SharonL.GardnerMD

Pediatric Hematology & Oncology • New York, NY

Associate Professor, Pediatrics, New York University School of Medicine

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Office
160 E 32nd street
Medical floor (L3)
New York, NY 10016
Phone+1 212-263-9913
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Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 1989 - 1992
Tower Health/St. Christopher's Hospital for ChildrenResidency, Pediatrics, 1986 - 1989
Drexel University College of MedicineClass of 1986

Certifications & Licensure

NY State Medical License 1989 - 2025
PA State Medical License 1987 - 2002
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Top Doctors: New York Metro Area Castle Connolly, 2013-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Super Doctor SuperDoctors.com

Clinical Trials

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Start of enrollment: 2000 Oct 01
Completed
Phase 1
Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma Start of enrollment: 2003 Nov 01
Completed
Phase 2, Phase 3
High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas Start of enrollment: 2004 Oct 01
Completed
Phase 3
Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Start of enrollment: 2005 Oct 01
Completed
Phase 2
Study of Peptide Vaccination With Tumor Associated Antigens Mixed With Montanide in Patients With CNS Tumors Start of enrollment: 2009 Jul 01
Completed
Phase 1
Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) Start of enrollment: 2011 Sep 01
Terminated
Phase 2
ONC201 in Pediatric H3 K27M Gliomas Start of enrollment: 2018 Jan 29
Active, not recruiting
Phase 1
Roles: Principal Investigator, Contact
Intermediate-size Expanded Access to ONC201 for Patients With H3 K27M-mutant and/or Midline Gliomas
Available
Roles: Contact, Principal Investigator
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Start of enrollment: 2015 Sep 01
Active, not recruiting
Phase 4
Roles: Contact
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Publications & Presentations

