StephenRRussellMD

Ophthalmology • Iowa City, IA

Retinal Disease

Schrage Professor for Macular Degeneration University of Iowa

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Office
200 Hawkins Dr
Iowa City, IA 52242
Phone+1 319-356-8161

Fax+1 319-356-0363
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Education & Training

University of Iowa Hospitals and ClinicsResidency, Ophthalmology, 1986 - 1988
University of Miami/Jackson Health System/Bascom Palmer Eye InstituteResidency, Ophthalmology, 1983 - 1986
Los Angeles County-Harbor-UCLA Medical CenterInternship, Transitional Year, 1982 - 1983
David Geffen School of Medicine at UCLAClass of 1982

Certifications & Licensure

AZ State Medical License 1995 - Present
IA State Medical License 2019 - 2025
IA State Medical License 1986 - 2025
CA State Medical License 1983 - 2024
IL State Medical License 1988 - 2005
FL State Medical License 1983 - 1989
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2013
Fellow (FAAO) American Academy of Ophthalmology

Clinical Trials

Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis Start of enrollment: 2012 Oct 01
Active, not recruiting
Phase 3
Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene Start of enrollment: 2017 Oct 16
Completed
Phase 1, Phase 2

Publications & Presentations

PubMed

A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease.
Beau J Fenner, S Scott Whitmore, Adam P DeLuca, Jean L Andorf, Heather T Daggett, Meagan A Luse, Lorena M Haefeli, Janet B Riley, Douglas B Critser, Mark E Wilkinson, ...> ;Ophthalmology. 2024 Feb 1
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa.
Burnight, E., Wiley, L., Mullin, N., Adur, M., Lang, M., Cranston, C., Jiao, C., Sohn, E., Ross, J., Mullins, R., Tucker, B., Russell, S., Han, I., Stone, E.> ;The CRISPR Journal. 2023 Dec 1
Vitreoretinal Procedures in Patients with Inherited Retinal Disease.
Beau J Fenner, Farzad Jamshidi, Rupak Bhuyan, Christopher R Fortenbach, Haoxing D Jin, Timothy M Boyce, Elaine M Binkley, Ian C Han, Elliott H Sohn, H Culver Boldt, Ja...> ;Ophthalmology. Retina. 2024 Mar 1
2 citations
The Ocular Trauma Score Underestimates Visual Recovery for the Most Severe Open-Globe Injuries.
Eli A Perez, David A Ramirez, Jared D Peterson, Elaine M Binkley, H Culver Boldt, Karen M Gehrs, Ian C Han, Stephen R Russell, Elliott H Sohn, Scott A Larson, Jonathan...> ;Ophthalmology. Retina. 2023 Jul 1
9 citations
RNA-based therapies in inherited retinal diseases.
Aniz Girach, Isabelle Audo, David G Birch, Rachel M Huckfeldt, Byron L Lam, Bart P Leroy, Michel Michaelides, Stephen R Russell, Juliana M F Sallum, Katarina Stingl, P...> ;Therapeutic Advances in Ophthalmology. 2022 Nov 4
6 citations
Restoration of Cone Sensitivity to Individuals with Congenital Photoreceptor Blindness within the Phase 1/2 Sepofarsen Trial.
Artur V Cideciyan, Samuel G Jacobson, Allen C Ho, Arun K Krishnan, Alejandro J Roman, Alexandra V Garafalo, Vivian Wu, Malgorzata Swider, Alexander Sumaroka, Caroline ...> ;Ophthalmology Science. 2022 Jun 1
32 citations
Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial.
Stephen R Russell, Arlene V Drack, Artur V Cideciyan, Samuel G Jacobson, Bart P Leroy, Caroline Van Cauwenbergh, Allen C Ho, Alina V Dumitrescu, Ian C Han, Mitchell Ma...> ;Nature Medicine. 2022 May 1
1 citations
Intrafamilial variability of ocular manifestations of von Hippel-Lindau disease
Randy Christopher Bowen, H. Culver Boldt, Robert F. Mullins, Matthew G. Field, Louisa M. Affatigato, Jeremy M. Hoffmann, James C. Folk, Karen M. Gehrs, Ian C. Han, Ell...> ;Ophthalmology. Retina. 2021 Aug 18
3 citations
Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV).
Timothy M. Boyce, S. Scott Whitmore, Katayoun Varzavand, Stephen R. Russell, Elliott H. Sohn, James C. Folk, Edwin M. Stone, Ian C. Han> ;American Journal of Ophthalmology. 2022 Jan 1
11 citations
LEBER CONGENITAL AMAUROSIS DUE TO CEP290 MUTATIONS-SEVERE VISION IMPAIRMENT WITH A HIGH UNMET MEDICAL NEED: A Review.
Bart P. Leroy, David G. Birch, Jacque L. Duncan, Byron L. Lam, Robert K. Koenekoop, Fernanda Belga Ottoni Porto, Stephen R. Russell, Aniz Girach> ;Retina. 2021 May 1
7 citations
The effect of retinal scaffold modulus on performance during surgical handling.
Rion J. Wendland, Chunhua Jiao, Stephen R. Russell, Ian C. Han, Luke A Wiley, Budd A. Tucker, Elliott H. Sohn, Kristan S. Worthington> ;Experimental Eye Research. 2021 Apr 7
