mardo Kõivomägi, Jan M. Skotheim> ;Molecular Cell. 2019 May 16
6 citations
Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets.
Seth M. Rubin, Julien Sage> ;Nature. 2019 May 1
23 citations
Structural mechanism of Myb-MuvB assembly.
Keelan Z. Guiley, Audra N. Iness, Siddharth Saini, Sarvind Tripathi, Joseph S. Lipsick, Larisa Litovchick, Seth M. Rubin> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Oct 2
42 citations
The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb.
Audra N. Iness, Jessica Felthousen, Varsha Ananthapadmanabhan, Fatmata Sesay, Siddharth Saini, Keelan Z. Guiley, Seth M. Rubin, Mikhail G. Dozmorov, Larisa Litovchick> ;Oncogene. 2019 Feb 1
1 citations
Heavy metal in cancer: The cell cycle jams with arsenic.
Alison K Barrett, Seth M. Rubin> ;Cell Cycle. 2017 Aug 18
29 citations
Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins
Denise A McGrath, Bre-Anne Fifield, Aimee H. Marceau, Sarvind Tripathi, Lisa A. Porter, Seth M. Rubin> ;The EMBO Journal. 2017 Aug 1
Conservation and Divergence of C-terminal Domain Structure in the Retinoblastoma Protein Family
Seth Rubin, MD> ;Proceedings of the National Academy of Sciences. 2017 Apr 26
104 citations
An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences
Charles A. Ishak, Aren E. Marshall, Daniel Thompsen Passos, Carlee R. White, Seung J. Kim, Matthew J. Cecchini, Sara Ferwati, William A. MacDonald, Christopher J. Howl...> ;Molecular Cell. 2016 Dec 15
28 citations
Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.
Tyler J. Liban, Michael J. Thwaites, Frederick A. Dick, Seth M. Rubin> ;Journal of Molecular Biology. 2016 Oct 9
41 citations
Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters
Aimee H. Marceau, Jessica Felthousen, Paul D. Goetsch, Audra N. Iness, Hsiau-Wei Lee, Sarvind Tripathi, Susan Strome, Larisa Litovchick, Seth M. Rubin> ;Nature Communications. 2016 Jul 28
2 citations
A Strategy for Direct Chemical Activation of the Retinoblastoma Protein
Cameron R. Pye, Walter M. Bray, Elise R. Brown, Jason R. Burke, R. Scott Lokey, Seth M. Rubin> ;ACS Chemical Biology. 2016 Feb 11
38 citations
Structural basis of template-boundary definition in Tetrahymena telomerase
Linnea I. Jansson, Benjamin M. Akiyama, Alexandra Ooms, Cheng Lu, Seth M. Rubin, Michael D. Stone> ;Nature Structural & Molecular Biology. 2015 Nov 1
82 citations
Structural mechanisms of DREAM complex assembly and regulation.
Keelan Z. Guiley, Tyler J. Liban, Jessica Felthousen, Parameshwaran Ramanan, Larisa Litovchick, Seth M. Rubin> ;Genes & Development. 2015 May 1
31 citations
Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.
Jason R. Burke, Tyler J. Liban, Tamara Restrepo, Hsiau-Wei Lee, Seth M. Rubin> ;Journal of Molecular Biology. 2014 Jan 9
94 citations
Multisite phosphorylation networks as signal processors for Cdk1.
Mardo Kõivomägi, Mihkel Örd, Anna Iofik, Ervin Valk, Rainis Venta, Ilona Faustova, Rait Kivi, Eva Rose M. Balog, Seth M. Rubin, Mart Loog> ;Nature Structural & Molecular Biology. 2013 Dec 1
59 citations
Cks confers specificity to phosphorylation-dependent CDK signaling pathways.
Denise A McGrath, Eva Rose M. Balog, Mardo Kõivomägi, Rafael Lucena, Michelle V Mai, Alexander Hirschi, Douglas R. Kellogg, Mart Loog, Seth M. Rubin> ;Nature Structural & Molecular Biology. 2013 Dec 1
Join now to see all

Grant Support

Determinants Of Cks Substrate SpecificityNational Center For Research Resources2010–2011
Molecular Mechanisms Regulating The Retinoblastoma ProteinNational Cancer Institute2008–2011
Molecular Mechanisms Regulating The Retinoblatoma ProteinNational Center For Research Resources2009–2010