ShaunWilliamJacksonMD

PubMed

• Resolving a paradox between mouse and man: a genetic link between TLR7 and the pathogenesis of human lupus nephritis.
  Shaun W Jackson, Brad H Rovin> ;Kidney International. 2023 May 1
• 6 citations
  Anti-HLA antibodies in recipients of CD19 versus BCMA-targeted CAR T-cell therapy.
  Joshua A Hill, Erika S Kiem, Atif Bhatti, Winnie Liu, Jacob Keane-Candib, Kristin S Fitzpatrick, Jim Boonyaratanakornkit, Rebecca A Gardner, Damian J Green, David G Ma...> ;American Journal of Transplantation. 2023 Mar 1
• 4 citations
  Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell D...
  Jonathan Woods, Sarah E Pemberton, Andrea D Largent, Kristy Chiang, Denny Liggitt, Mohamed Oukka, David J Rawlings, Shaun W Jackson> ;Journal of Immunology. 2022 Sep 15
• 5 citations
  Recent advances in immunotherapies for lupus nephritis.
  Machi Kaneko, Shaun W Jackson> ;Pediatric Nephrology. 2023 Apr 1
• 5 citations
  Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity.
  Kristy Chiang, Andrea D Largent, Tanvi Arkatkar, Christopher D. Thouvenel, Samuel W. Du, Natali Shumlak, Jonathan Woods, Quan Zhen Li, Yifan Liu, Baidong Hou, David J....> ;Journal of Immunology. 2021 Sep 29
• 1 citations
  TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.
  Holly M. Jacobs, Tanvi Arkatkar, Samuel W. Du, Nicole E. Scharping, Jonathan Woods, Quan Zhen Li, Kelly L. Hudkins, Charles E. Alpers, David J. Rawlings, Shaun W. Jackson> ;European Journal of Immunology. 2021 Jun 27
• 11 citations
  B Cells in Systemic Lupus Erythematosus: From Disease Mechanisms to Targeted Therapies.
  Susan P. Canny, Shaun W. Jackson> ;Rheumatic Diseases Clinics of North America. 2021 Jun 16
• 26 citations
  Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells.
  Samuel W. Du, Tanvi Arkatkar, Fahd Al Qureshah, Holly M. Jacobs, Christopher D. Thouvenel, Kristy Chiang, Andrea D Largent, Quan Zhen Li, Baidong Hou, David J. Rawling...> ;Journal of Immunology. 2019 Dec 1
• 36 citations
  BAFF inhibition in SLE-Is tolerance restored?
  Shaun W. Jackson, Anne Davidson> ;Immunological Reviews. 2019 Sep 28
• 29 citations
  The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
  Jacquelyn A. Gorman, Christian Hundhausen, Mackenzie Kinsman, Tanvi Arkatkar, Eric J. Allenspach, Courtnee Clough, West Samuel, Kerri R. Thomas, Ahmet Eken, Socheath K...> ;Frontiers in Immunology. 2019 Jan 25
• 40 citations
  Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression
  Samuel W. Du, Tanvi Arkatkar, Holly M. Jacobs, David J. Rawlings, Shaun W. Jackson> ;European Journal of Immunology. 2019 Jan 1
• 32 citations
  The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy.
  Malika Hale, David J. Rawlings, Shaun W. Jackson> ;Current Opinion in Immunology. 2018 Nov 1
• 23 citations
  Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells
  Samuel W. Du, Holly M. Jacobs, Tanvi Arkatkar, David J. Rawlings, Shaun W. Jackson> ;Journal of Immunology. 2018 Dec 1
• 13 citations
  TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.
  Tanvi Arkatkar, Holly M. Jacobs, Samuel W. Du, Quan Zhen Li, Kelly L. Hudkins, Charles E. Alpers, David J. Rawlings, Shaun W. Jackson> ;Kidney International. 2018 Oct 1
• 21 citations
  αv Integrins regulate germinal center B cell responses through noncanonical autophagy
  Fiona Raso, Sara Sagadiev, Samuel W. Du, Emily Gage, Tanvi Arkatkar, Genita Metzler, Lynda M. Stuart, Mark T. Orr, David J. Rawlings, Shaun W. Jackson, Adam Lacy-Hulbe...> ;The Journal of Clinical Investigation. 2018 Aug 31
• 74 citations
  Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.
  King L. Hung, Iana Meitlis, Malika Hale, Chun-Yu Chen, Swati Singh, Shaun W. Jackson, Carol H. Miao, Iram F. Khan, David J. Rawlings, Richard G. James> ;Molecular Therapy. 2017 Nov 22
• 141 citations
  B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity
  Tanvi Arkatkar, Samuel W. Du, Holly M. Jacobs, Elizabeth M. Dam, Baidong Hou, Jane H. Buckner, David J. Rawlings, Shaun W. Jackson> ;The Journal of Experimental Medicine. 2017 Nov 6
• 27 citations
  DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling.
  Akhilesh Kumar Singh, Ahmet Eken, David Hagin, Khushbu Komal, Gauri Bhise, Azima Shaji, Tanvi Arkatkar, Shaun W. Jackson, Estelle Bettelli, Troy R. Torgerson, Mohamed ...> ;JCI Insight. 2017 Oct 5
• 178 citations
  Altered B cell signalling in autoimmunity
  David J. Rawlings, Genita Metzler, Michelle N. Wray-Dutra, Shaun W. Jackson> ;Nature Reviews. Immunology. 2017 Apr 10
• 45 citations
  Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells
  Malika Hale, Baeckseung Lee, Honaker Yuchi Chiang, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenbe...> ;Molecular Therapy. Methods & Clinical Development. 2017 Mar 17
• 30 citations
  Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.
  Shaun W. Jackson, Nicole E. Scharping, Holly M. Jacobs, Shari Wang, Alan Chait, David J. Rawlings> ;Journal of Immunology. 2016 Dec 15
• 158 citations
  B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
  Shaun W. Jackson, Holly M. Jacobs, Tanvi Arkatkar, Elizabeth M. Dam, Nicole E. Scharping, Nikita S. Kolhatkar, Baidong Hou, Jane H. Buckner, David J. Rawlings> ;The Journal of Experimental Medicine. 2016 May 2
• 42 citations
  Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells
  Holly M. Jacobs, Christopher D. Thouvenel, Sarah Leach, Tanvi Arkatkar, Genita Metzler, Nicole E. Scharping, Nikita S. Kolhatkar, David J. Rawlings, Shaun W. Jackson> ;Journal of Immunology. 2016 Mar 28
• 17 citations
  B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.
  Nikita S. Kolhatkar, Nicole E. Scharping, Jenna M. Sullivan, Holly M. Jacobs, Marc A. Schwartz, Socheath Khim, Luigi D. Notarangelo, Adrian J. Thrasher, David J. Rawli...> ;European Journal of Immunology. 2015 Oct 1
• 43 citations
  B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production.
  Shaun W. Jackson, Nikita S. Kolhatkar, David J. Rawlings> ;Current Opinion in Immunology. 2015 Apr 1
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Journal Articles

• Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells  
  David J Rawlings, Shaun W Jackson, The Journal of Immunology
• B cells take the front seat: Dysregulated B cell signals orchestrate loss of tolerance and autoantibody production  
  Jackson SW, Kolhatkar N, Rawlings DJ, Current Opinion in Immunology, 1/10/2015
• Opposing impact of B cell intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation  
  Jackson SW, Scharping NE, Kolhatkar N, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ, J Immunol, 1/1/2014
• The PTPN22 Risk Variant Promotes Systemic Autoimmunity in Murine Models  
  Dai X, James R, Habib T, Singh S, Jackson SW, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ, J. Clin. Invest, 1/1/2013
• Trypanosoma cruzi Trans-sialidase initiates a Program Independent of the Transcription Factors ROR-gammat and Ahr that leads IL-17 Production by Activated B Cells  
  Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Liggitt D, Mucci J, Campetella O, Oukka M, Gruppi A, R..., Nature Immunology, 1/1/2013
• Cutting Edge: Regulation of TLR4-driven B cell Proliferation by RP105 is not B cell-autonomous  
  Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL, J Immunol, 1/1/2012
• WASp Deficient B Cells Play a Critical, Cell Intrinsic Role in Triggering Autoimmunity  
  Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Panigrahi AK, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Luning Prak ET, Alpers..., J Exp Med, 1/1/2011
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Books/Book Chapters

