Sharlene Mary Day MD

Cardiovascular Disease Genetics

Associate Professor, Internal Medicine, University of Pennsylvania Perelman School of Medicine

3400 Civic Center BoulevardSmilow 11-102Philadelphia, PA 19125

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Summary

Dr. Sharlene Day is a cardiologist in Philadelphia, PA and is affiliated with Penn Medicine. She received her medical degree from NYU School of Medicine and has been in practice 19 years. She specializes in adult genetic heart disease.

Education & Training

University of MichiganFellowship, Cardiovascular Disease, 1998 - 2001
University of MichiganResidency, Internal Medicine, 1995 - 1998
New York University School of MedicineClass of 1995, M.D.
Massachusetts Institute of TechnologyB.S., Biology, 1987 - 1991

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Certifications & Licensure

PA State Medical License 2019 - 2026
MI State Medical License 1998 - 2020
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 2 Certification Outgoing Public Health Reporting from EpicCare Functionality, Epic Systems Corporation, 2013-2017
CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2013-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2013-2017

Clinical Trials

Study of Exercise Training in Hypertrophic Cardiomyopathy
COMPLETED
NA
Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM
COMPLETED
PHASE2
Sodium Glucose Co-transporter (SGLT) Inhibitors in Nonobstructive Hypertrophic Cardiomyopathy Start of enrollment: 2024 Dec 17
RECRUITING
EARLY_PHASE1
Roles: Contact, Principal Investigator

Publications & Presentations

PubMed

Natural History of Asymptomatic Phenotypically Mild HCM: Insights From the SHaRe Registry.
Constantin-Cristian Topriceanu, Iswaree Devi Balakrishnan, Christoffer Rasmus Vissing, Anna Axelsson Raja, Victoria N Parikh
Journal of the American College of Cardiology. 2026-07-08
Variant Site-Specific Natural History of Titin-Induced Cardiomyopathy: An International Multicenter Registry.
Maria Perotto, Cinzia Radesich, Alessia Paldino, Ilaria Gandin, Job A J Verdonschot
Circulation. Genomic and Precision Medicine. 2026-07-08
Load-Dependent Effects of Sodium Glucose Co-Transporter Inhibitors on Work in Human Hypertrophic Cardiomyopathy Living Myocardial Slices.
Rebecca B Taichman, Julia N Smolyak, Jesse Chittams, Kelly Gallagher, Christopher M McAllister
Biorxiv. 2026-06-24

Journal Articles

Exercise Hemodynamics in Hypertrophic Cardiomyopathy Identify Risk of Incident Heart Failure but Not Ventricular Arrhythmias or Sudden Cardiac Death☆
Sharlene M Day, Sara Saberi, International Journal of Cardiology
Proinflammatory Effects of Interferon gamma in Mouse Adenovirus Type 1 Myocarditis
McCarthy M, Procario MC, Twisselmann N, Wilkinson JE, Archambeau AJ, Michele D, Day SM, Weinberg J, J Virology, 1/1/2015
Prediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy
Captur G, Lopes LR, Mahun TJ, Patel V, Li C, Bassett P, Finocchiaro G, Ferreira VM, Esteban MT, Muthurangu V, Sherrid MV, Day SM, Canter CE, McKenna WJ, Seidman CE, Bl..., J Am Coll Cardiol: Cardiovascular Imagin, 11/1/2014

Books/Book Chapters

Psychiatry and Heart Disease: the Mind, Brain, and Heart.
Chapter: Hypertrophic Cardiomyopathy.
Page 106 - 115Kessler M, Saberi S, Day SM, Gay T, Baty L, Deneke EEditors: Riba M, Wulsin L, Rubenfire M.Wiley-Blackwell, John Wiley & Sons, Ltd., West Sussex, UK2012

Abstracts/Posters

MYBPC3 Mutations Causative for Hypertrophic Cardiomyopathy Result in Locus-Dependent Alterations in Cellular Localization and Contractility.
Helms A, Glazier A, Bartolone A, Tang V, Yob J, Westfall MV, Schnell S, Day SM, Circulation, 1/1/2014
MYBPC3 Mutations Causative for Hypertrophic Cardiomyopathy Result in Altered Protein Folding, Sarcomere Localization and Contractility.
Helms A, Glazier A, Bartolone S, Tang V, Yob J, Westfall M, Schnell S, Day, SM, Internal Medicine Research Day, University of Michigan, 1/1/2014
Obstructive Sleep Apnea in Hypertrophic Cardiomyopathy: Comparing Exercise Tolerance, Cardiac Remodeling.
Ebner B, Kumar S, Bragg- Gresham J, Farrehi P, Day SM, Circulation QCOR, 1/1/2014

Lectures

How I Have a Shared Decision Making Discussion
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Hypertrophic Cardiomyopathy: More Than Just Myofibrillar Disarray
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019
Dysregulation of Proteostasis in the Cardiomyopathic Heart.
1/1/2014

Press Mentions

Testing for LMNA Gene Mutations Is ‘Woefully Underutilized’ but Can Help Predict Risk for Arrhythmia and Sudden Cardiac DeathJuly 15th, 2025
Cardiomyopathy Gene Variants Linked to Atrial FibrillationApril 30th, 2025
Sports Cardiologists — Should Athletes Determine Their Own Eligibility?April 15th, 2025

Grant Support

Missense Variants in Myosin Binding Protein C that Cause Hypertrophic CardiomyopathyUNIVERSITY OF PENNSYLVANIA2023–2027
Risk Alleles in Protein Quality Control Genes as Modifiers of Hypertrophic CardiomyopathyUNIVERSITY OF PENNSYLVANIA2023–2027
SGLT-inhibitors in patients with hypertrophic cardiomyopathyUNIVERSITY OF PENNSYLVANIA2023–2027
Regulation Of Proteasome Function In CardiomyopathiesNational Heart, Lung, And Blood Institute2009–2011