1275 York AvenueNew York, NY 10065
Overview of Dr. Powell
Dr. Simon Powell is a radiation oncologist based in New York, NY, specializing in breast cancer and translational research. He has been the Department Chair at Memorial Sloan Kettering (MSK) Radiation Oncology since 2008. A graduate of University College London Medical School (Class of 1981), Dr. Powell is actively involved in basic and clinical research and has contributed many publications in high-profile and oncology-focused journals. He has been funded by NIH research grants since 1992 and his principal investigator of the MSK Breast Cancer SPORE. His recent clinical trials focus on the use of DNA repair inhibitors with radiation; breast cancer radiotherapy studies and oligometastatic disease trials of radiotherapy.
Education & Training
Mass General Brigham/Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Radiation Oncology, 1991 - 1993
Royal Free Hospital and University College London Medical SchoolClass of 1981
Certifications & Licensure
FL State Medical License 2023 - Present
NY State Medical License 2008 - 2028
NJ State Medical License 2020 - 2027
MA State Medical License 1993 - 2006
American Board of Radiology Radiation Oncology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification Sunrise Ambulatory Care, Allscripts, 2016-2017
- CMS Meaningful Use Stage 1 Certification MyMSK, Memorial Sloan Kettering, 2016-2017
Clinical Trials
- Multi-Beam Intensity-Modulated Radiation Therapy for Node-Positive Breast Cancer Start of enrollment: 2010 May 11
- Partial Breast Irradiation (PBI) Using 40 Gy for Select Patients With Early Invasive or Noninvasive Breast Cancer
- Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer Start of enrollment: 2019 Aug 30
Publications & Presentations
PubMed
- Patient selection and toxicity predictors in proton reirradiation for locoregional breast cancer recurrence.Molly A Chakraborty, Charlie White, Atif J Khan, Siyu Yang, Zhigang Zhang
Clinical and Translational Radiation Oncology. 2026-09-01 - LIG1 Loss in TP53-mutant Triple Negative Breast Cancer Rewires DNA Repair and Confers Sensitivity to PARP-ATR Inhibitor Combinations.Anh Minh Tran Huynh, Jonathan T Lei, Rachel Brough, Christina Sallas, Jun Xu
Molecular Cancer Therapeutics. 2026-07-15 - Oncotype DX™ Recurrence Score (RS) in Very Small Tumors: Does RS Influence Clinical Outcome?Atif J Khan, Olufela Koleoso, Charlie White, Fiona Ehrich, Anne Grabenstetter
International Journal of Radiation Oncology, Biology, Physics. 2026-05-09
Press Mentions
Novavax CFO Greg Covino Makes a Quick Exit as Leadership Carousel Keeps Turning; Kite Execs Fly Away to a Cell Therapy Upstart Teaming up with LyellApril 16th, 2021- Chutes & Ladders—Lilly, Bidding Adieu to Shah, Lines up Apple Exec as CDOApril 15th, 2021
- For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising TreatmentDecember 1st, 2020
Grant Support
- MSK Paul Calabresi Career Development Award for Clinical OncologySLOAN-KETTERING INST CAN RESEARCH2015–2030
- Backup DNA repair in homologous recombination deficient cancersSLOAN-KETTERING INST CAN RESEARCH2024–2029
- MSK SPORE in Genomic Instability in Breast CancerSLOAN-KETTERING INST CAN RESEARCH2020–2026
- DNA Recombinational Repair: Role Of The P53 Tumor Suppressor ProteinNational Cancer Institute2008–2010
- Roles Of BRCA1, BRCA2 In Homologous RecombinationNational Cancer Institute2008
Insurance Accepted
- Aetna Choice POS II
Aetna HMO
BCBS Blue Card PPO
BCBS Texas BlueChoice
Blue Shield California PPO
CIGNA HMO
CIGNA Open Access
CIGNA PPO
First Health PPO
GHI PPO
Great West PPOHealth Net California Large Group PPO
Multiplan PHCS PPO
Multiplan PPO
MVP Healthcare PPO
Oxford Health Freedom
Oxford Health Liberty
QualCare HMO
QualCare PPO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO - Please verify your coverage with the provider's office directly when scheduling an appointment
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