SophiaKAppleMDMS

Pathology • Pasadena, CA

Cytopathology, Anatomic Pathology, Clinical Pathology

Emerita Professor, Pathology & Laboratory Medicine, UCLA School of Medicine

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Office
Pathology
100 West California Ave
Pasadena, CA 91109
Phone+1 626-397-8616
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Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Cytopathology, 1997 - 1998
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Pathology-Anatomic and Clinical, 1992 - 1997
Wright State University Boonshoft School of MedicineClass of 1992

Certifications & Licensure

CA State Medical License 1993 - 2025
American Board of Pathology Anatomic Pathology & Clinical Pathology
American Board of Pathology Cytopathology

Publications & Presentations

PubMed

4 citations
Quantitative Impact of the 2018 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Practice Guideline Update on Human Epidermal Growth...
Christina Hsiao Wei, Lino Garcia, Joyce Murata-Collins, Daniel Schmolze, Sophia Apple> ;Archives of Pathology & Laboratory Medicine. 2021 Jul 1
16 citations
Clinicopathological and Prognostic Significance of Programmed Death Ligand 1 Expression in Korean Patients With Triple-negative Breast Carcinoma.
Hyun Soo Kim, Sung-Im Do, Dong-Hoon Kim, Sophia Apple> ;Anticancer Research. 2020 Mar 1
Clinical vs genomic risks in breast cancer in 2019: Breast pathologist's appellate review of the controversial results from TAILORx trial.
Christina H. Wei, Robert B. West, Daniel Schmolze, Sophia K. Apple> ;The Breast Journal. 2020 Feb 20
30 citations
CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer.
Xinyu Deng, Sophia K. Apple, Hong Zhao, Jeongyoon Song, Minna Lee, William Y. Luo, Xiancheng Wu, Debra U. Chung, Richard J. Pietras, Helena R. Chang> ;Oncotarget. 2017 Mar 15
15 citations
Systematic assessment of HER2/ neu in gynecologic neoplasms, an institutional experience
Jennifer S. Woo, Sophia K. Apple, Peggy S. Sullivan, Jianyu Rao, Nora Ostrzega, Neda A. Moatamed> ;Diagnostic Pathology. 2016 Oct 22
73 citations
Upgrade rates of high-risk breast lesions diagnosed on core needle biopsy: a single-institution experience and literature review
Kelly L. Mooney, Lawrence W. Bassett, Sophia K. Apple> ;Modern Pathology. 2016 Aug 19
25 citations
Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist’s Point of View
Sophia K. Apple> ;Journal of Pathology and Translational Medicine. 2016 Jan 12
237 citations
Phyllodes tumours of the breast: a consensus review
Benjamin Y. Tan, Geza Acs, Sophia K. Apple, Sunil S. Badve, Ira J. Bleiweiss, Edi Brogi, José P. Calvo, David J. Dabbs, Ian O. Ellis, Vincenzo Eusebi, Gelareh Farshid,...> ;Histopathology. 2016 Jan 1
10 citations
“Score the Core” Web-based pathologist training tool improves the accuracy of breast cancer IHC4 scoring
Jesse A. Engelberg, Hanna Retallack, Ronald Balassanian, Mitchell Dowsett, Lila Zabaglo, Arishneel A. Ram, Sophia K. Apple, John W. Bishop, Alexander D. Borowsky, Phil...> ;Human Pathology. 2015 Nov 1
8 citations
A quality initiative of postoperative radiographic imaging performed on mastectomy specimens to reduce histology cost and pathology report turnaround time
Michael E. Kallen, Myung Sim, Bryan Radosavcev, Romney M. Humphries, D. Ward, Sophia K. Apple> ;Annals of Diagnostic Pathology. 2015 Oct 1
17 citations
The Effect of Young Age in Hormone Receptor Positive Breast Cancer.
Minna K. Lee, Leo A. Varzi, Debra U. Chung, Minh-an Cao, Jeffrey Gornbein, Sophia K. Apple, Helena R. Chang> ;Biomed Research International. 2015 Aug 16
7 citations
Cytokeratin 7 negative invasive breast carcinoma: clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.
Neda A. Moatamed, Annie Wu, Khaled Sarah, Sophia K. Apple> ;Journal of Clinical Pathology. 2015 Jun 1
