Shen-EnChenMDMPH, PhD

PubMed

• 3 citations
  Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function.
  Jay Chauhan, Shen En Chen, Katherine J. Fenstermacher, Aurash Naser-Tavakolian, Tali H. Reingewertz, Rosene Salmo, Christian Lee, Emori Williams, Mithun Raje, Eric J. ...> ;Bioorganic & Medicinal Chemistry. 2015 Nov 1
• 3 citations
  Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum
  Takuya Miura, Koushi Hidaka, Yukiko Azai, Keisuke Kashimoto, Yuko Kawasaki, Shen En Chen, Renato F. Freitas, Ernesto Freire, Yoshiaki Kiso> ;Bioorganic & Medicinal Chemistry Letters. 2014 Apr 1
• 55 citations
  Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies.
  Pillaiyar Thanigaimalai, Sho Konno, Takehito Yamamoto, Yuji Koiwai, Akihiro Taguchi, Kentaro Takayama, Fumika Yakushiji, Kenichi Akaji, Shen En Chen, Aurash Naser-Tava...> ;European Journal of Medicinal Chemistry. 2013 Oct 1
• 37 citations
  Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study.
  Pillaiyar Thanigaimalai, Sho Konno, Takehito Yamamoto, Yuji Koiwai, Akihiro Taguchi, Kentaro Takayama, Fumika Yakushiji, Kenichi Akaji, Yoshiaki Kiso, Yuko Kawasaki, S...> ;European Journal of Medicinal Chemistry. 2013 Jul 1
• 46 citations
  Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.
  Sho Konno, Pillaiyar Thanigaimalai, Takehito Yamamoto, Kiyohiko Nakada, Rie Kakiuchi, Kentaro Takayama, Yuri Yamazaki, Fumika Yakushiji, Kenichi Akaji, Yoshiaki Kiso, ...> ;Bioorganic & Medicinal Chemistry. 2013 Jan 15
• 19 citations
  Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L.
  Gustavo E. Chavarria, Michael R. Horsman, Wara M. Arispe, G.D. Kishore Kumar, Shen-En Chen, Tracy E. Strecker, Erica Parker, David J. Chaplin, Kevin G. Pinney, Mary Ly...> ;European Journal of Medicinal Chemistry. 2012 Dec 1
• 18 citations
  Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L
  Jiangli Song, Lindsay M. Jones, G.D. Kishore Kumar, Elizabeth S Conner, Liela Bayeh, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Shen-En Chen, David J. Chaplin, M...> ;ACS Medicinal Chemistry Letters. 2012 Apr 30
• 32 citations
  Helix formation in a pentapeptide: experiment and force-field dependent dynamics.
  Wendy A. Hegefeld, Shen-En Chen, Kristine Y. DeLeon, Krzysztof Kuczera, Gouri S. Jas> ;The Journal of Physical Chemistry. A. 2010 Nov 8
• 24 citations
  Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
  G.D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Wara M. Arispe, Matthew T. MacDonough, Tracy E. Strecker, Shen-En Chen, Bronwyn G. Siim, David J. ...> ;Bioorganic & Medicinal Chemistry Letters. 2010 Feb 15
• 48 citations
  Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease.
  Rogelio Siles, Shen-En Chen, Ming Zhou, Kevin G. Pinney, Mary Lynn Trawick> ;Bioorganic & Medicinal Chemistry Letters. 2006 Aug 15
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