Si M. Pham MD FACS

PubMed

• 7Improved 2-year Heart Transplant Survival with Moderate Hypothermic Donor Heart Preservation in the GUARDIAN Heart Registry.
  Scott Silvestry, Dan M Meyer, Si M Pham, Jeffrey P Jacobs, Yasuhiro Shudo
  The Journal of Heart and Lung Transplantation. 2025-11-13
• High profile transvalvular microaxial flow pump as a bridge to heart transplantation for amyloid cardiomyopathy: A case series.
  Pankaj Garg, Mohammad Alomari, Ishaq Wadiwala, Melissa Lyle, Si Pham
  JHLT Open. 2025-11-01
• Percutaneous Temporary Mechanical Circulatory Support as a Bridge to Heart Transplantation in the Current UNOS Allocation System.
  Rohan Goswami, Jose Ruiz, Aarti Desai, Peter Wlodkowski, Basar Sareyyupoglu
  Biomedicines. 2025-10-28

Journal Articles

• Use of Omental Flap for Treating Cardio-Cutaneous Fistula After Ventricular Aneurysm Repair  
  Jose M Martinez, Si M Pham, The Annals of Thoracic Surgery
• The Use of Extended Criteria Donors Decreases One-Year Survival in High-Risk Lung Recipients: A Review of the United Network of Organ Sharing Database  
  Charles F Evans, James S Gammie, Pablo G Sanchez, Keshava Rajagopal, Aldo T Iacono, Si M Pham, Matthew J Mulligan, Bartley P Griffith, Journal of Thoracic and Cardiovascular Surgery
• Research Paper Transcriptomic Evidence of Immune Activation in Macroscopically Normal-Appearing and Scarred Lung Tissues in Idiopathic Pulmonary Fibrosis  
  Jeffrey R Galvin, Andrew Clerman, Teri J Franks, Ashutosh Sachdeva, Edward J Britt, Si M Pham, Nevins W Todd, June Kim, Jeffrey D Hasday, Allen P Burke, ScienceDirect
• Treatment strategies for obliterative bronchiolitis.  
  Fertel DP, Qi X, Pham SM, Curr Opin Organ Transplant, 6:231-238
• Simultaneous donor bone marrow and cardiac transplantation: Can tolerance be induced with the development of chimerism.  
  Gammie JS, Pham SM, Current Opinion in Cardiology, 14:126-132
• Chronic rejection. A general overview of histopathology and pathophysiology with emphasis on liver, heart and intestinal allografts.  
  Demetris AJ, Murase N, Lee RG, Randhawa P, Zeevi A, Pham SM, Duquesnoy R, Fung JJ, Starzl TE, Annals of Transplantation, 2(2):27-44
• Successful Management of Fulminant H1N1 Myocarditis: Case Report and Review of the Literature.  
  Cobas, Miguel; Abbo, Lilian; Santos, Miguel; Baccini Jauregui, Clara; Pham, Si, British Medical Journal
• Human marrow-isolated adult multilineage-inducible (MIAMI) cells protect against peripheral vascular ischemia in a mouse model.  
  Rahnemai-Azar A, D'Ippolito G, Gomez LA, Reiner T, Vazquez-Padron RI, Perez-Stable C, Roos BA, Pham SM, Schiller PC, Cytotherapy;13: 179-192
• Novel role of Egr-1 in nicotine-related neointimal formation.  
  Vazquez-Padron RI, Mateu D, Rodriguez-Menocal L, Wei Y, Webster KA, Pham SM, Cardiovasc Res; 88(2):296-303
• Stress-induced senescence exaggerates postinjury neointimal formation in the old vasculature.  
  Khan SJ, Pham S, Wei Y, Mateo D, St-Pierre M, Fletcher TM, Vazquez-Padron RI, Am J Physiol Heart Circ Physiol; 298(1):H66-74
• A novel mouse model of in-stent restenosis.  
  Rodriguez-Menocal L, Wei Y, Pham SM, St-Pierre M, Li S, Webster K, Goldschmidt-Clermont P, Vazquez-Padron RI, Atherosclerosis; 209(2):359-66
• Interleukin-10 Delivery Via Mesenchymal Stem Cells: A Novel Gene Therapy Approach To Prevent Lung Ischemia-Reperfusion Injury.  
  Manning E, Pham S, Li S, Vazquez-Padron RI, Mathew J, Ruiz P, Salgar SK, Hum Gene Ther
• Report from a consensus conference on the sensitized patient awaiting heart transplantation.  