20 citations
Predictors for contralateral prophylactic mastectomy in breast cancer patients.
Yun Fu, Zhi-gang Zhuang, Michelle Dewing, Sophia K. Apple, Helena R. Chang> ;International Journal of Clinical and Experimental Pathology. 2015 Apr 1
1 citations
Recurrence Rates in Breast Cancer Patients Who Had Sentinel Lymph Node Biopsy Alone Versus Completion Axillary Lymph Node Dissection: A 7-Year Clinical Follow-Up Study
Maria E. Vergara-Lluri, Raquel Prati, Jeffrey Petersen, Yasaman Omidvar, Sophia K. Apple> ;The Breast Journal. 2014 Nov 1
Ductal carcinoma in-situ arising in a complex sclerosing lesion with secretory endometrium-like changes.
Ashhad Mahmood, Sophia K. Apple> ;The Breast Journal. 2014 Sep 1
7 citations
Comparative Evaluation of ProEx C and ImmunoCyt/uCyt Assays in Atypical Urine Cytology
Maria E. Vergara-Lluri, Eugenia Hu, Jianyu Rao, Mary Levin, Sophia Kim Apple, Neda A. Moatamed> ;Archives of Pathology & Laboratory Medicine. 2014 Aug 29
30 citations
Is Axillary Lymph Node Dissection Necessary After Sentinel Lymph Node Biopsy in Patients with Mastectomy and Pathological N1 Breast Cancer
Yun Fu, Debra U. Chung, Minh-an Cao, Sophia K. Apple, Helena R. Chang> ;Annals of Surgical Oncology. 2014 Aug 1
67 citations
The impact of atypia/follicular lesion of undetermined significance and repeat fine-needle aspiration: 5 years before and after implementation of the Bethesda System
Peggy S. Sullivan, Sharon L. Hirschowitz, Po Chu Fung, Sophia K. Apple> ;Cancer Cytopathology. 2014 Dec 1
23 citations
A pregnant dilemma: primary hyperparathyroidism due to parathyromatosis in pregnancy.
Kari L. Edling, Stanley G. Korenman, Carla Janzen, Marie Sohsman, Sophia K. Apple, Sunita Bhuta, Michael W. Yeh> ;Endocrine Practice. 2014 Feb 1
5 citations
Utility of ProEx C in the histologic evaluation of the neoplastic and nonneoplastic urothelial lesions.
Neda A. Moatamed, Maria E. Vergara-Lluri, David S.K. Lu, Sophia K. Apple, Susan Kerkoutian, Jianyu Rao> ;Human Pathology. 2013 Nov 1
12 citations
ProEx C as an adjunct marker to improve cytological detection of urothelial carcinoma in urinary specimens.
Neda A. Moatamed, Jianyu Rao, Serge Alexanian, Melissa Cobarrubias, Mary Levin, David S.K. Lu, Sophia K. Apple> ;Cancer Cytopathology. 2013 Jun 1
7 citations
In Papanicolaou smears, benign appearing endometrial cells bear no significance in predicting uterine endometrial adenocarcinomas
Neda A. Moatamed, Lam-Thuy Le, Mary Levin, Rekha Govind, Sophia K. Apple> ;Diagnostic Cytopathology. 2013 Apr 1
10 citations
Exclusion of the uniform tetraploid cells significantly improves specificity of the urine fish assay
Neda A. Moatamed, Sophia K. Apple, Carol J. Bennett, William J. Aronson, Ivana Klisak, Bobbi-Jo Shirley, Farhad Moatamed> ;Diagnostic Cytopathology. 2013 Mar 1
1 citations
Uterine leiomyosarcoma presenting as breast metastasis.
Yvonne S Noronha, Sophia K Apple> ;The Breast Journal. 2013 Jan 1
34 citations
High concordance between HercepTest immunohistochemistry and ERBB2 fluorescence in situ hybridization before and after implementation of American Society of Clinical O...
Maria E. Vergara-Lluri, Neda A. Moatamed, Elizabeth E. Hong, Sophia K. Apple> ;Modern Pathology. 2012 Jun 15
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Authored Content

Who says you have breast cancer? The unseen doctorsJuly 2022
COVID-19: Gripping novel inspired by real eventsJuly 2020
Forgive to LiveJanuary 2022

Press Mentions

The Unseen life of a pathologistMay 11th, 2022

Hospital Affiliations

Huntington HealthPasadena, California

External Links

The Unseen Doctorhttps://doctorsophiaonline.com
People in Pathologyhttps://podcasts.apple.com/us/podcast/people-of-pathology-podcast/id1490210201?i=1000587667165