ShaleshKaushalMD

PubMed

• Real-World Screening for Retinopathy in Youth With Type 1 Diabetes Using a Nonmydriatic Fundus Camera.
  Chelsea Zimmerman, Brittany S. Bruggeman, Amanda LaPorte, Shalesh Kaushal, Michael S. Stalvey, Giovanna Beauchamp, Kristin Dayton, Paul Hiers, Stephanie L. Filipp, Mat...> ;Diabetes Spectrum. 2021 Jan 1
• 142 citations
  Results at 2 Years after Gene Therapy for RPE65-Deficient Leber Congenital Amaurosis and Severe Early-Childhood-Onset Retinal Dystrophy.
  Richard G. Weleber, Mark E. Pennesi, David J. Wilson, Shalesh Kaushal, Laura R Erker, Lauren Jensen, Maureen T. McBride, Terence R. Flotte, Margaret Humphries, Roberto...> ;Ophthalmology. 2016 Jul 1
• 137 citations
  Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial
  Jeffrey S. Heier, Saleema Kherani, Shilpa J. Desai, Pravin U. Dugel, Shalesh Kaushal, Seng H. Cheng, Cheryl Delacono, Annie Purvis, Susan M. Richards, Annaig Le-Halper...> ;Lancet. 2017 Jul 1
• 29 citations
  Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell
  Lei Lei, Radouil Tzekov, Huapeng Li, J. Hugh McDowell, Guangping Gao, W. Clay Smith, Shibo Tang, Shalesh Kaushal> ;International Journal of Molecular Sciences. 2017 Mar 29
• 16 citations
  Cardiosphere‐Derived Cells from Pediatric End‐Stage Heart Failure Patients Have Enhanced Functional Activity Due to the Heat Shock Response Regulating the Secretome
  Sudhish Sharma, Rachana Mishra, David L. Simpson, Brody Wehman, Evan Colletti, Savitha Deshmukh, Srinivasa Raju Datla, Keerti Balachandran, Yin Guo, Ling Chen, Osama T...> ;Stem Cells. 2015 Apr 1
• 26 citations
  Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.
  Sudhish Sharma, Rachana Mishra, Brandon L. Walker, Savitha Deshmukh, Manuela Zampino, Jay Patel, Mani Anamalai, David L. Simpson, Ishwar S. Singh, Shalesh Kaushal, Sun...> ;Cell Stress & Chaperones. 2015 Jan 1
• 27 citations
  Photoactivation-Induced Instability of Rhodopsin Mutants T4K and T17M in Rod Outer Segments Underlies Retinal Degeneration in X. laevis Transgenic Models of Retinitis ...
  Beatrice M. Tam, S. M. Noorwez, Shalesh Kaushal, Masahiro Kono, Orson L. Moritz> ;The Journal of Neuroscience. 2014 Oct 1
• 53 citations
  Novel hydrophobically modified asymmetric RNAi compounds (sd-rxRNA) demonstrate robust efficacy in the eye.
  Michael Byrne, Radouil Tzekov, Yi Wang, Amanda Rodgers, James Cardia, Glenna Ford, Katherine Holton, Lakshmipathi Pandarinathan, Jennifer Lapierre, William Stanney, Ka...> ;Journal of Ocular Pharmacology and Therapeutics. 2013 Dec 3
• 9 citations
  Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments.
  Lei Lei, Radouil Tzekov, J. Hugh McDowell, Wesley C. Smith, Shibo Tang, Shalesh Kaushal> ;Experimental Eye Research. 2013 Jul 1
• 22 citations
  Accumulation and autofluorescence of phagocytized rod outer segment material in macrophages and microglial cells
  Lei Lei, Radouil Tzekov, Shibo Tang, Shalesh Kaushal> ;Molecular Vision. 2012 Jan 17
• 480 citations
  Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years
  Samuel G. Jacobson, Artur V. Cideciyan, R. Ratnakaram, Elise Héon, Sharon B. Schwartz, Alejandro J. Roman, Marc C. Peden, Tomas S. Aleman, Sanford L. Boye, Alexander S...> ;Archives of Ophthalmology. 2012 Jan 9
• 33 citations
  Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice.
