StevenCBorkanMD

Nephrology • Boston, MA

Acute Renal Failure

Associate Professor of Medicine

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Office
650 Albany St
EBRC, Room #546
Boston, MA 02118
Phone+1 617-638-7330

Fax+1 617-638-7326
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Education & Training

Boston University Medical CenterFellowship, Nephrology, 1987 - 1989
University of ChicagoFellowship, Nephrology, 1985 - 1986
Michael Reese Hospital and Medical CenterResidency, Internal Medicine, 1980 - 1985
University of Cincinnati College of MedicineClass of 1980

Certifications & Licensure

MA State Medical License 1987 - 2025
IL State Medical License 1982 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

Intractable hyponatremia complicated by a reset osmostat: a case report.
Mohamed Hassan Kamel, Ashish Upadhyay, Steven C Borkan> ;Journal of Medical Case Reports. 2023 Jan 14
1 citations
Mechanisms of nucleophosmin (NPM)-mediated regulated cell death elucidated by Hsp70 during renal ischemia
Zhiyong Wang, Andrea Havasi, Aaron A Beeler, Steven C. Borkan> ;Apoptosis. 2021 Nov 11
Effective Medical Lecturing: Practice Becomes Theory: A Narrative Review.
Robert C. Lowe, Steven C. Borkan> ;Medical Science Educator. 2021 Jan 12
2 citations
T95 nucleophosmin phosphorylation as a novel mediator and marker of regulated cell death in acute kidney injury.
Zhiyong Wang, Mostafa Belghasem, Erdjan Salih, Joel M. Henderson, Andrea Havasi, Steven C. Borkan> ;American Journal of Physiology. Renal Physiology. 2020 Jul 20
19 citations
Cross organelle stress response disruption promotes gentamicin-induced proteotoxicity
Julia A. Yaglom, Leah N Huiting, Hui Feng, Joshua D. Campbell, Zhiyong Wang, Andrea Havasi, David R. Pimentel, Michael Y. Sherman, Steven C. Borkan> ;Cell Death & Disease. 2020 Apr 3
6 citations
Nucleophosmin Phosphorylation as a Diagnostic and Therapeutic Target for Ischemic AKI
Zhiyong Wang, Erdjan Salih, Ryan M Mulhern, Ramon G. Bonegio, Andrea Havasi, Steven C. Borkan> ;Journal of the American Society of Nephrology. 2019 Jan 1
1 citations
Correction for Wang et al., "Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death".
Zhiyong Wang, Jonathan M. Gall, Ramon G. Bonegio, Andrea Havasi, Katarina Illanes, John H. Schwartz, Steven C. Borkan> ;Molecular and Cellular Biology. 2017 Sep 12
5 citations
Blocking peptides and molecular mimicry as treatment for kidney disease
Andrea Havasi, Weining Lu, Herbert T. Cohen, Laurence H. Beck, Zhiyong Wang, Chinaemare Igwebuike, Steven C. Borkan> ;American Journal of Physiology. Renal Physiology. 2017 Jun 1
1 citations
Sodium–glucose cotransporter 2 inhibitors and euglycemic diabetic ketoacidosis: Metabolic acidosis with a twist
Aala Jaberi, Bhavna Seth, Devin Steenkamp, Sara M. Alexanian, Steven C. Borkan> ;Clinical Diabetes. 2016 Oct 1
32 citations
Proteinuria causes dysfunctional autophagy in the proximal tubule
Angela Nolin, Ryan M Mulhern, Maria V. Panchenko, Ana Pisarek-Horowitz, Zhiyong Wang, Orian S. Shirihai, Steven C. Borkan, Andrea Havasi> ;American Journal of Physiology. Renal Physiology. 2016 Dec 1
41 citations
The Role of BCL-2 Family Members in Acute Kidney Injury.
Steven C. Borkan> ;Seminars in Nephrology. 2016 May 1
39 citations
Conditional Knockout of Proximal Tubule Mitofusin 2 Accelerates Recovery and Improves Survival after Renal Ischemia
Jonathan M. Gall, Zhiyong Wang, Ramon G. Bonegio, Andrea Havasi, Marc Liesa, Pradheep Vemula, Steven C. Borkan> ;Journal of the American Society of Nephrology. 2015 May 1
29 citations
Recapturing time: a practical approach to time management for physicians
Craig E. Gordon, Steven C. Borkan> ;Postgraduate Medical Journal. 2014 May 1
