SiddiqueAbbasiMDMSc

PubMed

• 1 citations
  The Effect of Omecamtiv Mecarbil in Hospitalized Patients as Compared With Outpatients With HFrEF: An Analysis of GALACTIC-HF.
  Kieran F Docherty, John J V McMurray, Rafael Diaz, G Michael Felker, Marco Metra, Scott D Solomon, Kirkwood F Adams, Michael Böhm, Douglas Marshall Brinkley, Luis E Ec...> ;Journal of Cardiac Failure. 2024 Jan 1
• 31 citations
  Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE.
  Prakriti Gaba, Michelle L O'Donoghue, Jeong-Gun Park, Stephen D Wiviott, Dan Atar, Julia F Kuder, KyungAh Im, Sabina A Murphy, Gaetano M De Ferrari, Zbigniew A Gaciong...> ;Circulation. 2023 Apr 18
• 13 citations
  Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial.
  Marco Metra, Matteo Pagnesi, Brian L Claggett, Rafael Díaz, G Michael Felker, John J V McMurray, Scott D Solomon, Diana Bonderman, James C Fang, Cândida Fonseca, Eva G...> ;European Heart Journal. 2022 Dec 21
• 85 citations
  Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease.
  Michelle L O'Donoghue, Robert P Giugliano, Stephen D Wiviott, Dan Atar, Anthony Keech, Julia F Kuder, KyungAh Im, Sabina A Murphy, Jose H Flores-Arredondo, J Antonio G...> ;Circulation. 2022 Oct 11
• 7 citations
  A First-in-Human Study of AMG 986, a Novel Apelin Receptor Agonist, in Healthy Subjects and Heart Failure Patients.
  Peter Winkle, Steven Goldsmith, Michael J Koren, Serge Lepage, Jennifer Hellawell, Ashit Trivedi, Kate Tsirtsonis, Siddique A Abbasi, Allegra Kaufman, Richard Troughto...> ;Cardiovascular Drugs and Therapy. 2023 Aug 1
• 46 citations
  Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial.
  G. Michael Felker, Scott D. Solomon, Brian Claggett, Rafael Diaz, John J.V. McMurray, Marco Metra, Inder S. Anand, Marisa G. Crespo-Leiro, Ulf Dahlström, Eva Goncalves...> ;JAMA Cardiology. 2021 Oct 13
• 2 citations
  Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Amiodarone and Digoxin in Healthy Subjects.
  Ashit Trivedi, Winnie Sohn, Cheng-Pang Hsu, Pegah Jafarinasabian, Hanze Zhang, Shauna Hutton, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacology in Drug Development. 2021 Oct 11
• Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects
  Ashit Trivedi, Fady I. Malik, Mia Mackowski, Shauna Hutton, Makoto Aoki, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;European Journal of Drug Metabolism and Pharmacokinetics. 2021 Aug 20
• 4 citations
  Evaluation of drug-drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a phys...
  Ashit Trivedi, Winnie Sohn, Priyanka Kulkarni, Pegah Jafarinasabian, Hanze Zhang, Marintan Spring, Stephen Flach, Siddique Abbasi, Jan Wahlstrom, Edward Lee, Sandeep D...> ;Clinical and Translational Science. 2021 Aug 20
• 2 citations
  Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects
  Ashit Trivedi, Winnie Sohn, Pegah Jafarinasabian, Hanze Zhang, Bianca Terminello, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacology in Drug Development. 2021 Jul 16
• 4 citations
  Pharmacokinetic Evaluation of the CYP3A4 and CYP2D6 Drug-Drug Interaction and CYP3A4 Induction Potential of Omecamtiv Mecarbil: Two Open-Label Studies in Healthy Subje...
  Ashit Trivedi, Fady I. Malik, Pegah Jafarinasabian, Hanze Zhang, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacology in Drug Development. 2021 Jun 19
• Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
  Ashit Trivedi, Cheng-Pang Hsu, Pegah Jafarinasabian, Bianca Terminello, Hanze Zhang, Stephen Flach, Samuel Israel, Ashley Brooks, Hongqi Xue, Borje Darpo, Siddique Abb...> ;British Journal of Clinical Pharmacology. 2021 Jul 16
• 5 citations
  Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
  Ashit Trivedi, Rajneet K. Oberoi, Mia Mackowski, Pegah Jafarinasabian, Hanze Zhang, Stephen Flach, Shauna Hutton, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacology in Drug Development. 2021 Jun 9
• 3 citations
  Effect of Omecamtiv Mecarbil on the Pharmacokinetics of Metformin, a Probe Substrate for MATE1/MATE2-K, in Healthy Subjects
