SharonLynelleAchillesMD

Obstetrics & Gynecology • Pittsburgh, PA

General Gynecology, STD Gynecology

Deputy Director, Bill & Melinda Gates Foundation; Adjunct Associate Professor, Ob/Gyn & Reproductive Science, University of Pittsburgh School of Medicine

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Office
300 Halket Street
Magee Womens Hospital
Pittsburgh, PA 15213
Phone+1 412-641-1403
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Education & Training

UPMC Medical EducationFellowship, Complex Family Planning, 2009 - 2011
UPMC Medical EducationResidency, Obstetrics and Gynecology, 2005 - 2009
University of Pittsburgh School of MedicineClass of 2004
Johns Hopkins UniversityPhD, Biology, 1994 - 2000
Indiana UniversityBachelor, Biology, Criminal Justice, 1989 - 1992

Certifications & Licensure

PA State Medical License 2005 - 2024
American Board of Obstetrics and Gynecology Obstetrics & Gynecology

Clinical Trials

Chlamydia Trachomatis Immunology and Vaccinology Study Start of enrollment: 2011 Jan 01
Completed
Study of Immune Cell Changes in the Genital Tract 2 Months After Initiation of an IUD for Contraception Start of enrollment: 2010 Nov 01
Completed
Not Applicable
Quantification of Immune Cells in Women Using Contraception (CHIC II) Start of enrollment: 2013 Aug 01
Completed
HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC Start of enrollment: 2014 Feb 01
Completed
Expression of IFN-epsilon in the Female Reproductive Tract Start of enrollment: 2015 Jul 01
Completed
PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel Start of enrollment: 2018 Jul 17
Completed
Phase 1
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Publications & Presentations