19 citations
Nucleophosmin, a critical Bax cofactor in ischemia-induced cell death.
Zhiyong Wang, Jonathan M. Gall, Ramon G. Bonegio, Andrea Havasi, Katarina Illanes, John H. Schwartz, Steven C. Borkan> ;Molecular and Cellular Biology. 2013 May 15
51 citations
Role of Mitofusin 2 in the Renal Stress Response
Jonathan M. Gall, Zhiyong Wang, Marc Liesa, Anthony J.A. Molina, Andrea Havasi, John H. Schwartz, Orian S. Shirihai, Steven C. Borkan, Ramon G. Bonegio> ;Plos One. 2012 Jan 26
The Authors reply:.
Havasi, A., Borkan, S.C.> ;Kidney Int. 2011-11-01
457 citations
Apoptosis and acute kidney injury.
Andrea Havasi, Steven C. Borkan> ;Kidney International. 2011 Jul 1
65 citations
Induction of heat shock protein 70 inhibits ischemic renal injury
Zhiyong Wang, Jonathan M. Gall, Ramon G. Bonegio, Andrea Havasi, Clayton R. Hunt, Michael Y. Sherman, John H. Schwartz, Steven C. Borkan> ;Kidney International. 2011 Apr 2
53 citations
Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress
Jonathan M. Gall, Vincent Wong, David R. Pimental, Andrea Havasi, Zhiyong Wang, John G. Pastorino, Ramon G. Bonegio, John H. Schwartz, Steven C. Borkan> ;Kidney International. 2011 Jun 1
56 citations
HSP72 Inhibits Smad3 Activation and Nuclear Translocation in Renal Epithelial-to-Mesenchymal Transition
Yi Zhou, Haiping Mao, Shu Li, Shirong Cao, Zhijian Li, Shougang Zhuang, Jinjin Fan, Xiuqing Dong, Steven C. Borkan, Yihan Wang, Xueqing Yu> ;Journal of the American Society of Nephrology. 2010 Apr 1
85 citations
GSK3β Promotes Apoptosis after Renal Ischemic Injury
Zhiyong Wang, Andrea Havasi, Jonathan M. Gall, Ramon G. Bonegio, Zhijian Li, Haiping Mao, John H. Schwartz, Steven C. Borkan> ;Journal of the American Society of Nephrology. 2010 Feb 1
88 citations
β-Catenin Promotes Survival of Renal Epithelial Cells by Inhibiting Bax
Zhiyong Wang, Andrea Havasi, Jonathan M. Gall, Haiping Mao, John H. Schwartz, Steven C. Borkan> ;Journal of the American Society of Nephrology. 2009 Sep 1
16 citations
Hsp27 inhibits sublethal, Src-mediated renal epithelial cell injury.
Andrea Havasi, Zhiyong Wang, Jonathan M. Gall, Max Spaderna, Vikram Suri, Ellery Canlas, Jody L. Martin, John H. Schwartz, Steven C. Borkan> ;American Journal of Physiology. Renal Physiology. 2009 Jun 24
78 citations
HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy
Haiping Mao, Zhilian Li, Yi Zhou, Zhijian Li, Shougang Zhuang, Xin An, Baiyu Zhang, Wei Chen, Jing Nie, Zhiyong Wang, Steven C. Borkan, Yihan Wang, Xueqing Yu> ;American Journal of Physiology. Renal Physiology. 2008 Jul 1
161 citations
Hsp27 Inhibits Bax Activation and Apoptosis via a Phosphatidylinositol 3-Kinase-dependent Mechanism
Andrea Havasi, Zhijian Li, Zhiyong Wang, Jody L. Martin, Venugopal Botla, Kathleen L. Ruchalski, John H. Schwartz, Steven C. Borkan> ;The Journal of Biological Chemistry. 2008 May 2
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Lectures

Controversies in Internal Medicine 2012
Boston University School of Medicine Continuing Medical Education, Hilton Head Island, South Carolin - 5/7/2012

Press Mentions

MD/PhD Students Match to Outstanding Residency ProgramsMay 19th, 2023
Alumna Offers Advice to MD/PhD Students at Annual RetreatSeptember 21st, 2017

Grant Support

Cytoprotective Role Of HSP72 In Renal Cell InjuryNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2011
Cytoprotective Role Of HSP 72 In Renal Cell InjuryNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Retrograde Protein Transport In Renal Epithelial CellsNational Institute Of Diabetes And Digestive And Kidney Diseases1998–1999
Retrograde Protein Transport In Renal Epithelial CellsNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1997