ShimogaRamaiahPrakashMD

PubMed

• 2 citations
  Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans.
  Sandeepraj Pusalkar, Mihaela Plesescu, Mark N. Milton, Suresh K. Balani, Swapan K. Chowdhury, Shimoga R. Prakash> ;Drug Metabolism Letters. 2016 Feb 29
• 7 citations
  Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles.
  Yuexian Li, Jiyeon Woo, Jessica M. Chmielecki, Cindy Q. Xia, Mingxiang Liao, Bei-Ching Chuang, Johnny J. Yang, Miao Y. Guan, Mihaela Plesescu, Shimoga Prakash> ;Bioorganic & Medicinal Chemistry Letters. 2016 Jan 15
• 22 citations
  Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based ...
  Chuang Lu, Ashish Suri, Wen Chyi Shyu, Shimoga Prakash> ;Biopharmaceutics & Drug Disposition. 2014 Dec 1
• Synthesis of isotope‐labeled HSP90 inhibitor: [13CD3] and [14C]‐TAK‐459
  Mihaela Plesescu, Eric L. Elliott, Yuexian Li, Shimoga R. Prakash> ;Journal of Labelled Compounds & Radiopharmaceuticals. 2014 Jul 1
• Synthesis of isotopically labeled versions of L-MTP-PE (mifamurtide) and MDP.
  Yuexian Li, Mihaela Plesescu, Shimoga R. Prakash> ;Journal of Labelled Compounds & Radiopharmaceuticals. 2013 Jul 1
• Syntheses of C‐13 and C‐14‐labeled versions of the investigational proteasome inhibitor MLN9708
  Mihaela Plesescu, Eric L. Elliott, Yuexian Li, Shimoga R. Prakash> ;Journal of Labelled Compounds & Radiopharmaceuticals. 2013 Jul 1
• 15 citations
  Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tu...
  Akifumi Kogame, Yoshihiko Tagawa, Sachio Shibata, Hideaki Tojo, Maki Miyamoto, Kimio Tohyama, Takahiro Kondo, Shimoga R. Prakash, Wen Chyi Shyu, Satoru Asahi> ;Drug Metabolism and Disposition. 2013 Jan 8
• 40 citations
  P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor
  Johnny J. Yang, Mark N. Milton, Shaoxia Yu, Mingxiang Liao, Ning Liu, Jing-Tao Wu, Liang-Shang Gan, Suresh K. Balani, Frank W. Lee, Shimoga R. Prakash, Cindy Q. Xia> ;Drug Metabolism Letters. 2010 Nov 30
• 12 citations
  Quantitative Prediction and Clinical Observation of a CYP3A Inhibitor-Based Drug-Drug Interactions with MLN3897, a Potent C-C Chemokine Receptor-1 Antagonist
  Chuang Lu, Suresh K. Balani, Mark G. Qian, Shimoga R. Prakash, Patricia S. Ducray, Lisa L. von Moltke> ;The Journal of Pharmacology and Experimental Therapeutics. 2010 Feb 1
• 6 citations
  Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 ((2R)-2-{(3R)-3-Amino-3-(4-(2-methylquinolin- 4-ylmethoxy)phenyl)-2-oxopyrrolidin-1-yl}-N-hydroxy-...
  C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Jingwu Duan, Carl P. Decicco, Thomas P. Maduskuie, Stephen E. Mercer, Lian-Shen Gan, M...> ;Drug Metabolism and Disposition. 2008 Jun 1
• 21 citations
  Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. III. In vitro-in vivo correlation...
  Chuang Lu, Cicely Berg, Shimoga R Prakash, Frank W Lee, Suresh K Balani> ;Drug Metabolism and Disposition. 2008 Jul 1
• 5 citations
  Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey
  J. Scott Daniels, Robert Espina, Kevin Cao, Haodan Yuan, Jianrong Lin, Sharon Diamond, Barry L. Johnson, James D. Rodgers, Shimoga R. Prakash, Steve Unger, David D. Ch...> ;Chemical Research in Toxicology. 2007 Oct 17
• 34 citations
  A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.
  Chuang Lu, Gerald T. Miwa, Shimoga R. Prakash, Liang-Shang Gan, Suresh K. Balani> ;Drug Metabolism and Disposition. 2007 Jan 1
• 36 citations
  Binding Sites of γ-Secretase Inhibitors in Rodent Brain: Distribution, Postnatal Development, and Effect of Deafferentation
  Xiao Xin Yan, Tong Li, Cynthia M. Rominger, Shimoga R. Prakash, Philip C. Wong, Richard E. Olson, Robert Zaczek, Yu Wen Li> ;The Journal of Neuroscience. 2004 Mar 24
• 22 citations
  Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazo...
  Ge Zhang, Ning Huang, Yu-Wen Li, Xiaoping Qi, Anne Marshall, Xiao-Xin Yan, Geraldine Hill, Cynthia M. Rominger, Shimoga R. Prakash, Rajagopal Bakthavatchalam, David H....> ;The Journal of Pharmacology and Experimental Therapeutics. 2003 Apr 1
• 19 citations
  Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metab...
  Abdul E Mutlib, John Shockcor, Shiang-Yuan Chen, Robert J Espina, Donald J. P. Pinto, Michael J. Orwat, Shimoga R. Prakash, Liang-Shang Gan> ;Chemical Research in Toxicology. 2002 Jan 1
• 16 citations
  P450-mediated metabolism of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)- [1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole- 5-carboxamide (DPC 423) a...
  Abdul E. Mutlib, Shiang-Yuan Chen, Robert J Espina, John Shockcor, Shimoga R Prakash, Liang-Shang Gan> ;Chemical Research in Toxicology. 2002 Jan 1
• 14 citations
  Formation of Unusual Glutamate Conjugates of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxa...
  Abdul E. Mutlib, John Shockcor, Shiang-Yuan Chen, Robert Espina, Jianrong Lin, Nilsa Graciani, Shimoga R. Prakash, Liang-Shang Gan> ;Drug Metabolism and Disposition. 2001 Oct 1
• 16 citations
  Characterization of novel glutathione adducts of a non-nucleoside reverse transcriptase inhibitor, (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro...
  Abdul E. Mutlib, Hao Chen, John Shockcor, Robert J Espina, Sy Chen, Kevin Cao, Alicia Du, Greg Nemeth, Shimoga R Prakash, Liang-Shang Gan> ;Chemical Research in Toxicology. 2000 Aug 1
• In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.
  Vickers S, Duncan CA, Vyas KP, Kari PH, Arison B, Prakash SR, Ramjit HG, Pitzenberger SM, Stokker G, Duggan DE> ;Drug Metab. Dispos.. 1990-01-01
• Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin.
  Vyas KP, Kari PH, Prakash SR, Duggan DE> ;Drug Metab. Dispos.. 1990-01-01
• Join now to see all