Stephen D. Silberstein MD
Headache
Professor of Neurology; and Director, Jefferson Headache Center, at Thomas Jefferson University
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900 Walnut StPhiladelphia, PA 19107
Phone+1 215-955-2243
Fax+1 215-955-2060
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Education & Training
University of Pennsylvania Health SystemResidency, Neurology, 1972 - 1975- University of Pennsylvania Health SystemResidency, Internal Medicine, 1967 - 1969
Perelman School of Medicine at the University of PennsylvaniaClass of 1967
Certifications & Licensure
PA State Medical License 1968 - 2026
MD State Medical License 1971 - 2023
NJ State Medical License 1974 - 2019
American Board of Psychiatry and Neurology Neurology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification Centricity Practice Solution, GE Healthcare, 2013-2015
- Philadelphia Magazine Castle Connolly, 2004-2014
- America's Top Doctors Castle Connolly, 2004-2014
Clinical Trials
- An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster Headaches.
- Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache
- A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity
Publications & Presentations
PubMed
- Comparing synthetic and biological therapy for the treatment of cluster headache: what is needed and when?Brendan A Parr, William B Young, Stephen D Silberstein
Expert Review of Neurotherapeutics. 2026-07-23 - Novel optimization of multi-mechanistic approaches for the acute treatment of a migraine attack: A review.Stephen Silberstein, Alan M Rapoport
Headache. 2026-05-01 - 1 citationsPractice advisory for intravenous management of headache disorders in hospitalized patients: a review of the evidence and consensus recommendations.Yasmine Hoydonckx, Alexander Feoktistov, Farnaz Amoozegar, Christopher C Anderson, Meredith Barad
Regional Anesthesia and Pain Medicine. 2026-02-05
Journal Articles
- Health Care Resource Utilization and Migraine Disability Along the Migraine Continuum Among Patients Treated for MigraineStephen Silberstein, MD, Headache: The Journal of Head and Face Pain
Press Mentions
Epilepsy Drug 'Cures Migraine, Cuts Weight'July 12th, 2025- Can Central Vein Sign Distinguish Multiple Sclerosis from Its Most Common Mimic?March 20th, 2025
- What Will Be the Next Big Breakthrough in Migraine Research?May 13th, 2022
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