• Pocket Pediatrics 
  Chapter: Hyponatremia 
  Jackson SWEditors: R. Vinci, MD & J. Moses, MD.PocketMedicine.com, Inc., New York, NYEdition 2nd,2009
• Pocket Pediatrics 
  Chapter: Hypernatremia 
  Jackson SWEditors: R. Vinci, MD & J. Moses, MD.PocketMedicine.com, Inc., New York, NYEdition 2nd,2009
• Pocket Pediatrics 
  Chapter: Hypokalemia 
  Jackson SWEditors: R. Vinci, MD & J. Moses, MD.PocketMedicine.com, Inc., New York, NYEdition 2nd,2009
• Pocket Pediatrics 
  Chapter: Hyperkalemia 
  Jackson SWEditors: R. Vinci, MD & J. Moses, MD.PocketMedicine.com, Inc., New York, NYEdition 2nd,2009
• Pocket Pediatrics 
  Chapter: Renal Tubular Acidosis 
  Jackson SWEditors: R. Vinci, MD & J. Moses, MD.PocketMedicine.com, Inc., New York, NYEdition 2nd,2009
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Abstracts/Posters

• Opposing impact of B cell intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation
  Jackson SW, Scharping NE, Kolhatkar N, Khim S, Schwartz MA, Li QZ, Hudkins KL, Alpers CE, Liggitt D, Rawlings DJ, Pediatric Academic Societies (PAS), 1/1/2014
• B Cell-Intrinsic Deletion of the Type 1 Interferon Receptor Does Not Impact the Development of Murine Lupus
  Jackson SW, Jacobs H, Scharping NE, Khim S, Rawlings DJ, American College of Rheumatology (ACR) annual meeting, 1/1/2014
• Trypanosoma cruzi trans-sialidase initiates an ROR-gt independent program leading to high-level IL-17 production by activated B cells
  Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Liggitt D, Mucci J, Campetella O, Oukka M, Gruppi A, R..., Keystone Symposium, “B Cell Development and Function”, 1/1/2013
• B cell intrinsic Toll-like receptor signals define the autoantibody repertoire of autoimmune-prone Wiskott-Aldrich syndrome chimeras
  Jackson SW, Kolhatkar NS, Schwartz MA, Khim S, Rawlings DJ, Seattle Children’s Hospital Fellow’s Research Day, 1/1/2012
• Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals
  Jackson SW, Kolhatkar NS, Schwartz MA, Khim S, Rawlings DJ, Federation of Clinical Immunology Societies meeting (FOCIS); American College of Rheumatology (ACR) annual meeting, 1/1/2012
• WASp Deficient B Cells Play a Critical, Cell Intrinsic Role in Triggering Autoimmunity
  Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Panigrahi AK, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Luning Prak ET, Alper..., Keystone Symposium, “B Cells: New Insights into Normal versus Dysregulated Function”, 1/1/2011
• The role of WASp deficient B cells in driving autoimmune disease and atherogenesis
  Jackson SW, Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Panigrahi AK, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Luning Prak ET, Alper..., Seattle Children’s Hospital Fellow’s Research Day, 1/1/2011
• Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE i...
  Jackson SW, Finn LS, Okamura DM, McDonald RA, Pediatric Rheumatology Symposium, 1/1/2011
• Decreased activity of endothelial alphaVBeta3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis
  Jackson SW, Hoshi T, Sundberg C, Enjyoji K, Cszimadia E, Robson SC, 4th International Symposium of Nucleosides and Nucleotides. Purines, 1/1/2004
• Disordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice
  Jackson SW, Sun X, Cardenas A, Enjyoji K, Cszimadia E, Robson SC, Young Investigator Award Session. Asia Pacific Association for the Study of the Liver, 1/1/2004
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