StephenSGrubbsMD

Practicing Oncologist and the managing partner of Medical Oncology Hematology Consultants, PA, located at Christiana Care's Helen F. Graham Cancer Center. Principal Investigator for Christiana Care's Community Clinical Oncology Program

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Office
4701 Ogletown Stanton Rd
Suite 2200
Newark, DE 19713
Phone+1 302-366-1200

Fax+1 302-366-1700
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Summary

Dr. Stephen Grubbs, MD is an oncologist in Newark, Delaware. He is currently licensed to practice medicine in Delaware, New Jersey, and Vermont. He is affiliated with ChristianaCare and is a Practicing Oncologist and the managing partner of Medical Oncology Hematology Consultants at located at Christiana Care's Helen F. Graham Cancer Center. Principal Investigator for Christiana Care's Community Clinical Oncology Program.

Education & Training

Dartmouth-Hitchcock/Mary Hitchcock Memorial HospitalFellowship, Hematology and Medical Oncology, 1982 - 1984
Sidney Kimmel Medical College at Thomas Jefferson University/Christiana Care Health ServicesResidency, Internal Medicine, 1979 - 1982
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 1979

Certifications & Licensure

DE State Medical License 1980 - 2025
VT State Medical License 1983 - 2016
NJ State Medical License 1984 - 2005
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia Start of enrollment: 1999 Apr 01
Active, not recruiting
Rituximab and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphoma Start of enrollment: 2005 May 01
Completed
Phase 3
Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Start of enrollment: 2005 Nov 01
Completed
Phase 3
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Start of enrollment: 2006 Jun 01
Completed
Phase 3
Combination Chemotherapy and Cetuximab in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer Start of enrollment: 2006 Sep 15
Completed
Phase 2
Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer Start of enrollment: 2007 May 08
Active, not recruiting
Phase 3
Cisplatin or Carboplatin, and Etoposide With or Without Sunitinib Malate in Treating Patients With Extensive-Stage Small Cell Lung Cancer Start of enrollment: 2007 Mar 15
Completed
Phase 1, Phase 2
L-Arginine Supplements in Treating Women Who Are Cancer Survivors Start of enrollment: 2007 May 01
Completed
Not Applicable
S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia Start of enrollment: 2007 Nov 15
Completed
Phase 2
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery Start of enrollment: 2008 Mar 01
Completed
Phase 2
Bortezomib and Lenalidomide in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma Start of enrollment: 2007 Nov 15
Completed
Phase 2
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2008 Mar 12
Active, not recruiting
Phase 2
Octreotide Acetate and Recombinant Interferon Alfa-2b or Bevacizumab in Treating Patients With Metastatic or Locally Advanced, High-Risk Neuroendocrine Tumor Start of enrollment: 2007 Dec 01
Active, not recruiting
Phase 3
Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage IIIB or Stage IV Breast Cancer Start of enrollment: 2008 May 15
Active, not recruiting
Phase 3
Fludarabine and Rituximab With or Without Lenalidomide or Cyclophosphamide in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia Start of enrollment: 2008 Jan 15
Completed
Phase 2
Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide Start of enrollment: 2008 Mar 01
Active, not recruiting
Phase 3
Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma Start of enrollment: 2008 Apr 01
Active, not recruiting
Phase 3
Sunitinib Malate as Maintenance Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Previously Treated With Combination Chemotherapy Start of enrollment: 2008 Jun 15
Completed
Phase 3
Pemetrexed and/or Sunitinib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer Start of enrollment: 2008 Apr 15
Completed
Phase 2
Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer Start of enrollment: 2008 Oct 13
Completed
Phase 3
S0809: Capecitabine, Gemcitabine, and RT in Patients w/Cholangiocarcinoma of the Gallbladder or Bile Duct Start of enrollment: 2008 Dec 01
Completed
Phase 2
S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma Start of enrollment: 2009 Jul 01
Completed
Phase 2
Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed by Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery Start of enrollment: 2009 May 15
Active, not recruiting
Phase 2
S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases Start of enrollment: 2008 Dec 01
Completed
Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia Start of enrollment: 2008 Jun 01
Active, not recruiting
Statins and Breast Cancer Biomarkers Start of enrollment: 2005 Jan 01
Unknown status
Phase 2
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Start of enrollment: 2009 Jul 15
Completed
Phase 3
S0819: Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer Start of enrollment: 2009 Jul 15
Terminated
Phase 3
Study of Biomarkers in Blood and Bone Marrow Samples From Patients With Previously Untreated Chronic Lymphocytic Leukemia Start of enrollment: 2009 Oct 01
Completed
Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer Start of enrollment: 2010 Feb 15
Completed
Phase 3
Pemetrexed Disodium/Observation in Treating Patients W/ Malignant Pleural Mesothelioma w/Out Progressive Disease After 1st Line Chemotherapy Start of enrollment: 2010 Apr 01
Completed
Phase 2
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Start of enrollment: 2010 Jun 01
Completed
Phase 3
S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery Start of enrollment: 2011 Apr 01
Active, not recruiting
Phase 3
Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin Lymphoma Start of enrollment: 2010 May 01
Completed
Phase 2
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Start of enrollment: 2010 Jun 01
Active, not recruiting
Phase 3
Ofatumumab in Treating Patients With Previously Untreated Stage II, Stage III, or Stage IV Follicular Non-Hodgkin Lymphoma Start of enrollment: 2011 Aug 01
Completed
Phase 2
Everolimus With or Without Bevacizumab in Treating Patients With Advanced Kidney Cancer That Progressed After First-Line Therapy Start of enrollment: 2010 Sep 15
Terminated
Phase 3
Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by Surgery Start of enrollment: 2010 Oct 15
Completed
Phase 2
Diet in Altering Disease Progression in Patients With Prostate Cancer on Active Surveillance Start of enrollment: 2011 Jan 01
Completed
Phase 3
Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2010 Dec 14
Completed
Phase 2
Sorafenib Tosylate and Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia Start of enrollment: 2011 Apr 01
Completed
Phase 2
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer Start of enrollment: 2011 Jan 01
Terminated
Phase 3
PET Scan Imaging in Assessing Response in Patients With Esophageal Cancer Receiving Combination Chemotherapy Start of enrollment: 2011 Jul 01
Completed
Phase 2
S0820, Adenoma and Second Primary Prevention Trial Start of enrollment: 2013 Aug 23
Active, not recruiting
Phase 3
Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia Start of enrollment: 2011 Nov 16
Completed
Phase 2
Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma Start of enrollment: 2011 Oct 01
Completed
Phase 2
S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer Start of enrollment: 2012 Feb 01
Completed
Phase 2
PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery Start of enrollment: 2012 Jun 12
Active, not recruiting
Phase 2, Phase 3
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
Active, not recruiting
Phase 3
Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma Start of enrollment: 2013 Jun 01
Completed
Phase 3
Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by Surgery Start of enrollment: 2013 Jul 31
Completed
Phase 2
Cabozantinib-s-malate or Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer Start of enrollment: 2013 Jul 08
Completed
Phase 2
Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia Start of enrollment: 2013 Dec 09
Active, not recruiting
Phase 3
Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Start of enrollment: 2014 Feb 20
Active, not recruiting
Phase 3
Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis Start of enrollment: 2014 Mar 21
Completed
Phase 3
Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic Start of enrollment: 2014 Mar 29
Active, not recruiting
Phase 3
Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Jul 08
Completed
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Publications & Presentations

