ShellyMarieSewardMD

Gynecologic Oncology

Associate Professor, Obstetrics & Gynecology, University of Central Florida COM

Overview of Dr. Seward

Dr. Shelly Seward is an obstetrician/gynecologist in Orlando, FL and is affiliated with multiple hospitals in the area, including Orlando Health Orlando Regional Medical Center, Orlando Health - Health Central Hospital, Orlando Health St. Cloud Hospital, Oviedo Medical Center, and AdventHealth Orlando. She received her medical degree from Eastern Virginia Medical School and has been in practice 13 years. Dr. Seward accepts several types of health insurance, listed below. She is one of 12 doctors at Oviedo Medical Center and one of 262 doctors at AdventHealth Orlando who specialize in Obstetrics & Gynecology. She has more than 20 publications and over 500 citings.

Office
105 W Miller St
Orlando, FL 32806
Book by Phone+1(321) 450-7044
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Education & Training

Detroit Medical Center/Wayne State UniversityFellowship, Gynecologic Oncology, 2008 - 2012
Ohio State University/Mt Carmel HospitalResidency, Obstetrics and Gynecology, 2004 - 2008
Eastern Virginia Medical SchoolClass of 2004

Certifications & Licensure

FL State Medical License 2018 - 2026
MI State Medical License 2008 - 2024
OH State Medical License 2004 - 2008
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Gynecologic Oncology

Clinical Trials

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Mirvetuximab Soravtansine in Adults With Ovarian Cancer and Other Folate Receptor 1 (FOLR1)-Positive Solid Tumors Start of enrollment: 2012 Jun 28
Completed
Phase 1
A Phase 1 Trial of NY-ESO-1 With GLA-SE in Patients With Unresectable or Metastatic Cancer Start of enrollment: 2013 Nov 01
Completed
Phase 1