8 citations
Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography
Hasenin Al-khersan, Jonathan F. Russell, Thomas A. Lazzarini, Nathan L. Scott, John W. Hinkle, Nimesh A. Patel, Nicolas A. Yannuzzi, Benjamin J. Fowler, Rehan M. Hussa...> ;American Journal of Ophthalmology. 2021 Apr 1
64 citations
Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease: Phase 3 Results at 3 Years and 4 Years.
Albert M. Maguire, Stephen R. Russell, Daniel C. Chung, Zi-Fan Yu, Amy Tillman, Arlene V. Drack, Francesca Simonelli, Bart P. Leroy, Kathleen Z Reape, Katherine A. Hig...> ;Ophthalmology. 2021 Mar 30
5 citations
Genetic Association betweenand Choroidal Neovascularization in Age-Related Macular Degeneration.
Elliott H Sohn, Ian C Han, Benjamin R Roos, Benjamin Faga, Meagan A Luse, Elaine M Binkley, H Culver Boldt, James C Folk, Stephen R Russell, Robert F Mullins, John H F...> ;Ophthalmology Science. 2021 Mar 1
22 citations
Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats
Ian C. Han, Justine L Cheng, Erin R Burnight, Christy L Ralston, Jessica L Fick, Gabriella J Thomsen, Emilio F Tovar, Stephen R. Russell, Elliott H. Sohn, Robert F. Mu...> ;Human Gene Therapy. 2020 Dec 16
8 citations
Attaining functional levels of visual acuity after vitrectomy for retinal detachment secondary to proliferative diabetic retinopathy.
Aaron Ricca, Kiley Boone, H. Culver Boldt, Karen M. Gehrs, Stephen R. Russell, James C. Folk, M. Bridget Zimmerman, Mark E. Wilkinson, Elliott H. Sohn> ;Scientific Reports. 2020 Sep 24
15 citations
Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.
Ian C. Han, Erin R Burnight, Mallory J Ulferts, Kristan S. Worthington, Stephen R. Russell, Elliott H. Sohn, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker, Luke A ...> ;Human Gene Therapy. 2019 Sep 26
48 citations
Distribution of Diabetic Neovascularization on Ultra-Widefield Fluorescein Angiography and on Simulated Widefield OCT Angiography
Jonathan F. Russell, Harry W. Flynn, Jayanth Sridhar, Justin H. Townsend, Yingying Shi, Kenneth C. Fan, Nathan L. Scott, John W. Hinkle, Cancan Lyu, Giovanni Gregori, ...> ;American Journal of Ophthalmology. 2019 Nov 1
2 citations
A novel, wearable, electronic visual aid to assist those with reduced peripheral vision.
Ffion E. Brown, Janice Sutton, Ho Ming Yuen, Dylan Green, Spencer Van Dorn, Terry A. Braun, Angela J. Cree, Stephen R. Russell, Andrew J. Lotery> ;Plos One. 2019 Oct 15
17 citations
Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments
Brittni A. Scruggs, Chunhua Jiao, Cathryn M. Cranston, Emily E. Kaalberg, Kai Wang, Stephen R. Russell, Luke A Wiley, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker...> ;Stem Cells Translational Medicine. 2019 Aug 1
199 citations
Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials.
Albert M. Maguire, Stephen R. Russell, Jennifer Wellman, Daniel C. Chung, Zi-Fan Yu, Amy Tillman, Janet Wittes, Julie Pappas, Okan U. Elci, Kathleen A. Marshall, Sarah...> ;Ophthalmology. 2019 Jun 22
28 citations
Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.
Jessica R. Thompson, Kristan S. Worthington, Brian J. Green, Nathaniel K. Mullin, Chunhua Jiao, Emily E. Kaalberg, Luke A Wiley, Ian C. Han, Stephen R. Russell, Elliot...> ;Acta Biomaterialia. 2019 May 3
34 citations
Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17
Jeannette J. Yu, Elvira Agrón, Traci E. Clemons, Amitha Domalpally, Freekje van Asten, Tiarnan D L Keenan, Catherine A Cukras, Emily Y. Chew, Frederick L. Ferris, John...> ;Ophthalmology. 2019 Feb 1
114 citations
Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.
Tiarnan D L Keenan, Elvira Agrón, Amitha Domalpally, Traci E. Clemons, Freekje van Asten, Wai T. Wong, Ronald G. Danis, Srinivas R. Sadda, Philip J. Rosenfeld, Michael...> ;Ophthalmology. 2018 Dec 1
145 citations
Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect
Artur V. Cideciyan, Samuel G. Jacobson, Arlene V. Drack, Allen C. Ho, Jason Charng, Alexandra V. Garafalo, Alejandro J. Roman, Alexander Sumaroka, Ian C. Han, Maria D....> ;Nature Medicine. 2019 Feb 1
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Press Mentions

3-Year-Old Born Blind Sees for First Time Thanks to Groundbreaking ProcedureDecember 4th, 2018
Making HistorySeptember 1st, 2018
The American Academy of Ophthalmology, Nov. 11-14November 16th, 2017
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