PubMed

1 citations
Phase II study of carboplatin, pemetrexed, and bevacizumab in advanced nonsquamous non-small-cell lung cancer.
Nicole F. Laslett, SuJung Park, Gregory A. Masters, David D. Biggs, Charles J. Schneider, Jamal Misleh, Kathir Suppiah, Pamela S. Simpson, Stephen S. Grubbs, Timothy F...> ;Cancer Medicine. 2018 Jun 14
A New Look at the State of Cancer Care in America.
Blase N. Polite, Laura A. Levit, M. Kelsey Kirkwood, Caroline Schenkel, Suanna S. Bruinooge, Stephen S. Grubbs, Deborah Y. Kamin, Richard L. Schilsky, Jerome E Seid> ;Journal of Oncology Practice. 2018 Jun 15
42 citations
Cost-Effectiveness Analysis of Monthly Zoledronic Acid, Zoledronic Acid Every 3 Months, and Monthly Denosumab in Women With Breast Cancer and Skeletal Metastases: CALG...
Charles L. Shapiro, James P. Moriarty, Stacie B. Dusetzina, Andrew L. Himelstein, Jared C. Foster, Stephen S. Grubbs, Paul J. Novotny, Bijan J. Borah> ;Journal of Clinical Oncology. 2017 Oct 12
1 citations
Making sense of advanced payment models.
Barbara L. McAneny, Stephen Grubbs, Walter Birch, Dan Sayam Zuckerman> ;The American Journal of Managed Care. 2017 Apr 19
212 citations
Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial.
Andrew L. Himelstein, Jared C. Foster, James L. Khatcheressian, John D. Roberts, Drew K. Seisler, Paul J. Novotny, Rui Qin, Ronald S. Go, Stephen Grubbs, Tracey O'Conn...> ;JAMA. 2017 Jan 3
Reply to P.B. Bach.
Blase N. Polite, Deborah Y. Kamin, Stephen Grubbs> ;Journal of Clinical Oncology. 2016 Oct 3
6 citations
Clinical Trial Assessment of Infrastructure Matrix Tool to Improve the Quality of Research Conduct in the Community.
Eileen P. Dimond, Robin Zon, Bryan J. Weiner, Diane St. Germain, Andrea M. Denicoff, Kandie Dempsey, Angela C. Carrigan, Randall Teal, Marjorie J. Good, Worta McCaskil...> ;Journal of Oncology Practice. 2016 Jan 1
14 citations
Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.
Thu P. Huynh, Sonali P. Barwe, Seung Joon Lee, Ryan P. McSpadden, Omar E. Franco, Simon W. Hayward, Robert Damoiseaux, Stephen S. Grubbs, Nicholas J. Petrelli, Ayyappa...> ;Plos One. 2015 Apr 2
32 citations
Eliminating racial disparities in colorectal cancer in the real world: it took a village.
Stephen S. Grubbs, Blase N. Polite, John Carney, William Bowser, Jill Rogers, Nora Katurakes, Paula Hess, Electra D. Paskett> ;Delaware Medical Journal. 2014 Oct 1
6 citations
Managing cumulative expectations in oncology: challenges and potential solutions.
Amy P. Abernethy, Stephen S. Grubbs> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2014 May 15
13 citations
Ethical considerations for the clinical oncologist in an era of oncology drug shortages
Reshma Jagsi, Rebecca Spence, W. Kimryn Rathmell, Angela R. Bradbury, Jeffrey Peppercorn, Stephen S. Grubbs, Beverly Moy> ;The Oncologist. 2014 Feb 1
37 citations
Use of the National Cancer Institute Community Cancer Centers Program Screening and Accrual Log to Address Cancer Clinical Trial Accrual
Diane St Germain, Andrea M. Denicoff, Eileen Dimond, Angela Carrigan, Rebecca A. Enos, Maria M. Gonzalez, Kathy Wilkinson, Michelle A. Mathiason, Brenda Duggan, Shaun ...> ;Journal of Oncology Practice. 2014 Jan 14
107 citations
The National Cancer Institute-American Society of Clinical Oncology Cancer Trial Accrual Symposium: Summary and recommendations
Andrea Denicoff, Worta McCaskill-Stevens, Stephen S. Grubbs, Suanna S. Bruinooge, Robert L. Comis, Peggy Devine, David M. Dilts, Michelle E. Duff, Jean G. Ford, Steven...> ;Journal of Oncology Practice. 2013 Oct 15
95 citations
Eliminating Racial Disparities in Colorectal Cancer in the Real World: It Took a Village
