ShyamasundaranKottililMDPhD, MACP, FRCP, FIDSA, FAASLD

Infectious Disease • Baltimore, MD

Director

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Office
725 W Lombard St
Baltimore, MD 21201
Phone+1 410-328-9102

Fax+1 410-706-4619
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Education & Training

National Institutes of Health Clinical CenterFellowship, Infectious Disease, 2000 - 2002
Brown UniversityResidency, Internal Medicine, 1997 - 2000
Government Medical College ThrissurClass of 1991

Certifications & Licensure

MD State Medical License 2014 - 2024
DC State Medical License 2009 - 2024
VA State Medical License 2001 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Clinical Trials

Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV Start of enrollment: 1993 Mar 09
Recruiting
Open Label Study to Evaluate Chronic Hepatitis C Treatment in Latino Subjects With and Without HIV Co-infection Start of enrollment: 2010 Jul 01
Terminated
Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV Infection Start of enrollment: 2011 Aug 23
Completed
Boceprevir Drug Combination for Hepatitis C Treatment in People With and Without HIV Start of enrollment: 2011 Sep 01
Terminated
Phase 4
Clinical Trial to eLiminate HCV-infection in Treatment-naïve, Renally Impaired EgyptiAn Patients on Renal Dialysis, With Chronic Hepatitis C Genotype 4 Start of enrollment: 2019 Dec 01
Withdrawn
Phase 4
Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003) Start of enrollment: 2020 Aug 31
Terminated
Phase 2
Efprezimod Alfa (CD24Fc, MK-7110) as a Non-antiviral Immunomodulator in COVID-19 Treatment (MK-7110-007) Start of enrollment: 2020 Apr 24
Completed
Phase 3
Clinical Trial to Evaluate the Safety of RQ-01 in SARS-CoV-2 Positive Subjects Start of enrollment: 2023 Sep 27
Completed
Phase 1
Roles: Contact
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Publications & Presentations