  Ashit Trivedi, Rajneet K. Oberoi, Pegah Jafarinasabian, Hanze Zhang, Marintan Spring, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Drug Investigation. 2021 Jun 7
• 6 citations
  Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator.
  Ashit Trivedi, Rajneet K. Oberoi, Mia Mackowski, Pegah Jafarinasabian, Hanze Zhang, Stephen Flach, Mary Ann Simiens, Bianca Terminello, Siddique Abbasi, Sandeep Dutta,...> ;Biopharmaceutics & Drug Disposition. 2021 Jun 4
• 53 citations
  Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF
  John R. Teerlink, Rafael Diaz, G. Michael Felker, John J.V. McMurray, Marco Metra, Scott D. Solomon, Tor Biering-Sørensen, Michael Böhm, Diana Bonderman, James C. Fang...> ;Journal of the American College of Cardiology. 2021 Jul 13
• 12 citations
  Effect of Varying Degrees of Renal Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
  Ashit Trivedi, Rajneet K. Oberoi, Pegah Jafarinasabian, Hanze Zhang, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee> ;Clinical Pharmacokinetics. 2021 Mar 26
• 302 citations
  Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
  John R. Teerlink, Rafael Diaz, G. Michael Felker, John J.V. McMurray, Marco Metra, Scott D. Solomon, Kirkwood F. Adams, Inder S. Anand, Alexandra Arias-Mendoza, Tor Bi...> ;The New England Journal of Medicine. 2021 Jan 14
• 18 citations
  The impact of heart failure on patients and caregivers: A qualitative study.
  Colleen A. McHorney, Sonal G. Mansukhani, Milena D. Anatchkova, Natalie Taylor, Heidi S. Wirtz, Siddique Abbasi, Lynwood Battle, Nihar R. Desai> ;Plos One. 2021 Mar 11
• 8 citations
  Cardiac Myosin Activator Omecamtiv Mecarbil Improves Left Ventricular Myocardial Deformation in Chronic Heart Failure: The COSMIC-HF Trial.
  Tor Biering-Sørensen, Masatoshi Minamisawa, Brian Claggett, Jiankang Liu, G. Michael Felker, John J.V. McMurray, Fady I. Malik, Siddique Abbasi, Christopher E. Kurtz, ...> ;Circulation. Heart Failure. 2020 Nov 12
• 7 citations
  Effects of Omecamtiv Mecarbil on Symptoms and Health-Related Quality of Life in Patients With Chronic Heart Failure: Results From the COSMIC-HF Study.
  G. Michael Felker, Scott D. Solomon, John J.V. McMurray, John G.F. Cleland, Siddique Abbasi, Fady I. Malik, Hanze Zhang, John R. Teerlink> ;Circulation. Heart Failure. 2020 Nov 12
• 1 citations
  Association of plasma adiponectin with pulmonary hypertension, mortality and heart failure in African Americans: Jackson Heart Study.
  Suvasini Lakshmanan, Matthew D. Jankowich, Wen-Chih Wu, Siddique Abbasi, Alan R. Morrison, Gaurav Choudhary> ;Pulmonary Circulation. 2020 Nov 11
• 43 citations
  Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction: GALACTIC-HF baseline characteristics and comparison with contemporary clinical trials.
  John R. Teerlink, Rafael Diaz, G. Michael Felker, John J.V. McMurray, Marco Metra, Scott D. Solomon, Kirkwood F. Adams, Inder S. Anand, Alexandra Arias-Mendoza, Tor Bi...> ;European Journal of Heart Failure. 2020 Nov 1
• 5 citations
  Gender Differences in Risk Factors Associated With Pulmonary Artery Systolic Pressure, Heart Failure, and Mortality in Blacks: Jackson Heart Study.
  Suvasini Lakshmanan, Matthew D. Jankowich, Wen-Chih Wu, Chad Blackshear, Siddique Abbasi, Gaurav Choudhary> ;Journal of the American Heart Association. 2020 Jan 7
• 6 citations
  Right Ventricular Fibrosis Is Related to Pulmonary Artery Stiffness in Pulmonary Hypertension: A Cardiac Magnetic Resonance Imaging Study.
  Matthew D. Jankowich, Siddique Abbasi, Alexander Vang, Gaurav Choudhary> ;American Journal of Respiratory and Critical Care Medicine. 2019 Sep 13
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Journal Articles

• Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure  
  John R Teerlink, David E Lanfear, Thomas M Suter, Narimon Honarpour, Siddique A Abbasi, Fady I Malik, Christopher E Kurtz, The New England Journal of Medicine