PubMed

1 citations
Development of, a web-based decision aid to support permanent contraception decision making.
Elizabeth A Mosley, Nikki Zite, Christine Dehlendorf, Ashley Deal, Raelynn O'Leary, Sharon Achilles, Amber E Barnato, Daniel Hall, Sonya Borrero> ;PEC Innovation. 2023 Dec 15
Participant experiences with a multipurpose vaginal ring for HIV and pregnancy prevention during a phase 1 clinical trial: learning from users to improve acceptability.
Mary Kate Shapley-Quinn, Mei Song, Beatrice A Chen, Brid Devlin, Ellen Luecke, Jill Brown, Diana L Blithe, Sharon L Achilles, Ariane van der Straten> ;Frontiers in Reproductive Health. 2023 Jan 1
Dextromethorphan as a novel nonopioid adjunctive agent for pain control with medication abortion: A randomized controlled trial.
Grace P Ferguson, Sharon L Achilles, Leslie A Meyn, Colleen M Krajewski, Catherine A Chappell, Kavita Vinekar, Beatrice A Chen> ;Contraception. 2023 Feb 1
6 citations
Tolerability and safety of the estetrol/drospirenone combined oral contraceptive: Pooled analysis of two multicenter, open-label phase 3 trials.
Melissa J Chen, Jeffrey T Jensen, Sharon L Achilles, János Zatik, Steven Weyers, Terhi Piltonen, Larisa Suturina, Inna Apolikhina, Celine Bouchard, David F Archer, Mau...> ;Contraception. 2022 Dec 1
6 citations
Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract.
Nollaig M Bourke, Sharon L Achilles, Stephanie U-Shane Huang, Helen E Cumming, San S Lim, Irene Papageorgiou, Linden J Gearing, Ross Chapman, Suruchi Thakore, Niamh E ...> ;JCI Insight. 2022 Sep 22
Early pregnancy confirmation availability at crisis pregnancy centers and abortion facilities in the United States.
Kavita Vinekar, Marian Jarlenski, Leslie Meyn, Beatrice A Chen, Sharon L Achilles, Sara Tyberg, Sonya Borrero> ;Contraception. 2023 Jan 1
5 citations
Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy wo...
Sharon L Achilles, János Zatik, Steven Weyers, Terhi Piltonen, Larisa Suturina, Inna Apolikhina, Celine Bouchard, Melissa J Chen, Jeffrey T Jensen, Carolyn L Westhoff,...> ;Contraception. 2022 Dec 1
5 citations
Pooled efficacy results of estetrol/drospirenone combined oral contraception phase 3 trials.
Jeffrey T Jensen, Sharon L Achilles, János Zatik, Steven Weyers, Terhi Piltonen, Larisa Suturina, Inna Apolikhina, Céline Bouchard, Melissa J Chen, Dan Apter, Maud Jos...> ;Contraception. 2022 Dec 1
13 citations
Vaginal ring acceptability: A systematic review and meta-analysis of vaginal ring experiences from around the world.
Kathleen Ridgeway, Elizabeth T. Montgomery, Kevin Smith, Kristine Torjesen, Ariane van der Straten, Sharon L. Achilles, Jennifer B. Griffin> ;Contraception. 2021 Oct 10
5 citations
A Randomized, Open-Label, Crossover Phase 1 Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel (the CHARM-03 Study).
Ian McGowan, Sylvain Chawki, Craig W. Hendrix, Peter A. Anton, Mark A. Marzinke, Rhonda M. Brand, Jarret Engstrom, Lisa C. Rohan, Kaleab Z. Abebe, Nicola Richardson-Ha...> ;AIDS Research and Human Retroviruses. 2021 Sep 14
Management of heterotopic pregnancy with uterine aspiration and systemic two-dose methotrexate.
Kavita Vinekar, Sharon L. Achilles, Beatrice A. Chen> ;Contraception. 2021 Oct 1
28 citations
Advances in long-acting injectables, implants, and vaginal rings for contraception and HIV prevention
Sai Archana Krovi, Leah M. Johnson, Ellen Luecke, Sharon L. Achilles, Ariane van der Straten> ;Advanced Drug Delivery Reviews. 2021 Sep 1
24 citations
Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results
Mitchell D. Creinin, Carolyn Westhoff, Céline Bouchard, Melissa J. Chen, Jeffrey T. Jensen, Sharon L. Achilles, Jean-Michel Foidart, David F. Archer> ;Contraception. 2021 May 15
4 citations
Effect of injectable progestin-only contraceptives, depot medroxyprogesterone acetate and norethisterone enanthate, on cytokine production during T-cell activation.
Allen Matubu, Sharon L. Hillier, Leslie A. Meyn, Kevin A. Stoner, Felix Mhlanga, Mike Mbizvo, Aaron Maramba, Zvavahera M. Chirenje, Sharon L. Achilles> ;American Journal of Reproductive Immunology. 2021 Feb 20
5 citations
Bridging the gap: advancing multipurpose prevention technologies from the lab into the hands of women†.
Bethany Young Holt, James Kiarie, Gregory S Kopf, Kavita Nanda, Anke Hemmerling, Sharon L. Achilles> ;Biology of Reproduction. 2020 Aug 4
1 citations
Pharmacokinetic and Pharmacodynamic Impacts of Depot Medroxyprogesterone Acetate Use on HIV Pre-exposure Prophylaxis in Women.
Jessica Tarleton, Beatrice A. Chen, Leslie A. Meyn, Craig W. Hendrix, Mark A. Marzinke, Sharon L. Achilles> ;Journal of Acquired Immune Deficiency Syndromes. 2020 Oct 1
11 citations
Zim CHIC: A cohort study of immune changes in the female genital tract associated with initiation and use of contraceptives.
Sharon L. Achilles, Leslie A. Meyn, Felix Mhlanga, Allen Matubu, Kevin A. Stoner, May A. Beamer, Zvavahera M. Chirenje, Sharon L. Hillier> ;American Journal of Reproductive Immunology. 2020 Jun 13
9 citations
Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood.
Lisa B. Haddad, Alison Swaims-Kohlmeier, C. Christina Mehta, Richard E. Haaland, Nakita L. Brown, Anandi N. Sheth, Hsin Chien, Kehmia Titanji, Sharon L. Achilles, Davi...> ;Plos One. 2020 Mar 26
2 citations
Depot medroxyprogesterone acetate and norethisterone enanthate differentially impact T-cell responses and expression of immunosuppressive markers.
Allen Matubu, Sharon L. Hillier, Leslie A. Meyn, Kevin A. Stoner, Felix Mhlanga, Mike Mbizvo, Aaron Maramba, Zvavahera M. Chirenje, Sharon L. Achilles> ;American Journal of Reproductive Immunology. 2020 Mar 1
2 citations
ECHO: context and limitations.
Jeanne M. Marrazzo, Jennifer E. Balkus, Sharon L. Achilles, Lisa M. Noguchi> ;Lancet. 2020 Feb 8
1 citations
Optimization of processing female genital tissue samples for lymphocyte analysis by flow cytometry
Kevin A. Stoner, May A. Beamer, H.A. Avolia, Leslie A. Meyn, Sharon L. Hillier, Sharon L. Achilles> ;American Journal of Reproductive Immunology. 2020 Jan 28
Drug interactions: not just for orally administered drugs.
Catherine A. Chappell, Sharon L. Achilles> ;The Lancet. HIV. 2019 Sep 1
9 citations
Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.
Megan Neary, Catherine A. Chappell, Kimberly K. Scarsi, Shadia Nakalema, Joshua Matovu, Sharon L. Achilles, Beatrice A. Chen, Marco Siccardi, Andrew Owen, Mohammed Lam...> ;The Journal of Antimicrobial Chemotherapy. 2019 Oct 1
Corrigendum to "Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact...
Renee Heffron, Sharon L. Achilles, Laneta J. Dorflinger, Janet P. Hapgood, James Kiarie, Chelsea B. Polis, Petrus S. Steyn> ;Contraception. 2019 Jul 1
145 citations
The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission.
Lyle R. McKinnon, Sharon L. Achilles, Catriona S. Bradshaw, Adam Burgener, Tania Crucitti, David N. Fredricks, Heather B. Jaspan, Rupert Kaul, Charu Kaushic, Nichole R...> ;AIDS Research and Human Retroviruses. 2019 Mar 1
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Press Mentions

Vaginal Ring That Targets Pregnancy, HIV Seems Safe: StudyOctober 26th, 2018