ShirleySOngMD

Neurology • Columbus, OH

Neurooncology

Assistant professor, Division of Neuro-oncology The Ohio State University Wexner Medical Center

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Office
300 W 10th Ave
Ground Floor
Columbus, OH 43210
Phone+1 614-293-4448

Fax+1 614-293-3277
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Education & Training

University of Texas M D Anderson Cancer CenterFellowship, Neuro-Oncology, 2008 - 2010
St Louis University School of MedicineResidency, Neurology, 2005 - 2008
St Louis University School of MedicineInternship, Internal Medicine, 2004 - 2005
University of the East College of MedicineClass of 1995

Certifications & Licensure

OH State Medical License 2019 - 2026
AR State Medical License 2011 - 2020
IL State Medical License 2010 - 2011
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation

Clinical Trials

Expanded Access Protocol for GBM Patients With Already Manufactured DCVax®-L Who Have Screen-Failed Protocol 020221
Available
Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects Start of enrollment: 2016 Oct 06
Completed
Phase 2
LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma Start of enrollment: 2020 Oct 21
Active, not recruiting
Phase 2
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme Start of enrollment: 2021 May 18
Active, not recruiting
Phase 2
A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden Start of enrollment: 2020 Dec 24
Suspended
Phase 2
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study) Start of enrollment: 2023 Jan 23
Recruiting
Phase 3
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma Start of enrollment: 2021 Nov 29
Recruiting
Phase 3
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Publications & Presentations

PubMed

40 citations
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
Farshad Nassiri, Vikas Patil, Leeor S Yefet, Olivia Singh, Jeff Liu, Rachel M A Dang, Takafumi N Yamaguchi, Mariza Daras, Timothy F Cloughesy, Howard Colman, Priya U K...> ;Nature Medicine. 2023 Jun 1
4 citations
Small Molecules and Immunotherapy Agents for Enhancing Radiotherapy in Glioblastoma.
Jennifer K Matsui, Haley K Perlow, Alex R Ritter, Rituraj Upadhyay, Raju R Raval, Evan M Thomas, Sasha J Beyer, Clement Pillainayagam, Justin Goranovich, Shirley Ong, ...> ;Biomedicines. 2022 Jul 21
6 citations
Dose-escalated accelerated hypofractionation for elderly or frail patients with a newly diagnosed glioblastoma.
Haley K Perlow, Alexander Yaney, Michael Yang, Brett Klamer, Jennifer Matsui, Raju R Raval, Dukagjin M Blakaj, Andrea Arnett, Sasha Beyer, James B Elder, Mario Ammirat...> ;Journal of Neuro-Oncology. 2022 Jan 1
3 citations
Targeted Therapy for BRAF Mutant Brain Tumors
Appaji Rayi, Iyad Alnahhas, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Current Treatment Options in Oncology. 2021 Oct 6
Erratum to: Characterizing Benefit from Temozolomide in MGMT Promoter Unmethylated and Methylated Glioblastoma: A Systematic Review and Meta-analysis.
Iyad Alnahhas, Mouaz Alsawas, Appaji Rayi, Joshua D Palmer, Raju Raval, Shirley Ong, Pierre Giglio, Mohammad Hassan Murad, Vinay Puduvalli> ;Neuro-Oncology Advances. 2021 Jul 10
2 citations
The role of VEGF receptor inhibitors in preventing cerebral radiation necrosis: a retrospective cohort study.
Iyad Alnahhas, Appaji Rayi, Joshua D. Palmer, Raju Raval, Edmund Folefac, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Neuro-Oncology Practice. 2021 Feb 25
7 citations
Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma.
Iyad Alnahhas, Appaji Rayi, Maria del Pilar Guillermo Prieto Eibl, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Neuro-Oncology Advances. 2021 Jan 1
3 citations
False-positive 1p/19q Testing Results in Gliomas: Clinical and Research Consequences.
Iyad Alnahhas, Appaji Rayi, Diana Thomas, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;American Journal of Clinical Oncology. 2020 Nov 1
5 citations
Management of gliomas in patients with Lynch syndrome
Iyad Alnahhas, Appaji Rayi, Shirley Ong, Pierre Giglio, Vinay K. Puduvalli> ;Neuro-Oncology. 2021 Jan 30
23 citations
Characterizing benefit from temozolomide in MGMT promoter unmethylated and methylated glioblastoma: a systematic review and meta-analysis.
Iyad Alnahhas, Mouaz Alsawas, Appaji Rayi, Joshua D Palmer, Raju Raval, Shirley Ong, Pierre Giglio, Mohammad Hassan Murad, Vinay Puduvalli> ;Neuro-Oncology Advances. 2020 Oct 30
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.
Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perr...> ;The Lancet. Oncology. 2017-08-23
32 citations
Ipilimumab-induced necrotic myelopathy in a patient with metastatic melanoma: A case report and review of literature
Al-Ola Abdallah, Aline Herlopian, Rahul Ravilla, Meghana Bansal, Sowmya Chandra-Reddy, Fade Mahmoud, Shirley Ong, Murat Gokden, Laura F. Hutchins> ;Journal of Oncology Pharmacy Practice. 2016 Jun 1
5 citations
Central pontine and extrapontine myelinolysis: the great masquerader-an autopsy case report.
Sajish Jacob, Harsh V. Gupta, Dejan Nikolic, Betul Gundogdu, Shirley Ong> ;Case Reports in Neurological Medicine. 2014 Mar 4
3 citations
Papillary endothelial hyperplasia presenting as recurrent malignant glioma
Shirley Ong, Janet M. Bruner, Dawid Schellingerhout, Vinay K. Puduvalli> ;Journal of Neuro-Oncology. 2011 May 1
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Journal Articles

Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
Nassiri F, Patil V, Yefet LS, Singh O, Liu J, Dang RMA, Yamaguchi TN, Daras M, Cloughesy TF, Colman H, Kumthekar PU, Chen CC, Aiken R, Groves MD, Ong SS, Ramakrishna R..., Nature Medicine, 6/29/2023

Books/Book Chapters

Neuro-Oncology Compedium for the Boards and Clinical Practice
Chapter: Ependymoma
Iyad Alnahhas, Appaji Rayi, Wayne Slone, Peter Kobalka, Shirley Ong, Pierre Giglio, Vinay K. PuduvalliEditors: Maciej Mrgala, Na Tosha Gaston, Jennifer L. Clarke, Sylvia C. Kurtz, Kathryn S. Nevel.Oxford University PressEdition 1st,2023