StevenAlanAkmanMD

Oncology • Varnville, SC

Professor, Internal Medicine, Bowman Gray School of Medicine of Wake Forest Univ

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Office
595 W Carolina Ave
Varnville, SC 29944
Phone+1 843-606-8250

Fax+1 843-958-2599
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Education & Training

Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1975 - 1977
Albert Einstein College of MedicineClass of 1975

Certifications & Licensure

CA State Medical License 1983 - Present
HI State Medical License 2019 - 2026
SC State Medical License 2012 - 2025
NC State Medical License 1995 - 2024
CO State Medical License 2020 - 2023
PA State Medical License 2019 - 2022
MD State Medical License 1980 - 1992
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Fruit and Vegetable Extracts in Treating Patients With Stage I-IV, Stage IVA/IVB Head and Neck Cancer Start of enrollment: 2004 Jan 01
Completed
Phase 2
Studying Urine and Blood Samples in Women With Newly Diagnosed Breast Cancer Start of enrollment: 1998 Nov 01
Completed
Tamoxifen Resistance in Women With Stage I, Stage II, Stage IIIA, or Stage IIIB Breast Cancer Start of enrollment: 2007 May 01
Terminated
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer Start of enrollment: 2014 Oct 03
Active, not recruiting
Phase 3
Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

4 citations
A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1.
Eric D. Routh, Steven D. Creacy, Peter E. Beerbower, Steven A. Akman, James P. Vaughn, Philip J. Smaldino> ;Journal of Visualized Experiments. 2017 Mar 18
17 citations
Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.
Julia Chifman, Seda Arat, Zhiyong Deng, Erica Lemler, James C. Pino, Leonard A. Harris, Michael A. Kochen, Carlos F. Lopez, Steven A. Akman, Frank M. Torti, Suzy V. To...> ;Plos Computational Biology. 2017 Feb 6
12 citations
Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Comple...
Philip J. Smaldino, Eric D. Routh, Jung H. Kim, Banabihari Giri, Steven D. Creacy, Roy R. Hantgan, Steven A. Akman, James P. Vaughn> ;Plos One. 2015 Jul 14
78 citations
Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
Jessica Swanner, Jade Mims, David L. Carroll, Steven A. Akman, Cristina M. Furdui, Suzy V. Torti, Ravi Singh> ;International Journal of Nanomedicine. 2015 Jun 11
22 citations
A phase II clinical trial of weekly paclitaxel and carboplatin in combination with panitumumab in metastatic triple negative breast cancer
S Cowherd, Lance D. Miller, Susan A. Melin, S Akman, Scott Isom, John Cole, Ashok K. Pullikuth, Julia Lawrence> ;Cancer Biology & Therapy. 2015 Apr 30
30 citations
Fatty Acid Metabolites in Rapidly Proliferating Breast Cancer
Joseph T. O'Flaherty, Rhonda E. Wooten, Michael P. Samuel, Michael J. Thomas, Edward A. Levine, L. Douglas Case, Steven A. Akman, Iris J. Edwards> ;Plos One. 2013 May 2
18 citations
Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer: a feasibility trial.
Julia Lawrence, Steven A. Akman, Susan A. Melin, L. Douglas Case, Gary G. Schwartz> ;Cancer Biology & Therapy. 2013 Apr 10
18 citations
The core control system of intracellular iron homeostasis: a mathematical model.
Julia Chifman, Ariel Kniss, P. Neupane, I. Williams, B. Leung, Zhiyong Deng, Pedro Mendes, Valerie Hower, Frank M. Torti, Steven A. Akman, Suzy V. Torti, Reinhard Laub...> ;Journal of Theoretical Biology. 2012 May 7
18 citations
Mutagenicity of Ochratoxin A and Its Hydroquinone Metabolite in the SupF Gene of the Mutation Reporter Plasmid Ps189
Steven A. Akman, Marissa Adams, Doug Case, Gyungse Park, Richard A. Manderville> ;Toxins. 2012 Apr 16
40 citations
Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro.
Cara F. Buchanan, Christopher S. Szot, Tia D. Wilson, Steven A. Akman, Linda J. Metheny-Barlow, John L. Robertson, Joseph W. Freeman, Marissa Nichole Rylander> ;Journal of Cellular Biochemistry. 2012 Apr 1
71 citations
Yin yang 1 plays an essential role in breast cancer and negatively regulates p27
Meimei Wan, Weiwei Huang, Timothy E. Kute, Lance D. Miller, Qiang Zhang, Heather Hatcher, Jingxuan Wang, Daniel B. Stovall, Gregory B. Russell, Paul Cao, Zhiyong Deng,...> ;The American Journal of Pathology. 2012 May 1
24 citations
Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy
Xuanfeng Ding, Ravi Singh, Andrew R. Burke, Heather Hatcher, John Olson, Robert A. Kraft, Michael Schmid, David L. Carroll, J. Daniel Bourland, Steven A. Akman, Frank ...> ;Nanomedicine. 2011 Oct 25
78 citations
Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1
Weiwei Huang, Philip J. Smaldino, Qiang Zhang, Lance D. Miller, Paul Cao, Kristin Stadelman, Meimei Wan, Banabihari Giri, Ming Lei, Yoshikuni Nagamine, James P. Vaughn...> ;Nucleic Acids Research. 2012 Feb 1
75 citations
Bioinformatics tools for cancer metabolomics
Grigoriy Blekherman, Reinhard Laubenbacher, Diego F. Cortes, Pedro Mendes, Frank M. Torti, Steven A. Akman, Suzy V. Torti, Vladimir Shulaev> ;Metabolomics. 2011 Jan 12
71 citations
G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA
Banabihari Giri, Philip J. Smaldino, Ryan G. Thys, Steven D. Creacy, Eric D. Routh, Roy R. Hantgan, Simon Lattmann, Yoshikuni Nagamine, Steven A. Akman, James P. Vaughn> ;Nucleic Acids Research. 2011 Sep 1
84 citations
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.
Simon Lattmann, Michael B. Stadler, James P. Vaughn, Steven A. Akman, Yoshikuni Nagamine> ;Nucleic Acids Research. 2011 Nov 1
Oral paricalcitol (19-nor-1,25-Dihydroxyvitamn D2) in women with metastatic breast cancer receiving taxanes or ixabepilone: A feasibility trial.
Lawrence J, Lovelace J, Akman SA, Melin SA, Case LD, Schwartz G> ;J. Clin. Oncol.. 2011-05-20
13 citations
Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress.
Diego F. Cortes, Wei Sha, Valerie Hower, Greg Blekherman, Reinhard Laubenbacher, Steven A. Akman, Suzy V. Torti, Vladimir Shulaev> ;Free Radical Biology & Medicine. 2011 Jun 1
101 citations
Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
Simon Lattmann, Banabihari Giri, James P. Vaughn, Steven A. Akman, Yoshikuni Nagamine> ;Nucleic Acids Research. 2010 Oct 1
64 citations
A systems biology view of cancer
Reinhard Laubenbacher, Valerie Hower, Abdul Salam Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti, Steven A. Akman> ;Biochimica Et Biophysica Acta. 2009 Dec 1
63 citations
A general map of iron metabolism and tissue-specific subnetworks
Valerie Hower, Pedro Mendes, Frank M. Torti, Reinhard Laubenbacher, Steven A. Akman, Vladmir Shulaev, Suzy V. Torti> ;Molecular Biosystems. 2009 Apr 16
138 citations
G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Act...
Steven D. Creacy, Eric D. Routh, Fumiko Iwamoto, Yoshikuni Nagamine, Steven A. Akman, James P. Vaughn> ;The Journal of Biological Chemistry. 2008 Dec 12
145 citations
Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
Tasha R. Smith, Edward A. Levine, Rita I. Freimanis, Steven A. Akman, Glenn O. Allen, Kimberly N. Hoang, Wen Liu-Mares, Jennifer J. Hu> ;Carcinogenesis. 2008 Nov 1
37 citations
Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin
Ewa Gajewski, Shikha Gaur, Steven A. Akman, Linda Matsumoto, Josephus N.A. van Balgooy, James H. Doroshow> ;Biochemical Pharmacology. 2007 Jun 15
15 citations
Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli
Dana C. Upton, Xueying Wang, Patrick Blans, Fred W. Perrino, James C. Fishbein, Steven A. Akman> ;Mutation Research. 2006 Jul 25
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Grant Support