  Kobashigawa, J, Mehra, M, West, L, Kerman, R, George, J, Rose, M, Zeevi, A, Reinsmoen, N, Patel, J, Reed, EF, J Heart Lung Transplant; 28(3): 213-25
• The origin of post-injury neointimal cells in the rat balloon injury model.  
  Rodriguez-Menocal L, St-Pierre M, Wei Y, Khan S, Mateu D, Calfa M, Rahnemai-Azar AA, Striker G, Pham SM, Vazquez-Padron RI, Cardiovasc Res, 81(1):46-53
• An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase β2 mRNA translation.  
  Roberto I. Vazquez-Padron, Si M. Pham, Dania Mateu, Sheik Khan, Abdelouahab Aitouche, FEBS J, 275:3598-3607
• Andreopoulos, Co-delivery of FGF-2 and G-CSF from gelatin-based hydrogels as angiogenic therapy in a murine critical limb ischemic model.  
  H. Layman, Marianne Sacasa, Ashley E. Murphy, Amy M. Murphy, Si M. Pham, Fotios M, Acta Biomaterialia, 5(1):230-9
• The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model.  
  Layman H, Spiga MG, Brooks T, Pham S, Webster KA, Andreopoulos FM, Biomaterials; 28(16):2646-54
• Should stable UNOS status 2 patients be transplanted?  
  Jimenez J, Edwards LB, Higgins R, Bauerlein J, Pham S, Mallon S, J Heart Lung Transplantation; (24); 2: 178-182
• Acanthamoeba infection in lung transplantation: report of a case and review of the literature.  
  Vernon SE. Acar BC. Pham SM. Fertel D, Transplant Infectious Disease; 7(3-4):154-7
• Extracorporeal life support in pulmonary failure after traumatic rupture of the thoracic aorta: a case report.  
  Masroor S. Tehrani H. Pham S. Neijman T. Martinez-Ruiz R. McKenney M. Salerno T, J Trauma-Injury Infection & Critical Care; 57(2):389-91
• Cryptic endotoxic nature of Bacillus thuringiensis Cry1Ab insecticidal crystal protein.  
  Vazquez-Padron RI, de la Riva G, Agüero G, Silva Y, Pham SM, Soberón M, Bravo A and Aïtouche A, Febs Letters; 570:30-6
• Aging exacerbates neointimal formation, increases the proliferation, and reduces susceptibility to apoptosis, of vascular smooth muscle cells in mice.  
  Vazquez-Padron R, Lasko D, Li S, Louis LB, Pestana I, Pang M, Liotta C, Fornoni A, Aitouche A, Pham SM, J Vasc Surg, (40):1199-1207
• Transmission of West Nile Virus from an organ donor to four transplant recipients.  
  Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S, Lanciotti RS, Lance-Parker SE, DiazGranados CA, Winquist AG, Perlino CA, Wier..., N. England J Med; 348:2196-203
• Long-term acceptance of composite tissue allografts through mixed chimerism and CD28 blockade.  
  Foster RD, Pham S, Li S, Aitouche A, Transplantation; 76:988-994
• Immobilization of quantum dots in the photo-cross-linked poly(ethylene glycol)-based hydrogel.  
  Gattas-Asfura KM, Zheng Y, Micic M, Snedaker MJ, Ji X, Sui G, Orbulescu J, Andreopoulos FM, Pham SM, J Phys Chem B; 107; 10464-10469
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Books/Book Chapters

• A textbook of Congenital and Acquired Diseases of the Aorta. 
  Pham SMEditors: Liotta D, del Rio M, Cooley DA, Cabrol C, Griepp RB, Safi H, Fraser Jr CD, Pham SM, Bachet J, Et al.Domingo Liotta Foundation Medical, Buenos Aires
• Principles of Pulmonary Protection in Heart Surgery.. 
  Chapter: Mechanisms of Pulmonary Edema 
  Pham SM, Manning DEditors: Gabriel E, Salerno T.Springer-Verlag, London
• Complications in Surgery and Trauma. 
  Chapter: Complications of Cardiac Transplantation 
  Page 357 - 366Xiao-Shi Qi, Louis B. Louis IV, and Si M. PhamEditors: Cohn, Stephen M, Barquist, Erik, Byers, Patricia M.Informa Healthcare USA, New York, NY
• Modern Myocardial Protection. 
  Chapter: Myocardial preservation in clinical cardiac transplantation: An update 
  Louis LB, Qi X, Pham SMEditors: Salerno T, Ricci M.Blackwell Publishing/Futura, New York
• Congenital and acquired diseases of the aorta. 