Publications & Presentations

PubMed

1 citations
Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial: An NRG Oncology/GOG Pilot Study.
Tatyana A. Grushko, Virginia L. Filiaci, Anthony G. Montag, Marsha A. Apushkin, Maria J. Gomez, Laura Monovich, Nilsa C. Ramirez, Carlton Schwab, Joshua Kesterson, She...> ;Applied Immunohistochemistry & Molecular Morphology. 2021 Jul 2
84 citations
First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid...
Raffit Hassan, George R. Blumenschein, Kathleen N. Moore, Alessandro D. Santin, Hedy L. Kindler, John Nemunaitis, Shelly Seward, Anish Thomas, Stella K. Kim, Prabhu Ra...> ;Journal of Clinical Oncology. 2020 Mar 26
4 citations
Antibody Drug Conjugates in the Treatment of Epithelial Ovarian Cancer
Debra L. Richardson, Shelly Seward, Kathleen N. Moore> ;Hematology/oncology Clinics of North America. 2018 Dec 1
65 citations
Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion s...
Lainie P. Martin, Jason A. Konner, Kathleen N. Moore, Shelly Seward, Ursula A. Matulonis, Raymond P. Perez, Ying Su, Anna Berkenblit, Rodrigo Ruiz-Soto, Michael J. Birrer> ;Gynecologic Oncology. 2017 Nov 1
19 citations
Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer.
Ismail Mert, Jasdeep Chhina, Ghassan Allo, Jing Dai, Shelly Seward, Mark S. Carey, Marta Llauradó, Shailendra Giri, Ramandeep Rattan, Adnan R. Munkarah> ;Gynecologic Oncology. 2017 Aug 1
76 citations
Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors.
Kathleen N. Moore, Hossein Borghaei, David M. O'Malley, Woondong Jeong, Shelly Seward, Todd M. Bauer, Raymond P. Perez, Ursula A. Matulonis, Kelli L. Running, Xiaoyan ...> ;Cancer. 2017 Aug 15
30 citations
Is age a prognostic biomarker for survival among women with locally advanced cervical cancer treated with chemoradiation? An NRG Oncology/Gynecologic Oncology Group an...
Kathleen N. Moore, James J. Java, Katrina N. Slaughter, Peter G. Rose, Rachelle Lanciano, Paul DiSilvestro, J. Tate Thigpen, Yi-Chun Lee, Krishnansu S. Tewari, Junzo C...> ;Gynecologic Oncology. 2016 Nov 1
11 citations
Primary debulking surgery and neoadjuvant chemotherapy in the treatment of advanced epithelial ovarian carcinoma
Shelly Seward, Ira Winer> ;Cancer Metastasis Reviews. 2015 Jan 18
10 citations
Endometrial cancer in morbidly obese women: do racial disparities affect surgical or survival outcomes?
Michele L. Cote, Julie J. Ruterbusch, Quratulain Ahmed, Sudeshna Bandyopadhyay, B. Alosh, Eman Abdulfatah, Shelly Seward, R.T. Morris, Rouba Ali-Fehmi> ;Gynecologic Oncology. 2014 Apr 1
6 citations
EZH2-shRNA–mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic ductal adenocarcinoma
Ramesh B. Batchu, Aamer Qazi, Oksana V. Gruzdyn, Assaad Semaan, Shelly Seward, Sreedhar Chamala, Vasu B. Dhulipala, David L. Bouwman, Donald W. Weaver, Scott A. Gruber> ;Surgery. 2013 Oct 1
27 citations
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53
Shelly Seward, Assaad Semaan, Aamer Qazi, Oksana V. Gruzdyn, Sreedhar Chamala, Christopher C. Bryant, Sanjeev Kumar, David Cameron, Seema Sethi, Rouba Ali-Fehmi, Rober...> ;Cancer Letters. 2013 Aug 9
28 citations
Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101
Aamer Qazi, Oksana V. Gruzdyn, Assaad Semaan, Shelly Seward, Sreedhar Chamala, Vasu Dhulipala, Seema Sethi, Rouba Ali-Fehmi, Philip A. Philip, David L. Bouwman, Donald...> ;Surgery. 2012 Oct 1
8 citations
Outcomes of patients with uterine serous carcinoma using the revised FIGO staging system
Shelly Seward, Rouba Ali-Fehmi, Adnan R. Munkarah, Assaad Semaan, Z. Al-Wahab, Mohamed A. Elshaikh, Michele L. Cote, Robert T. Morris, Sudeshna Bandyopadhyay> ;International Journal of Gynecological Cancer. 2012 Mar 1
15 citations
Therapy-related myeloid leukemia after treatment for epithelial ovarian carcinoma: an epidemiological analysis.
Agnieszka Vay, Sanjeev Kumar, Shelly Seward, Assaad Semaan, Charles A. Schiffer, Adnan R. Munkarah, Robert T. Morris> ;Gynecologic Oncology. 2011 Dec 1
46 citations
MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21 waf1/cip1
Assaad Semaan, Aamer Qazi, Shelly Seward, Sreedhar Chamala, Christopher S. Bryant, Sanjeev Kumar, Robert W. Morris, Christopher P. Steffes, David L. Bouwman, Adnan R. ...> ;Pharmaceutical Research. 2011 Aug 5
17 citations
The prognostic impact of the ratio of positive lymph nodes on survival of epithelial ovarian cancer patients.
Haider Mahdi, Melissa M. Thrall, Sanjeev Kumar, Rabbie K. Hanna, Shelly Seward, David Lockhart, Robert T. Morris, Ron E. Swensen, Adnan R. Munkarah> ;Journal of Surgical Oncology. 2011 Jun 1
52 citations
Expression of GLUT-1 in epithelial ovarian carcinoma: Correlation with tumor cell proliferation, angiogenesis, survival and ability to predict optimal cytoreduction
Assaad Semaan, Adnan R. Munkarah, Haitham Arabi, Sudeshna Bandyopadhyay, Shelly Seward, Sanjeev Kumar, Aamer Qazi, Yasser Hussein, Robert T. Morris, Rouba Ali-Fehmi> ;Gynecologic Oncology. 2011 Apr 1
19 citations
Prognostic impact of laterality in malignant ovarian germ cell tumors.
Haider Mahdi, Sanjeev Kumar, Shelly Seward, Assaad Semaan, Ramesh B. Batchu, David Lockhart, Hisham K. Tamimi, Adnan R. Munkarah> ;International Journal of Gynecological Cancer. 2011 Jan 1
12 citations
The prognostic significance of the triple negative phenotype in endometrial cancer
Rajul Kothari, Carl Morrison, Debra L. Richardson, Shelly Seward, David M. O'Malley, Larry J. Copeland, Jeffrey M. Fowler, David E. Cohn> ;Gynecologic Oncology. 2010 Aug 1
48 citations
Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells
Christopher S. Bryant, Sanjeev Kumar, Sreedhar Chamala, Jay P. Shah, Jagannath Pal, Mahdi Haider, Shelly Seward, Aamer Qazi, Robert T. Morris, Assaad Semaan, Masood A....> ;Molecular Cancer. 2010 Mar 2
4 citations
Metastatic squamous cell carcinoma of the vulva to the lung confirmed with allelotyping.
Shelly Seward, Debra L. Richardson, Marino E. Leon, Weiqiang Zhao, David E. Cohn, Charles L. Hitchcock> ;International Journal of Gynecological Pathology. 2009 Sep 1
Combined weekly docetaxel (D) and gemcitabine (G) for relapsed ovarian cancer (OC) and peritoneal cancer (PC): A multi-institutional phase II study.
Morris RT, Cohn DE, Fowler J, Solomon LA, Vay A, Seward S, Heilbrun L, Smith D, Munkarah AR> ;J. Clin. Oncol.. 2009-05-20
70 citations
Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells.
Sanjeev Kumar, Christopher S. Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P. Steffes, Donald W. Weaver, Robert T. Morris, John M. M...> ;Molecular Cancer. 2009 Apr 22
15 citations
Radiation-associated endometrial cancer.
Sanjeev Kumar, Jay P. Shah, Christopher S. Bryant, Shelly Seward, Rouba Ali-Fehmi, Robert T. Morris, John M. Malone> ;Obstetrics and Gynecology. 2009 Feb 1
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Press Mentions

Healthcare Professionals & ResearchJanuary 11th, 2017
Karmanos Cancer InstituteJanuary 11th, 2017

Professional Memberships

American College of Obstetricians and Gynecologists
Fellow

Hospital Affiliations

Orlando Health Orlando Regional Medical CenterOrlando, Florida
Orlando Health - Health Central HospitalOcoee, Florida
Orlando Health St. Cloud HospitalSaint Cloud, Florida
Oviedo Medical CenterOviedo, Florida
AdventHealth OrlandoOrlando, Florida

Insurance Accepted

Aetna Choice POS II
BCBS Blue Card PPO
BCBS Illinois PPO
CIGNA Open Access
CIGNA PPO
Great West PPO
Lifewise Health Plan of Oregon
Multiplan PHCS PPO
ODS Network
PriorityHealth HMO
Providence Health System Personal Option
Providence Health System Preferred PPO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO
Please verify your coverage with the provider's office directly when scheduling an appointment