PubMed

Phase II study of everolimus for recurrent or progressive pediatric ependymoma.
Daniel C Bowers, Veena Rajaram, Matthias A Karajannis, Sharon L Gardner, Jack Meng-Fen Su, Patricia Baxter, Sonia Partap, Laura J Klesse> ;Neuro-Oncology Advances. 2023 Feb 10
10 citations
Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset.
Jiil Chung, Logine Negm, Vanessa Bianchi, Lucie Stengs, Anirban Das, Zhihui Amy Liu, Sumedha Sudhaman, Melyssa Aronson, Ledia Brunga, Melissa Edwards, Victoria Forster...> ;Journal of Clinical Oncology. 2023 Feb 1
12 citations
Phase I dose escalation and expansion trial of single agent ONC201 in pediatric diffuse midline gliomas following radiotherapy.
Sharon L Gardner, Rohinton S Tarapore, Jeffrey Allen, Susan L McGovern, Wafik Zaky, Yazmin Odia, Doured Daghistani, Zuanel Diaz, Matthew D Hall, Ziad Khatib, Carl Kosc...> ;Neuro-Oncology Advances. 2022 Sep 13
15 citations
Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.
Evan Cantor, Kyle Wierzbicki, Rohinton S Tarapore, Karthik Ravi, Chase Thomas, Rodrigo Cartaxo, Viveka Nand Yadav, Ramya Ravindran, Amy K Bruzek, Jack Wadden, Vishal J...> ;Neuro-Oncology. 2022 Aug 1
5 citations
Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol.
Cara F Levitch, Benjamin Malkin, Lauren Latella, Whitney Guerry, Sharon Gardner, Jonathan L. Finlay, Stephen A. Sands> ;Neuro-Oncology Practice. 2021 May 18
25 citations
Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.
Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G. Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Musa Alharb...> ;Journal of Clinical Oncology. 2021 May 4
47 citations
Excellent outcome of young children with nodular desmoplastic medulloblastoma treated on "Head Start" III: a multi-institutional, prospective clinical trial.
Girish Dhall, Sharon H. O'Neil, Lingyun Ji, Kelley Haley, Ashley M Whitaker, Marvin D. Nelson, Floyd H. Gilles, Sharon Gardner, Jeffrey C. Allen, Albert Cornelius, Kam...> ;Neuro-Oncology. 2020 Dec 18
12 citations
The Role of Liquid Biopsies in Pediatric Brain Tumors.
Karen Tang, Sharon Gardner, Matija Snuderl> ;Journal of Neuropathology and Experimental Neurology. 2020 Sep 1
7 citations
Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma
Karen Tang, David B. Kurland, Varshini Vasudevaraja, Jonathan Serrano, Michael Delorenzo, Alireza Radmanesh, Cheddhi Thomas, Marissa Spino, Sharon Gardner, Jeffrey C. ...> ;Journal of Neuropathology and Experimental Neurology. 2020 Aug 1
5 citations
Orbital Rosai-Dorfman disease initially diagnosed as IgG4-related disease: a case report
Nishanth Iyengar, Danielle Golub, Michelle W McQuinn, Travis C. Hill, Karen Tang, Sharon Gardner, David H. Harter, Chandranath Sen, David A. Staffenberg, Kristen Thoma...> ;Acta Neuropathologica Communications. 2020 Jul 18
10 citations
Pineoblastoma in children less than six years of age: The Head Start I, II, and III experience.
Mohamed S. AbdelBaki, Mohammad H Abu-Arja, Tom B. Davidson, Jason Fangusaro, Joseph Stanek, Ira J. Dunkel, Girish Dhall, Sharon Gardner, Jonathan L. Finlay> ;Pediatric Blood & Cancer. 2020 Mar 18
3 citations
Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol
Eveline Teresa Hidalgo, Matija Snuderl, Cordelia Orillac, Svetlana Kvint, Jonathan Serrano, Peter Wu, Matthias A. Karajannis, Sharon Gardner> ;Child's Nervous System. 2020 Jan 1
110 citations
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.
Andrew S. Chi, Rohinton Tarapore, Matthew Hall, Nicole Shonka, Sharon Gardner, Yoshie Umemura, Ashley Sumrall, Ziad Khatib, Sabine Mueller, Cassie Kline, Wafik Zaky, S...> ;Journal of Neuro-Oncology. 2019 Oct 1
5 citations
Pre-irradiation intensive induction and marrow-ablative consolidation chemotherapy in young children with newly diagnosed high-grade brainstem gliomas: report of the "...
Diana S Osorio, Neha Patel, Lingyun Ji, Richard Sposto, Joseph Stanek, Sharon Gardner, Jeffrey C. Allen, Albert Cornelius, Geoffrey McCowage, Amanda M. Termuhlen, Ira ...> ;Journal of Neuro-Oncology. 2018 Nov 3
70 citations
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma
Nalin Gupta, Liliana Goumnerova, Peter E. Manley, Susan N. Chi, Donna Neuberg, Maneka Puligandla, Jason Fangusaro, Stewart Goldman, Tadanori Tomita, Tord D. Alden, Art...> ;Neuro-Oncology. 2018 Oct 9
43 citations
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev,...> ;Nature Communications. 2018 Jul 20
18 citations
Fair, just and compassionate: A pilot for making allocation decisions for patients requesting experimental drugs outside of clinical trials
Arthur L. Caplan, J. Russell Teagarden, Lisa Kearns, Alison Bateman-House, Edith P. Mitchell, Thalia Arawi, Ross E.G. Upshur, Ilina Singh, Joanna Różyńska, Valerie Cwi...> ;Journal of Medical Ethics. 2018 Jul 7
5 citations
Tandem thiotepa with autologous hematopoietic cell rescue in patients with recurrent, refractory, or poor prognosis solid tumor malignancies.
Diana S Osorio, Ira J. Dunkel, Kelly Ann Cervone, Rakesh K. Goyal, K. M. Steve Lo, Jonathan L. Finlay, Sharon Gardner> ;Pediatric Blood & Cancer. 2018 Jan 1
22 citations
Outcome of young children with high-grade glioma treated with irradiation-avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials
Juan Espinoza, Kelley Haley, Neha Patel, Girish Dhall, Sharon Gardner, Jeffrey C. Allen, Joseph Torkildson, Albert Cornelius, Rod Rassekh, Antranik A. Bedros, Morris E...> ;Pediatric Blood & Cancer. 2016 Jun 22
14 citations
High Incidence of Veno‐Occlusive Disease With Myeloablative Chemotherapy Following Craniospinal Irradiation in Children With Newly Diagnosed High‐Risk CNS Embryonal Tu...
Kellie J. Nazemi, Violet Shen, Jonathan L. Finlay, James M. Boyett, Mehmet Kocak, Deborah Lafond, Sharon Gardner, Roger J. Packer, H. Stacy Nicholson> ;Pediatric Blood & Cancer. 2016 Sep 1
4 citations
Utility of MRI versus tumor markers for post-treatment surveillance of marker-positive CNS germ cell tumors
Victoria Cheung, Devorah Segal, Sharon Gardner, David Zagzag, Jeffrey H. Wisoff, Jeffrey C. Allen, Matthias A. Karajannis> ;Journal of Neuro-Oncology. 2016 Jul 12
Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor.
Nicholas A Vitanza, Theresa M. Shaw, Sharon Gardner, Jeffrey C. Allen, David H. Harter, Matthias A. Karajannis> ;Journal of Pediatric Hematology/oncology. 2016 May 1
12 citations
Decreased morbidity and mortality of autologous hematopoietic transplants for children with malignant central nervous system tumors: the ‘Head Start’ trials, 1991–2009
C Altshuler, Kelley Haley, Girish Dhall, Laura Vasquez, Sharon Gardner, Joseph Stanek, Jonathan L. Finlay> ;Bone Marrow Transplantation. 2016 Mar 7
5 citations
Phase I study of temozolomide in combination with thiotepa and carboplatin with autologous hematopoietic cell rescue in patients with malignant brain tumors with minim...
Grace Egan, K A Cervone, P C Philips, Jean B. Belasco, Jonathan L. Finlay, Sharon Gardner> ;Bone Marrow Transplantation. 2016 Apr 1
9 citations
Relapse and outcome patterns of patients with central nervous system mixed malignant germ cell tumors treated without irradiation: Findings from the third internationa...
Rachel Pruitt, Nasjla S. DaSilva, Andrea Cappellano, Clara Belessiotis, Blanca Diez, Sharon Gardner, Jeffrey C. Allen, Mark Weinblatt, Nicholas G. Gottardo, Girish Dha...> ;Pediatric Blood & Cancer. 2015 Nov 1
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