North Carolina A&T University-Wake Forest Cancer Center Partnership (2 Of 2)National Cancer Institute2008–2011
North Carolina A&T University-Wake Forest Cancer Center Partnership (1of 2)National Cancer Institute2008–2011
Training Program In Cancer BiologyNational Cancer Institute2008
Molecular Epidemiology And Prevention Of Breast CancerNational Center For Research Resources2005–2006
Effects Of Fruit &Vegetable Extracts On Cancer MarkersNational Cancer Institute2004
N2 Alkyig Adducts--Mutations And Polymerase InteractionsNational Cancer Institute2001–2004
Mechanisms Of Oxidative Damage Induced P53 MutationsNational Cancer Institute1996–1998
Cccwfu Breast Cancer Research Program Planning GrantNational Cancer Institute1994
DNA Damage And Mutations Caused By Activated LeukocytesNational Cancer Institute1992–1994
Selenium-Dependent Glutathione Peroxidase In Human PlasmaNational Center For Research Resources1990

Professional Memberships

American Society of Clinical Oncology - ASCO
Member

Hospital Affiliations

Roper St. Francis Mount Pleasant HospitalMount Pleasant, South Carolina
Bon Secours St. Francis HospitalCharleston, South Carolina
Roper HospitalCharleston, South Carolina
Hampton Regional Medical CenterVarnville, South Carolina