Stephen S. Grubbs, Blase N. Polite, John Carney, William Bowser, Jill Rogers, Nora Katurakes, Paula Hess, Electra D. Paskett> ;Journal of Clinical Oncology. 2013 Jun 1
2 citations
The new national cancer institute national clinical trials network.
Stephen S. Grubbs> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2012 May 17
A statewide evaluation of adjuvant chemotherapy for stage III colon cancer.
Petrelli NJ, Grubbs SS, Spellman JE, English CL, Shevock A, Nunley K> ;J. Clin. Oncol.. 2011-05-20
Early success in narrowing age, gender, and racial disparities in clinical trial accrual: Targeted screening efforts through the National Cancer Institute Community Ca...
Grubbs SS, Go RS, Berger MZ, Gonzalez M, Thompson MA, Enos R, St Germain DC, Denicoff A, Servididio C, Bearden JD, Zaren H, Wilkinson K, Krasna M, McCaskill-Stevens W,...> ;J. Clin. Oncol.. 2011-05-20
Tracking clinical trial accrual strategies and barriers via a Web-based screening tool.
Grubbs SS, Gonzalez M, Krasna M, Siegel R, Bryant D, Tschetter L, Hayenga L, Duggan B, St Germaine D, Denicoff A> ;J. Clin. Oncol.. 2009-05-20
17 citations
Health-related Quality of Life in Long-Term Breast Cancer Survivors : Differences by Adjuvant Chemotherapy Dose in Cancer and Leukemia Group B Study 8541
Electra D. Paskett, James E. Herndon, Kathleen Donohue, Michelle J. Naughton, Stephen S. Grubbs, Michael D. Pavy, Martee L. Hensley, Nancy Stark, Alice B. Kornblith, M...> ;Cancer. 2009 Mar 1
13 citations
Clinical Trial Investigator Status: You Need to Earn It
Nicholas J. Petrelli, Stephen S. Grubbs, Kandie Price> ;Journal of Clinical Oncology. 2008 May 20
29 citations
Applying a conceptual model for examining health-related quality of life in long-term breast cancer survivors: CALGB study 79804.
Electra D. Paskett, James E. Herndon, Jeannette M. Day, Nancy Stark, Eric P. Winer, Stephen S. Grubbs, Michael D. Pavy, Charles L. Shapiro, Marcy A. List, Martee L. He...> ;Psycho-Oncology. 2008 Nov 1
Is it cost-effective to add erlotinib to gemcitabine in advanced pancreatic cancer?
Grubbs SS, Grusenmeyer PA, Petrelli NJ, Gralla RJ> ;J. Clin. Oncol.. 2006-06-20
A phase I study of pegylated doxorubicin (DOX) and weekly topotecan (TOP) in patients (pts) with advanced solid tumors.
Masters GA, Guarino M, Schneider C, Biggs D, Grubbs S> ;J. Clin. Oncol.. 2006-06-20
63 citations
Criterion Validity of Medicare Chemotherapy Claims in Cancer and Leukemia Group B Breast and Lung Cancer Trial Participants
Elizabeth B. Lamont, James E. Herndon, Jane C. Weeks, I. Craig Henderson, Rogerio Lilenbaum, Richard L. Schilsky, Nicholas A. Christakis, Lee S. Schwartzberg, Stephen ...> ;Journal of the National Cancer Institute. 2005 Jul 20
Barriers exist to patient participation in clinical trials.
Guarino MJ, Masters GA, Schneider CJ, Biggs DD, Grubbs SS, Himelstein AL, Martin SE, Michaels LM, Guarino AJ, Rejtos L> ;J. Clin. Oncol.. 2005-06-01
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Press Mentions

ASCO/COA Program Helping Practices With a Value-Based ModelOctober 27th, 2022
How Patient Navigators Are Closing Cancer Health Disparities in DelawareMarch 9th, 2022
Delaware Is Shrinking Racial Gaps in Cancer Death. Its Secret? Patient NavigatorsMarch 7th, 2022
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Grant Support

Delaware/Christiana Care CCOPNational Cancer Institute2007–2011
Delaware Christiana Care CCOPNational Cancer Institute2003–2006
Christiana Care CCOPNational Cancer Institute2002

Professional Memberships

American Society of Clinical Oncology - ASCO
Member

Hospital Affiliations

ChristianaCareNewark, Delaware