PubMed

1 citations
IFNα induces CCR5 in CD4T cells of HIV patients causing pathogenic elevation.
Hélène Le Buanec, Valérie Schiavon, Marine Merandet, Alexandre How-Kit, Hongshuo Song, David Bergerat, Céline Fombellida-Lopez, Armand Bensussan, Jean-David Bouaziz, A...> ;Communications Medicine. 2024 Mar 19
1 citations
Early elevated IFNα is a key mediator of HIV pathogenesis.
Hélène Le Buanec, Valérie Schiavon, Marine Merandet, Alexandre How-Kit, David Bergerat, Céline Fombellida-Lopez, Armand Bensussan, Jean-David Bouaziz, Arsène Burny, Gi...> ;Communications Medicine. 2024 Mar 19
1 citations
Neuronal and Glial Metabolite Abnormalities in Participants With Persistent Neuropsychiatric Symptoms After COVID-19: A Brain Proton Magnetic Resonance Spectroscopy St...
Thomas Ernst, Meghann C Ryan, Hua-Jun Liang, Justin P Wang, Eric Cunningham, Muhammad G Saleh, Shyamasundaran Kottilil, Linda Chang> ;The Journal of Infectious Diseases. 2023 Nov 28
1 citations
Use of nonstigmatizing language is associated with improved outcomes in hospitalized people who inject drugs.
Rosenthal, E. S., Joseph E Carpenter, Jillian Catalanotti, Melissa Notis, Christopher Brokus, Timothy P Moran, Hana Akselrod, Greer Burkholder, Ellen F Eaton, Irene Ku...> ;Journal of Hospital Medicine. 2023 Aug 1
4 citations
Quantifying the Neuropsychiatric Symptoms in Post-Acute Sequelae of COVID-19 (PASC) using the NIH Toolboxand PROMIS.
Meghann C Ryan, Huajun Liang, Eleanor Wilson, Andrea Levine, Shyamasundaran Kottilil, Thomas Ernst, Linda Chang> ;Neuroimmune Pharmacology and Therapeutics. 2023 Jun 20
5 citations
Ongoing oxidative stress in individuals with post-acute sequelae of COVID-19.
Muhammad G Saleh, Linda Chang, Huajun Liang, Meghann C Ryan, Eric Cunningham, Jonathan Garner, Eleanor Wilson, Andrea R Levine, Shyamasundaran Kottilil, Thomas Ernst> ;Neuroimmune Pharmacology and Therapeutics. 2023 Jun 1
IFNα induces CCR5 in CD4T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy.
Hélène Le Buanec, Valérie Schiavon, Marine Merandet, Alexandre How-Kit, Hongshuo Song, David Bergerat, Céline Fombellida-Lopez, Armand Bensussan, Jean-David Bouaziz, A...> ;Research Square. 2023 May 11
1 citations
Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers.
Hélène Le Buanec, Valérie Schiavon, Marine Merandet, Alexandre How-Kit, David Bergerat, Céline Fombellida-Lopez, Armand Bensussan, Jean-David Bouaziz, Arsène Burny, Gi...> ;Research Square. 2023 May 11
1 citations
Immune drivers of HBsAg loss in HBeAg-negative CHB patients after stopping nucleotide analog and administration of Peg-IFN.
Mojahidul Islam, Karan Kumar, Jayesh K Sevak, Ankur Jindal, Ashish K Vyas, Gayatri Ramakrishna, Shyamasundaran Kottilil, Manoj K Sharma, Shiv K Sarin, Nirupama Trehanpati> ;Hepatology Communications. 2023 May 1
5 citations
Changes in Brain Activation Patterns During Working Memory Tasks in People With Post-COVID Condition and Persistent Neuropsychiatric Symptoms.
Linda Chang, Meghann C Ryan, Huajun Liang, Xin Zhang, Eric Cunningham, Justin Wang, Eleanor Wilson, Edward H Herskovits, Shyamasundaran Kottilil, Thomas M Ernst> ;Neurology. 2023 Jun 6
3 citations
Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19.
Huajun Liang, Thomas Ernst, Kenichi Oishi, Meghann C Ryan, Edward Herskovits, Eric Cunningham, Eleanor Wilson, Shyamasundaran Kottilil, Linda Chang> ;Neuroimmune Pharmacology and Therapeutics. 2023 Mar 25
6 citations
Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.
Gane, E., Dunbar, P., Brooks, A., Zhang, F., Chen, D., Wallin, J., van Buuren, N., Arora, P., Fletcher, S., Tan, S., Yang, J., Tang, L., Gaggar, A., Kottilil, S.> ;Journal of Hepatology. 2023 Mar 1
4 citations
Viral hepatitis elimination challenges in low- and middle-income countries-Uzbekistan Hepatitis Elimination Program (UHEP).
Erkin Musabaev, Chris Estes, Shakhlo Sadirova, Shokhista Bakieva, Krestina Brigida, Rick Dunn, Shyamasundaran Kottilil, Poonam Mathur, Ameer Abutaleb, Kathryn Razavi-S...> ;Liver International. 2023 Apr 1