  Chapter: Traumatic injury to the thoracic aorta 
  Page 497 - 508Katariya K, Tehrani H, Cohn SM, Salerno TA, Pham SMEditors: Liotta D, del Rio M, Cooley DA, Cabrol C, Griepp RB, Safi H, Fraser Jr. CD, Pham SM, Bachet J, Eleft.Domingo Liotta Foundation Medical, Buenos Aires
• Lung Biology in Health Disease. 
  Chapter: Cytokines in pulmonary transplantation 
  Page 365 - 402Pham SM, Mitruka SN, Li SEditors: Nelson S, Martin TR.Marcel Dekker, Inc, New York
• Clinical Transplants 1997. 
  Chapter: Lung and heart-lung transplantation at the University of Pittsburgh 
  Page 209 - 218McCurry KR, Iacono AT, Dauber JH, Grgurich WF, Pham SM, Hattler BG, Keenan RJ, Griffith BPEditors: Cecka and Terasaki.UCLA Tissue Typing Laboratory, Los Angeles
• The Transplantation and Replacement of Thoracic Organs. 
  Chapter: Tacrolimus (FK506) in thoracic organ transplantation 
  Page 89 - 95Gammie JS, Pham SMEditors: Cooper DKC, Miller LW, Patterson GA.Dordrecht: Kluwer Academic PublishersEdition 2nd,
• Clinical Transplants 1994. 
  Chapter: Lung Transplantation at the University of Pittsburgh: 1982 to 1994 
  Page 111 - 120Kawai A, Pardis IL, Keenan RJ, Hardesty RL, Hattler BG, Pham SM, Griffithy BPEditors: Terasaki P, Cecka T.UCLA Tissue Typing Laboratory, Los Angeles
• Clinical Transplants 1994. 
  Chapter: Cardiac Transplantation at the University of Pittsburgh: 1994 Update 
  Page 121 - 125Pham SM, Kormos RL, Murali S, Kawai A, Demetris AJ, Hattler BG, Williams PA, McNamara D, Rosenblum W, Griffith BPEditors: Terasaki P, Cecka T.UCLA Tissue Typing Laboratory, Los Angeles
• Cardiology. 
  Chapter: Cardiac and Cardiopulmonary Transplantation 
  Page 1 - 47Thompson, ME, Paradis I, Dummer JS, Uretsky BF, Pham SEditors: Parmley WW, Chatterjee K.J.B. Lippincott Co, Philadelphia
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Abstracts/Posters

• New concepts in immunobiology.
  Pham SM, Ildstad ST, Seminars in Anesthesia, 14(2):73-84
• New approaches to achieve immunologic acceptance of lung allografts.
  Pham SM, Keenan RJ, Griffith B, Semin Respir Crit Care Med, 17(2):197-205
• Efficacy of the Cylex Test in Detecting Rejection in Pediatric Heart Transplant Patients.
  Rusconi P, Novero LJ, Bueno T, Lopez-Mitnik G, Ludwig D, Pham SM, American Journal of Transplantation; 9: 649-649
• Dramatic Increase of Micro-RNAs Targeting Cell Cycle, Angiogenesis, and Epicardial Differentiation in CD34+/Lin- Bone Marrow Stem Cells From Patients With Coronary Art...
  Adi N, Adi J, Cesar L, de Marchena E, Grant D, Ma Q, Kall CMY, Panos AL, Pham SM, Salerno T, Suarez SV, Xu QY, Webster JC, Webster KA, Circulation Research; 105: 5291
• Endothelial layer restoration after vascular injury is delayed with aging bone marrow while the inflammatory response and intimal formation are increased.
  Calfa M, Vazquez-Padron R, Aitouche A, Li S, Pham S, Journal of the American College of Cardiology; 49: 319A-319A
• Human Marrow-isolated adult multilineage inducible (MIAMI) cells protect against peripheral vascular ischemia in a mouse model.
  Rahnemai-Azar A, D'Ippolito G, Gomez LA, Reiner T, Vazquez-Padron RI, Perez-Stable C, Roos BA, Pham SM, Schiller PC, Symposium on Cardiovascular Regenerative Medicine, NIH, Bethesda Maryland
• Postinjury Accumulation of Interleukin-18 Inhibits Vascular Smooth Muscle Cell Apoptosis and Exaggerated Neointimal Formation in Aged Rats.
  Rodriguez-Menocal, L, Wei, YT, Mateu, D, Pham, SM, Vazquez-Padron, R, Arteriosclerosis Thrombosis and Vascular Biology; 29(7): E84-E85
• Campath-1H in Clinical Heart Transplantation.
