
Stanley Leon Hazen MD
Endocrinology
Professor, Molecular Medicine, Case Western Reserve University School of Medicine. Preventative Cardiology
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9500 Euclid Ave# Jb1Cleveland, OH 44195
Phone+1 800-223-2273
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Summary
- Dr. Hazen, based in Cleveland Ohio, is an elected fellow to the National Academy of Medicine, USA. He also is an elected fellow of the American Association for the Advancement of Science, and an elected member of the American Association of Physicians.
Dr. Hazen ranks among the top 0.05% most cited investigators worldwide (H-index 163; citations >175,000) and has published >500 articles in basic and clinical journals alike in the fields of cardiovascular disease (CVD), lipid metabolism and inflammation. He has made pioneering discoveries in mechanisms contributing to cardiovascular and inflammatory diseases, including fundamental studies linking defined oxidation pathways to CVD risk, diagnostics and therapeutics. He made the seminal discovery linking gut microbial pathways to CVD pathogenesis; and in recent studies identified sugar alcohols as clinical and mechanistic contributors to heightened thrombosis and adverse CVD events. His research in multiple areas has impacted clinical practice, and lays the foundation for both FDA- and EU-cleared diagnostic tests for CVD risk assessment in use worldwide. His research has also helped to spawn pharmaceutical development of CVD drugs in clinical trials.
Education & Training
- Washington University/B-JH/SLCH ConsortiumFellowship, Endocrinology, Diabetes, and Metabolism, 1994 - 1996
- Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1992 - 1994
- Washington University in St. Louis School of MedicineClass of 1992
Certifications & Licensure
- OH State Medical License 1997 - 2026
Awards, Honors, & Recognition
- Elected Fellow National Academy of Medicine, 2016
- Election, Fellow American Association for the Advancement of Science (AAAS), 2008
- Election, Fellow Association of American Physicians, 2007
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Clinical Trials
Publications & Presentations
PubMed
- Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis.Vanasa Nageswaran, Alba Carreras, Leander Reinshagen, Katharina R Beck, Jakob Steinfeldt
Arteriosclerosis, Thrombosis, and Vascular Biology. 2025-05-01 - NADboosting increases atherosclerotic plaques and inflammation in Apoe knockout mice.Yu-Jen Wang, Daniel S Gaul, Era Gorica, Jürgen Pahla, Zeneng Wang
Atherosclerosis. 2025-05-01 - Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes.Hao Wu, Bomin Lv, Luqian Zhi, Yikai Shao, Xinyan Liu
Nature Medicine. 2025-04-08
Journal Articles
- Dietary Metabolism, the Gut Microbiome, and Heart FailureStanley L Hazen, Daniel Y Li, Nature
- Development of a Gut Microbe–Targeted Nonlethal Therapeutic to Inhibit Thrombosis PotentialStanley Hazen, MD, Nature
- Elevated Levels of Plasma Symmetric Dimethylarginine and Increased Arginase Activity as Potential Indicators of Cardiovascular Comorbidity in Rheumatoid ArthritisStanley Hazen, MD, BioMed Central
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Press Mentions
- Medical Minute: Long-Term Heart Risks from COVID-19March 18th, 2025
- Xylitol Linked to Increased Blood Clot RiskMarch 11th, 2025
- Unexpected Aftermath: The COVID HeartFebruary 4th, 2025
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Grant Support
- Artificial sweeteners and cardiovascular diseaseCLEVELAND CLINIC LERNER COM-CWRU2025–2028
- Nutrition, terminal NAD metabolites and cardiovascular diseaseCLEVELAND CLINIC LERNER COM-CWRU2024–2028
- Aromatic Amino Acids, Microbiome-Generated Metabolites, and Incident Subclinical and Clinical CVD and MortalityTUFTS UNIVERSITY BOSTON2017–2028
- Gut microbial dietary phenylalanine metabolism and heart failureCLEVELAND CLINIC LERNER COM-CWRU2024–2027
- Gut microbial dietary phenylalanine metabolism and heart failureCLEVELAND CLINIC LERNER COM-CWRU2024–2027
- Gut Microbiota and Cardiometabolic DiseasesCLEVELAND CLINIC LERNER COM-CWRU2019–2025
- Gut Flora metabolism of dietary carnitine and cardiovascular diseaseCLEVELAND CLINIC LERNER COM-CWRU2010–2025
Professional Memberships
- Member
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