Predictors of Nonadherence Among Patients With Infectious Complications of Substance Use Who Are Discharged on Parenteral Antimicrobial Therapy.
Shivakumar Narayanan, Patrick R Ching, Edward C Traver, Nivya George, Anthony Amoroso, Shyam Kottilil> ;Open Forum Infectious Diseases. 2023 Jan 1
PrEP Indications and PrEP Knowledge, Access, and Interest Among Individuals With HCV.
Kristi C Hill, Sarah M Kattakuzhy, Rachel Silk, Rahwa Eyasu, Onyinyechi Ogbumbadiugha, Emade Ebah, Amelia A Cover, Ashley Davis, Britt Gayle, David Sternberg, Phyllis ...> ;Open Forum Infectious Diseases. 2022 Oct 1
1 citations
A Phase 2 open label study of ledipasvir/sofosbuvir for 12 weeks in subjects with hepatitis B virus infection.
Angie S Price, Amy K Nelson, Alip Ghosh, Shyamasundaran Kottilil, Joel V Chua> ;Journal of Medical Virology. 2023 Jan 1
2 citations
Persistent CD38 Expression on CD8 + T Lymphocytes Contributes to Altered Mitochondrial Function and Chronic Inflammation in People With HIV, Despite ART.
Poonam Mathur, Shyamasundaran Kottilil, Suresh Pallikkuth, Daniela Frasca, Alip Ghosh> ;Journal of Acquired Immune Deficiency Syndromes. 2022 Dec 1
5 citations
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy.
James Ahodantin, Kouki Nio, Masaya Funaki, Xuguang Zhai, Eleanor Wilson, Shyamasundaran Kottilil, Liang Cheng, Guangming Li, Lishan Su> ;JCI Insight. 2022 Jul 8
25 citations
Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study.
James Welker, Juan D Pulido, Andrew T Catanzaro, Carlos D Malvestutto, Zihai Li, Jonathan B Cohen, Eric D Whitman, Dana Byrne, Olivia K Giddings, Jordan E Lake, Joel V...> ;The Lancet. Infectious Diseases. 2022 May 1
Toward demystifying HIV as a risk factor for coronavirus disease 2019 complications.
Alejandro R Gener, Shyam Kottilil> ;AIDS. 2022 Apr 1
2 citations
Suboptimal Uptake, Retention, and Adherence of Daily Oral Prexposure Prophylaxis Among People With Opioid Use Disorder Receiving Hepatitis C Virus Treatment.
Christopher Brokus, Sarah Kattakuzhy, Britt Gayle, Shivakumar Narayanan, Ashley Davis, Amelia Cover, Rahwa Eyasu, Emade Ebah, Onyinyechi Ogbumbadiugha-Weekes, Jennifer...> ;Open Forum Infectious Diseases. 2022 Mar 1
3 citations
Immunomodulatory therapies for COVID-19.
Poonam Mathur, Shyamasundaran Kottilil> ;Frontiers in Medicine. 2022 Jan 1
13 citations
Use of oral polio vaccine and the incidence of COVID-19 in the world.
Farrokh Habibzadeh, Konstantin Chumakov, Mohammad M Sajadi, Mahboobeh Yadollahie, Kristen Stafford, Ashraf Simi, Shyamasundaran Kottilil, Iman Hafizi-Rastani, Robert C...> ;Plos One. 2022 Jan 1
7 citations
Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans
Natarajan Ayithan, Alip Ghosh, Ankit Dwivedi, Jeffrey J. Wallin, Susanna K. Tan, Diana Chen, Shyam Kottilil, Bhawna Poonia> ;Viruses. 2021 Dec 1
16 citations
COVID-19 Infection Among Women in Iran Exposed vs Unexposed to Children Who Received Attenuated Poliovirus Used in Oral Polio Vaccine.
Farrokh Habibzadeh, Mohammad M. Sajadi, Konstantin Chumakov, Mahboobeh Yadollahie, Shyamasundaran Kottilil, Ashraf Simi, Kristen A Stafford, Saeid Saeidimehr, Mohammad...> ;JAMA Network Open. 2021 Nov 1
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Press Mentions

Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients with Unfavorable Treatment CharacteristicsA Randomized Clinical TrialSeptember 19th, 2019
UM School of Medicine Awarded Nearly $30 Million to Improve Health Outcomes of IV Drug UsersDecember 13th, 2023
UM School of Medicine Awarded Nearly $30 Million to Prevent Infections Associated with IV Drug UseDecember 21st, 2023

Grant Support

Therapeutic Strategies For The Management Of HCV/HIV CO-National Institute Of Allergy And Infectious Diseases2006
Role Of Innate Immunity In The Initiation And PathogenesNational Institute Of Allergy And Infectious Diseases2006