  Pham, SM, Aycart, M, Bednar, BM, Bauerlein, EJ, Panos, A, Chaparro, S, Jimenez, J, Ricci, M, Mallon, SM, Rusconi, P, Rosenkranz, EE, Hershberger, R, American Journal of Transplantation; 9: 646-647
• Liver Cirrhosis in Patients after Fontan Operation.
  Gupta, R, Pham, SM, Rodriguez, M, Bueno, TG, Rusconi, P, Journal of Heart and Lung Transplantation; 28(2): 664
• Soluble Triggering Receptor Expressed on Myeloid Cells and the Diagnosis of Pneumonia in Lung Transplant Patients.
  Shafazand, S, Alazemi,S, Vadia,E, Manning,E, Fertel,D, Pham,SM, Am J Respir Crit Care Med 179:A4620
• Postinjury neointima cells are predominantly of local origin rather than from circulating progenitors.
  Vazquez-Padron, RI, Wei, Y, Menocal-Rodriguez, L, Mateu, D, Salgar, S, Li, S, Pham, SM, Arteriosclerosis Thrombosis and Vascular Biology; 28(6): P472
• Nicotine Upregulates Early Growth Factor-1 Expression in Vascular Smooth Muscle Cell via ERK 1/2-Elk-1 Signaling and Exacerbates Neointimal Formation after Vascular In...
  Rodriguez-Menocal, L, Mateu, D, Wei, YT, Pham, SI, Vazquez-Padron, RI, Circulation; 118(18): S367-S368
• Vascular Injury Causes Early-Onset Apoptosis of Medial Vascular Smooth Muscle Cells.
  Roberto I. Vazquez-Padron, Luis Rodriguez-Menocal, Danea Mateu, Yuntao Wei, Sashi Salgar, Sen Li, Si M. Pham, Journal of Surgical Research;144 (2): 414
• Interleukin-10 delivery via mesenchymal stem cells (MSC): A novel approach to prevent lung ischemia/reperfusion injury.
  Manning, E, Pham, S, Li, S, Vazquez-Padron, R, Mathew, J, Ruiz, P, Salgar, S, American Journal of Transplantation; 8: 271-271
• Mesenchymal Stem Cell Therapy Prevents Ischemia/Reperfusion Injury.
  Manning, E, Pham, S, Li, S, Vazquez-Padron, R, Mathew, J, Ruiz, P, Salgar, S, Circulation; 118(18): S362-S362
• Stress Induced Senescence Exacerbates Post Injury Neointimal Formation.
  Khan, S, Wei, YT, Mateu, D, Pierre, MS, Fletcher, T, Pham, S, Vazquez-Padron, RI, Circulation; 118(18): S560-S560
• Aging increases oxidative stress-induced senescence during vascular remodeling.
  Khan, S, Wei, YT, Mateo, D, Li, S, Fletcher, T, Pham, S, Vazquez-Padron, R, Arteriosclerosis Thrombosis and Vascular Biology; 28(6): P621
• 392: Infection and Rejection Risk Using Induction with Interleukin II Receptor Blockers vs. Antithymocyte Globulin vs. No Induction: A Multi-Institutional Study.
  Pamboukian SV, Pham SM, Higgins RSD, Czerska B, Clemson BS, Kirklin JK, Brown RN, White-Williams C, J. Heart Lung Transplantation, 27:S202
• Donor Predictors of Successful Lung Recovery for Transplantation.
  Ganz SS, Gaynor JJ, Levi DM, Moon JI, Nishida S, Osorio M, Pham SM, American J. Transplantation, 7(Supplement 2):386
• Young bone marrow as opposed to aging bone marrow attenuates intimal formation promotes re-endothelialization and diminishes the inflammatory response associated with ...
  Calfa M., Vazquez-Padron RI, Li S, Salgar S, and Pham SM, Journal of Surgical Research; 137(2):209
• Endothelial layer restoration after vascular injury is delayed with aging bone marrow while the inflammatory response and intimal formation are increased.
  Calfa, M, Vazquez-Padron, R, Aitouche, A, Li, S, Pham, S, Journal of the American College of Cardiology; 49(9): 319A-319A
• Nicotine Activates p44/42 MAPK Signaling in Vascular Smooth Cells and Exacerbates Vascular Inflammation and Neointimal Formation after Vascular Injury.
  Vazquez-Padron RI, Wei Y, Mateo D, Hernandez M, Pestana I, Li S, Salgar S, Pham SM, Circulation Supplement II, 114(18):II-179
• Prolongation of allogenic skin graft survival by exogenous ubiquitin.