  Huiming Xia, Mark P. Krebs, Shalesh Kaushal, Edward W. Scott> ;Experimental Eye Research. 2011 Dec 1
• 27 citations
  Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
  John D. Hulleman, Shalesh Kaushal, William E. Balch, Jeffery W. Kelly> ;Molecular Biology of the Cell. 2011 Dec 15
• 40 citations
  Protein Misfolding and Retinal Degeneration
  Radouil Tzekov, Linda Stein, Shalesh Kaushal> ;Cold Spring Harbor Perspectives in Biology. 2011 Aug 8
• 120 citations
  Vitreous Substitutes: A Comprehensive Review
  Teri T. Kleinberg, Radouil Tzekov, Linda Stein, V. Nathan Ravi, Shalesh Kaushal> ;Survey of Ophthalmology. 2011 Jul 1
• 16 citations
  Clinical gene therapy for the treatment of RPE65-associated Leber congenital amaurosis.
  Linda Stein, Kamolika Roy, Lei Lei, Shalesh Kaushal> ;Expert Opinion on Biological Therapy. 2011 Feb 8
• 61 citations
  Therapeutic potential of valproic acid for retinitis pigmentosa
  C. M. Clemson, Radouil Tzekov, Mark P. Krebs, J. Checchi, C. Bigelow, Shalesh Kaushal> ;The British Journal of Ophthalmology. 2011 Jan 1
• 16 citations
  Ocular gene therapy: an evaluation of recombinant adeno-associated virus-mediated gene therapy interventions for the treatment of ocular disease.
  Kamolika Roy, Linda Stein, Shalesh Kaushal> ;Human Gene Therapy. 2010 Jul 8
• 82 citations
  Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
  Shalesh Kaushal, Mani Annamali, Keith Blomenkamp, David A. Rudnick, Donna R Halloran, Elizabeth M. Brunt, Jeffrey Teckman> ;Experimental Biology and Medicine. 2010 Jun 1
• 35 citations
  Calnexin Improves the Folding Efficiency of Mutant Rhodopsin in the Presence of Pharmacological Chaperone 11-cis-Retinal
  S. M. Noorwez, Reddy Ranjith Kumar Sama, Shalesh Kaushal> ;The Journal of Biological Chemistry. 2009 Nov 27
• 83 citations
  Molecular mechanisms of rhodopsin retinitis pigmentosa and the efficacy of pharmacological rescue.
  Mark P. Krebs, David Holden, Parth Joshi, Charles L. Clark, Andrew Lee, Shalesh Kaushal> ;Journal of Molecular Biology. 2010 Feb 5
• 43 citations
  Rabbit study of an in situ forming hydrogel vitreous substitute.
  Katelyn E Swindle-Reilly, Milan Shah, Paul D. Hamilton, Thomas A. Eskin, Shalesh Kaushal, Nathan Ravi> ;Investigative Ophthalmology & Visual Science. 2009 Oct 1
• 91 citations
  Vision 1 year after gene therapy for Leber's congenital amaurosis.
  Artur V Cideciyan, William W Hauswirth, Tomas S Aleman, Shalesh Kaushal, Sharon B Schwartz, Sanford L Boye, Elizabeth A M Windsor, Thomas J Conlon, Alexander Sumaroka,...> ;The New England Journal of Medicine. 2009 Aug 13
• 252 citations
  Human RPE65 Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year
  Artur V. Cideciyan, William W. Hauswirth, Tomas S. Aleman, Shalesh Kaushal, Sharon B. Schwartz, Sanford L. Boye, Elizabeth A. M. Windsor, Thomas J. Conlon, Alexander S...> ;Human Gene Therapy. 2009 Aug 3
• 11 citations
  Short-term response of macular oedema to intravitreal bevacizumab.
  Damon E Welch, Hany Elmariah, Marc C. Peden, Serrhel G Adams, R. Ratnakaram, Shalesh Kaushal> ;The British Journal of Ophthalmology. 2009 Aug 1
• Join now to see all