  Earle SA, Patel MB, Pham S, Majetschak M, Journal of Surgical Research; 130(2):273
• Aging exacerbates stress-induced senescence in vascular smooth muscle cells during vascular remodeling.
  Vazquez-Padron RI, Farji A, Aitouche A, Pham SM, Journal of Surgical Research; 130(2):313
• Therapeutic angiogenesis in critical limb ischemia via the localized delivery of BFGF from ionic hydrogels.
  Layman H, Li S, Pham SM, Andreopoulos FM, Journal of Surgical Research; 130(2):265
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Lectures

• Current Status in Lung Transplantation. 
  South Miami Hospital’s Annual Symposium on Cystic Fibrosis, Miami, FL
• Update in Cardiac Transplantation. 
  Medical Grand Rounds, St. Francis Hospital, Pittsburgh, PA
• Current Status on Lung Transplantation. 
  Surgical Grand Rounds, Western Pennsylvania Hospital, Pittsburgh, PA
• Simultaneous Infusion of Donor-Specific Bone Marrow and Heart Lung Transplantation. 
  Transplantation Grand Rounds, University of Pittsburgh, School of Medicine, Pittsburgh, PA
• New Immunosuppressive Agents in Heart Transplantation. 
  Temple University Hospital, Philadelphia, PA
• Outcome in Heart Transplantation. State of the Art Treatment of Ischemic Heart Disease. 
  University of Pittsburgh Medical Center. Station Square, Pittsburgh, PA
• Tacrolimus in Clinical Heart Transplantation. 
  Cleveland Clinic Foundation, Cleveland, OH, 1995
• Chimerism in Thoracic Organ Transplantation. 
  Buffalo General Hospital, Buffalo, NY
• Chimerism in Thoracic Organ Transplant Recipient. 
  Pittsburgh Transplantation Institute Conference, 1996. Pittsburgh, PA
• Induction of Donor-Specific Transplantation Tolerance by Intrathymic Inoculation of Donor Cells: Experimental and Clinical Studies. 
  Children's Hospital of Pittsburgh, Pittsburgh, PA
• Ventricular Assist Device as a Bridge to Cardiac Transplantation. 
  Thomas E. Starzl Transplantation Institute Conference, Pittsburgh, PA
• Novel Approaches to Prevent Acute and Chronic Rejection in Organ Allografts. 
  Institute of Cellular Therapeutics, Allegheny University of the Health Sciences, Philadelphia, PA
• Ex-Vivo Donor Manipulation Results of Inducible Nitric Oxide Synthase Gene Transfection. 
  1st Annual Fall Education Meeting on Coronary Allograft Vasculopathy, Washington D.C
• Novel Approaches to Prevent Rejection in Transplanted Hearts. 
  University of Pittsburgh, School of Medicine, Division of Cardiology, Cardiovascular Research Confer
• Induction of Donor-Specific Transplantation Tolerance by Intrathymic Inoculation of Donor Cells. 
  University of Pittsburgh, School of Medicine, Department of Pathology Research Conference, Pittsburg
• Update in Heart, Lung Transplantation and Ventricular Assist Devices. 
  Grand Round Celebration of 40 years of Excellence; Miami Transplant Institute, Miami, Florida
• Heart Transplant. 
  Pediatrics Grand Rounds. University of Miami School of Medicine. Miami, FL
• Cardiothoracic Diseases. 
  Transplant Forum 2000. Florida International University. Miami, FL
• Management of the Pediatric Patient Post-Transplant: Diagnosis and Management of Rejection and Other Complications. 
  IX Congress of the Latin Society of Pediatric Cardiology and Cardiovascular Surgery. Key Biscayne,
• Approaches to Induce Long-Term Acceptance to Transplant Organs. 
  Research Seminar. Institute for Cellular Therapeutics. Louisville, KY
• Induction of Tolerance to Lung Allografts. 
  Research Seminar. Division of Pulmonary Medicine, University of Miami School of Medicine. Miami, F
• Current Status of Heart Transplantation. 
  Grand Rounds at Holy Cross Hospital, Fort Lauderdale, FL
• Intraabdominal Malignancies after Thoracic Transplantation and the Incidence, Treatment and Outcome. 
  American College of Surgeons 89th Annual Clinical Congress. Chicago, IL
• Current Status of Heart and Lung Transplantation. 
  South Miami Hospital, Miami, FL
• Recent Advances in Heart Transplantation. 
  Scientific Forum XV-International Congress of Cardiovascular Sciences, Rio de Janeiro, Brazil
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